1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure activity relationships at N1 for the quinolone antibacterials
Domagala, John M, Heifetz, Carl L, Hutt, Marland P, Mich, Thomas F, Nichols, Jeffry B, Solomon, Marjorie, Worth, Donald F
Published in Journal of medicinal chemistry (01.05.1988)
Published in Journal of medicinal chemistry (01.05.1988)
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Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application
Hamilton, Harriet W, Ortwine, Daniel F, Worth, Donald F, Badger, Edward W, Bristol, James A, Bruns, Robert F, Haleen, Stephen J, Steffen, Robert P
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Published in Journal of medicinal chemistry (01.08.1985)
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Antimalarial drugs. 60. Synthesis, antimalarial activity, and quantitative structure-activity relationships of tebuquine and a series of related 5-[(7-chloro-4-quinolinyl)amino]-3-[(alkylamino)methyl][1,1'-biphenyl]-2-ols and N.omega.-oxides
Werbel, Leslie M, Cook, P. Dan, Elslager, Edward F, Hung, Jocelyn H, Johnson, Judith L, Kesten, Stephen J, McNamara, Dennis J, Ortwine, Daniel F, Worth, Donald F
Published in Journal of medicinal chemistry (01.06.1986)
Published in Journal of medicinal chemistry (01.06.1986)
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Inhibitors of platelet aggregation. 1. 5,10-Dihydro-3-(phenyl, thienyl, and furyl)thiazolo[3,2-b][2,4]benzodiazepines and related compounds
Elslager, Edward F, McLean, J. R, Perricone, Salvatore C, Potoczak, Doris, Veloso, H, Worth, Donald F, Wheelock, R. H
Published in Journal of medicinal chemistry (01.05.1971)
Published in Journal of medicinal chemistry (01.05.1971)
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Quinolone antibacterials: preparation and activity of bridged bicyclic analogues of the C7-piperazine
Kiely, John S, Hutt, Marland P, Culbertson, Townley P, Bucsh, Ruth A, Worth, Donald F, Lesheski, Lawrence E, Gogliotti, Rocco D, Sesnie, Josephine C, Solomon, Marjorie, Mich, Thomas F
Published in Journal of medicinal chemistry (01.02.1991)
Published in Journal of medicinal chemistry (01.02.1991)
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Basically substituted ellipticine analogs as potential antitumor agents
Werbel, Leslie M, Angelo, Mario, Fry, David W, Worth, Donald F
Published in Journal of medicinal chemistry (01.07.1986)
Published in Journal of medicinal chemistry (01.07.1986)
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N2-1H-Benzimidazol-2-yl-N4-phenyl-2,4-pyrimidinediamines and N2-1H-benzimidazol-2-yl-5,6,7,8-tetrahydro-N4-phenyl-2,4-quinazolinediamines as potential antifilarial agents
Angelo, Mario M, Ortwine, Daniel, Worth, Donald F, Werbel, Leslie M
Published in Journal of medicinal chemistry (01.09.1983)
Published in Journal of medicinal chemistry (01.09.1983)
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Antimalarial drugs. 38. Folate antagonists. 10. Synthesis and antimalarial effects of 6-[[(aryl and aralkyl)amino]methyl]-2,4-pteridinediamines and -pteridinediamine 8-oxides
Worth, Donald F, Johnson, Judith, Elslager, Edward F, Werbel, Leslie M
Published in Journal of medicinal chemistry (01.04.1978)
Published in Journal of medicinal chemistry (01.04.1978)
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Long-acting, repository antimalarial agents. Duration of protection in mice and monkeys following administration of pyrimethamine pamoate
Werbel, L M, Jacobs, R L, Steinkampf, R W, Worth, D F
Published in The American journal of tropical medicine and hygiene (01.07.1984)
Published in The American journal of tropical medicine and hygiene (01.07.1984)
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Antimalarial drugs. 39. Folate antagonists. 13. 2,4-Diamino-6-[(.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)thio]quinazoline and related 2,4-diamino-6-[(phenyl- and naphthyl)thio]quinazolines, a unique class of antimetabolites with extraordinary antimalarial and antibacterial effects
Elslager, Edward F, Jacob, Patricia, Johnson, Judith, Werbel, Leslie M, Worth, Donald F, Rane, Leo
Published in Journal of medicinal chemistry (01.10.1978)
Published in Journal of medicinal chemistry (01.10.1978)
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Antimalarial drugs. 46. Folate antagonists. 15. 2,4-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity
Elslager, Edward F, Hutt, Marland P, Jacob, Patricia, Johnson, Judith, Temporelli, Barbara, Werbel, Leslie M, Worth, Donald F, Rane, Leo
Published in Journal of medicinal chemistry (01.10.1979)
Published in Journal of medicinal chemistry (01.10.1979)
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Repository drugs. IV. 4',4'''-Sulfonylbisacetanilide (acedapsone, DADDS) and related sulfanilylanilides with prolonged antimalarial and antileprotic action
Elslager, Edward F, Gavrilis, Zoe B, Phillips, Annette A, Worth, Donald F
Published in Journal of medicinal chemistry (01.05.1969)
Published in Journal of medicinal chemistry (01.05.1969)
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Antimalarial drugs. 25. Folate antagonists. 3. 2,4-Diamino-6-(heterocyclic)quinazolines, a novel class of antimetabolites with potent antimalarial and antibacterial activity
Elslager, Edward F, Clarke, J, Werbel, Leslie M, Worth, Donald F, Davoll, John
Published in Journal of medicinal chemistry (01.08.1972)
Published in Journal of medicinal chemistry (01.08.1972)
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Folate antagonists. 11. Synthesis and antimalarial effects of 6-[(aryloxy- and arylthio-)methyl]-2,4-pteridinediamines and -pteridinediamine 8-oxides
Werbel, Leslie M, Johnson, Judith, Elslager, Edward F, Worth, Donald F
Published in Journal of medicinal chemistry (01.04.1978)
Published in Journal of medicinal chemistry (01.04.1978)
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Synthetic schistosomicides. IX. N-(dialkylaminoalkyl)-4-nitroso-1-naphthylamines
Werbel, Leslie M, Elslager, Edward F, Worth, Donald F
Published in Journal of medicinal chemistry (01.09.1968)
Published in Journal of medicinal chemistry (01.09.1968)
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