Positive Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor: SAR Investigation Around PNU-120596
Acker, Brad A, Badescu, Valentina O, Berkenpas, Mitchell B, Groppi, Vincent E, Hajós, Mihaly, Higdon, Nicole R, Hurst, Raymond S, Jon Jacobsen, E, Margolis, Brandon J, McWhorter, William W, Myers, Jason K, Piotrowski, David W, Rogers, Bruce N, Sarapa, Dusan, Vetman, Tatiana N, Walker, Daniel P, Wall, Theron M, Wilhite, David M, Wishka, Donn G, Xu, Wenjian, Yates, Karen M
Published in Bioorganic & medicinal chemistry letters (01.09.2023)
Published in Bioorganic & medicinal chemistry letters (01.09.2023)
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Journal Article
Modulation of TARP γ8-Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain
Knopp, Kelly L, Simmons, Rosa Maria A, Guo, Wenhong, Adams, Benjamin L, Gardinier, Kevin M, Gernert, Douglas L, Ornstein, Paul L, Porter, Warren, Reel, Jon, Ding, Chunjin, Wang, He, Qian, Yuewei, Burris, Kevin D, Need, Anne, Barth, Vanessa, Swanson, Steven, Catlow, John, Witkin, Jeffrey M, Zwart, Ruud, Sher, Emanuele, Choong, Kar-Chan, Wall, Theron M, Schober, Douglas, Felder, Christian C, Kato, Akihiko S, Bredt, David S, Nisenbaum, Eric S
Published in The Journal of pharmacology and experimental therapeutics (01.06.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2019)
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Journal Article
Discovery and Structure−Activity Relationship of Quinuclidine Benzamides as Agonists of α7 Nicotinic Acetylcholine Receptors
Bodnar, Alice L, Cortes-Burgos, Luz A, Cook, Karen K, Dinh, Dac M, Groppi, Vincent E, Hajos, Mihaly, Higdon, Nicole R, Hoffmann, William E, Hurst, Raymond S, Myers, Jason K, Rogers, Bruce N, Wall, Theron M, Wolfe, Mark L, Wong, Erik
Published in Journal of medicinal chemistry (24.02.2005)
Published in Journal of medicinal chemistry (24.02.2005)
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Journal Article
Modulation of TARP γ 8-Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain
Knopp, Kelly L, Simmons, Rosa Maria A, Guo, Wenhong, Adams, Benjamin L, Gardinier, Kevin M, Gernert, Douglas L, Ornstein, Paul L, Porter, Warren, Reel, Jon, Ding, Chunjin, Wang, He, Qian, Yuewei, Burris, Kevin D, Need, Anne, Barth, Vanessa, Swanson, Steven, Catlow, John, Witkin, Jeffrey M, Zwart, Ruud, Sher, Emanuele, Choong, Kar-Chan, Wall, Theron M, Schober, Douglas, Felder, Christian C, Kato, Akihiko S, Bredt, David S, Nisenbaum, Eric S
Published in The Journal of pharmacology and experimental therapeutics (01.06.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2019)
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Journal Article
Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship
Wishka, Donn G, Walker, Daniel P, Yates, Karen M, Reitz, Steven C, Jia, Shaojuan, Myers, Jason K, Olson, Kirk L, Jacobsen, E. Jon, Wolfe, Mark L, Groppi, Vincent E, Hanchar, Alexander J, Thornburgh, Bruce A, Cortes-Burgos, Luz A, Wong, Erik H. F, Staton, Brian A, Raub, Thomas J, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Walters, Rodney R, Hoffmann, William E, Hajos, Mihaly, Franklin, Stanley, Carey, Galen, Gold, Lisa H, Cook, Karen K, Sands, Steven B, Zhao, Sabrina X, Soglia, John R, Kalgutkar, Amit S, Arneric, Stephen P, Rogers, Bruce N
Published in Journal of medicinal chemistry (13.07.2006)
Published in Journal of medicinal chemistry (13.07.2006)
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Journal Article
Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha 7 nicotinic acetylcholine receptor agonists
Walker, Daniel P, Wishka, Donn G, Piotrowski, David W, Jia, Shaojuan, Reitz, Steven C, Yates, Karen M, Myers, Jason K, Vetman, Tatiana N, Margolis, Brandon J, Jacobsen, EJon, Acker, Brad A, Groppi, Vincent E, Wolfe, Mark L, Thornburgh, Bruce A, Tinholt, Paula M, Cortes-Burgos, Luz A, Walters, Rodney R, Hester, Matthew R, Seest, Eric P, Dolak, Lester A, Han, Fusen, Olson, Barbara A, Fitzgerald, Laura, Staton, Brian A, Raub, Thomas J, Hajos, Mihaly, Hoffmann, William E, Li, Kai S, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Wong, Erik HF, Rogers, Bruce N
Published in Bioorganic & medicinal chemistry (15.12.2006)
Published in Bioorganic & medicinal chemistry (15.12.2006)
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Journal Article
Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists
Walker, Daniel P., Wishka, Donn G., Piotrowski, David W., Jia, Shaojuan, Reitz, Steven C., Yates, Karen M., Myers, Jason K., Vetman, Tatiana N., Margolis, Brandon J., Jacobsen, E. Jon, Acker, Brad A., Groppi, Vincent E., Wolfe, Mark L., Thornburgh, Bruce A., Tinholt, Paula M., Cortes-Burgos, Luz A., Walters, Rodney R., Hester, Matthew R., Seest, Eric P., Dolak, Lester A., Han, Fusen, Olson, Barbara A., Fitzgerald, Laura, Staton, Brian A., Raub, Thomas J., Hajos, Mihaly, Hoffmann, William E., Li, Kai S., Higdon, Nicole R., Wall, Theron M., Hurst, Raymond S., Wong, Erik H.F., Rogers, Bruce N.
Published in Bioorganic & medicinal chemistry (01.12.2006)
Published in Bioorganic & medicinal chemistry (01.12.2006)
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Journal Article
Positive allosteric modulators of the a7 nicotinic acetylcholine receptor: SAR investigation around PNU-120596
Acker, Brad A., Badescu, Valentina O., Berkenpas, Mitchell B., Groppi, Vincent E., Hajos, Mihaly, Higdon, Nicole R., Hurst, Raymond S., Jacobsen, E. Jon, Margolis, Brandon J., Mcwhorter, William W., Myers, Jason K., Piotrowski, David W., Rogers, Bruce N., Sarapa, Dusan, Vetman, Tatiana N., Walker, Daniel P., Wall, Theron M., Wilhite, David M., Wishka, Donn G., Xu, Wenjian, Yates, Karen M.
Published in Bioorganic & medicinal chemistry letters (01.09.2023)
Published in Bioorganic & medicinal chemistry letters (01.09.2023)
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Journal Article
A Novel Positive Allosteric Modulator of the α7 Neuronal Nicotinic Acetylcholine Receptor: In Vitro and In Vivo Characterization
Hurst, Raymond S., Hajós, Mihaly, Raggenbass, Mario, Wall, Theron M., Higdon, Nicole R., Lawson, Judy A., Rutherford-Root, Karen L., Berkenpas, Mitchell B., Hoffmann, W. E., Piotrowski, David W., Groppi, Vincent E., Allaman, Geraldine, Ogier, Roch, Bertrand, Sonia, Bertrand, Daniel, Arneric, Stephen P.
Published in The Journal of neuroscience (27.04.2005)
Published in The Journal of neuroscience (27.04.2005)
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Journal Article
A Novel Positive Allosteric Modulator of the alpha 7 Neuronal Nicotinic Acetylcholine Receptor: In Vitro and In Vivo Characterization
Hurst, Raymond S, Hajos, Mihaly, Raggenbass, Mario, Wall, Theron M, Higdon, Nicole R, Lawson, Judy A, Rutherford-Root, Karen L, Berkenpas, Mitchell B, Hoffmann, W E, Piotrowski, David W, Groppi, Vincent E, Allaman, Geraldine, Ogier, Roch, Bertrand, Sonia, Bertrand, Daniel, Arneric, Stephen P
Published in The Journal of neuroscience (27.04.2005)
Published in The Journal of neuroscience (27.04.2005)
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Journal Article
Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha 7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: Synthesis and structure-activity relationship
Wishka, Donn G., Walker, Daniel P., Yates, Karen M., Reitz, Steven C., Jia, Shaojuan, Myers, Jason K., Olson, Kirk L., Jacobsen, E. Jon, Wolfe, Mark L., Groppi, Vincent E., Hanchar, Alexander J., Thornburgh, Bruce A., Cortes-Burgos, Luz A., Wong, Erik H. F., Staton, Brian A., Raub, Thomas J., Higdon, Nicole R., Wall, Theron M., Hurst, Raymond S., Walters, Rodney R., Hoffmann, William E., Hajos, Mihaly, Franklin, Stanley, Carey, Galen, Gold, Lisa H., Cook, Karen K., Sands, Steven B., Zhao, Sabrina X., Soglia, John R., Kalgutkar, Amit S., Arneric, Stephen P., Rogers, Bruce N.
Published in Journal of medicinal chemistry (13.07.2006)
Published in Journal of medicinal chemistry (13.07.2006)
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Journal Article
Evaluation of dose, time, and frequency dependent ototoxic response to cisplatin administration in the albino guinea pig
Baird, Theodore J., Foy, Jeffrey W.-D., Dolan, David D., Wall, Theron, Posthumus, Tara, Eliel, Michael, Tapp, Rachel L., Gauvin, David V.
Published in Journal of pharmacological and toxicological methods (01.09.2009)
Published in Journal of pharmacological and toxicological methods (01.09.2009)
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EFFECTS OF CISAPRIDE, SOTALOL AND HALOPERIDOL IN A LANGENDORFF ASSAY AND COMPARISON TO hERG, PURKINJE FIBER AND IN VIVO TELEMETRY ASSAYS
Wall, Theron, Dalton, Jill, Wolfe, Mark, Higdon, Nicole, Clark, Mike, Gauvin, David, Baird, Theodore
Published in Journal of pharmacological and toxicological methods (01.09.2007)
Published in Journal of pharmacological and toxicological methods (01.09.2007)
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Development and characterization of in vitro hyperexcitability induction models for use in screening antiepileptic drugs
Wall, Theron, Dalton, J., Wolfe, M., Higdon, N., Clark, M., Gauvin, D., Baird, T.
Published in Journal of pharmacological and toxicological methods (01.10.2008)
Published in Journal of pharmacological and toxicological methods (01.10.2008)
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Journal Article
Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors
Bodnar, Alice L, Cortes-Burgos, Luz A, Cook, Karen K, Dinh, Dac M, Groppi, Vincent E, Hajos, Mihaly, Higdon, Nicole R, Hoffmann, William E, Hurst, Raymond S, Myers, Jason K, Rogers, Bruce N, Wall, Theron M, Wolfe, Mark L, Wong, Erik
Published in Journal of medicinal chemistry (24.02.2005)
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Published in Journal of medicinal chemistry (24.02.2005)
Journal Article
Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship
Wishka, Donn G, Walker, Daniel P, Yates, Karen M, Reitz, Steven C, Jia, Shaojuan, Myers, Jason K, Olson, Kirk L, Jacobsen, E Jon, Wolfe, Mark L, Groppi, Vincent E, Hanchar, Alexander J, Thornburgh, Bruce A, Cortes-Burgos, Luz A, Wong, Erik H F, Staton, Brian A, Raub, Thomas J, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Walters, Rodney R, Hoffmann, William E, Hajos, Mihaly, Franklin, Stanley, Carey, Galen, Gold, Lisa H, Cook, Karen K, Sands, Steven B, Zhao, Sabrina X, Soglia, John R, Kalgutkar, Amit S, Arneric, Stephen P, Rogers, Bruce N
Published in Journal of medicinal chemistry (13.07.2006)
Get full text
Published in Journal of medicinal chemistry (13.07.2006)
Journal Article
Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 nicotinic acetylcholine receptor agonists
Walker, Daniel P, Wishka, Donn G, Piotrowski, David W, Jia, Shaojuan, Reitz, Steven C, Yates, Karen M, Myers, Jason K, Vetman, Tatiana N, Margolis, Brandon J, Jacobsen, E Jon, Acker, Brad A, Groppi, Vincent E, Wolfe, Mark L, Thornburgh, Bruce A, Tinholt, Paula M, Cortes-Burgos, Luz A, Walters, Rodney R, Hester, Matthew R, Seest, Eric P, Dolak, Lester A, Han, Fusen, Olson, Barbara A, Fitzgerald, Laura, Staton, Brian A, Raub, Thomas J, Hajos, Mihaly, Hoffmann, William E, Li, Kai S, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Wong, Erik H F, Rogers, Bruce N
Published in Bioorganic & medicinal chemistry (15.12.2006)
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Published in Bioorganic & medicinal chemistry (15.12.2006)
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Protection of ischemic/reperfused canine myocardium by CL18/6, a monoclonal antibody to adhesion molecule ICAM-1
Hartman, J.Craig, Anderson, Donald C., Wiltse, Ann L., Lane, Caryl L., Rosenbloom, Craig L., Manning, Anthony M., Humphrey, William R., Wall, Theron M., Shebuski, Ronald J.
Published in Cardiovascular research (01.07.1995)
Published in Cardiovascular research (01.07.1995)
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