Search Results - "Ward, George A." :: K.UTB vyhledávací portál

Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways

by Dittmann, Jessica, Haydn, Tinka, Metzger, Patrick, Ward, George A, Boerries, Melanie, Vogler, Meike, Fulda, Simone
Published in Cell death and differentiation (01.06.2020)

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ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth

by Ward, George A, Lewis, Edward J, Ahn, Jong Sook, Johnson, Christopher N, Lyons, John F, Martins, Vanessa, Munck, Joanne M, Rich, Sharna J, Smyth, Tomoko, Thompson, Neil T, Williams, Pamela A, Wilsher, Nicola E, Wallis, Nicola G, Chessari, Gianni
Published in Molecular cancer therapeutics (01.07.2018)

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Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X‑Linked Inhibitor of Apoptosis Protein (XIAP)

by Tamanini, Emiliano, Buck, Ildiko M, Chessari, Gianni, Chiarparin, Elisabetta, Day, James E. H, Frederickson, Martyn, Griffiths-Jones, Charlotte M, Hearn, Keisha, Heightman, Tom D, Iqbal, Aman, Johnson, Christopher N, Lewis, Edward J, Martins, Vanessa, Peakman, Torren, Reader, Michael, Rich, Sharna J, Ward, George A, Williams, Pamela A, Wilsher, Nicola E
Published in Journal of medicinal chemistry (08.06.2017)

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Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP

by Chessari, Gianni, Buck, Ildiko M, Day, James E. H, Day, Philip J, Iqbal, Aman, Johnson, Christopher N, Lewis, Edward J, Martins, Vanessa, Miller, Darcey, Reader, Michael, Rees, David C, Rich, Sharna J, Tamanini, Emiliano, Vitorino, Marc, Ward, George A, Williams, Pamela A, Williams, Glyn, Wilsher, Nicola E, Woolford, Alison J.-A
Published in Journal of medicinal chemistry (27.08.2015)

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A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660)

by Johnson, Christopher N, Ahn, Jong Sook, Buck, Ildiko M, Chiarparin, Elisabetta, Day, James E H, Hopkins, Anna, Howard, Steven, Lewis, Edward J, Martins, Vanessa, Millemaggi, Alessia, Munck, Joanne M, Page, Lee W, Peakman, Torren, Reader, Michael, Rich, Sharna J, Saxty, Gordon, Smyth, Tomoko, Thompson, Neil T, Ward, George A, Williams, Pamela A, Wilsher, Nicola E, Chessari, Gianni
Published in Journal of medicinal chemistry (23.08.2018)

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Epigenetic priming by hypomethylation enhances the immunogenic potential of tolinapant in T-cell lymphoma

by Ward, George A, Zhang, Zhiqiang, Jueliger, Simone, Potapov, Ilya S, Davis, Matthew P, Boxall, Adam R, Taylor, Jason, Keer, Harold, Biondo, Andrea, Lyons, John F, Sims, Martin, Smyth, Tomoko
Published in Cancer research communications (06.06.2024)

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PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy

by Armstrong, Chris W D, Maxwell, Pamela J, Ong, Chee Wee, Redmond, Kelly M, McCann, Christopher, Neisen, Jessica, Ward, George A, Chessari, Gianni, Johnson, Christopher, Crawford, Nyree T, LaBonte, Melissa J, Prise, Kevin M, Robson, Tracy, Salto-Tellez, Manuel, Longley, Daniel B, Waugh, David J J
Published in Oncotarget (16.02.2016)

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Small Interfering RNA-Mediated Knockdown of Notch Ligands in Primary CD4+ T Cells and Dendritic Cells Enhances Cytokine Production

by Stallwood, Yvette, Briend, Emmanuel, Ray, Katrina M, Ward, George A, Smith, Beverley J, Nye, Emma, Champion, Brian R, McKenzie, Grahame J
Published in The Journal of immunology (1950) (15.07.2006)

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Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor- α inhibitor

by Clements, John M, Cossins, Judy A, Wells, Graham M.A, Corkill, Dominic J, Helfrich, Karen, Wood, L.Mike, Pigott, Rod, Stabler, Gary, Ward, George A, Gearing, Andrew J.H, Miller, Karen M
Published in Journal of neuroimmunology (01.04.1997)

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Stringent Chemical and Thermal Regulation of Recombinant Gene Expression by Vaccinia Virus Vectors in Mammalian Cells

by Ward, George A., Stover, C. Kendall, Moss, Bernard, Fuerst, Thomas R.
Published in Proceedings of the National Academy of Sciences - PNAS (18.07.1995)

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Tolinapant, a Non-Peptidomimetic Antagonist of Inhibitors of Apoptosis Proteins, cIAP1/2 and XIAP, in Combination with the Hypomethylating Agents, Azacytidine and Decitabine Are Highly Synergistic in in Vitro Models of T Cell Lymphoma

by Manavalan, John Sanil, Pal, Ipsita, Pursley, Aidan, Ward, George A., Smyth, Tomoko, Sims, Martin, Taylor, Jason A., Feith, David J, Loughran, Thomas P., O'Connor, Owen A., Marchi, Enrica
Published in Blood (15.11.2022)

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Tolinapant (ASTX660), a Non-Peptidomimetic Antagonist of cIAP1/2 and XIAP, and the HDAC Inhibitor Romidepsin Are Synergistic in in Vitro Models of T Cell Lymphoma

by Manavalan, John S, Pal, Ipsita, Pursley, Aidan, Ward, George A., Smyth, Tomoko, Sims, Martin, Feith, David J, Loughran, Thomas P., O'Connor, Owen A., Marchi, Enrica
Published in Blood (23.11.2021)

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Combining the IAP Antagonist Tolinapant with a DNA Hypomethylating Agent Enhances Immunogenic Cell Death in Preclinical Models of T-Cell Lymphoma

by Ward, George A., Jueliger, Simone, Sims, Martin, Davis, Matthew, Boxall, Adam, Saini, Harpreet, Taylor, Jason A., Biondo, Andrea, Lyons, John F., Smyth, Tomoko
Published in Blood (23.11.2021)

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A Fragment-Derived Clinical Candidate for Antagonism of X‑Linked and Cellular Inhibitor of Apoptosis Proteins: 1‑(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl‑1H,2H,3H‑pyrrolo[3,2‑b]pyridin-1-yl)-2-[(2R,5R)‑5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660)

by Johnson, Christopher N., Ahn, Jong Sook, Buck, Ildiko M., Chiarparin, Elisabetta, Day, James E. H., Hopkins, Anna, Howard, Steven, Lewis, Edward J., Martins, Vanessa, Millemaggi, Alessia, Munck, Joanne M., Page, Lee W., Peakman, Torren, Reader, Michael, Rich, Sharna J., Saxty, Gordon, Smyth, Tomoko, Thompson, Neil T., Ward, George A., Williams, Pamela A., Wilsher, Nicola E., Chessari, Gianni
Published in Journal of medicinal chemistry (23.08.2018)

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Stereochemistry of phenylpalladation of cyclohexene

by Henry, Patrick M, Ward, George A
Published in Journal of the American Chemical Society (01.01.1972)

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Small Interfering RNA-Mediated Knockdown of Notch Ligands in Primary CD4 super(+) T Cells and Dendritic Cells Enhances Cytokine Production

by Stallwood, Yvette, Briend, Emmanuel, Ray, Katrina M, Ward, George A, Smith, Beverley J, Nye, Emma, Champion, Brian R, McKenzie, Grahame J
Published in Journal of Immunology (01.07.2006)

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