Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease
Jennings, Danna, Huntwork-Rodriguez, Sarah, Henry, Anastasia G, Sasaki, Jennifer C, Meisner, René, Diaz, Dolores, Solanoy, Hilda, Wang, Xiang, Negrou, Elvira, Bondar, Vitaliy V, Ghosh, Rajarshi, Maloney, Michael T, Propson, Nicholas E, Zhu, Yuda, Maciuca, Romeo D, Harris, Laura, Kay, Angela, LeWitt, Peter, King, T Alex, Kern, Drew, Ellenbogen, Aaron, Goodman, Ira, Siderowf, Andrew, Aldred, Jason, Omidvar, Omid, Masoud, Shababa T, Davis, Sonnet S, Arguello, Annie, Estrada, Anthony A, de Vicente, Javier, Sweeney, Zachary K, Astarita, Giuseppe, Borin, Marie T, Wong, Bradley K, Wong, Harvey, Nguyen, Hoang, Scearce-Levie, Kimberly, Ho, Carole, Troyer, Matthew D
Published in Science translational medicine (08.06.2022)
Published in Science translational medicine (08.06.2022)
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Modern radiation therapy for keratinocyte cancer: What the general practitioner needs to know
Potter, Andrew E, Baxi, Siddhartha, Wong, Bradley
Published in Australian journal of general practice (01.09.2024)
Published in Australian journal of general practice (01.09.2024)
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Preliminary efficacy and safety analysis: 12-month results in 83 patients using a novel approach of widefield radiation therapy for extensive skin field cancerization with or without keratinocyte cancers
Potter, Andrew E., Baker, Christopher, Shumack, Stephen, Sinclair, Robert, Curran, Walter J., Christie, David, Wong, Bradley, Foley, Peter, O'Brien, Peter, Spelman, Lynda
Published in The Journal of dermatological treatment (04.07.2022)
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Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine: Discovery of N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974)
Paone, Daniel V, Shaw, Anthony W, Nguyen, Diem N, Burgey, Christopher S, Deng, James Z, Kane, Stefanie A, Koblan, Kenneth S, Salvatore, Christopher A, Mosser, Scott D, Johnston, Victor K, Wong, Bradley K, Miller-Stein, Cynthia M, Hershey, James C, Graham, Samuel L, Vacca, Joseph P, Williams, Theresa M
Published in Journal of medicinal chemistry (15.11.2007)
Published in Journal of medicinal chemistry (15.11.2007)
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A fully automated plasma protein precipitation sample preparation method for LC–MS/MS bioanalysis
Ma, Ji, Shi, Jianxia, Le, Hoa, Cho, Robert, Huang, Judy Chi-jou, Miao, Shichang, Wong, Bradley K.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.02.2008)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.02.2008)
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Efficacy and safety analysis: 24‐month outcomes from a prospective cohort of 106 fields treated with widefield radiation therapy for extensive skin field cancerization, with or without keratinocyte cancers
Spelman, Lynda, Potter, Andrew E., Baker, Chris, Shumack, Stephen, Sinclair, Robert, Christie, David, Wong, Bradley, Foley, Peter, Hacker, Steven, Allison, Cody C.
Published in JEADV clinical practice (01.06.2024)
Published in JEADV clinical practice (01.06.2024)
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Deletion of Abcg2 has differential effects on excretion and pharmacokinetics of probe substrates in rats
Huang, Liyue, Be, Xuhai, Tchaparian, Eskouhie H, Colletti, Adria E, Roberts, Jonathan, Langley, Meghan, Ling, Yun, Wong, Bradley K, Jin, Lixia
Published in The Journal of pharmacology and experimental therapeutics (01.11.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2012)
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Pharmacokinetics and metabolism of AMG 232, a novel orally bioavailable inhibitor of the MDM2-p53 interaction, in rats, dogs and monkeys: in vitro-in vivo correlation
Ye, Qiuping, Jiang, Min, Huang, Wotang T., Ling, Yun, Olson, Steven H., Sun, Daqing, Xu, Guifen, Yan, Xuelei, Wong, Bradley K., Jin, Lixia
Published in Xenobiotica (03.08.2015)
Published in Xenobiotica (03.08.2015)
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Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme
Henne, Kirk R, Tran, Thuy B, VandenBrink, Brooke M, Rock, Dan A, Aidasani, Divesh K, Subramanian, Raju, Mason, Andrew K, Stresser, David M, Teffera, Yohannes, Wong, Simon G, Johnson, Michael G, Chen, Xiaoqi, Tonn, George R, Wong, Bradley K
Published in Drug metabolism and disposition (01.07.2012)
Published in Drug metabolism and disposition (01.07.2012)
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An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
Tonn, George R, Wong, Simon G, Wong, Sylvia C, Johnson, Michael G, Ma, Ji, Cho, Robert, Floren, Leslie C, Kersey, Kathryn, Berry, Karen, Marcus, Andrew P, Wang, Xuemei, Van Lengerich, Bettina, Medina, Julio C, Pearson, Paul G, Wong, Bradley K
Published in Drug metabolism and disposition (01.03.2009)
Published in Drug metabolism and disposition (01.03.2009)
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A peptide-doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo
Jones, Raymond E, DeFeo-Jones, Deborah, Garsky, Victor M, Wong, Bradley K, Feng, Dong-Mei, Bolyar, Trina, Haskell, Kathleen, Kiefer, David M, Leander, Karen, McAvoy, Elizabeth, Lumma, Patricia, Wai, Jenny, Senderak, Edith T, Motzel, Sherri L, Keenan, Kevin, Zwieten, Matthew Van, Lin, Jiunn H, Freidinger, Roger, Huff, Joel, Oliff, Allen
Published in Nature medicine (01.11.2000)
Published in Nature medicine (01.11.2000)
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A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells
Embrey, Mark W., Wai, John S., Funk, Timothy W., Homnick, Carl F., Perlow, Debbie S., Young, Steven D., Vacca, Joseph P., Hazuda, Daria J., Felock, Peter J., Stillmock, Kara A., Witmer, Marc V., Moyer, Gregory, Schleif, William A., Gabryelski, Lori J., Jin, Lixia, Chen, I-Wu, Ellis, Joan D., Wong, Bradley K., Lin, Jiunn H., Leonard, Yvonne M., Tsou, Nancy N., Zhuang, Linghang
Published in Bioorganic & medicinal chemistry letters (15.10.2005)
Published in Bioorganic & medicinal chemistry letters (15.10.2005)
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Bioactivation of a Novel 2-Methylindole-Containing Dual Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type-2 Cells/D-Prostanoid Receptor Antagonist Leads to Mechanism-Based CYP3A Inactivation: Glutathione Adduct Characterization and Prediction of In Vivo Drug-Drug Interaction
WONG, Simon G, FAN, Peter W, SUBRAMANIAN, Raju, TONN, George R, HENNE, Kirk R, JOHNSON, Michael G, TADANO LOHR, Michelle, WONG, Bradley K
Published in Drug metabolism and disposition (01.05.2010)
Published in Drug metabolism and disposition (01.05.2010)
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Discovery and Evaluation of Potent P1 Aryl Heterocycle-Based Thrombin Inhibitors
Young, Mary Beth, Barrow, James C, Glass, Kristen L, Lundell, George F, Newton, Christina L, Pellicore, Janetta M, Rittle, Kenneth E, Selnick, Harold G, Stauffer, Kenneth J, Vacca, Joseph P, Williams, Peter D, Bohn, Dennis, Clayton, Franklin C, Cook, Jacquelynn J, Krueger, Julie A, Kuo, Lawrence C, Lewis, S. Dale, Lucas, Bobby J, McMasters, Daniel R, Miller-Stein, Cynthia, Pietrak, Beth L, Wallace, Audrey A, White, Rebecca B, Wong, Bradley, Yan, Youwei, Nantermet, Philippe G
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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Potent N-(1,3-Thiazol-2-yl)pyridin-2-amine Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors with Excellent Pharmacokinetics and Low Affinity for the hERG Ion Channel
Bilodeau, Mark T, Balitza, Adrienne E, Koester, Timothy J, Manley, Peter J, Rodman, Leonard D, Buser-Doepner, Carolyn, Coll, Kathleen E, Fernandes, Christine, Gibbs, Jackson B, Heimbrook, David C, Huckle, William R, Kohl, Nancy, Lynch, Joseph J, Mao, Xianzhi, McFall, Rosemary C, McLoughlin, Debra, Miller-Stein, Cynthia M, Rickert, Keith W, Sepp-Lorenzino, Laura, Shipman, Jennifer M, Subramanian, Raju, Thomas, Kenneth A, Wong, Bradley K, Yu, Sean, Hartman, George D
Published in Journal of medicinal chemistry (02.12.2004)
Published in Journal of medicinal chemistry (02.12.2004)
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Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists
Bell, Ian M., Bednar, Rodney A., Fay, John F., Gallicchio, Steven N., Hochman, Jerome H., McMasters, Daniel R., Miller-Stein, Cynthia, Moore, Eric L., Mosser, Scott D., Pudvah, Nicole T., Quigley, Amy G., Salvatore, Christopher A., Stump, Craig A., Theberge, Cory R., Wong, Bradley K., Zartman, C. Blair, Zhang, Xu-Fang, Kane, Stefanie A., Graham, Samuel L., Vacca, Joseph P., Williams, Theresa M.
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
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Enzyme kinetics of cytochrome P450-mediated reactions
Shou, M, Lin, Y, Lu, P, Tang, C, Mei, Q, Cui, D, Tang, W, Ngui, J S, Lin, C C, Singh, R, Wong, B K, Yergey, J A, Lin, J H, Pearson, P G, Baillie, T A, Rodrigues, A D, Rushmore, T H
Published in Current drug metabolism (01.03.2001)
Published in Current drug metabolism (01.03.2001)
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P3 optimization of functional potency, in vivo efficacy and oral bioavailability in 3-aminopyrazinone thrombin inhibitors bearing non-charged groups at the P1 position
Isaacs, Richard C.A., Newton, Christina L., Cutrona, Kellie J., Mercer, Swati P., Dorsey, Bruce D., McDonough, Colleen M., Cook, Jacquelynn J., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J., Lyle, Elizabeth A., Lynch, Joseph J., Miller-Stein, Cynthia, Michener, Maria T., Wallace, Audrey A., White, Rebecca B., Wong, Bradley K.
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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