Search Results - "Wang, Ellen Q" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Results of Bococizumab, A Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9, from a Randomized, Placebo-Controlled, Dose-Ranging Study in Statin-Treated Subjects With Hypercholesterolemia

Results of Bococizumab, A Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9, from a Randomized, Placebo-Controlled, Dose-Ranging Study in Statin-Treated Subjects With Hypercholesterolemia

by Ballantyne, Christie M., MD, Neutel, Joel, MD, Cropp, Anne, PharmD, Duggan, William, PhD, Wang, Ellen Q., PhD, Plowchalk, David, PhD, Sweeney, Kevin, PhD, Kaila, Nitin, PhD, Vincent, John, MD, PhD, Bays, Harold, MD
Published in The American journal of cardiology (01.05.2015)

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Population PK/PD modeling of low‐density lipoprotein cholesterol response in hypercholesterolemic participants following administration of bococizumab, a potent anti‐PCSK9 monoclonal antibody

Population PK/PD modeling of low‐density lipoprotein cholesterol response in hypercholesterolemic participants following administration of bococizumab, a potent anti‐PCSK9 monoclonal antibody

by Wang, Ellen Q., Kaila, Nitin, Plowchalk, David, Gibiansky, Leonid, Yunis, Carla, Sweeney, Kevin
Published in CPT: pharmacometrics and systems pharmacology (01.12.2023)

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Genome-wide pharmacogenetics of anti-drug antibody response to bococizumab highlights key residues in HLA DRB1 and DQB1

Genome-wide pharmacogenetics of anti-drug antibody response to bococizumab highlights key residues in HLA DRB1 and DQB1

by Chasman, Daniel I, Hyde, Craig L, Giulianini, Franco, Danning, Rebecca D, Wang, Ellen Q, Hickling, Timothy, Ridker, Paul M, Loomis, A Katrina
Published in Scientific reports (11.03.2022)

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MET Receptor Sequence Variants R970C and T992I Lack Transforming Capacity

MET Receptor Sequence Variants R970C and T992I Lack Transforming Capacity

by TYNER, Jeffrey W, FLETCHER, Luke B, LORIAUX, Marc M, WANG, Ellen Q, YANG, Wayne F, RUTENBERG-SCHOENBERG, Michael L, BEADLING, Carol, MORI, Motomi, HEINRICH, Michael C, DEININGER, Michael W, DRUKER, Brian J
Published in Cancer research (Chicago, Ill.) (01.08.2010)

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Effects of Hepatic Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites

Effects of Hepatic Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites

by Wang, Ellen Q., Le, Vu, O'Gorman, Melissa, Tripathy, Sakambari, Dowty, Martin E., Wang, Lisy, Malhotra, Bimal K.
Published in Journal of clinical pharmacology (01.10.2021)

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Effects of Renal Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites

Effects of Renal Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites

by Wang, Ellen Q., Le, Vu, Winton, Jennifer A., Tripathy, Sakambari, Raje, Sangeeta, Wang, Lisy, Dowty, Martin E., Malhotra, Bimal K.
Published in Journal of clinical pharmacology (01.04.2022)

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A Phase Ib First-In-Patient Study Assessing the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Ponsegromab in Participants with Cancer and Cachexia

A Phase Ib First-In-Patient Study Assessing the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Ponsegromab in Participants with Cancer and Cachexia

by Crawford, Jeffrey, Calle, Roberto A, Collins, Susie M, Weng, Yan, Lubaczewski, Shannon L, Buckeridge, Clare, Wang, Ellen Q, Harrington, Magdalena A, Tarachandani, Anil, Rossulek, Michelle I, Revkin, James H
Published in Clinical cancer research (01.02.2024)

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Pharmacokinetics and pharmacodynamics of bococizumab, a monoclonal antibody to PCSK9, after single subcutaneous injection at three sites [NCT 02043301]

Pharmacokinetics and pharmacodynamics of bococizumab, a monoclonal antibody to PCSK9, after single subcutaneous injection at three sites [NCT 02043301]

by Wang, Ellen Q., Plotka, Anna, Salageanu, Joanne, Sattler, Catherine, Yunis, Carla
Published in Cardiovascular therapeutics (01.10.2017)

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Assessing the Potential Risk of Cross-Reactivity Between Anti-Bococizumab Antibodies and Other Anti-PCSK9 Monoclonal Antibodies

Assessing the Potential Risk of Cross-Reactivity Between Anti-Bococizumab Antibodies and Other Anti-PCSK9 Monoclonal Antibodies

by Wang, Ellen Q., Bukowski, Jack F., Yunis, Carla, Shear, Charles L., Ridker, Paul M., Schwartz, Pamela F., Baltrukonis, Daniel
Published in BioDrugs : clinical immunotherapeutics, biopharmaceuticals, and gene therapy (01.10.2019)

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Comparative Pharmacokinetics and Pharmacodynamics of Bococizumab Following a Single Subcutaneous Injection Using Drug Substance Manufactured at Two Sites or Administration via Two Different Devices

Comparative Pharmacokinetics and Pharmacodynamics of Bococizumab Following a Single Subcutaneous Injection Using Drug Substance Manufactured at Two Sites or Administration via Two Different Devices

by Wang, Ellen Q., Plotka, Anna, Salageanu, Joanne, Baltrukonis, Daniel, Mridha, Khurshid, Frederich, Robert, Sullivan, Beth E.
Published in Clinical pharmacology in drug development (01.01.2019)

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Quantitative PK–PD Model-Based Translational Pharmacology of a Novel Kappa Opioid Receptor Antagonist Between Rats and Humans

Quantitative PK–PD Model-Based Translational Pharmacology of a Novel Kappa Opioid Receptor Antagonist Between Rats and Humans

by Chang, Cheng, Byon, Wonkyung, Lu, Yifeng, Jacobsen, Leslie K., Badura, Lori L., Sawant-Basak, Aarti, Miller, Emily, Liu, Jing, Grimwood, Sarah, Wang, Ellen Q., Maurer, Tristan S.
Published in The AAPS journal (01.12.2011)

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Improved preclinical cardiovascular therapeutic indices with long-term inhibition of norepinephrine reuptake using reboxetine

Improved preclinical cardiovascular therapeutic indices with long-term inhibition of norepinephrine reuptake using reboxetine

by Fossa, Anthony A., Wisialowski, Todd A., Cremers, Thomas, van der Hart, Marieke, Tseng, Elaine, Deng, Shibing, Rollema, Hans, Wang, Ellen Q.
Published in Toxicology and applied pharmacology (01.11.2012)

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Dose-escalating study of the pharmacokinetics and tolerability of fesoterodine in children with overactive bladder

Dose-escalating study of the pharmacokinetics and tolerability of fesoterodine in children with overactive bladder

by Malhotra, Bimal, El-Tahtawy, Ahmed, Wang, Ellen Q, Darekar, Amanda, Cossons, Nandini, Crook, Tim J, Scholfield, David, Reddy, Pramod
Published in Journal of pediatric urology (01.08.2012)

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Pharmacokinetic/pharmacodynamic analysis of β-amyloid response following modulation of the gamma secretase enzyme

Pharmacokinetic/pharmacodynamic analysis of β-amyloid response following modulation of the gamma secretase enzyme

by Wang, Ellen Q, Tseng, Elaine, Lu, Yasong, Becker, Stacey, Hudson, Emily, Zhang, Liming, Wood, Kathleen M, Bales, Kelly R, Marconi, Michael, Johnson, Doug S
Published in Alzheimer's & dementia (01.07.2010)

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Pharmacokinetic and pharmacodynamic evaluation of PF-04360365, a humanized monoclonal anti-amyloid antibody, in young and aged cynomolgus monkeys

Pharmacokinetic and pharmacodynamic evaluation of PF-04360365, a humanized monoclonal anti-amyloid antibody, in young and aged cynomolgus monkeys

by Wang, Ellen Q, Wentland, Jo-Ann, Rajadhyaksha, Manoj, Durham, Robert A, Freeman, Gary B
Published in Alzheimer's & dementia (01.07.2009)

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PF-04447943, a novel PDE9A inhibitor, increases cGMP levels in cerebrospinal fluid: Translation from non-clinical species to healthy human volunteers

PF-04447943, a novel PDE9A inhibitor, increases cGMP levels in cerebrospinal fluid: Translation from non-clinical species to healthy human volunteers

by Nicholas, Timothy, Evans, Rebecca, Styren, Scot, Qiu, Ruolun, Wang, Ellen Q, Nelson, Frederick, Le, Vu, Grimwood, Sarah, Christoffersen, Curt, Banerjee, Subhashis, Corrigan, Brian, Kocan, Geralyn, Geoghegan, Kieran, Carrieri, Charles, Raha, Nancy, Verhoest, Patrick, Soares, Holly
Published in Alzheimer's & dementia (01.07.2009)

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Aβ variability and effect of gamma secretase inhibition on cerebrospinal fluid levels of Aβ in healthy volunteers

Aβ variability and effect of gamma secretase inhibition on cerebrospinal fluid levels of Aβ in healthy volunteers

by Soares, Holly, Raha, Nancy, Sikpi, Matthew, Liston, Dane, Brodney, Mike, Coffman, Karen, Tate, Barbara, Qiu, Ruolun, Wang, Ellen Q, Li, Xiaoxi, Hidi, Rabia, Banerjee, Subhashis, Jhee, Stanford, Ereshefsky, Larry, Fullerton, Terence
Published in Alzheimer's & dementia (01.07.2009)

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Lack of critical involvement of endothelial nitric oxide synthase in vascular nitrate tolerance in mice

Lack of critical involvement of endothelial nitric oxide synthase in vascular nitrate tolerance in mice

by Wang, Ellen Q, Lee, Woo‐In, Fung, Ho‐Leung
Published in British journal of pharmacology (01.01.2002)

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H3 receptor antagonism increases methylhistamine levels in the cerebrospinal fluid of dogs and healthy human volunteers

H3 receptor antagonism increases methylhistamine levels in the cerebrospinal fluid of dogs and healthy human volunteers

by Soares, Holly, Wager, Travis T, Schmidt, Anne W, Sweeney, Francis J, McLellan, Thomas J, Nelson, Frederick R, Spracklin, Doug, Wang, Ellen Q, Faessel, Helene, Pinter, Garry W, Li, Xiaoxi, Chappell, Phillip B
Published in Alzheimer's & dementia (01.07.2009)

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Pharmacodynamics of in vivo nitroglycerin tolerance in normal conscious rats: effects of dose and dosing protocol

Pharmacodynamics of in vivo nitroglycerin tolerance in normal conscious rats: effects of dose and dosing protocol

by Wang, Ellen Q, Balthasar, Joseph P, Fung, Ho-Leung
Published in Pharmaceutical research (01.01.2004)

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