Structural basis for potency differences between GDF8 and GDF11
Walker, Ryan G, Czepnik, Magdalena, Goebel, Erich J, McCoy, Jason C, Vujic, Ana, Cho, Miook, Oh, Juhyun, Aykul, Senem, Walton, Kelly L, Schang, Gauthier, Bernard, Daniel J, Hinck, Andrew P, Harrison, Craig A, Martinez-Hackert, Erik, Wagers, Amy J, Lee, Richard T, Thompson, Thomas B
Published in BMC biology (03.03.2017)
Published in BMC biology (03.03.2017)
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Journal Article
Molecular characterization of latent GDF8 reveals mechanisms of activation
Walker, Ryan G., McCoy, Jason C., Czepnik, Magdalena, Mills, Melanie J., Hagg, Adam, Walton, Kelly L., Cotton, Thomas R., Hyvönen, Marko, Lee, Richard T., Gregorevic, Paul, Harrison, Craig A., Thompson, Thomas B.
Published in Proceedings of the National Academy of Sciences - PNAS (30.01.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (30.01.2018)
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Journal Article
An Evaluation of the Crystal Structure of C-terminal Truncated Apolipoprotein A-I in Solution Reveals Structural Dynamics Related to Lipid Binding
Melchior, John T., Walker, Ryan G., Morris, Jamie, Jones, Martin K., Segrest, Jere P., Lima, Diogo B., Carvalho, Paulo C., Gozzo, Fábio C., Castleberry, Mark, Thompson, Thomas B., Davidson, W. Sean
Published in The Journal of biological chemistry (04.03.2016)
Published in The Journal of biological chemistry (04.03.2016)
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Journal Article
Analysis of the Interaction between Heparin and Follistatin and Heparin and Follistatin–Ligand Complexes Using Surface Plasmon Resonance
Zhang, Fuming, Beaudet, Julie M, Luedeke, David M, Walker, Ryan G, Thompson, Thomas B, Linhardt, Robert J
Published in Biochemistry (Easton) (28.08.2012)
Published in Biochemistry (Easton) (28.08.2012)
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Journal Article
Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation
Walker, Ryan G, Poggioli, Tommaso, Katsimpardi, Lida, Buchanan, Sean M, Oh, Juhyun, Wattrus, Sam, Heidecker, Bettina, Fong, Yick W, Rubin, Lee L, Ganz, Peter, Thompson, Thomas B, Wagers, Amy J, Lee, Richard T
Published in Circulation research (01.04.2016)
Published in Circulation research (01.04.2016)
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Journal Article
Circulating Growth Differentiation Factor 11/8 Levels Decline With Age
Poggioli, Tommaso, Vujic, Ana, Yang, Peiguo, Macias-Trevino, Claudio, Uygur, Aysu, Loffredo, Francesco S, Pancoast, James R, Cho, Miook, Goldstein, Jill, Tandias, Rachel M, Gonzalez, Emilia, Walker, Ryan G, Thompson, Thomas B, Wagers, Amy J, Fong, Yick W, Lee, Richard T
Published in Circulation research (08.01.2016)
Published in Circulation research (08.01.2016)
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Journal Article
Crystal structure of the WFIKKN2 follistatin domain reveals insight into how it inhibits growth differentiation factor 8 (GDF8) and GDF11
McCoy, Jason C., Walker, Ryan G., Murray, Nathan H., Thompson, Thomas B.
Published in The Journal of biological chemistry (19.04.2019)
Published in The Journal of biological chemistry (19.04.2019)
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Journal Article
A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state
Melchior, John T, Walker, Ryan G, Cooke, Allison L, Morris, Jamie, Castleberry, Mark, Thompson, Thomas B, Jones, Martin K, Song, Hyun D, Rye, Kerry-Anne, Oda, Michael N, Sorci-Thomas, Mary G, Thomas, Michael J, Heinecke, Jay W, Mei, Xiaohu, Atkinson, David, Segrest, Jere P, Lund-Katz, Sissel, Phillips, Michael C, Davidson, W Sean
Published in Nature structural & molecular biology (01.12.2017)
Published in Nature structural & molecular biology (01.12.2017)
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Journal Article
Heparin-mediated dimerization of follistatin
Walker, Ryan G, Kattamuri, Chandramohan, Goebel, Erich J, Zhang, Fuming, Hammel, Michal, Tainer, John A, Linhardt, Robert J, Thompson, Thomas B
Published in Experimental biology and medicine (Maywood, N.J.) (01.02.2021)
Published in Experimental biology and medicine (Maywood, N.J.) (01.02.2021)
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Journal Article
Myostatin Attenuation In Vivo Reduces Adiposity, but Activates Adipogenesis
Li, Naisi, Yang, Qiyuan, Walker, Ryan G, Thompson, Thomas B, Du, Min, Rodgers, Buel D
Published in Endocrinology (Philadelphia) (01.01.2016)
Published in Endocrinology (Philadelphia) (01.01.2016)
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Journal Article
Analysis of Cre-mediated genetic deletion of Gdf11 in cardiomyocytes of young mice
Garbern, Jessica, Kristl, Amy C, Bassaneze, Vinicius, Vujic, Ana, Schoemaker, Henk, Sereda, Rebecca, Peng, Liming, Ricci-Blair, Elisabeth M, Goldstein, Jill M, Walker, Ryan G, Bhasin, Shalender, Wagers, Amy J, Lee, Richard T
Published in American journal of physiology. Heart and circulatory physiology (01.07.2019)
Published in American journal of physiology. Heart and circulatory physiology (01.07.2019)
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Journal Article
Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice
Walker, Ryan G., Barrandon, Ornella, Poggioli, Tommaso, Dagdeviren, Sezin, Carroll, Shannon H., Mills, Melanie J., Mendello, Kourtney R., Gomez, Yanet, Loffredo, Francesco S., Pancoast, James R., Macias-Trevino, Claudio, Marts, Colin, LeClair, Katherine B., Noh, Hye-Lim, Kim, Taekyoon, Banks, Alexander S., Kim, Jason K., Cohen, David E., Wagers, Amy J., Melton, Douglas A., Lee, Richard T.
Published in Scientific reports (12.03.2020)
Published in Scientific reports (12.03.2020)
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Journal Article
Myostatin Stimulates, Not Inihibits, C2C12 Myoblast Proliferation
Rodgers, Buel D, Wiedeback, Benjamin D, Hoversten, Knut E, Jackson, Melissa F, Walker, Ryan G, Thompson, Thomas B
Published in Endocrinology (Philadelphia) (01.03.2014)
Published in Endocrinology (Philadelphia) (01.03.2014)
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Journal Article
Alternative Binding Modes Identified for Growth and Differentiation Factor-associated Serum Protein (GASP) Family Antagonism of Myostatin
Walker, Ryan G., Angerman, Elizabeth B., Kattamuri, Chandramohan, Lee, Yun-Sil, Lee, Se-Jin, Thompson, Thomas B.
Published in The Journal of biological chemistry (20.03.2015)
Published in The Journal of biological chemistry (20.03.2015)
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Journal Article
Variation in zygotic CRISPR/Cas9 gene editing outcomes generates novel reporter and deletion alleles at the Gdf11 locus
Goldstein, Jill M., Valido, Austin, Lewandowski, Jordan P., Walker, Ryan G., Mills, Melanie J., Messemer, Kathleen A., Besseling, Paul, Lee, Kyu Ha, Wattrus, Samuel J., Cho, Miook, Lee, Richard T., Wagers, Amy J.
Published in Scientific reports (09.12.2019)
Published in Scientific reports (09.12.2019)
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Journal Article
The Structure of Human Apolipoprotein A-IV as Revealed by Stable Isotope-assisted Cross-linking, Molecular Dynamics, and Small Angle X-ray Scattering
Walker, Ryan G., Deng, Xiaodi, Melchior, John T., Morris, Jamie, Tso, Patrick, Jones, Martin K., Segrest, Jere P., Thompson, Thomas B., Davidson, W. Sean
Published in The Journal of biological chemistry (28.02.2014)
Published in The Journal of biological chemistry (28.02.2014)
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Journal Article