Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation
Wurz, Ryan P, Rui, Huan, Dellamaggiore, Ken, Ghimire-Rijal, Sudipa, Choi, Kaylee, Smither, Kate, Amegadzie, Albert, Chen, Ning, Li, Xiaofen, Banerjee, Abhisek, Chen, Qing, Mohl, Dane, Vaish, Amit
Published in Nature communications (13.07.2023)
Published in Nature communications (13.07.2023)
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A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation
Wurz, Ryan P, Dellamaggiore, Ken, Dou, Hannah, Javier, Noelle, Lo, Mei-Chu, McCarter, John D, Mohl, Dane, Sastri, Christine, Lipford, J. Russell, Cee, Victor J
Published in Journal of medicinal chemistry (25.01.2018)
Published in Journal of medicinal chemistry (25.01.2018)
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Structural Elucidation and Absolute Stereochemistry for Pharma Compounds Using MicroED
de Moraes, Lygia Silva, Burch, Jessica E., Delgadillo, David A., Rodriguez, Isabel Hernandez, Mai, Huanghao, Smith, Austin G., Caille, Seb, Walker, Shawn D., Wurz, Ryan P., Cee, Victor J., Rodriguez, Jose A., Gostovic, Dan, Quasdorf, Kyle, Nelson, Hosea M.
Published in Organic letters (23.08.2024)
Published in Organic letters (23.08.2024)
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TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation
Ou, Yi-Hung, Torres, Michael, Ram, Rosalyn, Formstecher, Etienne, Roland, Christina, Cheng, Tzuling, Brekken, Rolf, Wurz, Ryan, Tasker, Andrew, Polverino, Tony, Tan, Seng-Lai, White, Michael A.
Published in Molecular cell (18.02.2011)
Published in Molecular cell (18.02.2011)
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Discovery of [1,2,4]Triazolo[1,5‑a]pyridine Derivatives as Potent and Orally Bioavailable RORγt Inverse Agonists
Nakajima, Ryota, Oono, Hiroyuki, Sugiyama, Sakae, Matsueda, Yohei, Ida, Tomohide, Kakuda, Shinji, Hirata, Jun, Baba, Atsushi, Makino, Akito, Matsuyama, Ryo, White, Ryan D, Wurz, Ryan Ρ, Shin, Youngsook, Min, Xiaoshan, Guzman-Perez, Angel, Wang, Zhulun, Symons, Antony, Singh, Sanjay K, Mothe, Srinivasa Reddy, Belyakov, Sergei, Chakrabarti, Anjan, Shuto, Satoshi
Published in ACS medicinal chemistry letters (09.04.2020)
Published in ACS medicinal chemistry letters (09.04.2020)
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Discovery of (R)‑8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4‑b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3H)‑one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies
Wang, Hui-Ling, Andrews, Kristin L, Booker, Shon K, Canon, Jude, Cee, Victor J, Chavez, Frank, Chen, Yuping, Eastwood, Heather, Guerrero, Nadia, Herberich, Brad, Hickman, Dean, Lanman, Brian A, Laszlo, Jimmy, Lee, Matthew R, Lipford, J. Russell, Mattson, Bethany, Mohr, Christopher, Nguyen, Yen, Norman, Mark H, Pettus, Liping H, Powers, David, Reed, Anthony B, Rex, Karen, Sastri, Christine, Tamayo, Nuria, Wang, Paul, Winston, Jeffrey T, Wu, Bin, Wu, Qiong, Wu, Tian, Wurz, Ryan P, Xu, Yang, Zhou, Yihong, Tasker, Andrew S
Published in Journal of medicinal chemistry (14.02.2019)
Published in Journal of medicinal chemistry (14.02.2019)
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Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors
Pettus, Liping H, Andrews, Kristin L, Booker, Shon K, Chen, Jie, Cee, Victor J, Chavez, Frank, Chen, Yuping, Eastwood, Heather, Guerrero, Nadia, Herberich, Bradley, Hickman, Dean, Lanman, Brian A, Laszlo, Jimmy, Lee, Matthew R, Lipford, J. Russell, Mattson, Bethany, Mohr, Christopher, Nguyen, Yen, Norman, Mark H, Powers, David, Reed, Anthony B, Rex, Karen, Sastri, Christine, Tamayo, Nuria, Wang, Paul, Winston, Jeffrey T, Wu, Bin, Wu, Tian, Wurz, Ryan P, Xu, Yang, Zhou, Yihong, Tasker, Andrew S, Wang, Hui-Ling
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
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Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors
Wurz, Ryan P., Sastri, Christine, D’Amico, Derin C., Herberich, Brad, Jackson, Claire L.M., Pettus, Liping H., Tasker, Andrew S., Wu, Bin, Guerrero, Nadia, Lipford, J. Russell, Winston, Jeffrey T., Yang, Yajing, Wang, Paul, Nguyen, Yen, Andrews, Kristin L., Huang, Xin, Lee, Matthew R., Mohr, Christopher, Zhang, J.D., Reid, Darren L., Xu, Yang, Zhou, Yihong, Wang, Hui-Ling
Published in Bioorganic & medicinal chemistry letters (15.11.2016)
Published in Bioorganic & medicinal chemistry letters (15.11.2016)
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Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases
Smith, Adrian L, D’Angelo, Noel D, Bo, Yunxin Y, Booker, Shon K, Cee, Victor J, Herberich, Brad, Hong, Fang-Tsao, Jackson, Claire L. M, Lanman, Brian A, Liu, Longbin, Nishimura, Nobuko, Pettus, Liping H, Reed, Anthony B, Tadesse, Seifu, Tamayo, Nuria A, Wurz, Ryan P, Yang, Kevin, Andrews, Kristin L, Whittington, Douglas A, McCarter, John D, Miguel, Tisha San, Zalameda, Leeanne, Jiang, Jian, Subramanian, Raju, Mullady, Erin L, Caenepeel, Sean, Freeman, Daniel J, Wang, Ling, Zhang, Nancy, Wu, Tian, Hughes, Paul E, Norman, Mark H
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
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Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors
Wu, Bin, Wang, Hui-Ling, Cee, Victor J., Lanman, Brian A., Nixey, Thomas, Pettus, Liping, Reed, Anthony B., Wurz, Ryan P., Guerrero, Nadia, Sastri, Christine, Winston, Jeff, Lipford, J. Russell, Lee, Matthew R., Mohr, Christopher, Andrews, Kristin L., Tasker, Andrew S.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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Discovery of a Covalent Inhibitor of KRAS G12C (AMG 510) for the Treatment of Solid Tumors
Lanman, Brian A, Allen, Jennifer R, Allen, John G, Amegadzie, Albert K, Ashton, Kate S, Booker, Shon K, Chen, Jian Jeffrey, Chen, Ning, Frohn, Michael J, Goodman, Guy, Kopecky, David J, Liu, Longbin, Lopez, Patricia, Low, Jonathan D, Ma, Vu, Minatti, Ana E, Nguyen, Thomas T, Nishimura, Nobuko, Pickrell, Alexander J, Reed, Anthony B, Shin, Youngsook, Siegmund, Aaron C, Tamayo, Nuria A, Tegley, Christopher M, Walton, Mary C, Wang, Hui-Ling, Wurz, Ryan P, Xue, May, Yang, Kevin C, Achanta, Pragathi, Bartberger, Michael D, Canon, Jude, Hollis, L Steven, McCarter, John D, Mohr, Christopher, Rex, Karen, Saiki, Anne Y, San Miguel, Tisha, Volak, Laurie P, Wang, Kevin H, Whittington, Douglas A, Zech, Stephan G, Lipford, J Russell, Cee, Victor J
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
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