Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells
Chu, Van Trung, Weber, Timm, Wefers, Benedikt, Wurst, Wolfgang, Sander, Sandrine, Rajewsky, Klaus, Kühn, Ralf
Published in Nature biotechnology (01.05.2015)
Published in Nature biotechnology (01.05.2015)
Get full text
Journal Article
Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity
Fecher, Caroline, Trovò, Laura, Müller, Stephan A., Snaidero, Nicolas, Wettmarshausen, Jennifer, Heink, Sylvia, Ortiz, Oskar, Wagner, Ingrid, Kühn, Ralf, Hartmann, Jana, Karl, Rosa Maria, Konnerth, Arthur, Korn, Thomas, Wurst, Wolfgang, Merkler, Doron, Lichtenthaler, Stefan F., Perocchi, Fabiana, Misgeld, Thomas
Published in Nature neuroscience (01.10.2019)
Published in Nature neuroscience (01.10.2019)
Get full text
Journal Article
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury
Mazaheri, Fargol, Snaidero, Nicolas, Kleinberger, Gernot, Madore, Charlotte, Daria, Anna, Werner, Georg, Krasemann, Susanne, Capell, Anja, Trümbach, Dietrich, Wurst, Wolfgang, Brunner, Bettina, Bultmann, Sebastian, Tahirovic, Sabina, Kerschensteiner, Martin, Misgeld, Thomas, Butovsky, Oleg, Haass, Christian
Published in EMBO reports (01.07.2017)
Published in EMBO reports (01.07.2017)
Get full text
Journal Article
Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders
Blanco, Sandra, Dietmann, Sabine, Flores, Joana V, Hussain, Shobbir, Kutter, Claudia, Humphreys, Peter, Lukk, Margus, Lombard, Patrick, Treps, Lucas, Popis, Martyna, Kellner, Stefanie, Hölter, Sabine M, Garrett, Lillian, Wurst, Wolfgang, Becker, Lore, Klopstock, Thomas, Fuchs, Helmut, Gailus-Durner, Valerie, Hrabĕ de Angelis, Martin, Káradóttir, Ragnhildur T, Helm, Mark, Ule, Jernej, Gleeson, Joseph G, Odom, Duncan T, Frye, Michaela
Published in The EMBO journal (17.09.2014)
Published in The EMBO journal (17.09.2014)
Get full text
Journal Article
The FTD‐like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism
Kleinberger, Gernot, Brendel, Matthias, Mracsko, Eva, Wefers, Benedikt, Groeneweg, Linda, Xiang, Xianyuan, Focke, Carola, Deußing, Maximilian, Suárez‐Calvet, Marc, Mazaheri, Fargol, Parhizkar, Samira, Pettkus, Nadine, Wurst, Wolfgang, Feederle, Regina, Bartenstein, Peter, Mueggler, Thomas, Arzberger, Thomas, Knuesel, Irene, Rominger, Axel, Haass, Christian
Published in The EMBO journal (03.07.2017)
Published in The EMBO journal (03.07.2017)
Get full text
Journal Article
Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis
Beckervordersandforth, Ruth, Ebert, Birgit, Schäffner, Iris, Moss, Jonathan, Fiebig, Christian, Shin, Jaehoon, Moore, Darcie L., Ghosh, Laboni, Trinchero, Mariela F., Stockburger, Carola, Friedland, Kristina, Steib, Kathrin, von Wittgenstein, Julia, Keiner, Silke, Redecker, Christoph, Hölter, Sabine M., Xiang, Wei, Wurst, Wolfgang, Jagasia, Ravi, Schinder, Alejandro F., Ming, Guo-li, Toni, Nicolas, Jessberger, Sebastian, Song, Hongjun, Lie, D. Chichung
Published in Neuron (Cambridge, Mass.) (08.02.2017)
Published in Neuron (Cambridge, Mass.) (08.02.2017)
Get full text
Journal Article
Genome editing for Duchenne muscular dystrophy: a glimpse of the future?
Kupatt, Christian, Windisch, Alina, Moretti, Alessandra, Wolf, Eckhard, Wurst, Wolfgang, Walter, Maggie C.
Published in Gene therapy (01.09.2021)
Published in Gene therapy (01.09.2021)
Get full text
Journal Article
FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis
Schäffner, Iris, Minakaki, Georgia, Khan, M. Amir, Balta, Elli-Anna, Schlötzer-Schrehardt, Ursula, Schwarz, Tobias J., Beckervordersandforth, Ruth, Winner, Beate, Webb, Ashley E., DePinho, Ronald A., Paik, Jihye, Wurst, Wolfgang, Klucken, Jochen, Lie, D. Chichung
Published in Neuron (Cambridge, Mass.) (19.09.2018)
Published in Neuron (Cambridge, Mass.) (19.09.2018)
Get full text
Journal Article
Rapamycin extends murine lifespan but has limited effects on aging
Neff, Frauke, Flores-Dominguez, Diana, Ryan, Devon P, Horsch, Marion, Schröder, Susanne, Adler, Thure, Afonso, Luciana Caminha, Aguilar-Pimentel, Juan Antonio, Becker, Lore, Garrett, Lillian, Hans, Wolfgang, Hettich, Moritz M, Holtmeier, Richard, Hölter, Sabine M, Moreth, Kristin, Prehn, Cornelia, Puk, Oliver, Rácz, Ildikó, Rathkolb, Birgit, Rozman, Jan, Naton, Beatrix, Ordemann, Rainer, Adamski, Jerzy, Beckers, Johannes, Bekeredjian, Raffi, Busch, Dirk H, Ehninger, Gerhard, Graw, Jochen, Höfler, Heinz, Klingenspor, Martin, Klopstock, Thomas, Ollert, Markus, Stypmann, Jörg, Wolf, Eckhard, Wurst, Wolfgang, Zimmer, Andreas, Fuchs, Helmut, Gailus-Durner, Valérie, Hrabe de Angelis, Martin, Ehninger, Dan
Published in The Journal of clinical investigation (01.08.2013)
Published in The Journal of clinical investigation (01.08.2013)
Get full text
Journal Article
Engrailed 1 deficiency induces changes in ciliogenesis during human neuronal differentiation
Hembach, Sina, Schmidt, Sebastian, Orschmann, Tanja, Burtscher, Ingo, Lickert, Heiko, Giesert, Florian, Weisenhorn, Daniela Vogt, Wurst, Wolfgang
Published in Neurobiology of disease (01.05.2024)
Published in Neurobiology of disease (01.05.2024)
Get full text
Journal Article
The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans
Xiang, Xianyuan, Piers, Thomas M, Wefers, Benedikt, Zhu, Kaichuan, Mallach, Anna, Brunner, Bettina, Kleinberger, Gernot, Song, Wilbur, Colonna, Marco, Herms, Jochen, Wurst, Wolfgang, Pocock, Jennifer M, Haass, Christian
Published in Molecular neurodegeneration (06.09.2018)
Published in Molecular neurodegeneration (06.09.2018)
Get full text
Journal Article
Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
Dedic, Nina, Kühne, Claudia, Jakovcevski, Mira, Hartmann, Jakob, Genewsky, Andreas J., Gomes, Karina S., Anderzhanova, Elmira, Pöhlmann, Max L., Chang, Simon, Kolarz, Adam, Vogl, Annette M., Dine, Julien, Metzger, Michael W., Schmid, Bianca, Almada, Rafael C., Ressler, Kerry J., Wotjak, Carsten T., Grinevich, Valery, Chen, Alon, Schmidt, Mathias V., Wurst, Wolfgang, Refojo, Damian, Deussing, Jan M.
Published in Nature neuroscience (01.06.2018)
Published in Nature neuroscience (01.06.2018)
Get full text
Journal Article
Mutant non-coding RNA resource in mouse embryonic stem cells
Hansen, Jens, von Melchner, Harald, Wurst, Wolfgang
Published in Disease models & mechanisms (01.02.2021)
Published in Disease models & mechanisms (01.02.2021)
Get full text
Journal Article
Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides
Wefers, Benedikt, Meyer, Melanie, Ortiz, Oskar, de Angelis, Martin Hrabé, Hansen, Jens, Wurst, Wolfgang, Kühn, Ralf
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2013)
Get full text
Journal Article
A protein quality control pathway regulated by linear ubiquitination
van Well, Eva M, Bader, Verian, Patra, Maria, Sánchez‐Vicente, Ana, Meschede, Jens, Furthmann, Nikolas, Schnack, Cathrin, Blusch, Alina, Longworth, Joseph, Petrasch‐Parwez, Elisabeth, Mori, Kohji, Arzberger, Thomas, Trümbach, Dietrich, Angersbach, Lena, Showkat, Cathrin, Sehr, Dominik A, Berlemann, Lena A, Goldmann, Petra, Clement, Albrecht M, Behl, Christian, Woerner, Andreas C, Saft, Carsten, Wurst, Wolfgang, Haass, Christian, Ellrichmann, Gisa, Gold, Ralf, Dittmar, Gunnar, Hipp, Mark S, Hartl, F Ulrich, Tatzelt, Jörg, Winklhofer, Konstanze F
Published in The EMBO journal (02.05.2019)
Published in The EMBO journal (02.05.2019)
Get full text
Journal Article
Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP
Simeone, Antonio, Di Salvio, Michela, Di Giovannantonio, Luca Giovanni, Acampora, Dario, Prosperi, Raffaele, Omodei, Daniela, Prakash, Nilima, Wurst, Wolfgang
Published in Nature neuroscience (01.12.2010)
Published in Nature neuroscience (01.12.2010)
Get full text
Journal Article
Glutamatergic and Dopaminergic Neurons Mediate Anxiogenic and Anxiolytic Effects of CRHR1
Refojo, Damian, Schweizer, Martin, Kuehne, Claudia, Ehrenberg, Stefanie, Thoeringer, Christoph, Vogl, Annette M., Dedic, Nina, Schumacher, Marion, von Wolff, Gregor, Avrabos, Charilaos, Touma, Chadi, Engblom, David, Schütz, Günther, Nave, Klaus-Armin, Eder, Matthias, Wotjak, Carsten T., Sillaber, Inge, Holsboer, Florian, Wurst, Wolfgang, Deussing, Jan M.
Published in Science (American Association for the Advancement of Science) (30.09.2011)
Published in Science (American Association for the Advancement of Science) (30.09.2011)
Get full text
Journal Article