3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration
Wang, Hongbing, Brown, Paul C., Chow, Edwin C.Y., Ewart, Lorna, Ferguson, Stephen S., Fitzpatrick, Suzanne, Freedman, Benjamin S., Guo, Grace L., Hedrich, William, Heyward, Scott, Hickman, James, Isoherranen, Nina, Li, Albert P., Liu, Qi, Mumenthaler, Shannon M., Polli, James, Proctor, William R., Ribeiro, Alexandre, Wang, Jian‐Ying, Wange, Ronald L., Huang, Shiew‐Mei
Published in Clinical and translational science (01.09.2021)
Published in Clinical and translational science (01.09.2021)
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FDA and industry collaboration: Identifying opportunities to further reduce reliance on nonhuman primates for nonclinical safety evaluations
Ackley, David, Birkebak, Joanne, Blumel, Jorg, Bourcier, Todd, de Zafra, Christina, Goodwin, Andrew, Halpern, Wendy, Herzyk, Danuta, Kronenberg, Sven, Mauthe, Robert, Shenton, Jacintha, Shuey, Dana, Wange, Ronald L.
Published in Regulatory toxicology and pharmacology (01.02.2023)
Published in Regulatory toxicology and pharmacology (01.02.2023)
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Exploring rabbit as a nonrodent species for general toxicology studies
Sokolowski, Katie, Turner, Patricia V, Lewis, Elise, Wange, Ronald L, Fortin, Marie C
Published in Toxicological sciences (29.04.2024)
Published in Toxicological sciences (29.04.2024)
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An FDA/CDER perspective on nonclinical testing strategies: Classical toxicology approaches and new approach methodologies (NAMs)
Avila, Amy M., Bebenek, Ilona, Bonzo, Jessica A., Bourcier, Todd, Davis Bruno, Karen L., Carlson, David B., Dubinion, John, Elayan, Ikram, Harrouk, Wafa, Lee, Shwu-Luan, Mendrick, Donna L., Merrill, Jill C., Peretz, Jackye, Place, Emily, Saulnier, Muriel, Wange, Ronald L., Yao, Jia, Zhao, Dong, Brown, Paul C.
Published in Regulatory toxicology and pharmacology (01.07.2020)
Published in Regulatory toxicology and pharmacology (01.07.2020)
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Weight of Evidence: Is an Animal Study Warranted? Assessments for Carcinogenicity, Drug Abuse Liability, and Pediatric Safety
Ramani, Thulasi, Wange, Ronald L, Manetz, T Scott, Kruzich, Paul J, Laffan, Susan B, Compton, David R
Published in International journal of toxicology (01.10.2024)
Published in International journal of toxicology (01.10.2024)
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PTEN permits acute increases in D3‐phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt
Seminario, Maria‐Cristina, Precht, Patricia, Bunnell, Stephen C., Warren, Sarah E., Morris, Christa M., Taub, Dennis, Wange, Ronald L.
Published in European journal of immunology (01.11.2004)
Published in European journal of immunology (01.11.2004)
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Kinase-Independent Functions for Itk in TCR-Induced Regulation of Vav and the Actin Cytoskeleton
Dombroski, Derek, Houghtling, Richard A, Labno, Christine M, Precht, Patricia, Takesono, Aya, Caplen, Natasha J, Billadeau, Daniel D, Wange, Ronald L, Burkhardt, Janis K, Schwartzberg, Pamela L
Published in The Journal of immunology (1950) (01.02.2005)
Published in The Journal of immunology (1950) (01.02.2005)
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Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation
Shan, Xiaochuan, Czar, Michael J., Bunnell, Stephen C., Liu, Pinghu, Liu, Yusen, Schwartzberg, Pamela L., Wange, Ronald L.
Published in Molecular and Cellular Biology (01.09.2000)
Published in Molecular and Cellular Biology (01.09.2000)
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ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists
Madrenas, Joaquín, Wange, Ronald L., Wang, Jennifer L., Isakov, Noah, Samelson, Lawrence E., Germain, Ronald N.
Published in Science (American Association for the Advancement of Science) (27.01.1995)
Published in Science (American Association for the Advancement of Science) (27.01.1995)
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Genetic Evidence for Differential Coupling of Syk Family Kinases to the T-Cell Receptor: Reconstitution Studies in a ZAP-70-Deficient Jurkat T-Cell Line
Williams, Brandi L., Schreiber, Kathy L., Zhang, Weiguo, Wange, Ronald L., Samelson, Lawrence E., Leibson, Paul J., Abraham, Robert T.
Published in Molecular and Cellular Biology (01.03.1998)
Published in Molecular and Cellular Biology (01.03.1998)
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Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN
Gao, Ping, Wange, Ronald L., Zhang, Ning, Oppenheim, Joost J., Howard, O. M. Zack
Published in Blood (15.10.2005)
Published in Blood (15.10.2005)
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