Development of Highly Sensitive Fluorescent Sensors for Separation-Free Detection and Quantitation Systems of Pepsin Enzyme Applying a Structure-Guided Approach
Mostafa, Aya M, Barton, Stephen J, Wren, Stephen P, Barker, James
Published in Biosensors (Basel) (20.03.2024)
Published in Biosensors (Basel) (20.03.2024)
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Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse
Tinsley, Jonathon M, Fairclough, Rebecca J, Storer, Richard, Wilkes, Fraser J, Potter, Allyson C, Squire, Sarah E, Powell, Dave S, Cozzoli, Anna, Capogrosso, Roberta F, Lambert, Adam, Wilson, Francis X, Wren, Stephen P, De Luca, Annamaria, Davies, Kay E
Published in PloS one (06.05.2011)
Published in PloS one (06.05.2011)
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Journal Article
Discovery of 2-Arylbenzoxazoles as Upregulators of Utrophin Production for the Treatment of Duchenne Muscular Dystrophy
Chancellor, Daniel R, Davies, Kay E, De Moor, Olivier, Dorgan, Colin R, Johnson, Peter D, Lambert, Adam G, Lawrence, Daniel, Lecci, Cristina, Maillol, Carole, Middleton, Penny J, Nugent, Gary, Poignant, Séverine D, Potter, Allyson C, Price, Paul D, Pye, Richard J, Storer, Richard, Tinsley, Jonathon M, van Well, Renate, Vickers, Richard, Vile, Julia, Wilkes, Fraser J, Wilson, Francis X, Wren, Stephen P, Wynne, Graham M
Published in Journal of medicinal chemistry (12.05.2011)
Published in Journal of medicinal chemistry (12.05.2011)
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Journal Article
Fructose malabsorption: causes, diagnosis and treatment
Benardout, Miles, Le Gresley, Adam, ElShaer, Amr, Wren, Stephen P.
Published in British journal of nutrition (28.02.2022)
Published in British journal of nutrition (28.02.2022)
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Journal Article
Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection
Paulsson-Habegger, Lukas, Snabaitis, Andrew K., Wren, Stephen P.
Published in Bioorganic & medicinal chemistry (15.10.2021)
Published in Bioorganic & medicinal chemistry (15.10.2021)
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Journal Article
A Virtual Screening Approach to Finding Novel and Potent Antagonists at the Melanin-Concentrating Hormone 1 Receptor
Clark, David E, Higgs, Christopher, Wren, Stephen P, Dyke, Hazel J, Wong, Melanie, Norman, Dennis, Lockey, Peter M, Roach, Alan G
Published in Journal of medicinal chemistry (29.07.2004)
Published in Journal of medicinal chemistry (29.07.2004)
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Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue
Green, Jonathan, Tinson, Ryan A.J., Betts, Jacob H.J., Piras, Monica, Pelut, Aylin, Steverding, Dietmar, Wren, Stephen P., Searcey, Mark, Troeberg, Linda
Published in Bioorganic & medicinal chemistry (07.09.2023)
Published in Bioorganic & medicinal chemistry (07.09.2023)
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Journal Article
In silico design of bioisosteric modifications of drugs for the treatment of diabetes
Vink, Guillaume, Nebel, Jean-Christophe, Wren, Stephen P
Published in Future medicinal chemistry (01.04.2021)
Published in Future medicinal chemistry (01.04.2021)
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Journal Article
Suramin: Effectiveness of analogues reveals structural features that are important for the potent trypanocidal activity of the drug
Steverding, Dietmar, Tinson, Ryan A.J., Piras, Monica, Wren, Stephen P., Rushworth, Stuart A., Searcey, Mark, Troeberg, Linda
Published in Experimental parasitology (01.05.2024)
Published in Experimental parasitology (01.05.2024)
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Journal Article
Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3
Chanalaris, Anastasios, Doherty, Christine, Marsden, Brian D, Bambridge, Gabriel, Wren, Stephen P, Nagase, Hideaki, Troeberg, Linda
Published in Molecular pharmacology (01.10.2017)
Published in Molecular pharmacology (01.10.2017)
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Journal Article
Design and preparation of a fluorescent molecularly imprinted membrane for the selective detection of pepsin enzyme as a biomarker for gastroesophageal reflux disease
Mostafa, Aya M., Barton, Stephen J., Wren, Stephen P., Barker, James
Published in Talanta open (01.12.2024)
Published in Talanta open (01.12.2024)
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Journal Article
The synthesis and SAR of 2-arylsulfanyl-phenyl piperazinyl acetic acids as glyT-1 inhibitors
Smith, Garrick, Ruhland, Thomas, Mikkelsen, Gitte, Andersen, Kim, Christoffersen, Claus Tornby, Alifrangis, Lene Hjorth, Mørk, Arne, Wren, Stephen P, Harris, Neil, Wyman, Barry M, Brandt, Guillaume
Published in Bioorganic & medicinal chemistry letters (02.08.2004)
Published in Bioorganic & medicinal chemistry letters (02.08.2004)
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Journal Article
Synthesis of Squaric Acid Monoamides as Building Blocks for Drug Discovery
Long, Nathan, Le Gresley, Adam, Solomonsz, Arran, Wozniak, Antony, Brough, Steve, Wren, Stephen P.
Published in SynOpen (2017) (01.08.2023)
Published in SynOpen (2017) (01.08.2023)
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Journal Article
Computational Design and Fabrication of Optical Fibre Fluorescent Chemical Probes for the Detection of Cocaine
Wren, Stephen P., Piletsky, Sergey A., Karim, Kal, Gascoine, Paul, Lacey, Richard, Tong Sun, Grattan, Kenneth T. V.
Published in Journal of lightwave technology (15.06.2015)
Published in Journal of lightwave technology (15.06.2015)
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Journal Article
Discovery and SAR of 2-arylbenzotriazoles and 2-arylindazoles as potential treatments for Duchenne muscular dystrophy
De Moor, Olivier, Dorgan, Colin R., Johnson, Peter D., Lambert, Adam G., Lecci, Cristina, Maillol, Carole, Nugent, Gary, Poignant, Séverine D., Price, Paul D., Pye, Richard J., Storer, Richard, Tinsley, Jonathon M., Vickers, Richard, Well, Renate van, Wilkes, Fraser J., Wilson, Francis X., Wren, Stephen P., Wynne, Graham M.
Published in Bioorganic & medicinal chemistry letters (15.08.2011)
Published in Bioorganic & medicinal chemistry letters (15.08.2011)
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Journal Article
Studies on Pyrrolopyrimidines as Selective Inhibitors of Multidrug-Resistance- Associated Protein in Multidrug Resistance
Wang, Shouming, Folkes, Adrian, Chuckowree, Irina, Cockcroft, Xiaoling, Sohal, Sukhjit, Miller, Warren, Milton, John, Wren, Stephen P, Vicker, Nigel, Depledge, Paul, Scott, John, Smith, Lyndsay, Jones, Hazel, Mistry, Prakash, Faint, Richard, Thompson, Deanne, Cocks, Simon
Published in Journal of medicinal chemistry (11.03.2004)
Published in Journal of medicinal chemistry (11.03.2004)
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