Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor
Zheng, Barbara, D’Andrea, Stanley V, Sun, Li-Qiang, Wang, Alan Xiangdong, Chen, Yan, Hrnciar, Peter, Friborg, Jacques, Falk, Paul, Hernandez, Dennis, Yu, Fei, Sheaffer, Amy K, Knipe, Jay O, Mosure, Kathy, Rajamani, Ramkumar, Good, Andrew C, Kish, Kevin, Tredup, Jeffrey, Klei, Herbert E, Paruchuri, Manjula, Ng, Alicia, Gao, Qi, Rampulla, Richard A, Mathur, Arvind, Meanwell, Nicholas A, McPhee, Fiona, Scola, Paul M
Published in ACS medicinal chemistry letters (08.02.2018)
Published in ACS medicinal chemistry letters (08.02.2018)
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Potent Long-Acting Inhibitors Targeting the HIV‑1 Capsid Based on a Versatile Quinazolin-4-one Scaffold
Gillis, Eric P., Parcella, Kyle, Bowsher, Michael, Cook, James H., Iwuagwu, Christiana, Naidu, B. Narasimhulu, Patel, Manoj, Peese, Kevin, Huang, Haichang, Valera, Lourdes, Wang, Chunfu, Kieltyka, Kasia, Parker, Dawn D., Simmermacher, Jean, Arnoult, Eric, Nolte, Robert T., Wang, Liping, Bender, John A., Frennesson, David B., Saulnier, Mark, Wang, Alan Xiangdong, Meanwell, Nicholas A., Belema, Makonen, Hanumegowda, Umesh, Jenkins, Susan, Krystal, Mark, Kadow, John F., Cockett, Mark, Fridell, Robert
Published in Journal of medicinal chemistry (09.02.2023)
Published in Journal of medicinal chemistry (09.02.2023)
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Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection
Scola, Paul M., Wang, Alan Xiangdong, Good, Andrew C., Sun, Li-Qiang, Combrink, Keith D., Campbell, Jeffrey A., Chen, Jie, Tu, Yong, Sin, Ny, Venables, Brian L., Sit, Sing-Yuen, Chen, Yan, Cocuzza, Anthony, Bilder, Donna M., D’Andrea, Stanley, Zheng, Barbara, Hewawasam, Piyasena, Ding, Min, Thuring, Jan, Li, Jianqing, Hernandez, Dennis, Yu, Fei, Falk, Paul, Zhai, Guangzhi, Sheaffer, Amy K., Chen, Chaoqun, Lee, Min S., Barry, Diana, Knipe, Jay O., Li, Wenying, Han, Yong-Hae, Jenkins, Susan, Gesenberg, Christoph, Gao, Qi, Sinz, Michael W., Santone, Kenneth S., Zvyaga, Tatyana, Rajamani, Ramkumar, Klei, Herbert E., Colonno, Richard J., Grasela, Dennis M., Hughes, Eric, Chien, Caly, Adams, Stephen, Levesque, Paul C., Li, Danshi, Zhu, Jialong, Meanwell, Nicholas A., McPhee, Fiona
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection
Scola, Paul M., Sun, Li-Qiang, Wang, Alan Xiangdong, Chen, Jie, Sin, Ny, Venables, Brian L., Sit, Sing-Yuen, Chen, Yan, Cocuzza, Anthony, Bilder, Donna M., D’Andrea, Stanley V., Zheng, Barbara, Hewawasam, Piyasena, Tu, Yong, Friborg, Jacques, Falk, Paul, Hernandez, Dennis, Levine, Steven, Chen, Chaoqun, Yu, Fei, Sheaffer, Amy K., Zhai, Guangzhi, Barry, Diana, Knipe, Jay O., Han, Yong-Hae, Schartman, Richard, Donoso, Maria, Mosure, Kathy, Sinz, Michael W., Zvyaga, Tatyana, Good, Andrew C., Rajamani, Ramkumar, Kish, Kevin, Tredup, Jeffrey, Klei, Herbert E., Gao, Qi, Mueller, Luciano, Colonno, Richard J., Grasela, Dennis M., Adams, Stephen P., Loy, James, Levesque, Paul C., Sun, Huabin, Shi, Hong, Sun, Lucy, Warner, William, Li, Danshi, Zhu, Jialong, Meanwell, Nicholas A., McPhee, Fiona
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor
Venables, Brian L., Sin, Ny, Wang, Alan Xiangdong, Sun, Li-Qiang, Tu, Yong, Hernandez, Dennis, Sheaffer, Amy, Lee, Min, Dunaj, Cindy, Zhai, Guangzhi, Barry, Diana, Friborg, Jacques, Yu, Fei, Knipe, Jay, Sandquist, Jason, Falk, Paul, Parker, Dawn, Good, Andrew C., Rajamani, Ramkumar, McPhee, Fiona, Meanwell, Nicholas A., Scola, Paul M.
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
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Journal Article
HEPATITIS C VIRUS INHIBITORS
SIN NY, SCOLA PAUL MICHAEL, HEWAWASAM PIYASENA, CHEN YAN, SUN LI QUANG, SIT SING YUEN, GOOD ANDREW CHARLES, WANG XIANGDONG ALAN, CAMPBELL JEFFREY ALLEN
Year of Publication 24.08.2010
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Year of Publication 24.08.2010
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Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing
Sun, Li-Qiang, Mull, Eric, Zheng, Barbara, D’Andrea, Stanley, Zhao, Qian, Wang, Alan Xiangdong, Sin, Ny, Venables, Brian L, Sit, Sing-Yuen, Chen, Yan, Chen, Jie, Cocuzza, Anthony, Bilder, Donna M, Mathur, Arvind, Rampulla, Richard, Chen, Bang-Chi, Palani, Theerthagiri, Ganesan, Sivakumar, Arunachalam, Pirama Nayagam, Falk, Paul, Levine, Steven, Chen, Chaoqun, Friborg, Jacques, Yu, Fei, Hernandez, Dennis, Sheaffer, Amy K, Knipe, Jay O, Han, Yong-Hae, Schartman, Richard, Donoso, Maria, Mosure, Kathy, Sinz, Michael W, Zvyaga, Tatyana, Rajamani, Ramkumar, Kish, Kevin, Tredup, Jeffrey, Klei, Herbert E, Gao, Qi, Ng, Alicia, Mueller, Luciano, Grasela, Dennis M, Adams, Stephen, Loy, James, Levesque, Paul C, Sun, Huabin, Shi, Hong, Sun, Lucy, Warner, William, Li, Danshi, Zhu, Jialong, Wang, Ying-Kai, Fang, Hua, Cockett, Mark I, Meanwell, Nicholas A, McPhee, Fiona, Scola, Paul M
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
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Journal Article
Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus
Wang, Alan Xiangdong, Chen, Jie, Zhao, Qian, Sun, Li-Qiang, Friborg, Jacques, Yu, Fei, Hernandez, Dennis, Good, Andrew C., Klei, Herbert E., Rajamani, Ramkumar, Mosure, Kathy, Knipe, Jay O., Li, Danshi, Zhu, Jialong, Levesque, Paul C., McPhee, Fiona, Meanwell, Nicholas A., Scola, Paul M.
Published in Bioorganic & medicinal chemistry letters (01.02.2017)
Published in Bioorganic & medicinal chemistry letters (01.02.2017)
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Improved Synthesis of 1-Chloro-6-methoxy-isoquinolin-3-ol and Its Derivatives
Zheng, Zhizhen Barbara, Wang, Alan Xiangdong, Scola, Paul, D'Andrea, Stanley
Published in Synthetic communications (10.03.2009)
Published in Synthetic communications (10.03.2009)
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Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity
Wang, Xiangdong Alan, Cianci, Christopher W., Yu, Kuo-Long, Combrink, Keith D., Thuring, Jan W., Zhang, Yi, Civiello, Rita L., Kadow, Kathleen F., Roach, Julia, Li, Zhufang, Langley, David R., Krystal, Mark, Meanwell, Nicholas A.
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo
Yu, Kuo-Long, Wang, Xiangdong Alan, Civiello, Rita L., Trehan, Ashok K., Pearce, Bradley C., Yin, Zhiwei, Combrink, Keith D., Gulgeze, H. Belgin, Zhang, Yi, Kadow, Kathleen F., Cianci, Christopher W., Clarke, Junius, Genovesi, Eugene V., Medina, Ivette, Lamb, Lucinda, Wyde, Philip R., Krystal, Mark, Meanwell, Nicholas A.
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives
YU, Kuo-Long, YI ZHANG, CIANCI, Christopher W, KRYSTAL, Mark, MEANWELL, Nicholas A, CIVIELLO, Rita L, TREHAN, A. Ashok K, PEARCE, Bradley C, ZHIWEI YIN, COMBRINK, Keith D, GULGEZE, H. Belgin, WANG, Xiangdong Alan, KADOW, Kathleen F
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
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Year of Publication 24.01.2024
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Year of Publication 23.12.2021
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