The history and future of targeting cyclin-dependent kinases in cancer therapy
Asghar, Uzma, Witkiewicz, Agnieszka K., Turner, Nicholas C., Knudsen, Erik S.
Published in Nature reviews. Drug discovery (01.02.2015)
Published in Nature reviews. Drug discovery (01.02.2015)
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Journal Article
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
Briggs, Kimberly J., Koivunen, Peppi, Cao, Shugeng, Backus, Keriann M., Olenchock, Benjamin A., Patel, Hetalben, Zhang, Qing, Signoretti, Sabina, Gerfen, Gary J., Richardson, Andrea L., Witkiewicz, Agnieszka K., Cravatt, Benjamin F., Clardy, Jon, Kaelin, William G.
Published in Cell (30.06.2016)
Published in Cell (30.06.2016)
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Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets
Witkiewicz, Agnieszka K., McMillan, Elizabeth A., Balaji, Uthra, Baek, GuemHee, Lin, Wan-Chi, Mansour, John, Mollaee, Mehri, Wagner, Kay-Uwe, Koduru, Prasad, Yopp, Adam, Choti, Michael A., Yeo, Charles J., McCue, Peter, White, Michael A., Knudsen, Erik S.
Published in Nature communications (09.04.2015)
Published in Nature communications (09.04.2015)
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Journal Article
Functional Determinants of Cell Cycle Plasticity and Sensitivity to CDK4/6 Inhibition
Kumarasamy, Vishnu, Vail, Paris, Nambiar, Ram, Witkiewicz, Agnieszka K, Knudsen, Erik S
Published in Cancer research (Chicago, Ill.) (01.03.2021)
Published in Cancer research (Chicago, Ill.) (01.03.2021)
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Journal Article
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
Martinez-Outschoorn, Ubaldo E., Balliet, Renee M., Rivadeneira, Dayana, Chiavarina, Barbara, Pavlides, Stephanos, Wang, Chenguang, Whitaker-Menezes, Diana, Daumer, Kristin, Lin, Zhao, Witkiewicz, Agnieszka, Flomenberg, Neal, Howell, Anthony, Pestell, Richard, Knudsen, Erik, Sotgia, Federica, Lisanti, Michael P.
Published in Cell cycle (Georgetown, Tex.) (15.08.2010)
Published in Cell cycle (Georgetown, Tex.) (15.08.2010)
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Journal Article
Cancer takes many paths through G1/S
Knudsen, Erik S., Witkiewicz, Agnieszka K., Rubin, Seth M.
Published in Trends in cell biology (01.08.2024)
Published in Trends in cell biology (01.08.2024)
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Journal Article
Phase I Clinical Trial of Combination Propranolol and Pembrolizumab in Locally Advanced and Metastatic Melanoma: Safety, Tolerability, and Preliminary Evidence of Antitumor Activity
Gandhi, Shipra, Pandey, Manu R, Attwood, Kristopher, Ji, Wenyan, Witkiewicz, Agnieszka K, Knudsen, Erik S, Allen, Cheryl, Tario, Joseph D, Wallace, Paul K, Cedeno, Carlos D, Levis, Maria, Stack, Suzanne, Funchain, Pauline, Drabick, Joseph J, Bucsek, Mark J, Puzanov, Igor, Mohammadpour, Hemn, Repasky, Elizabeth A, Ernstoff, Marc S
Published in Clinical cancer research (01.01.2021)
Published in Clinical cancer research (01.01.2021)
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Journal Article
Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers
Knudsen, Erik S, Vail, Paris, Balaji, Uthra, Ngo, Hoai, Botros, Ihab W, Makarov, Vladimir, Riaz, Nadeem, Balachandran, Vinod, Leach, Steven, Thompson, Debrah M, Chan, Timothy A, Witkiewicz, Agnieszka K
Published in Clinical cancer research (01.08.2017)
Published in Clinical cancer research (01.08.2017)
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Journal Article
Chemotherapy and CDK4/6 Inhibitors: Unexpected Bedfellows
Roberts, Patrick J, Kumarasamy, Vishnu, Witkiewicz, Agnieszka K, Knudsen, Erik S
Published in Molecular cancer therapeutics (01.08.2020)
Published in Molecular cancer therapeutics (01.08.2020)
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Journal Article
p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition
Guiley, Keelan Z, Stevenson, Jack W, Lou, Kevin, Barkovich, Krister J, Kumarasamy, Vishnu, Wijeratne, Tilini U, Bunch, Katharine L, Tripathi, Sarvind, Knudsen, Erik S, Witkiewicz, Agnieszka K, Shokat, Kevan M, Rubin, Seth M
Published in Science (American Association for the Advancement of Science) (13.12.2019)
Published in Science (American Association for the Advancement of Science) (13.12.2019)
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Journal Article
MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies
Baek, GuemHee, Tse, Yan F., Hu, Zeping, Cox, Derek, Buboltz, Noah, McCue, Peter, Yeo, Charles J., White, Michael A., DeBerardinis, Ralph J., Knudsen, Erik S., Witkiewicz, Agnieszka K.
Published in Cell reports (Cambridge) (24.12.2014)
Published in Cell reports (Cambridge) (24.12.2014)
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Journal Article
Coordinately Targeting Cell-Cycle Checkpoint Functions in Integrated Models of Pancreatic Cancer
Chung, Sejin, Vail, Paris, Witkiewicz, Agnieszka K, Knudsen, Erik S
Published in Clinical cancer research (01.04.2019)
Published in Clinical cancer research (01.04.2019)
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Journal Article
Pancreatic cancer cell lines as patient-derived avatars: genetic characterisation and functional utility
Knudsen, Erik S, Balaji, Uthra, Mannakee, Brian, Vail, Paris, Eslinger, Cody, Moxom, Christopher, Mansour, John, Witkiewicz, Agnieszka K
Published in Gut (01.03.2018)
Published in Gut (01.03.2018)
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Journal Article
KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
Vaseva, Angelina V., Blake, Devon R., Gilbert, Thomas S.K., Ng, Serina, Hostetter, Galen, Azam, Salma H., Ozkan-Dagliyan, Irem, Gautam, Prson, Bryant, Kirsten L., Pearce, Kenneth H., Herring, Laura E., Han, Haiyong, Graves, Lee M., Witkiewicz, Agnieszka K., Knudsen, Erik S., Pecot, Chad V., Rashid, Naim, Houghton, Peter J., Wennerberg, Krister, Cox, Adrienne D., Der, Channing J.
Published in Cancer cell (12.11.2018)
Published in Cancer cell (12.11.2018)
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Journal Article
Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer
Witkiewicz, Agnieszka K., Balaji, Uthra, Eslinger, Cody, McMillan, Elizabeth, Conway, William, Posner, Bruce, Mills, Gordon B., O’Reilly, Eileen M., Knudsen, Erik S.
Published in Cell reports (Cambridge) (16.08.2016)
Published in Cell reports (Cambridge) (16.08.2016)
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