CRISPR/Cas9-Induced (CTG⋅CAG)n Repeat Instability in the Myotonic Dystrophy Type 1 Locus: Implications for Therapeutic Genome Editing
van Agtmaal, Ellen L., André, Laurène M., Willemse, Marieke, Cumming, Sarah A., van Kessel, Ingeborg D.G., van den Broek, Walther J.A.A., Gourdon, Geneviève, Furling, Denis, Mouly, Vincent, Monckton, Darren G., Wansink, Derick G., Wieringa, Bé
Published in Molecular therapy (04.01.2017)
Published in Molecular therapy (04.01.2017)
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Differentiation shifts from a reversible to an irreversible heterochromatin state at the DM1 locus
Handal, Tayma, Juster, Sarah, Abu Diab, Manar, Yanovsky-Dagan, Shira, Zahdeh, Fouad, Aviel, Uria, Sarel-Gallily, Roni, Michael, Shir, Bnaya, Ester, Sebban, Shulamit, Buganim, Yosef, Drier, Yotam, Mouly, Vincent, Kubicek, Stefan, van den Broek, Walther J. A. A., Wansink, Derick G., Epsztejn-Litman, Silvina, Eiges, Rachel
Published in Nature communications (16.04.2024)
Published in Nature communications (16.04.2024)
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CRISPR/Cas Applications in Myotonic Dystrophy: Expanding Opportunities
Raaijmakers, Renée H L, Ripken, Lise, Ausems, C Rosanne M, Wansink, Derick G
Published in International journal of molecular sciences (27.07.2019)
Published in International journal of molecular sciences (27.07.2019)
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Journal Article
Block or degrade? Balancing on- and off-target effects of antisense strategies against transcripts with expanded triplet repeats in DM1
El Boujnouni, Najoua, van der Bent, M. Leontien, Willemse, Marieke, ’t Hoen, Peter A.C., Brock, Roland, Wansink, Derick G.
Published in Molecular therapy. Nucleic acids (13.06.2023)
Published in Molecular therapy. Nucleic acids (13.06.2023)
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Journal Article
Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy
Mulders, Susan A.M, van den Broek, Walther J.A.A, Wheeler, Thurman M, Croes, Huib J.E, van Kuik-Romeijn, Petra, de Kimpe, Sjef J, Furling, Denis, Platenburg, Gerard J, Gourdon, Geneviève, Thornton, Charles A, Wieringa, Bé, Wansink, Derick G
Published in Proceedings of the National Academy of Sciences - PNAS (18.08.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (18.08.2009)
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Ameliorated cellular hallmarks of myotonic dystrophy in hybrid myotubes from patient and unaffected donor cells
Raaijmakers, Renée H L, Ausems, C Rosanne M, Willemse, Marieke, Cumming, Sarah A, van Engelen, Baziel G M, Monckton, Darren G, van Bokhoven, Hans, Wansink, Derick G
Published in Stem cell research & therapy (15.09.2024)
Published in Stem cell research & therapy (15.09.2024)
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Journal Article
Assisted delivery of antisense therapeutics in animal models of heritable neurodegenerative and neuromuscular disorders: a systematic review and meta-analysis
van der Bent, M. Leontien, Paulino da Silva Filho, Omar, van Luijk, Judith, Brock, Roland, Wansink, Derick G.
Published in Scientific reports (08.03.2018)
Published in Scientific reports (08.03.2018)
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Human male meiotic sex chromosome inactivation
de Vries, Marieke, Vosters, Sanne, Merkx, Gerard, D'Hauwers, Kathleen, Wansink, Derick G, Ramos, Liliana, de Boer, Peter
Published in PloS one (15.02.2012)
Published in PloS one (15.02.2012)
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Journal Article
Cell membrane integrity in myotonic dystrophy type 1: implications for therapy
González-Barriga, Anchel, Kranzen, Julia, Croes, Huib J E, Bijl, Suzanne, van den Broek, Walther J A A, van Kessel, Ingeborg D G, van Engelen, Baziel G M, van Deutekom, Judith C T, Wieringa, Bé, Mulders, Susan A M, Wansink, Derick G
Published in PloS one (23.03.2015)
Published in PloS one (23.03.2015)
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Abnormalities in Skeletal Muscle Myogenesis, Growth, and Regeneration in Myotonic Dystrophy
André, Laurène M, Ausems, C Rosanne M, Wansink, Derick G, Wieringa, Bé
Published in Frontiers in neurology (28.05.2018)
Published in Frontiers in neurology (28.05.2018)
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Certainty-based marking in a formative assessment improves student course appreciation but not summative examination scores
Hendriks, Wiljan J A J, Bakker, Nicole, Pluk, Helma, de Brouwer, Arjan, Wieringa, Bé, Cambi, Alessandra, Zegers, Mirjam, Wansink, Derick G, Leunissen, Ron, Klaren, Peter H M
Published in BMC medical education (31.05.2019)
Published in BMC medical education (31.05.2019)
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Journal Article
Design and Analysis of Effects of Triplet Repeat Oligonucleotides in Cell Models for Myotonic Dystrophy
González-Barriga, Anchel, Mulders, Susan AM, van de Giessen, Jeroen, Hooijer, Jeroen D, Bijl, Suzanne, van Kessel, Ingeborg DG, van Beers, Josee, van Deutekom, Judith CT, Fransen, Jack AM, Wieringa, Bé, Wansink, Derick G
Published in Molecular therapy. Nucleic acids (01.03.2013)
Published in Molecular therapy. Nucleic acids (01.03.2013)
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Journal Article
A tail-anchored myotonic dystrophy protein kinase isoform induces perinuclear clustering of mitochondria, autophagy, and apoptosis
Oude Ophuis, Ralph J A, Wijers, Mietske, Bennink, Miranda B, van de Loo, Fons A J, Fransen, Jack A M, Wieringa, Bé, Wansink, Derick G
Published in PloS one (25.11.2009)
Published in PloS one (25.11.2009)
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Gene duplication and conversion events shaped three homologous, differentially expressed myosin regulatory light chain (MLC2) genes
Gerrits, Lieke, Overheul, Gijs J., Derks, Ronny C., Wieringa, Bé, Hendriks, Wiljan J.A.J., Wansink, Derick G.
Published in European journal of cell biology (01.08.2012)
Published in European journal of cell biology (01.08.2012)
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Abnormal actomyosin assembly in proliferating and differentiating myoblasts upon expression of a cytosolic DMPK isoform
Mulders, Susan A.M., van Horssen, Remco, Gerrits, Lieke, Bennink, Miranda B., Pluk, Helma, de Boer-van Huizen, Roelie T., Croes, Huib J.E., Wijers, Mietske, van de Loo, Fons A.J., Fransen, Jack, Wieringa, Bé, Wansink, Derick G.
Published in Biochimica et biophysica acta (01.05.2011)
Published in Biochimica et biophysica acta (01.05.2011)
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Journal Article
The nuclear concentration required for antisense oligonucleotide activity in myotonic dystrophy cells
van der Bent, M Leontien, Paulino da Silva Filho, Omar, Willemse, Marieke, Hällbrink, Mattias, Wansink, Derick G, Brock, Roland
Published in The FASEB journal (01.10.2019)
Published in The FASEB journal (01.10.2019)
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