Semi-Mechanistic Pharmacokinetic/Pharmacodynamic Modeling of the Antitumor Activity of LY2835219, a New Cyclin-Dependent Kinase 4/6 Inhibitor, in Mice Bearing Human Tumor Xenografts
TATE, Sonya C, SHUFEN CAI, AJAMIE, Rose T, BURKE, Teresa, BECKMANN, Richard P, CHAN, Edward M, DE DIOS, Alfonso, WISHART, Graham N, GELBERT, Lawrence M, CRONIER, Damien M
Published in Clinical cancer research (15.07.2014)
Published in Clinical cancer research (15.07.2014)
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A novel CDK9 inhibitor shows potent antitumor efficacy in preclinical hematologic tumor models
Yin, Tinggui, Lallena, Maria J, Kreklau, Emiko L, Fales, Kevin R, Carballares, Santiago, Torrres, Raquel, Wishart, Graham N, Ajamie, Rose T, Cronier, Damien M, Iversen, Phillip W, Meier, Timothy I, Foreman, Robert T, Zeckner, Douglas, Sissons, Sean E, Halstead, Bart W, Lin, Aimee B, Donoho, Gregory P, Qian, Yuewei, Li, Shuyu, Wu, Song, Aggarwal, Amit, Ye, Xiang S, Starling, James J, Gaynor, Richard B, de Dios, Alfonso, Du, Jian
Published in Molecular cancer therapeutics (01.06.2014)
Published in Molecular cancer therapeutics (01.06.2014)
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Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft
Raub, Thomas J, Wishart, Graham N, Kulanthaivel, Palaniappan, Staton, Brian A, Ajamie, Rose T, Sawada, Geri A, Gelbert, Lawrence M, Shannon, Harlan E, Sanchez-Martinez, Concepcion, De Dios, Alfonso
Published in Drug metabolism and disposition (01.09.2015)
Published in Drug metabolism and disposition (01.09.2015)
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Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine
Gelbert, Lawrence M., Cai, Shufen, Lin, Xi, Sanchez-Martinez, Concepcion, del Prado, Miriam, Lallena, Maria Jose, Torres, Raquel, Ajamie, Rose T., Wishart, Graham N., Flack, Robert Steven, Neubauer, Blake Lee, Young, Jamie, Chan, Edward M., Iversen, Philip, Cronier, Damien, Kreklau, Emiko, de Dios, Alfonso
Published in Investigational new drugs (01.10.2014)
Published in Investigational new drugs (01.10.2014)
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Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M1 receptors
Broad, Lisa M, Sanger, Helen E, Mogg, Adrian J, Colvin, Ellen M, Zwart, Ruud, Evans, David A, Pasqui, Francesca, Sher, Emanuele, Wishart, Graham N, Barth, Vanessa N, Felder, Christian C, Goldsmith, Paul J
Published in British journal of pharmacology (01.01.2019)
Published in British journal of pharmacology (01.01.2019)
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Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site
Sheehan, Scott M., Mest, Hans-Juergen, Watson, Brian M., Klimkowski, Valentine J., Timm, David E., Cauvin, Annick, Parsons, Stephen H., Shi, Qing, Canada, Emily J., Wiley, Michael R., Ruehter, Gerd, Evers, Britta, Petersen, Soenke, Blaszczak, Larry C., Pulley, Shon R., Margolis, Brandon J., Wishart, Graham N., Renson, Beatrice, Hankotius, Dirk, Mohr, Michael, Zechel, Johann-Christian, Michael Kalbfleisch, J., Dingess-Hammond, Elizabeth A., Boelke, Andre, Weichert, Andreas G.
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M 1 receptors
Broad, Lisa M, Sanger, Helen E, Mogg, Adrian J, Colvin, Ellen M, Zwart, Ruud, Evans, David A, Pasqui, Francesca, Sher, Emanuele, Wishart, Graham N, Barth, Vanessa N, Felder, Christian C, Goldsmith, Paul J
Published in British journal of pharmacology (01.01.2019)
Published in British journal of pharmacology (01.01.2019)
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Abstract B234: LY2835219, a potent oral inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/6) that crosses the blood-brain barrier and demonstrates in vivo activity against intracranial human brain tumor xenografts
Sanchez-Martinez, Concepcion, Gelbert, Lawrence M., Shannon, Harlan, De Dios, Alfonso, Staton, Brian A., Ajamie, Rose T., Sawada, Geri, Wishart, Graham N., Raub, Thomas J.
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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Abstract 2819: Identification and characterization of a novel smoothened antagonist for the treatment of cancer with deregulated hedgehog signaling
Bender, Mark H., Hipskind, Philip A., Capen, Andrew R., Cockman, Michael, Credille, Kelly M., Gao, Hong, Bastian, Jolie A., Clay, Julia M., Lobb, Karen L., Sall, Daniel J., Thompson, Michelle L., Wilson, Takako, Wishart, Graham N., Patel, Bharvin K.R
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Abstract B233: Identification and characterization of LY2835219: A potent oral inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/6) with broad in vivo antitumor activity
Gelbert, Lawrence M., Cai, Shufen, Lin, Xi, Sanchez-Martinez, Concepcion, del Prado, Miriam, Lallena, Maria Jose, Torres, Raquel, Ajamie, Rose T., Kreklau, Emiko, Wishart, Graham N., Flack, Robert Steven, Neubauer, Blake, Young, Jamie, Chan, Edward M., Iversen, Phillip, Cronier, Damien, De Dios, Alfonso
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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The anti-rheumatic potential of a series of 2,4-di-substituted-4H-naphtho[1,2-b]pyran-3-carbonitriles
Smith, Colin W., Bailey, James M., Billingham, Michael E.J., Chandrasekhar, Srinivasan, Dell, Colin P., Harvey, Anita K., Hicks, Caroline A., Kingston, Ann E., Wishart, Graham N.
Published in Bioorganic & medicinal chemistry letters (07.12.1995)
Published in Bioorganic & medicinal chemistry letters (07.12.1995)
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