Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7
Jaeger, Kathrin, Bruenle, Steffen, Weinert, Tobias, Guba, Wolfgang, Muehle, Jonas, Miyazaki, Takuya, Weber, Martin, Furrer, Antonia, Haenggi, Noemi, Tetaz, Tim, Huang, Chia-Ying, Mattle, Daniel, Vonach, Jean-Marie, Gast, Alain, Kuglstatter, Andreas, Rudolph, Markus G., Nogly, Przemyslaw, Benz, Joerg, Dawson, Roger J.P., Standfuss, Joerg
Published in Cell (22.08.2019)
Published in Cell (22.08.2019)
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Journal Article
Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors
Scott-Dennis, Morgan, Rafani, Fikri A., Yi, Yicheng, Perera, Themiya, Harwood, Clare R., Guba, Wolfgang, Rufer, Arne C., Grether, Uwe, Veprintsev, Dmitry B., Sykes, David A.
Published in Frontiers in pharmacology (11.08.2023)
Published in Frontiers in pharmacology (11.08.2023)
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Journal Article
Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis
Porter, Richard Frederick, Szczesniak, Anna-Maria, Toguri, James Thomas, Gebremeskel, Simon, Johnston, Brent, Lehmann, Christian, Fingerle, Jürgen, Rothenhäusler, Benno, Perret, Camille, Rogers-Evans, Mark, Kimbara, Atsushi, Nettekoven, Matthias, Guba, Wolfgang, Grether, Uwe, Ullmer, Christoph, Kelly, Melanie E M
Published in Molecules (Basel, Switzerland) (13.09.2019)
Published in Molecules (Basel, Switzerland) (13.09.2019)
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Journal Article
VolSurf: a new tool for the pharmacokinetic optimization of lead compounds
Cruciani, Gabriele, Pastor, Manuel, Guba, Wolfgang
Published in European journal of pharmaceutical sciences (01.10.2000)
Published in European journal of pharmaceutical sciences (01.10.2000)
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Journal Article
Conference Proceeding
Tritium Labeling of Neuromedin S by Conjugation with [3H]N‑Succinimidyl Propionate
Edelmann, Martin R., Erny, Johannes, Guba, Wolfgang, Hierl, Markus
Published in ACS omega (17.01.2023)
Published in ACS omega (17.01.2023)
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Journal Article
RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models
Grether, Uwe, Foxton, Richard H, Gruener, Sabine, Korn, Claudia, Kimbara, Atsushi, Osterwald, Anja, Zirwes, Elisabeth, Uhles, Sabine, Thoele, Janina, Colé, Nadine, Rogers-Evans, Mark, Röver, Stephan, Nettekoven, Matthias, Martin, Rainer E, Adam, Jean-Michel, Fingerle, Jürgen, Bissantz, Caterina, Guba, Wolfgang, Alker, André, Szczesniak, Anna M, Porter, Ross F, Toguri, Tom J, Revelant, Franco, Poirier, Agnès, Perret, Camille, Winther, Lotte, Caruso, Antonello, Fezza, Filomena, Maccarrone, Mauro, Kelly, Melanie E M, Fauser, Sascha, Ullmer, Christoph
Published in Frontiers in pharmacology (12.07.2024)
Published in Frontiers in pharmacology (12.07.2024)
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Journal Article
Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2‑Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl‑1H‑imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases
Jaeschke, Georg, Kolczewski, Sabine, Spooren, Will, Vieira, Eric, Bitter-Stoll, Nadia, Boissin, Patrick, Borroni, Edilio, Büttelmann, Bernd, Ceccarelli, Simona, Clemann, Nicole, David, Beatrice, Funk, Christoph, Guba, Wolfgang, Harrison, Anthony, Hartung, Thomas, Honer, Michael, Huwyler, Jörg, Kuratli, Martin, Niederhauser, Urs, Pähler, Axel, Peters, Jens-Uwe, Petersen, Ann, Prinssen, Eric, Ricci, Antonio, Rueher, Daniel, Rueher, Marianne, Schneider, Manfred, Spurr, Paul, Stoll, Theodor, Tännler, Daniel, Wichmann, Jürgen, Porter, Richard H, Wettstein, Joseph G, Lindemann, Lothar
Published in Journal of medicinal chemistry (12.02.2015)
Published in Journal of medicinal chemistry (12.02.2015)
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Journal Article
BACE1 inhibitors: A head group scan on a series of amides
Woltering, Thomas J., Wostl, Wolfgang, Hilpert, Hans, Rogers-Evans, Mark, Pinard, Emmanuel, Mayweg, Alexander, Göbel, Martin, Banner, David W., Benz, Jörg, Travagli, Massimiliano, Pollastrini, Martina, Marconi, Guido, Gabellieri, Emanuele, Guba, Wolfgang, Mauser, Harald, Andreini, Matteo, Jacobsen, Helmut, Power, Eoin, Narquizian, Robert
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
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Journal Article
6‑Alkoxy-5-aryl-3-pyridinecarboxamides, a New Series of Bioavailable Cannabinoid Receptor Type 1 (CB1) Antagonists Including Peripherally Selective Compounds
Röver, Stephan, Andjelkovic, Mirjana, Bénardeau, Agnès, Chaput, Evelyne, Guba, Wolfgang, Hebeisen, Paul, Mohr, Susanne, Nettekoven, Matthias, Obst, Ulrike, Richter, Wolfgang F, Ullmer, Christoph, Waldmeier, Pius, Wright, Matthew B
Published in Journal of medicinal chemistry (27.12.2013)
Published in Journal of medicinal chemistry (27.12.2013)
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Journal Article
Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists
Kosar, Miroslav, Sarott, Roman C., Sykes, David A., Viray, Alexander E. G., Vitale, Rosa Maria, Tomašević, Nataša, Li, Xiaoting, Ganzoni, Rudolf L. Z., Kicin, Bilal, Reichert, Lisa, Patej, Kacper J., Gómez-Bouzó, Uxía, Guba, Wolfgang, McCormick, Peter J., Hua, Tian, Gruber, Christian W., Veprintsev, Dmitry B., Frank, James A., Grether, Uwe, Carreira, Erick M.
Published in ACS central science (22.05.2024)
Published in ACS central science (22.05.2024)
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Journal Article
Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport
Ruderisch, Nadine, Schlatter, Daniel, Kuglstatter, Andreas, Guba, Wolfgang, Huber, Sylwia, Cusulin, Carlo, Benz, Jörg, Rufer, Arne Christian, Hoernschemeyer, Joerg, Schweitzer, Christophe, Bülau, Tina, Gärtner, Achim, Hoffmann, Eike, Niewoehner, Jens, Patsch, Christoph, Baumann, Karlheinz, Loetscher, Hansruedi, Kitas, Eric, Freskgård, Per-Ola
Published in EBioMedicine (01.10.2017)
Published in EBioMedicine (01.10.2017)
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Journal Article
Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries
Roche, Olivier, Schneider, Petra, Zuegge, Jochen, Guba, Wolfgang, Kansy, Manfred, Alanine, Alexander, Bleicher, Konrad, Danel, Franck, Gutknecht, Eva-Maria, Rogers-Evans, Mark, Neidhart, Werner, Stalder, Henri, Dillon, Michael, Sjögren, Eric, Fotouhi, Nader, Gillespie, Paul, Goodnow, Robert, Harris, William, Jones, Phil, Taniguchi, Mikio, Tsujii, Shinji, von der Saal, Wolfgang, Zimmermann, Gerd, Schneider, Gisbert
Published in Journal of medicinal chemistry (03.01.2002)
Published in Journal of medicinal chemistry (03.01.2002)
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Journal Article
G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey
Kratochwil, Nicole A, Gatti-McArthur, Silvia, Hoener, Marius C, Lindemann, Lothar, Christ, Andreas D, Green, Luke G, Guba, Wolfgang, Martin, Rainer E, Malherbe, Pari, Porter, Richard H P, Slack, Jay P, Winnig, Marcel, Dehmlow, Henrietta, Grether, Uwe, Hertel, Cornelia, Narquizian, Robert, Panousis, Constantinos G, Kolczewski, Sabine, Steward, Lucinda
Published in Current topics in medicinal chemistry (01.08.2011)
Published in Current topics in medicinal chemistry (01.08.2011)
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Journal Article
Discovery of an Orally Active Non-Peptide Fibrinogen Receptor Antagonist Based on the Hydantoin Scaffold
Stilz, Hans Ulrich, Guba, Wolfgang, Jablonka, Bernd, Just, Melitta, Klingler, Otmar, König, Wolfgang, Wehner, Volkmar, Zoller, Gerhard
Published in Journal of medicinal chemistry (12.04.2001)
Published in Journal of medicinal chemistry (12.04.2001)
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Journal Article
Using macromolecular phasing and refinement techniques for a small molecule gyrase inhibitor
Rudolph, Markus G., Guba, Wolfgang, Xuefei, Tan, Xu, Bruce
Published in Biophysical journal (10.02.2023)
Published in Biophysical journal (10.02.2023)
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Journal Article