Engineering of a red-light–activated human cAMP/cGMP-specific phosphodiesterase
Gasser, Carlos, Taiber, Sandra, Yeh, Chen-Min, Wittig, Charlotte Helene, Hegemann, Peter, Ryu, Soojin, Wunder, Frank, Möglich, Andreas
Published in Proceedings of the National Academy of Sciences - PNAS (17.06.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (17.06.2014)
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Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure
Follmann, Markus, Ackerstaff, Jens, Redlich, Gorden, Wunder, Frank, Lang, Dieter, Kern, Armin, Fey, Peter, Griebenow, Nils, Kroh, Walter, Becker-Pelster, Eva-Maria, Kretschmer, Axel, Geiss, Volker, Li, Volkhart, Straub, Alexander, Mittendorf, Joachim, Jautelat, Rolf, Schirok, Hartmut, Schlemmer, Karl-Heinz, Lustig, Klemens, Gerisch, Michael, Knorr, Andreas, Tinel, Hanna, Mondritzki, Thomas, Trübel, Hubert, Sandner, Peter, Stasch, Johannes-Peter
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
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Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGC
Becker-Pelster, Eva M., Hahn, Michael G., Delbeck, Martina, Dietz, Lisa, Hüser, Jörg, Kopf, Johannes, Kraemer, Thomas, Marquardt, Tobias, Mondritzki, Thomas, Nagelschmitz, Johannes, Nikkho, Sylvia M., Pires, Philippe V., Tinel, Hanna, Weimann, Gerrit, Wunder, Frank, Sandner, Peter, Schuhmacher, Joachim, Stasch, Johannes-Peter, Truebel, Hubert K. F.
Published in Respiratory research (01.10.2022)
Published in Respiratory research (01.10.2022)
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Discovery of Riociguat (BAY 63-2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension
Mittendorf, Joachim, Weigand, Stefan, Alonso-Alija, Cristina, Bischoff, Erwin, Feurer, Achim, Gerisch, Michael, Kern, Armin, Knorr, Andreas, Lang, Dieter, Muenter, Klaus, Radtke, Martin, Schirok, Hartmut, Schlemmer, Karl-Heinz, Stahl, Elke, Straub, Alexander, Wunder, Frank, Stasch, Johannes-Peter
Published in ChemMedChem (11.05.2009)
Published in ChemMedChem (11.05.2009)
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Atrial natriuretic peptide and nitric oxide signaling antagonizes vasopressin-mediated water permeability in inner medullary collecting duct cells
Klokkers, Jens, Langehanenberg, Patrik, Kemper, Björn, Kosmeier, Sebastian, von Bally, Gert, Riethmüller, Christoph, Wunder, Frank, Sindic, Aleksandra, Pavenstädt, Hermann, Schlatter, Eberhard, Edemir, Bayram
Published in American journal of physiology. Renal physiology (01.09.2009)
Published in American journal of physiology. Renal physiology (01.09.2009)
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A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology
Durrant, Jacob D, Amaro, Rommie E, Xie, Lei, Urbaniak, Michael D, Ferguson, Michael A J, Haapalainen, Antti, Chen, Zhijun, Di Guilmi, Anne Marie, Wunder, Frank, Bourne, Philip E, McCammon, J Andrew
Published in PLoS computational biology (01.01.2010)
Published in PLoS computational biology (01.01.2010)
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Immunohistochemical localization of five members of the Kv1 channel subunits: contrasting subcellular locations and neuron-specific co-localizations in rat brain
Veh, R W, Lichtinghagen, R, Sewing, S, Wunder, F, Grumbach, I M, Pongs, O
Published in The European journal of neuroscience (01.11.1995)
Published in The European journal of neuroscience (01.11.1995)
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PDE2 at the crossway between cAMP and cGMP signalling in the heart
Weber, Silvio, Zeller, Miriam, Guan, Kaomei, Wunder, Frank, Wagner, Michael, El-Armouche, Ali
Published in Cellular signalling (01.10.2017)
Published in Cellular signalling (01.10.2017)
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Journal Article
Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042)
Hahn, Michael G, Lampe, Thomas, El Sheikh, Sherif, Griebenow, Nils, Woltering, Elisabeth, Schlemmer, Karl-Heinz, Dietz, Lisa, Gerisch, Michael, Wunder, Frank, Becker-Pelster, Eva-Maria, Mondritzki, Thomas, Tinel, Hanna, Knorr, Andreas, Kern, Armin, Lang, Dieter, Hueser, Joerg, Schomber, Tibor, Benardeau, Agnes, Eitner, Frank, Truebel, Hubert, Mittendorf, Joachim, Kumar, Vijay, van den Akker, Focco, Schaefer, Martina, Geiss, Volker, Sandner, Peter, Stasch, Johannes-Peter
Published in Journal of medicinal chemistry (13.05.2021)
Published in Journal of medicinal chemistry (13.05.2021)
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BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α 2B Antagonist
Meibom, Daniel, Meyer, Jutta, von Buehler, Clemens-Jeremias, Collins, Karl D, Maassen, Stefanie, Gericke, Kersten Matthias, Hüser, Jörg, Mittendorf, Joachim, Ortega Hernandez, Nuria, Schamberger, Jens, Stampfuss, Jan, Straub, Alexander, Torge, Afra, Witowski, Norbert, Wunder, Frank
Published in Journal of medicinal chemistry (13.04.2023)
Published in Journal of medicinal chemistry (13.04.2023)
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Journal Article
BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic ?(2B) Antagonist
Meibom, Daniel, Meyer, Jutta, von Buehler, Clemens-Jeremias, Collins, Karl D., Maassen, Stefanie, Gericke, Kersten Matthias, Hueser, Joerg, Mittendorf, Joachim, Hernandez, Nuria Ortega, Schamberger, Jens, Stampfuss, Jan, Straub, Alexander, Torge, Afra, Witowski, Norbert, Wunder, Frank
Published in Journal of medicinal chemistry (13.04.2023)
Published in Journal of medicinal chemistry (13.04.2023)
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Establishment of a novel, cell-based autotaxin assay
Dobersalske, Celia, Grundmann, Manuel, Timmermann, Andreas, Theisen, Laura, Kölling, Florian, Harris, Raymond C., Fuerstner, Chantal, Becker, Michael S., Wunder, Frank
Published in Analytical biochemistry (01.10.2021)
Published in Analytical biochemistry (01.10.2021)
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Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes
Egbert, Jeremy R, Shuhaibar, Leia C, Edmund, Aaron B, Van Helden, Dusty A, Robinson, Jerid W, Uliasz, Tracy F, Baena, Valentina, Geerts, Andreas, Wunder, Frank, Potter, Lincoln R, Jaffe, Laurinda A
Published in Development (Cambridge) (01.09.2014)
Published in Development (Cambridge) (01.09.2014)
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Identification and characterization of the new generation soluble guanylate cyclase stimulator BAY‐747 designed for the treatment of resistant hypertension
Wunder, Frank, Stasch, Johannes‐Peter, Knorr, Andreas, Mondritzki, Thomas, Brockschnieder, Damian, Becker‐Pelster, Eva‐Maria, Sandner, Peter, Tinel, Hanna, Redlich, Gorden, Hartung, Ingo V., Vakalopoulos, Alexandros, Follmann, Markus
Published in British journal of pharmacology (01.10.2023)
Published in British journal of pharmacology (01.10.2023)
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BAY-7081: A Potent, Selective, and Orally Bioavailable Cyanopyridone-Based PDE9A Inhibitor
Meibom, Daniel, Micus, Sina, Andreevski, Anna Lena, Anlauf, Sonja, Bogner, Pamela, von Buehler, Clemens-Jeremias, Dieskau, André P., Dreher, Jan, Eitner, Frank, Fliegner, Daniela, Follmann, Markus, Gericke, Kersten Matthias, Maassen, Stefanie, Meyer, Jutta, Schlemmer, Karl-Heinz, Steuber, Holger, Tersteegen, Adrian, Wunder, Frank
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
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