Using human genetics to understand the disease impacts of testosterone in men and women
Ruth, Katherine S, Day, Felix R, Tyrrell, Jessica, Thompson, Deborah J, Wood, Andrew R, Mahajan, Anubha, Beaumont, Robin N, Wittemans, Laura, Martin, Susan, Busch, Alexander S, Erzurumluoglu, A Mesut, Hollis, Benjamin, O'Mara, Tracy A, McCarthy, Mark I, Langenberg, Claudia, Easton, Douglas F, Wareham, Nicholas J, Burgess, Stephen, Murray, Anna, Ong, Ken K, Frayling, Timothy M, Perry, John R B
Published in Nature medicine (01.02.2020)
Published in Nature medicine (01.02.2020)
Get full text
Journal Article
Genetic predictors of participation in optional components of UK Biobank
Tyrrell, Jessica, Zheng, Jie, Beaumont, Robin, Hinton, Kathryn, Richardson, Tom G, Wood, Andrew R, Davey Smith, George, Frayling, Timothy M, Tilling, Kate
Published in Nature communications (09.02.2021)
Published in Nature communications (09.02.2021)
Get full text
Journal Article
Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms
Jones, Samuel E, Lane, Jacqueline M, Wood, Andrew R, van Hees, Vincent T, Tyrrell, Jessica, Beaumont, Robin N, Jeffries, Aaron R, Dashti, Hassan S, Hillsdon, Melvyn, Ruth, Katherine S, Tuke, Marcus A, Yaghootkar, Hanieh, Sharp, Seth A, Jie, Yingjie, Thompson, William D, Harrison, Jamie W, Dawes, Amy, Byrne, Enda M, Tiemeier, Henning, Allebrandt, Karla V, Bowden, Jack, Ray, David W, Freathy, Rachel M, Murray, Anna, Mazzotti, Diego R, Gehrman, Philip R, Lawlor, Debbie A, Frayling, Timothy M, Rutter, Martin K, Hinds, David A, Saxena, Richa, Weedon, Michael N
Published in Nature communications (29.01.2019)
Published in Nature communications (29.01.2019)
Get full text
Journal Article
Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis
Sharp, Seth A, Rich, Stephen S, Wood, Andrew R, Jones, Samuel E, Beaumont, Robin N, Harrison, James W, Schneider, Darius A, Locke, Jonathan M, Tyrrell, Jess, Weedon, Michael N, Hagopian, William A, Oram, Richard A
Published in Diabetes care (01.02.2019)
Published in Diabetes care (01.02.2019)
Get full text
Journal Article
Biological interpretation of genome-wide association studies using predicted gene functions
Pers, Tune H, Karjalainen, Juha M, Chan, Yingleong, Westra, Harm-Jan, Wood, Andrew R, Yang, Jian, Lui, Julian C, Vedantam, Sailaja, Gustafsson, Stefan, Esko, Tonu, Frayling, Tim, Speliotes, Elizabeth K, Boehnke, Michael, Raychaudhuri, Soumya, Fehrmann, Rudolf S N, Hirschhorn, Joel N, Franke, Lude
Published in Nature communications (19.01.2015)
Published in Nature communications (19.01.2015)
Get full text
Journal Article
Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting
Wright, Caroline F., West, Ben, Tuke, Marcus, Jones, Samuel E., Patel, Kashyap, Laver, Thomas W., Beaumont, Robin N., Tyrrell, Jessica, Wood, Andrew R., Frayling, Timothy M., Hattersley, Andrew T., Weedon, Michael N.
Published in American journal of human genetics (07.02.2019)
Published in American journal of human genetics (07.02.2019)
Get full text
Journal Article
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
Wang, Heming, Lane, Jacqueline M, Jones, Samuel E, Dashti, Hassan S, Ollila, Hanna M, Wood, Andrew R, van Hees, Vincent T, Brumpton, Ben, Winsvold, Bendik S, Kantojärvi, Katri, Palviainen, Teemu, Cade, Brian E, Sofer, Tamar, Song, Yanwei, Patel, Krunal, Anderson, Simon G, Bechtold, David A, Bowden, Jack, Emsley, Richard, Kyle, Simon D, Little, Max A, Loudon, Andrew S, Scheer, Frank A J L, Purcell, Shaun M, Richmond, Rebecca C, Spiegelhalder, Kai, Tyrrell, Jessica, Zhu, Xiaofeng, Hublin, Christer, Kaprio, Jaakko A, Kristiansson, Kati, Sulkava, Sonja, Paunio, Tiina, Hveem, Kristian, Nielsen, Jonas B, Willer, Cristen J, Zwart, John-Anker, Strand, Linn B, Frayling, Timothy M, Ray, David, Lawlor, Deborah A, Rutter, Martin K, Weedon, Michael N, Redline, Susan, Saxena, Richa
Published in Nature communications (13.08.2019)
Published in Nature communications (13.08.2019)
Get full text
Journal Article
Quantification of the overall contribution of gene-environment interaction for obesity-related traits
Sulc, Jonathan, Mounier, Ninon, Günther, Felix, Winkler, Thomas, Wood, Andrew R, Frayling, Timothy M, Heid, Iris M, Robinson, Matthew R, Kutalik, Zoltán
Published in Nature communications (13.03.2020)
Published in Nature communications (13.03.2020)
Get full text
Journal Article
Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome
Porcu, Eleonora, Sadler, Marie C, Lepik, Kaido, Auwerx, Chiara, Wood, Andrew R, Weihs, Antoine, Sleiman, Maroun S Bou, Ribeiro, Diogo M, Bandinelli, Stefania, Tanaka, Toshiko, Nauck, Matthias, Völker, Uwe, Delaneau, Olivier, Metspalu, Andres, Teumer, Alexander, Frayling, Timothy, Santoni, Federico A, Reymond, Alexandre, Kutalik, Zoltán
Published in Nature communications (24.09.2021)
Published in Nature communications (24.09.2021)
Get full text
Journal Article
Higher adiposity and mental health: causal inference using Mendelian randomization
Casanova, Francesco, O’Loughlin, Jessica, Martin, Susan, Beaumont, Robin N, Wood, Andrew R, Watkins, Edward R, Freathy, Rachel M, Hagenaars, Saskia P, Frayling, Timothy M, Yaghootkar, Hanieh, Tyrrell, Jess
Published in Human molecular genetics (30.11.2021)
Published in Human molecular genetics (30.11.2021)
Get full text
Journal Article
A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor
Green, Harry D, Jones, Alistair, Evans, Jonathan P, Wood, Andrew R, Beaumont, Robin N, Tyrrell, Jessica, Frayling, Timothy M, Smith, Christopher, Weedon, Michael N
Published in PLoS genetics (10.06.2021)
Published in PLoS genetics (10.06.2021)
Get full text
Journal Article
Effects of physical activity and sedentary time on depression, anxiety and well-being: a bidirectional Mendelian randomisation study
Casanova, Francesco, O'Loughlin, Jessica, Karageorgiou, Vasilis, Beaumont, Robin N, Bowden, Jack, Wood, Andrew R, Tyrrell, Jessica
Published in BMC medicine (18.12.2023)
Published in BMC medicine (18.12.2023)
Get full text
Journal Article
Identification and analysis of individuals who deviate from their genetically-predicted phenotype
Hawkes, Gareth, Yengo, Loic, Vedantam, Sailaja, Marouli, Eirini, Beaumont, Robin N, Tyrrell, Jessica, Weedon, Michael N, Hirschhorn, Joel, Frayling, Timothy M, Wood, Andrew R
Published in PLoS genetics (21.09.2023)
Published in PLoS genetics (21.09.2023)
Get full text
Journal Article
Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing
Harries, Lorna W., Hernandez, Dena, Henley, William, Wood, Andrew R., Holly, Alice C., Bradley‐Smith, Rachel M., Yaghootkar, Hanieh, Dutta, Ambarish, Murray, Anna, Frayling, Timothy M., Guralnik, Jack M., Bandinelli, Stefania, Singleton, Andrew, Ferrucci, Luigi, Melzer, David
Published in Aging cell (01.10.2011)
Published in Aging cell (01.10.2011)
Get full text
Journal Article
Association of maternal circulating 25(OH)D and calcium with birth weight: A mendelian randomisation analysis
Thompson, William D, Tyrrell, Jessica, Borges, Maria-Carolina, Beaumont, Robin N, Knight, Bridget A, Wood, Andrew R, Ring, Susan M, Hattersley, Andrew T, Freathy, Rachel M, Lawlor, Debbie A
Published in PLoS medicine (01.06.2019)
Published in PLoS medicine (01.06.2019)
Get full text
Journal Article
A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure
Frayling, Timothy M., Beaumont, Robin N., Jones, Samuel E., Yaghootkar, Hanieh, Tuke, Marcus A., Ruth, Katherine S., Casanova, Francesco, West, Ben, Locke, Jonathan, Sharp, Seth, Ji, Yingjie, Thompson, William, Harrison, Jamie, Etheridge, Amy S., Gallins, Paul J., Jima, Dereje, Wright, Fred, Zhou, Yihui, Innocenti, Federico, Lindgren, Cecilia M., Grarup, Niels, Murray, Anna, Freathy, Rachel M., Weedon, Michael N., Tyrrell, Jessica, Wood, Andrew R.
Published in Cell reports (Cambridge) (10.04.2018)
Published in Cell reports (Cambridge) (10.04.2018)
Get full text
Journal Article
Cell Specific eQTL Analysis without Sorting Cells
Westra, Harm-Jan, Arends, Danny, Esko, Tõnu, Peters, Marjolein J, Schurmann, Claudia, Schramm, Katharina, Kettunen, Johannes, Yaghootkar, Hanieh, Fairfax, Benjamin P, Andiappan, Anand Kumar, Li, Yang, Fu, Jingyuan, Karjalainen, Juha, Platteel, Mathieu, Visschedijk, Marijn, Weersma, Rinse K, Kasela, Silva, Milani, Lili, Tserel, Liina, Peterson, Pärt, Reinmaa, Eva, Hofman, Albert, Uitterlinden, André G, Rivadeneira, Fernando, Homuth, Georg, Petersmann, Astrid, Lorbeer, Roberto, Prokisch, Holger, Meitinger, Thomas, Herder, Christian, Roden, Michael, Grallert, Harald, Ripatti, Samuli, Perola, Markus, Wood, Andrew R, Melzer, David, Ferrucci, Luigi, Singleton, Andrew B, Hernandez, Dena G, Knight, Julian C, Melchiotti, Rossella, Lee, Bernett, Poidinger, Michael, Zolezzi, Francesca, Larbi, Anis, Wang, De Yun, van den Berg, Leonard H, Veldink, Jan H, Rotzschke, Olaf, Makino, Seiko, Salomaa, Veikko, Strauch, Konstantin, Völker, Uwe, van Meurs, Joyce B J, Metspalu, Andres, Wijmenga, Cisca, Jansen, Ritsert C, Franke, Lude
Published in PLoS genetics (01.05.2015)
Published in PLoS genetics (01.05.2015)
Get full text
Journal Article
Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers
Pilling, Luke C, Atkins, Janice L, Duff, Michael O, Beaumont, Robin N, Jones, Samuel E, Tyrrell, Jessica, Kuo, Chia-Ling, Ruth, Katherine S, Tuke, Marcus A, Yaghootkar, Hanieh, Wood, Andrew R, Murray, Anna, Weedon, Michael N, Harries, Lorna W, Kuchel, George A, Ferrucci, Luigi, Frayling, Timothy M, Melzer, David
Published in PloS one (28.09.2017)
Published in PloS one (28.09.2017)
Get full text
Journal Article
A 3D Renal Proximal Tubule on Chip Model Phenocopies Lowe Syndrome and Dent II Disease Tubulopathy
Naik, Sindhu, Wood, Andrew R, Ongenaert, Maté, Saidiyan, Paniz, Elstak, Edo D, Lanz, Henriëtte L, Stallen, Jan, Janssen, Richard, Smythe, Elizabeth, Erdmann, Kai S
Published in International journal of molecular sciences (19.05.2021)
Published in International journal of molecular sciences (19.05.2021)
Get full text
Journal Article
A single nucleotide polymorphism genetic risk score to aid diagnosis of coeliac disease: a pilot study in clinical care
Sharp, Seth A., Jones, Samuel E., Kimmitt, Robert A., Weedon, Michael N., Halpin, Anne M., Wood, Andrew R., Beaumont, Robin N., King, Seema, Heel, David A., Campbell, Patricia M., Hagopian, William A., Turner, Justine M., Oram, Richard A
Published in Alimentary pharmacology & therapeutics (01.10.2020)
Published in Alimentary pharmacology & therapeutics (01.10.2020)
Get full text
Journal Article