In Vivo Reversal of P-Glycoprotein-Mediated Drug Resistance in a Breast Cancer Xenograft and in Leukemia Models Using a Novel, Potent, and Nontoxic Epicatechin EC31
Sun, Wenqin, Wong, Iris L K, Law, Helen Ka-Wai, Su, Xiaochun, Chan, Terry C F, Sun, Gege, Yang, Xinqing, Wang, Xingkai, Chan, Tak Hang, Wan, Shengbiao, Chow, Larry M C
Published in International journal of molecular sciences (22.02.2023)
Published in International journal of molecular sciences (22.02.2023)
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Journal Article
A New Class of Safe, Potent, and Specific P‑gp Modulator: Flavonoid Dimer FD18 Reverses P‑gp-Mediated Multidrug Resistance in Human Breast Xenograft in Vivo
Yan, Clare S. W, Wong, Iris L. K, Chan, Kin-Fai, Kan, Jason W. Y, Chong, Tsz Cheung, Law, Man Chun, Zhao, Yunzhe, Chan, Shun Wan, Chan, Tak Hang, Chow, Larry M. C
Published in Molecular pharmaceutics (05.10.2015)
Published in Molecular pharmaceutics (05.10.2015)
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Journal Article
Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors
Zhu, Xuezhen, Wong, Iris L. K, Chan, Kin-Fai, Cui, Jiahua, Law, Man Chun, Chong, Tsz Cheung, Hu, Xuesen, Chow, Larry M. C, Chan, Tak Hang
Published in Journal of medicinal chemistry (26.09.2019)
Published in Journal of medicinal chemistry (26.09.2019)
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Journal Article
Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with “Click Chemistry”
Wong, Iris L. K, Zhu, Xuezhen, Chan, Kin-Fai, Law, Man Chun, Lo, Aya M. Y, Hu, Xuesen, Chow, Larry M. C, Chan, Tak Hang
Published in Journal of medicinal chemistry (21.11.2018)
Published in Journal of medicinal chemistry (21.11.2018)
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Journal Article
Flavonoid Dimers as Bivalent Modulators for Pentamidine and Sodium Stiboglucanate Resistance in Leishmania
Wong, Iris L K, Chan, Kin-Fai, Burkett, Brendan A, Zhao, Yunzhe, Chai, Yi, Sun, Hongzhe, Chan, Tak Hang, Chow, Larry M C
Published in Antimicrobial Agents and Chemotherapy (01.03.2007)
Published in Antimicrobial Agents and Chemotherapy (01.03.2007)
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Journal Article
Efficient Synthesis of Amine-Linked 2,4,6-Trisubstituted Pyrimidines as a New Class of Bacterial FtsZ Inhibitors
Chan, Kin-Fai, Sun, Ning, Yan, Siu-Cheong, Wong, Iris L. K, Lui, Hok-Kiu, Cheung, Kwan-Choi, Yuan, Jian, Chan, Fung-Yi, Zheng, Zhiwei, Chan, Edward W. C, Chen, Sheng, Leung, Yun-Chung, Chan, Tak Hang, Wong, Kwok-Yin
Published in ACS omega (31.10.2017)
Published in ACS omega (31.10.2017)
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Journal Article
Amine-Linked Flavonoids as Agents Against Cutaneous Leishmaniasis
Chan, Chin-Fung, Liu, Zhen, Wong, Iris L K, Zhao, Xianliang, Yang, Zaofeng, Zheng, Jiale, Lee, Marianne M, Chan, Michael K, Chan, Tak Hang, Chow, Larry M C
Published in Antimicrobial agents and chemotherapy (19.04.2021)
Published in Antimicrobial agents and chemotherapy (19.04.2021)
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Journal Article
Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel
Kan, Jason W Y, Yan, Clare S W, Wong, Iris L K, Su, Xiaochun, Liu, Zhen, Chan, Tak Hang, Chow, Larry M C
Published in International journal of molecular sciences (04.12.2022)
Published in International journal of molecular sciences (04.12.2022)
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Journal Article
Potent and Nontoxic Chemosensitizer of P‑Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives
Wong, Iris L. K, Wang, Bao-Chao, Yuan, Jian, Duan, Liang-Xing, Liu, Zhen, Liu, Tao, Li, Xue-Min, Hu, Xuesen, Zhang, Xiao-Yu, Jiang, Tao, Wan, Sheng-Biao, Chow, Larry M. C
Published in Journal of medicinal chemistry (11.06.2015)
Published in Journal of medicinal chemistry (11.06.2015)
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Journal Article
Flavonoid Dimers as Bivalent Modulators for P-Glycoprotein-Based Multidrug Resistance: Structure-Activity Relationships
Chan, Kin-Fai, Zhao, Yunzhe, Chow, Toby W. S., Yan, Clare S. W., Ma, Dik Lung, Burkett, Brendan A., Wong, Iris L. K., Chow, Larry M. C., Chan, Tak Hang
Published in ChemMedChem (17.04.2009)
Published in ChemMedChem (17.04.2009)
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Journal Article
Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8)2, in Reversing Multidrug Resistance Mediated by Breast Cancer Resistance Protein (BCRP/ABCG2)
Chong, Tsz Cheung, Wong, Iris L. K., Cui, Jiahua, Law, Man Chun, Zhu, Xuezhen, Hu, Xuesen, Kan, Jason W. Y., Yan, Clare S. W., Chan, Tak Hang, Chow, Larry M. C.
Published in International journal of molecular sciences (31.10.2022)
Published in International journal of molecular sciences (31.10.2022)
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Journal Article
Amine Linked Flavonoid Dimers as Modulators for P-Glycoprotein-Based Multidrug Resistance: Structure–Activity Relationship and Mechanism of Modulation
Chan, Kin-Fai, Wong, Iris L. K, Kan, Jason W. Y, Yan, Clare S. W, Chow, Larry M. C, Chan, Tak Hang
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
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Journal Article
Quinacrine and a novel apigenin dimer can synergistically increase the pentamidine susceptibility of the protozoan parasite Leishmania
Wong, Iris L. K., Chan, Kin-Fai, Zhao, Yunzhe, Chan, Tak Hang, Chow, Larry M. C.
Published in Journal of antimicrobial chemotherapy (01.06.2009)
Published in Journal of antimicrobial chemotherapy (01.06.2009)
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Journal Article
Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells
Yuan, Jian, Wong, Iris L.K., Jiang, Tao, Wang, Si Wen, Liu, Tao, Jin Wen, Bin, Chow, Larry M.C., Wan Sheng, Biao
Published in European journal of medicinal chemistry (01.08.2012)
Published in European journal of medicinal chemistry (01.08.2012)
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Journal Article
Flavonoid Dimers as Novel, Potent Antileishmanial Agents
Wong, Iris L. K, Chan, Kin-Fai, Chan, Tak Hang, Chow, Larry M. C
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
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Journal Article
Structure–Activity Relationship Study of Permethyl Ningalin B Analogues as P‑Glycoprotein Chemosensitizers
Bin, Jin Wen, Wong, Iris L. K, Hu, Xuesen, Yu, Zhang Xiao, Xing, Li Fu, Jiang, Tao, Chow, Larry M. C, Biao, Wan Sheng
Published in Journal of medicinal chemistry (27.11.2013)
Published in Journal of medicinal chemistry (27.11.2013)
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Journal Article
Modulation of Multidrug Resistance Protein 1 (MRP1/ABCC1)-Mediated Multidrug Resistance by Bivalent Apigenin Homodimers and Their Derivatives
Wong, Iris L. K, Chan, Kin-Fai, Tsang, Ka Hing, Lam, Chi Yin, Zhao, Yunzhe, Chan, Tak Hang, Chow, Larry Ming Cheung
Published in Journal of medicinal chemistry (10.09.2009)
Published in Journal of medicinal chemistry (10.09.2009)
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Journal Article
Localization of Epigenetic Markers in Leishmania Chromatin
McDonald, Jacquelyn R., Jensen, Bryan C., Sur, Aakash, Wong, Iris L. K., Beverley, Stephen M., Myler, Peter J.
Published in Pathogens (Basel) (18.08.2022)
Published in Pathogens (Basel) (18.08.2022)
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Journal Article
Design and Syntheses of Permethyl Ningalin B Analogues: Potent Multidrug Resistance (MDR) Reversal Agents of Cancer Cells
Zhang, Pu Yong, Wong, Iris L. K, Yan, Clare S. W, Zhang, Xiao Yu, Jiang, Tao, Chow, Larry M. C, Wan, Sheng Biao
Published in Journal of medicinal chemistry (22.07.2010)
Published in Journal of medicinal chemistry (22.07.2010)
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