RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist
McLure, Kevin G, Gesner, Emily M, Tsujikawa, Laura, Kharenko, Olesya A, Attwell, Sarah, Campeau, Eric, Wasiak, Sylwia, Stein, Adam, White, Andre, Fontano, Eric, Suto, Robert K, Wong, Norman C W, Wagner, Gregory S, Hansen, Henrik C, Young, Peter R
Published in PloS one (31.12.2013)
Published in PloS one (31.12.2013)
Get full text
Journal Article
RVX-297, a BET Bromodomain Inhibitor, Has Therapeutic Effects in Preclinical Models of Acute Inflammation and Autoimmune Disease
Jahagirdar, Ravi, Attwell, Sarah, Marusic, Suzana, Bendele, Alison, Shenoy, Narmada, McLure, Kevin G, Gilham, Dean, Norek, Karen, Hansen, Henrik C, Yu, Raymond, Tobin, Jennifer, Wagner, Gregory S, Young, Peter R, Wong, Norman C W, Kulikowski, Ewelina
Published in Molecular pharmacology (01.12.2017)
Published in Molecular pharmacology (01.12.2017)
Get full text
Journal Article
In vitro biosynthesis, isolation, and identification of predominant metabolites of 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (RVX-208)
Khmelnitsky, Yuri L., Mozhaev, Vadim V., Cotterill, Ian C., Michels, Peter C., Boudjabi, Sihem, Khlebnikov, Vladimir, Madhava Reddy, M., Wagner, Gregory S., Hansen, Henrik C.
Published in European journal of medicinal chemistry (01.06.2013)
Published in European journal of medicinal chemistry (01.06.2013)
Get full text
Journal Article
A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice
Jahagirdar, Ravi, Zhang, Haiyan, Azhar, Salman, Tobin, Jennifer, Attwell, Sarah, Yu, Raymond, Wu, Jin, McLure, Kevin G, Hansen, Henrik C, Wagner, Gregory S, Young, Peter R, Srivastava, Rai Ajit K, Wong, Norman C.W, Johansson, Jan
Published in Atherosclerosis (01.09.2014)
Published in Atherosclerosis (01.09.2014)
Get full text
Journal Article
RVX-208: A Small Molecule That Increases Apolipoprotein A-I and High-Density Lipoprotein Cholesterol In Vitro and In Vivo
BAILEY, Dana, JAHAGIRDAR, Ravi, KRIMBOU, Larbi, WONG, Norman C. W, GENEST, Jacques, GORDON, Allan, HAFIANE, Anouar, CAMPBELL, Steven, CHATUR, Safia, WAGNER, Gregory S, HANSEN, Henrik C, CHIACCHIA, Fabrizio S, JOHANSSON, Jan
Published in Journal of the American College of Cardiology (08.06.2010)
Published in Journal of the American College of Cardiology (08.06.2010)
Get full text
Journal Article
Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design
Duffy, Bryan C., Liu, Shuang, Martin, Gregory S., Wang, Ruifang, Hsia, Ming Min, Zhao, He, Guo, Cheng, Ellis, Michael, Quinn, John F., Kharenko, Olesya A., Norek, Karen, Gesner, Emily M., Young, Peter R., McLure, Kevin G., Wagner, Gregory S., Lakshminarasimhan, Damodharan, White, Andre, Suto, Robert K., Hansen, Henrik C., Kitchen, Douglas B.
Published in Bioorganic & medicinal chemistry letters (15.07.2015)
Published in Bioorganic & medicinal chemistry letters (15.07.2015)
Get full text
Journal Article
RVX-208 DECREASES PROGRESSION OF ATHEROSCLEROSIS IN APOE NULL MICE
Wong, Norman C, Jahagirdar, Ravi, Azhar, Salam, Zhang, Haiyan, Gordon, Allan, Chiacchia, Fabrizio S, Wagner, Gregory S, Johansson, Jan
Published in Journal of the American College of Cardiology (05.04.2011)
Published in Journal of the American College of Cardiology (05.04.2011)
Get full text
Journal Article
Novel anti-inflammatory agents
KULIKOWSKI EWELINA B, ATTWELL SARAH C, HANSEN HENRIK C, WAGNER GREGORY S, MCLURE KEVIN G
Year of Publication 07.10.2020
Get full text
Year of Publication 07.10.2020
Patent
RVX-208
Bailey, Dana, MSc, Jahagirdar, Ravi, DVM, MS, Gordon, Allan, MD, PhD, Hafiane, Anouar, MSc, Campbell, Steven, BSc, Chatur, Safia, BSc, Wagner, Gregory S., PhD, Hansen, Henrik C., PhD, Chiacchia, Fabrizio S., MBT, Johansson, Jan, MD, PhD, Krimbou, Larbi, DES, Wong, Norman C.W., MD, Genest, Jacques, MD
Published in Journal of the American College of Cardiology (08.06.2010)
Published in Journal of the American College of Cardiology (08.06.2010)
Get full text
Journal Article
Novel anti-inflammatory agents
KULIKOWSKI EWELINA B, ATTWELL SARAH C, HANSEN HENRIK C, WAGNER GREGORY S, MCLURE KEVIN G
Year of Publication 06.08.2019
Get full text
Year of Publication 06.08.2019
Patent
Novel anti-inflammatory agents
KULIKOWSKI EWELINA B, ATTWELL SARAH C, HANSEN HENRIK C, WAGNER GREGORY S, MCLURE KEVIN G
Year of Publication 29.08.2018
Get full text
Year of Publication 29.08.2018
Patent
Pharmacokinetics and interspecies scaling of a novel VEGF receptor inhibitor, SU5416
Sukbuntherng, J, Cropp, G, Hannah, A, Wagner, G S, Shawver, L K, Antonian, L
Published in Journal of pharmacy and pharmacology (01.12.2001)
Published in Journal of pharmacy and pharmacology (01.12.2001)
Get more information
Journal Article
NOVEL ANTI-INFLAMMATORY AGENTS
KULIKOWSKI EWELINA B, ATTWELL SARAH C, HANSEN HENRIK C, WAGNER GREGORY S, MCLURE KEVIN G
Year of Publication 03.05.2012
Get full text
Year of Publication 03.05.2012
Patent
Abstract LB-92: RVX-2135 is a novel, orally bioavailable epigenetic BET inhibitor that synergizes with cytarabine and idarubicin to inhibit proliferation of acute myeloid leukemia cells
Campeau, Eric, Jahagirdar, Ravi, Wu, Jin, Gesner, Emily M., Kharenko, Olesya, Yu, Raymond, Attwell, Sarah, Hansen, Henrik C., Wagner, Gregory S., McLure, Kevin G., Young, Peter R.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Get full text
Journal Article
Abstract 1696: Compound RVX-208 Modulates HDL-C Levels and Function in Non-human Primates and in Early (phase I) Human Trials
Krimbou, Larbi, Jahagirdar, Ravi, Bailey, Dana, Hafiane, Anouar, Ruel, Isabelle, Wong, Norman, Wagner, Gregory S, Chiacchia, Fabrizio, Gordon, Allan, Hansen, Henrik C, Johansson, Jan, Genest, Jacques
Published in Circulation (New York, N.Y.) (28.10.2008)
Published in Circulation (New York, N.Y.) (28.10.2008)
Get full text
Journal Article
NOVEL ANTI-INFLAMMATORY AGENTS
WAGNER, Gregory, S, ATTWELL, Sarah, C, HANSEN, Henrik, C, MCLURE, Kevin, G, KULIKOWSKI, Ewelina, B
Year of Publication 17.06.2020
Get full text
Year of Publication 17.06.2020
Patent
NOVEL ANTI-INFLAMMATORY AGENTS
Wagner, Gregory S, Attwell, Sarah C, Hansen, Henrik C, Mclure, Kevin G, Kulikowski, Ewelina B
Year of Publication 30.04.2020
Get full text
Year of Publication 30.04.2020
Patent