Mapping the binding sites of challenging drug targets
Wakefield, Amanda E., Kozakov, Dima, Vajda, Sandor
Published in Current opinion in structural biology (01.08.2022)
Published in Current opinion in structural biology (01.08.2022)
Get full text
Journal Article
Cryptic binding sites on proteins: definition, detection, and druggability
Vajda, Sandor, Beglov, Dmitri, Wakefield, Amanda E, Egbert, Megan, Whitty, Adrian
Published in Current opinion in chemical biology (01.06.2018)
Published in Current opinion in chemical biology (01.06.2018)
Get full text
Journal Article
Exploring the structural origins of cryptic sites on proteins
Beglov, Dmitri, Hall, David R., Wakefield, Amanda E., Luo, Lingqi, Allen, Karen N., Kozakov, Dima, Whitty, Adrian, Vajda, Sandor
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2018)
Get full text
Journal Article
Analysis of tractable allosteric sites in G protein-coupled receptors
Wakefield, Amanda E, Mason, Jonathan S, Vajda, Sandor, Keserű, György M
Published in Scientific reports (16.04.2019)
Published in Scientific reports (16.04.2019)
Get full text
Journal Article
Molecular Simulation of Conformational Pre-Organization in Cyclic RGD Peptides
Wakefield, Amanda E, Wuest, William M, Voelz, Vincent A
Published in Journal of chemical information and modeling (27.04.2015)
Published in Journal of chemical information and modeling (27.04.2015)
Get full text
Journal Article
Benchmark Sets for Binding Hot Spot Identification in Fragment-Based Ligand Discovery
Wakefield, Amanda E, Yueh, Christine, Beglov, Dmitri, Castilho, Marcelo S, Kozakov, Dima, Keserű, György M, Whitty, Adrian, Vajda, Sandor
Published in Journal of chemical information and modeling (28.12.2020)
Published in Journal of chemical information and modeling (28.12.2020)
Get full text
Journal Article
Interaction Energetics and Druggability of the Protein–Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2)
Zhong, Mengqi, Lynch, Andrew, Muellers, Samantha N, Jehle, Stefan, Luo, Lingqi, Hall, David R, Iwase, Reina, Carolan, James P, Egbert, Megan, Wakefield, Amanda, Streu, Kristina, Harvey, Christine M, Ortet, Paula C, Kozakov, Dima, Vajda, Sandor, Allen, Karen N, Whitty, Adrian
Published in Biochemistry (Easton) (04.02.2020)
Published in Biochemistry (Easton) (04.02.2020)
Get full text
Journal Article
Exploring protein hotspots by optimized fragment pharmacophores
Bajusz, Dávid, Wade, Warren S, Satała, Grzegorz, Bojarski, Andrzej J, Ilaš, Janez, Ebner, Jessica, Grebien, Florian, Papp, Henrietta, Jakab, Ferenc, Douangamath, Alice, Fearon, Daren, von Delft, Frank, Schuller, Marion, Ahel, Ivan, Wakefield, Amanda, Vajda, Sándor, Gerencsér, János, Pallai, Péter, Keserű, György M
Published in Nature communications (27.05.2021)
Published in Nature communications (27.05.2021)
Get full text
Journal Article
API Development Increases Access to Shared Computing Resources at Boston University
Jones, George, Wakefield, Amanda E, Triplett, Jeff, Idrissa, Kojo, Goebel, James, Kozakov, Dima, Vajda, Sandor
Published in Journal of software engineering and applications (01.06.2022)
Published in Journal of software engineering and applications (01.06.2022)
Get more information
Journal Article
Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A Protease
Turner, Lewis D, Nielsen, Alexander L, Lin, Lucy, Campedelli, Antonio J, Silvaggi, Nicholas R, Chen, Jason S, Wakefield, Amanda E, Allen, Karen N, Janda, Kim D
Published in ACS medicinal chemistry letters (12.08.2021)
Published in ACS medicinal chemistry letters (12.08.2021)
Get full text
Journal Article
Structure-Based Analysis of Cryptic-Site Opening
Sun, Zhuyezi, Wakefield, Amanda Elizabeth, Kolossvary, Istvan, Beglov, Dmitri, Vajda, Sandor
Published in Structure (London) (04.02.2020)
Published in Structure (London) (04.02.2020)
Get full text
Journal Article
Tandem CAR T cells targeting HER2 and IL13R alpha 2 mitigate tumor antigen escape
Hegde, Meenakshi, Mukherjee, Malini, Grada, Zakaria, Pignata, Antonella, Landi, Daniel, Navai, Shoba A, Wakefield, Amanda, Fousek, Kristen, Bielamowicz, Kevin, Chow, Kevin K H, Brawley, Vita S, Byrd, Tiara T, Krebs, Simone, Gottschalk, Stephen, Wels, Winfried S, Baker, Matthew L, Dotti, Gianpietro, Mamonkin, Maksim, Brenner, Malcolm K, Orange, Jordan S, Ahmed, Nabil
Published in The Journal of clinical investigation (01.08.2016)
Published in The Journal of clinical investigation (01.08.2016)
Get full text
Journal Article
Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape
Hegde, Meenakshi, Mukherjee, Malini, Grada, Zakaria, Pignata, Antonella, Landi, Daniel, Navai, Shoba A, Wakefield, Amanda, Fousek, Kristen, Bielamowicz, Kevin, Chow, Kevin K H, Brawley, Vita S, Byrd, Tiara T, Krebs, Simone, Gottschalk, Stephen, Wels, Winfried S, Baker, Matthew L, Dotti, Gianpietro, Mamonkin, Maksim, Brenner, Malcolm K, Orange, Jordan S, Ahmed, Nabil
Published in The Journal of clinical investigation (01.08.2016)
Published in The Journal of clinical investigation (01.08.2016)
Get full text
Journal Article
HER2-Specific Chimeric Antigen Receptor-Modified Virus-Specific T Cells for Progressive Glioblastoma: A Phase 1 Dose-Escalation Trial
Ahmed, Nabil, Brawley, Vita, Hegde, Meenakshi, Bielamowicz, Kevin, Kalra, Mamta, Landi, Daniel, Robertson, Catherine, Gray, Tara L, Diouf, Oumar, Wakefield, Amanda, Ghazi, Alexia, Gerken, Claudia, Yi, Zhongzhen, Ashoori, Aidin, Wu, Meng-Fen, Liu, Hao, Rooney, Cliona, Dotti, Gianpietro, Gee, Adrian, Su, Jack, Kew, Yvonne, Baskin, David, Zhang, Yi Jonathan, New, Pamela, Grilley, Bambi, Stojakovic, Milica, Hicks, John, Powell, Suzanne Z, Brenner, Malcolm K, Heslop, Helen E, Grossman, Robert, Wels, Winfried S, Gottschalk, Stephen
Published in JAMA oncology (01.08.2017)
Published in JAMA oncology (01.08.2017)
Get more information
Journal Article
Abstract 6605: Functional screening of bispecific CAR ectodomains targeting HER2 and GD2 in melanoma
Joseph, Sujith K., Navai, Shoba A., Grada, Zakaria, Fousek, Kristen, Mathew, Pretty R., Shree, Ankita, Wakefield, Amanda, Ahmed, Nabil, Hegde, Meenakshi
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Get full text
Journal Article
Tandem CAR T cells targeting HER2 and IL13Ra2 mitigate tumor antigen escape
Hegde, Meenakshi, Mukherjee, Malini, Grada, Zakaria, Pignata, Antonella, Landi, Daniel, Navai, Shoba A, Wakefield, Amanda, Fousek, Kristen, Bielamowicz, Kevin, Chow, Kevin K.H, Brawley, Vita S, Byrd, Tiara T, Krebs, Simone, Gottschalk, Stephen, Wels, Winfried S, Baker, Matthew L, Dotti, Gianpietro, Mamonkin, Maksim, Brenner, Malcolm K, Orange, Jordan S, Ahmed, Nabil
Published in The Journal of clinical investigation (01.07.2021)
Published in The Journal of clinical investigation (01.07.2021)
Get full text
Journal Article
Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape
Hegde, Meenakshi, Mukherjee, Malini, Grada, Zakaria, Pignata, Antonella, Landi, Daniel, Navai, Shoba A, Wakefield, Amanda, Fousek, Kristen, Bielamowicz, Kevin, Chow, Kevin Kh, Brawley, Vita S, Byrd, Tiara T, Krebs, Simone, Gottschalk, Stephen, Wels, Winfried S, Baker, Matthew L, Dotti, Gianpietro, Mamonkin, Maksim, Brenner, Malcolm K, Orange, Jordan S, Ahmed, Nabil
Published in The Journal of clinical investigation (01.07.2021)
Published in The Journal of clinical investigation (01.07.2021)
Get full text
Journal Article
Is CMV a target in pediatric glioblastoma? Expression of CMV proteins, pp65 and IE1-72 and CMV nucleic acids in a cohort of pediatric glioblastoma patients
Wakefield, Amanda, Pignata, Antonella, Ghazi, Alexia, Ashoori, Aidin, Hegde, Meenakshi, Landi, Daniel, Gray, Tara, Scheurer, Michael E., Chintagumpala, Murali, Adesina, Adekunle, Gottschalk, Stephen, Hicks, John, Powell, Suzanne Z., Ahmed, Nabil
Published in Journal of neuro-oncology (01.11.2015)
Published in Journal of neuro-oncology (01.11.2015)
Get full text
Journal Article
Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape
Hegde, Meenakshi, Mukherjee, Malini, Grada, Zakaria, Pignata, Antonella, Landi, Daniel, Navai, Shoba A, Wakefield, Amanda, Fousek, Kristen, Bielamowicz, Kevin, Chow, Kevin Kh, Brawley, Vita S, Byrd, Tiara T, Krebs, Simone, Gottschalk, Stephen, Wels, Winfried S, Baker, Matthew L, Dotti, Gianpietro, Mamonkin, Maksim, Brenner, Malcolm K, Orange, Jordan S, Ahmed, Nabil
Published in The Journal of clinical investigation (02.07.2019)
Published in The Journal of clinical investigation (02.07.2019)
Get full text
Journal Article