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Pacold, Michael E, Brimacombe, Kyle R, Chan, Sze Ham, Rohde, Jason M, Lewis, Caroline A, Swier, Lotteke J Y M, Possemato, Richard, Chen, Walter W, Sullivan, Lucas B, Fiske, Brian P, Cho, Steve, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D, Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M, Luengo, Alba, Wang, Amy Q, Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D, Vander Heiden, Matthew G, Shen, Min, Gray, Nathanael S, Boxer, Matthew B, Sabatini, David M
Published in Nature chemical biology (01.06.2016)
Published in Nature chemical biology (01.06.2016)
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Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection
He, Shanshan, Lin, Billy, Chu, Virginia, Hu, Zongyi, Hu, Xin, Xiao, Jingbo, Wang, Amy Q, Schweitzer, Cameron J, Li, Qisheng, Imamura, Michio, Hiraga, Nobuhiko, Southall, Noel, Ferrer, Marc, Zheng, Wei, Chayama, Kazuaki, Marugan, Juan J, Liang, T Jake
Published in Science translational medicine (08.04.2015)
Published in Science translational medicine (08.04.2015)
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Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus
Mukhopadhyay, Rupkatha, Roy, Sujayita, Venkatadri, Rajkumar, Su, Yu-Pin, Ye, Wenjuan, Barnaeva, Elena, Mathews Griner, Lesley, Southall, Noel, Hu, Xin, Wang, Amy Q, Xu, Xin, Dulcey, Andrés E, Marugan, Juan J, Ferrer, Marc, Arav-Boger, Ravit
Published in PLoS pathogens (01.06.2016)
Published in PLoS pathogens (01.06.2016)
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Preclinical Pharmacokinetics and In Vitro Properties of GS-441524, a Potential Oral Drug Candidate for COVID-19 Treatment
Wang, Amy Q., Hagen, Natalie R., Padilha, Elias C., Yang, Mengbi, Shah, Pranav, Chen, Catherine Z., Huang, Wenwei, Terse, Pramod, Sanderson, Philip, Zheng, Wei, Xu, Xin
Published in Frontiers in pharmacology (16.08.2022)
Published in Frontiers in pharmacology (16.08.2022)
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Use of physiological based pharmacokinetic modeling for cross-species prediction of pharmacokinetic and tissue distribution profiles of a novel niclosamide prodrug
Yang, Mengbi, Wang, Amy Q, Padilha, Elias C, Shah, Pranav, Hagen, Natalie R, Ryu, China, Shamim, Khalida, Huang, Wenwei, Xu, Xin
Published in Frontiers in pharmacology (11.04.2023)
Published in Frontiers in pharmacology (11.04.2023)
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Development and validation of PAMPA-BBB QSAR model to predict brain penetration potential of novel drug candidates
Kato, Rintaro, Zeng, Wenyu, Siramshetty, Vishal B, Williams, Jordan, Kabir, Md, Hagen, Natalie, Padilha, Elias C, Wang, Amy Q, Mathé, Ewy A, Xu, Xin, Shah, Pranav
Published in Frontiers in pharmacology (01.12.2023)
Published in Frontiers in pharmacology (01.12.2023)
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In vitro and in vivo pharmacokinetic characterization, chiral conversion and PBPK scaling towards human PK simulation of S-MRI-1867, a drug candidate for Hermansky-Pudlak syndrome pulmonary fibrosis
Padilha, Elias C., Yang, Mengbi, Shah, Pranav, Wang, Amy Q., Duan, Jianmin, Park, Joshua K., Zawatsky, Charles N., Malicdan, May Christine V., Kunos, George, Iyer, Malliga R., Gaucher, Geneviève, Ravenelle, François, Cinar, Resat, Xu, Xin
Published in Biomedicine & pharmacotherapy (01.12.2023)
Published in Biomedicine & pharmacotherapy (01.12.2023)
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Discovery and lead identification of quinazoline-based BRD4 inhibitors
Yang, Shyh-Ming, Urban, Daniel J., Yoshioka, Makoto, Strovel, Jeffrey W., Fletcher, Steven, Wang, Amy Q., Xu, Xin, Shah, Pranav, Hu, Xin, Hall, Matthew D., Jadhav, Ajit, Maloney, David J.
Published in Bioorganic & medicinal chemistry letters (15.11.2018)
Published in Bioorganic & medicinal chemistry letters (15.11.2018)
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Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection
He, Shanshan, Xiao, Jingbo, Dulcey, Andrés E, Lin, Billy, Rolt, Adam, Hu, Zongyi, Hu, Xin, Wang, Amy Q, Xu, Xin, Southall, Noel, Ferrer, Marc, Zheng, Wei, Liang, T. Jake, Marugan, Juan J
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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Quantification of cyclocreatine in mouse and rat plasma using hydrophilic-interaction ultra-performance liquid chromatography-tandem mass spectrometry
Wang, Amy Q., Hughes, Emma, Huang, Wenwei, Kerns, Edward H., Xu, Xin
Published in Journal of pharmaceutical and biomedical analysis (25.10.2017)
Published in Journal of pharmaceutical and biomedical analysis (25.10.2017)
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Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: A double-blind, randomized, placebo-controlled study in healthy male volunteers
Bergman, Arthur J., Stevens, Catherine, Zhou, YanYan, Yi, Bingming, Laethem, Martine, De Smet, Marina, Snyder, Karen, Hilliard, Deborah, Tanaka, Wesley, Zeng, Wei, Tanen, Michael, Wang, Amy Q., Chen, Li, Winchell, Gregory, Davies, Michael J., Ramael, Steven, Wagner, John A., Herman, Gary A.
Published in Clinical therapeutics (2006)
Published in Clinical therapeutics (2006)
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Pharmacokinetics and pharmacodynamic effects of the oral DPP-4 inhibitor sitagliptin in middle-aged obese subjects
Herman, Gary A, Bergman, Arthur, Liu, Fang, Stevens, Cathy, Wang, Amy Q, Zeng, Wei, Chen, Li, Snyder, Karen, Hilliard, Deborah, Tanen, Michael, Tanaka, Wesley, Meehan, Alan G, Lasseter, Kenneth, Dilzer, Stacy, Blum, Robert, Wagner, John A
Published in Journal of clinical pharmacology (01.08.2006)
Published in Journal of clinical pharmacology (01.08.2006)
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Phosphocyclocreatine is the dominant form of cyclocreatine in control and creatine transporter deficiency patient fibroblasts
Gorshkov, Kirill, Wang, Amy Q., Sun, Wei, Fisher, Ethan, Frigeni, Marta, Singleton, Marc, Thorne, Natasha, Class, Bradley, Huang, Wenwei, Longo, Nicola, Do, Minh‐Ha T., Ottinger, Elizabeth A., Xu, Xin, Zheng, Wei
Published in Pharmacology research & perspectives (01.12.2019)
Published in Pharmacology research & perspectives (01.12.2019)
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Evaluation of pharmacokinetic parameters and dipeptidyl peptidase‐4 inhibition following single doses of sitagliptin in healthy, young Japanese males
Herman, Gary A., Mistry, Goutam C., Yi, Bingming, Bergman, Arthur J., Wang, Amy Q., Zeng, Wei, Chen, Li, Snyder, Karen, Ruckle, Jon L., Larson, Patrick J., Davies, Michael J., Langdon, Ronald B., Gottesdiener, Keith M., Wagner, John A.
Published in British journal of clinical pharmacology (01.03.2011)
Published in British journal of clinical pharmacology (01.03.2011)
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Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors
Thakur, Ashish, Tawa, Gregory J, Henderson, Mark J, Danchik, Carina, Liu, Suiyang, Shah, Pranav, Wang, Amy Q, Dunn, Garrett, Kabir, Md, Padilha, Elias C, Xu, Xin, Simeonov, Anton, Kharbanda, Surender, Stone, Richard, Grewal, Gurmit
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
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Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity
Yang, Shyh-Ming, Martinez, Natalia J, Yasgar, Adam, Danchik, Carina, Johansson, Catrine, Wang, Yuhong, Baljinnyam, Bolormaa, Wang, Amy Q, Xu, Xin, Shah, Pranav, Cheff, Dorian, Wang, Xinran S, Roth, Jacob, Lal-Nag, Madhu, Dunford, James E, Oppermann, Udo, Vasiliou, Vasilis, Simeonov, Anton, Jadhav, Ajit, Maloney, David J
Published in Journal of medicinal chemistry (14.06.2018)
Published in Journal of medicinal chemistry (14.06.2018)
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Using in vitro ADME data for lead compound selection: An emphasis on PAMPA pH 5 permeability and oral bioavailability
Williams, Jordan, Siramshetty, Vishal, Nguyễn, Ðắc-Trung, Padilha, Elias Carvalho, Kabir, Md, Yu, Kyeong-Ri, Wang, Amy Q., Zhao, Tongan, Itkin, Misha, Shinn, Paul, Mathé, Ewy A., Xu, Xin, Shah, Pranav
Published in Bioorganic & medicinal chemistry (15.02.2022)
Published in Bioorganic & medicinal chemistry (15.02.2022)
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An Orally Efficacious Thyrotropin Receptor Ligand Inhibits Growth and Metastatic Activity of Thyroid Cancers
Sarkar, Rhitajit, Bolel, Priyanka, Kapoor, Abhijeet, Eliseeva, Elena, Dulcey, Andrés E, Templin, Jay S, Wang, Amy Q, Xu, Xin, Southall, Noel, Klubo-Gwiezdzinska, Joanna, Neumann, Susanne, Marugan, Juan J, Gershengorn, Marvin C
Published in The journal of clinical endocrinology and metabolism (13.08.2024)
Published in The journal of clinical endocrinology and metabolism (13.08.2024)
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Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of ( 2R,6R )-hydroxynorketamine
Highland, Jaclyn N, Morris, Patrick J, Zanos, Panos, Lovett, Jacqueline, Ghosh, Soumita, Wang, Amy Q, Zarate, Jr, Carlos A, Thomas, Craig J, Moaddel, Ruin, Gould, Todd D
Published in Journal of psychopharmacology (Oxford) (01.01.2019)
Published in Journal of psychopharmacology (Oxford) (01.01.2019)
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Impact of Polymer-TLR-7/8 Agonist (Adjuvant) Morphology on the Potency and Mechanism of CD8 T Cell Induction
Lynn, Geoffrey M, Chytil, Petr, Francica, Joseph R, Lagová, Anna, Kueberuwa, Gray, Ishizuka, Andrew S, Zaidi, Neeha, Ramirez-Valdez, Ramiro A, Blobel, Nicolas J, Baharom, Faezzah, Leal, Joseph, Wang, Amy Q, Gerner, Michael Y, Etrych, Tomáš, Ulbrich, Karel, Seymour, Leonard W, Seder, Robert A, Laga, Richard
Published in Biomacromolecules (11.02.2019)
Published in Biomacromolecules (11.02.2019)
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