T cell-induced CSF1 promotes melanoma resistance to PD1 blockade
Neubert, Natalie J, Schmittnaegel, Martina, Bordry, Natacha, Nassiri, Sina, Wald, Noémie, Martignier, Christophe, Tillé, Laure, Homicsko, Krisztian, Damsky, William, Maby-El Hajjami, Hélène, Klaman, Irina, Danenberg, Esther, Ioannidou, Kalliopi, Kandalaft, Lana, Coukos, George, Hoves, Sabine, Ries, Carola H, Fuertes Marraco, Silvia A, Foukas, Periklis G, De Palma, Michele, Speiser, Daniel E
Published in Science translational medicine (11.04.2018)
Published in Science translational medicine (11.04.2018)
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Journal Article
Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies
Preillon, Julie, Cuende, Julia, Rabolli, Virginie, Garnero, Lucile, Mercier, Marjorie, Wald, Noémie, Pappalardo, Angela, Denies, Sofie, Jamart, Diane, Michaux, Anne-Catherine, Pirson, Romain, Pitard, Vincent, Bagot, Martine, Prasad, Shruthi, Houthuys, Erica, Brouwer, Margreet, Marillier, Reece, Lambolez, Florence, Marchante, Joäo R, Nyawouame, Florence, Carter, Mathew J, Baron-Bodo, Véronique, Marie-Cardine, Anne, Cragg, Mark, Déchanet-Merville, Julie, Driessens, Gregory, Hoofd, Catherine
Published in Molecular cancer therapeutics (01.01.2021)
Published in Molecular cancer therapeutics (01.01.2021)
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Journal Article
74 a-TIGIT mAb belrestotug in combination with anti-PD1 induces an immunocompetent tumor microenvironment (TME)
Cuende, Julia, Ma, Stephanie, Welsby, Iain, Rosewick, Nicolas, Wald, Noemie, Vezzu, Anais, Mercier, Marjorie, Tieppo, Paola, Claes, Bart, McGrath, Yvonne, Henau, Olivier De, Driessens, Gregory, Ceppi, Maurizio, Libouban, Marion
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Lymphatic vessel density is associated with CD8+ T cell infiltration and immunosuppressive factors in human melanoma
Bordry, Natacha, Broggi, Maria A. S., de Jonge, Kaat, Schaeuble, Karin, Gannon, Philippe O., Foukas, Periklis G., Danenberg, Esther, Romano, Emanuela, Baumgaertner, Petra, Fankhauser, Manuel, Wald, Noémie, Cagnon, Laurène, Abed-Maillard, Samia, Hajjami, Hélène Maby-El, Murray, Timothy, Ioannidou, Kalliopi, Letovanec, Igor, Yan, Pu, Michielin, Olivier, Matter, Maurice, Swartz, Melody A., Speiser, Daniel E.
Published in Oncoimmunology (01.01.2018)
Published in Oncoimmunology (01.01.2018)
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Journal Article
Beyond PD-1: Investigating the Therapeutic Potential of TIGIT Blockade in DLBCL
Sunseri, Nicole, Chen, Xiufen, Wald, Noemie, Preillon, Julie, Smith, Sonali M., Driessens, Gregory, Kline, Justin
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Abstract 4154: EOS100850 inhibits A2A receptor signaling in human whole blood: Two pharmacodynamic assays to monitor EOS100850 activity in clinical studies
Martinoli, Chiara, Brouwer, Margreet, Houthuys, Erica, Mercier, Marjorie, Wald, Noemie, Gomes, Bruno, Crosignani, Stefano, Bodo, Veronique
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 4149: Extensive characterization of the adenosine pathway in human solid tumors gives a hint on cancer indication selection for the A2A receptor antagonist EOS100850
Wald, Noemie, Martinoli, Chiara, Mercier, Marjorie, Hermant, Annelise, Nyawouame, Florence, Marchante, Joao, Moulin, Charlotte, Bol, Vanesa, Crosignani, Stefano, Bodo, Veronique
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 4135: A novel plasma cell-based mechanism of action of adenosine immunomodulation and A2AR antagonism
Martinoli, Chiara, Tieppo, Paola, Mercier, Marjorie, Shehade, Hussein, Wald, Noemie, Vezzu, Anais, Hermant, Annelise, Pirlot, Boris, Ma, Stephanie, Ceppi, Maurizio, McGrath, Yvonne, Rossetti, Maura
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract LB-291: EOS100850, an insurmountable and non-brain penetrant A2A receptor antagonist, inhibits adenosine-mediated T cell suppression, demonstrates anti-tumor activity and exhibits best-in class characteristics
Houthuys, Erica, Marillier, Reece, Deregnaucourt, Théo, Brouwer, margreet, Basilico, Paola, Pirson, Romain, Marchante, Joao, Prasad, Shruthi, Hermant, Annelise, Nyawouame, Florence, Preillon, Julie, Frederix, Kim, Michaux, Anne Catherine, Lambolez, Florence, Swiercz, Jakub, Driessens, Gregory, Wald, Noemie, Martinoli, Chiara, Bodo, Veronique, Detheux, Michel, Leroy, Xavier, Crosignani, Stefano
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract LB189: Pharmacodynamic assessment of a-TIGIT mAb EOS-448 highlights multiple FcγR-mediated mode-of-actions in blood and tumor of patients with advanced solid tumors
Cuende, Julia, Preillon, Julie, Wald, Noemie, Mercier, Marjorie, Tieppo, Paola, Welsby, Iain, Bodo, Veronique, McGrath, Yvonne, Van Den Mooter, Tom F., Machiels, Jean-Pascal, Truong, Clarisse, De Henau, Olivier, Driessens, Gregory, Libouban, Marion
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract 3161: Preparation of aclinical trial with a-TIGIT antagonist antibody EOS884448, which demonstrates potent preclinical activity and safe toxicology profile
Nguyen, Thi Lien-Anh, Cuende, Julia, Preillon, Julie, Garnero, Lucile, Rabolli, Virginie, Wald, Noémie, Hoofd, Catherine, Chevron, Patricia, Mercier, Marjorie, De Henau, Olivier, Bodo, Véronique, Driessens, Gregory
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Compounds, Compositions and Methods of Treatment Thereof
Wald, Noemie, Lager, Joanne, Srivastava, Shouraydeep, Martinoli, Chiara, Ross, Sally
Year of Publication 02.05.2024
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Year of Publication 02.05.2024
Patent
Phase 1 trial of the adenosine A 2A receptor antagonist inupadenant (EOS-850): Update on tolerability, and antitumor activity potentially associated with the expression of the A 2A receptor within the tumor
Buisseret, Laurence, Rottey, Sylvie, De Bono, Johann S., Migeotte, Ariane, Delafontaine, Brant, Manickavasagar, Thubeena, Martinoli, Chiara, Wald, Noémie, Rossetti, Maura, Gangolli, Esha A., Wiegert, Erol, McIntyre, Nicola, Lager, Joanne J., Machiels, Jean-Pascal H.
Published in Journal of clinical oncology (20.05.2021)
Published in Journal of clinical oncology (20.05.2021)
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Journal Article
COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT THEREOF
SRIVASTAVA, Shouraydeep, ROSS, Sally, MARTINOLI, Chiara, WALD, Noemie, LAGER, Joanne
Year of Publication 27.12.2023
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Year of Publication 27.12.2023
Patent
Abstract 4969: TIGIT pathway phenotyping sheds light on promising strategies to restore anti-tumor immunity
Wald, Noémie, Mercier, Marjorie, Cuende, Julia, Nyawouame, Florence, Prasad, Shruthi, Brouwer, Margreet, Houthuys, Erica, Marie-Cardine, Anne, Bagot, Martine, Driessens, Grégory, Bodo, Véronique, Hoofd, Catherine
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract LB-114: a-TIGIT antagonist antibody EOS884448 shows dual mechanism of action by restoration of T cell effector functions and preferential depletion of Treg
LEROY, XAVIER, Hoofd, Catherine, Cuende, Julia, Denies, Sofie, Rabolli, Virginie, Preillon, Julie, Lambolez, Florence, Prasad, Shruthi, Mercier, Marjorie, Nyawouame, Florence, Bodo, Véronique, Wald, Noémie, Driessens, Grégory, Detheux, Michel
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT THEREOF
SRIVASTAVA, Shouraydeep, ROSS, Sally, MARTINOLI, Chiara, WALD, Noemie, LAGER, Joanne
Year of Publication 25.08.2022
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Year of Publication 25.08.2022
Patent