Diketo Acid Inhibitor Mechanism and HIV-1 Integrase: Implications for Metal Binding in the Active Site of Phosphotransferase Enzymes
Grobler, Jay A., Stillmock, Kara, Hu, Binghua, Witmer, Marc, Felock, Peter, Espeseth, Amy S., Wolfe, Abigail, Egbertson, Melissa, Bourgeois, Michele, Melamed, Jeffrey, Wai, John S., Young, Steve, Vacca, Joseph, Hazuda, Daria J.
Published in Proceedings of the National Academy of Sciences - PNAS (14.05.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (14.05.2002)
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Inhibition of HIV-1 Ribonuclease H by a Novel Diketo Acid, 4-[5-(Benzoylamino)thien-2-yl]-2,4-dioxobutanoic Acid
Shaw-Reid, Cathryn A, Munshi, Vandna, Graham, Pia, Wolfe, Abigail, Witmer, Marc, Danzeisen, Renee, Olsen, David B, Carroll, Steven S, Embrey, Mark, Wai, John S, Miller, Michael D, Cole, James L, Hazuda, Daria J
Published in The Journal of biological chemistry (31.01.2003)
Published in The Journal of biological chemistry (31.01.2003)
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4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells
Wai, John S, Egbertson, Melissa S, Payne, Linda S, Fisher, Thorsten E, Embrey, Mark W, Tran, Lekhanh O, Melamed, Jeffrey Y, Langford, H. Marie, Guare, James P, Zhuang, Linghang, Grey, Vanessa E, Vacca, Joseph P, Holloway, M. Katharine, Naylor-Olsen, Adel M, Hazuda, Daria J, Felock, Peter J, Wolfe, Abigail L, Stillmock, Kara A, Schleif, William A, Gabryelski, Lori J, Young, Steven D
Published in Journal of medicinal chemistry (28.12.2000)
Published in Journal of medicinal chemistry (28.12.2000)
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Effect of suberoylanilide hydroxamic acid (SAHA) administration on the residual virus pool in a model of combination antiretroviral therapy-mediated suppression in SIVmac239-infected indian rhesus macaques
Del Prete, Gregory Q, Shoemaker, Rebecca, Oswald, Kelli, Lara, Abigail, Trubey, Charles M, Fast, Randy, Schneider, Douglas K, Kiser, Rebecca, Coalter, Vicky, Wiles, Adam, Wiles, Rodney, Freemire, Brandi, Keele, Brandon F, Estes, Jacob D, Quiñones, Octavio A, Smedley, Jeremy, Macallister, Rhonda, Sanchez, Rosa I, Wai, John S, Tan, Christopher M, Alvord, W Gregory, Hazuda, Daria J, Piatak, Jr, Michael, Lifson, Jeffrey D
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Published in Antimicrobial agents and chemotherapy (01.11.2014)
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A Naphthyridine Carboxamide Provides Evidence for Discordant Resistance between Mechanistically Identical Inhibitors of HIV-1 Integrase
Hazuda, Daria J., Anthony, Neville J., Gomez, Robert P., Jolly, Samson M., Wai, John S., Zhuang, Linghang, Fisher, Thorsten E., Embrey, Mark, Guare, James P., Egbertson, Melissa S., Vacca, Joseph P., Huff, Joel R., Felock, Peter J., Witmer, Marc V., Stillmock, Kara A., Danovich, Robert, Grobler, Jay, Miller, Michael D., Espeseth, Amy S., Jin, Lixia, I-Wu Chen, Lin, Jiunn H., Kassahun, Kelem, Ellis, Joan D., Wong, Bradley K., Xu, Wei, Pearson, Paul G., Schleif, William A., Cortese, Riccardo, Emini, Emilio, Summa, Vincenzo, Holloway, M. Katharine, Young, Steven D., Coffin, John M.
Published in Proceedings of the National Academy of Sciences - PNAS (03.08.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (03.08.2004)
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Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold
Williams, Peter D., Staas, Donnette D., Venkatraman, Shankar, Loughran, H. Marie, Ruzek, Rowena D., Booth, Theresa M., Lyle, Terry A., Wai, John S., Vacca, Joseph P., Feuston, Bradley P., Ecto, Linda T., Flynn, Jessica A., DiStefano, Daniel J., Hazuda, Daria J., Bahnck, Carolyn M., Himmelberger, Amy L., Dornadula, Geetha, Hrin, Renee C., Stillmock, Kara A., Witmer, Marc V., Miller, Michael D., Grobler, Jay A.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Discovery of MK-8970: An Acetal Carbonate Prodrug of Raltegravir with Enhanced Colonic Absorption
Walji, Abbas M., Sanchez, Rosa I., Clas, Sophie-Dorothee, Nofsinger, Rebecca, de Lera Ruiz, Manuel, Li, Jing, Bennet, Amrithraj, John, Christopher, Bennett, David Jonathan, Sanders, John M., Di Marco, Christina N., Kim, Somang Hope, Balsells, Jaume, Ceglia, Scott S., Dang, Qun, Manser, Kimberly, Nissley, Becky, Wai, John S., Hafey, Michael, Wang, Junying, Chessen, Gene, Templeton, Allen, Higgins, John, Smith, Ronald, Wu, Yunhui, Grobler, Jay, Coleman, Paul J.
Published in ChemMedChem (01.02.2015)
Published in ChemMedChem (01.02.2015)
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Cover Picture: Discovery of MK-8970: An Acetal Carbonate Prodrug of Raltegravir with Enhanced Colonic Absorption (ChemMedChem 2/2015)
Walji, Abbas M., Sanchez, Rosa I., Clas, Sophie-Dorothee, Nofsinger, Rebecca, de Lera Ruiz, Manuel, Li, Jing, Bennet, Amrithraj, John, Christopher, Bennett, David Jonathan, Sanders, John M., Di Marco, Christina N., Kim, Somang Hope, Balsells, Jaume, Ceglia, Scott S., Dang, Qun, Manser, Kimberly, Nissley, Becky, Wai, John S., Hafey, Michael, Wang, Junying, Chessen, Gene, Templeton, Allen, Higgins, John, Smith, Ronald, Wu, Yunhui, Grobler, Jay, Coleman, Paul J.
Published in ChemMedChem (01.02.2015)
Published in ChemMedChem (01.02.2015)
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8-Hydroxy-3,4-dihydropyrrolo[1,2- a]pyrazine-1(2 H)-one HIV-1 integrase inhibitors
Fisher, Thorsten E., Kim, Boyoung, Staas, Donnette D., Lyle, Terry A., Young, Steven D., Vacca, Joseph P., Zrada, Matthew M., Hazuda, Daria J., Felock, Peter J., Schleif, William A., Gabryelski, Lori J., Anari, M. Reza, Kochansky, Christopher J., Wai, John S.
Published in Bioorganic & medicinal chemistry (01.12.2007)
Published in Bioorganic & medicinal chemistry (01.12.2007)
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A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells
Embrey, Mark W., Wai, John S., Funk, Timothy W., Homnick, Carl F., Perlow, Debbie S., Young, Steven D., Vacca, Joseph P., Hazuda, Daria J., Felock, Peter J., Stillmock, Kara A., Witmer, Marc V., Moyer, Gregory, Schleif, William A., Gabryelski, Lori J., Jin, Lixia, Chen, I-Wu, Ellis, Joan D., Wong, Bradley K., Lin, Jiunn H., Leonard, Yvonne M., Tsou, Nancy N., Zhuang, Linghang
Published in Bioorganic & medicinal chemistry letters (15.10.2005)
Published in Bioorganic & medicinal chemistry letters (15.10.2005)
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A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors
Guare, James P., Wai, John S., Gomez, Robert P., Anthony, Neville J., Jolly, Samson M., Cortes, Amanda R., Vacca, Joseph P., Felock, Peter J., Stillmock, Kara A., Schleif, William A., Moyer, Gregory, Gabryelski, Lori J., Jin, Lixia, Chen, I-Wu, Hazuda, Daria J., Young, Steven D.
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
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Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors
Wai, John S., Kim, Boyoung, Fisher, Thorsten E., Zhuang, Linghang, Embrey, Mark W., Williams, Peter D., Staas, Donnette D., Culberson, Chris, Lyle, Terry A., Vacca, Joseph P., Hazuda, Daria J., Felock, Peter J., Schleif, William A., Gabryelski, Lori J., Jin, Lixia, Chen, I-Wu, Ellis, Joan D., Mallai, Rama, Young, Steven D.
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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10-Hydroxy-7,8-dihydropyrazino[1′,2′:1,5]pyrrolo[2,3- d]pyridazine-1,9(2 H,6 H)-diones: Potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants
Wiscount, Catherine M., Williams, Peter D., Tran, Lekhanh O., Embrey, Mark W., Fisher, Thorsten E., Sherman, Vanessa, Homnick, Carl F., Donnette Staas, D., Lyle, Terry A., Wai, John S., Vacca, Joseph P., Wang, ZiQiang, Felock, Peter J., Stillmock, Kara A., Witmer, Marc V., Miller, Michael D., Hazuda, Daria J., Day, Alysha M., Gabryelski, Lori J., Ecto, Linda T., Schleif, William A., DiStefano, Daniel J., Kochansky, Christopher J., Reza Anari, M.
Published in Bioorganic & medicinal chemistry (15.08.2008)
Published in Bioorganic & medicinal chemistry (15.08.2008)
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HIV SUBSTITUTED QUINOLIZINE DERIVATIVES USEFUL AS HIV INTEGRASE INHIBITORS
WADDELL SHERMAN TIM, COLEMAN PAUL J, WAI JOHN S, SANDERS JOHN M, FERGUSON RONALD, YU TAO, ZHANG YONGLIAN, STAMFORD ANDREW
Year of Publication 05.12.2017
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Year of Publication 05.12.2017
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SUBSTITUTED QUINOLIZINE DERIVATIVES USEFUL AS HIV INTEGRASE INHIBITORS
JOHN M SANDERS, COLEMAN PAUL J, WAI JOHN S, YU TAO, ZHANG YONGLIAN, SHERMAN TIM WADDELL, ANDREW STAMFORD, RONALD FERGUSON
Year of Publication 15.06.2017
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Year of Publication 15.06.2017
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SUBSTITUTED QUINOLIZINE DERIVATIVES USEFUL AS HIV INTEGRASE INHIBITORS
WADDELL SHERMAN TIM, COLEMAN PAUL J, WAI JOHN S, SANDERS JOHN M, FERGUSON RONALD, YU TAO, ZHANG YONGLIAN, STAMFORD ANDREW
Year of Publication 31.05.2016
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Year of Publication 31.05.2016
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P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes
CHIBA, Masato, CUYUE TANG, NEWAY, William E, WILLIAMS, Theresa M, DESOLMS, S. Jane, DINSMORE, Christopher J, WAI, John S, LIN, Jiunn H
Published in Biochemical pharmacology (15.09.2001)
Published in Biochemical pharmacology (15.09.2001)
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Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogs of 3-aminopyridin-2(1H)-one
Saari, Walfred S, Wai, John S, Fisher, Thorsten E, Thomas, Craig M, Hoffman, Jacob M, Rooney, Clarence S, Smith, Anthony M, Jones, James H, Bamberger, Dona L
Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
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