A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model
Yant, Stephen R., Mulato, Andrew, Hansen, Derek, Tse, Winston C., Niedziela-Majka, Anita, Zhang, Jennifer R., Stepan, George J., Jin, Debi, Wong, Melanie H., Perreira, Jill M., Singer, Eric, Papalia, Giuseppe A., Hu, Eric Y., Zheng, Jim, Lu, Bing, Schroeder, Scott D., Chou, Kevin, Ahmadyar, Shekeba, Liclican, Albert, Yu, Helen, Novikov, Nikolai, Paoli, Eric, Gonik, Daniel, Ram, Renee R., Hung, Magdeleine, McDougall, William M., Brass, Abraham L., Sundquist, Wesley I., Cihlar, Tomas, Link, John O.
Published in Nature medicine (01.09.2019)
Published in Nature medicine (01.09.2019)
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The Allyl Leaving Group Approach to Tricoordinate Silyl, Germyl, and Stannyl Cations
Lambert, Joseph B, Zhao, Yan, Wu, Hongwei, Tse, Winston C, Kuhlmann, Barbara
Published in Journal of the American Chemical Society (02.06.1999)
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Lenacapavir Exhibits Atropisomerism-Mechanistic Pharmacokinetics and Disposition Studies of Lenacapavir Reveal Intestinal Excretion as a Major Clearance Pathway
Zheng, Jim, Lu, Bing, Carr, Gavin, Mwangi, Judy, Wang, Kelly, Hao, Jia, Staiger, Kelly McLennan, Kozon, Nathan, Murray, Bernard P, Bashir, Mohammad, Gohdes, Mark A, Tse, Winston C, Schroeder, Scott, Graupe, Michael, Link, John O, Yoon, Jungjoo, Chiu, Anna, Rowe, William, Smith, Bill J, Subramanian, Raju
Published in The Journal of pharmacology and experimental therapeutics (18.09.2024)
Published in The Journal of pharmacology and experimental therapeutics (18.09.2024)
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Lenacapavir: A Novel, Potent, and Selective First-in-Class Inhibitor of HIV-1 Capsid Function Exhibits Optimal Pharmacokinetic Properties for a Long-Acting Injectable Antiretroviral Agent
Subramanian, Raju, Tang, Jennifer, Zheng, Jim, Lu, Bing, Wang, Kelly, Yant, Stephen R, Stepan, George J, Mulato, Andrew, Yu, Helen, Schroeder, Scott, Shaik, Naveed, Singh, Renu, Wolckenhauer, Scott, Chester, Anne, Tse, Winston C, Chiu, Anna, Rhee, Martin, Cihlar, Tomas, Rowe, William, Smith, Bill J
Published in Molecular pharmaceutics (04.12.2023)
Published in Molecular pharmaceutics (04.12.2023)
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539. GS-CA2: A Novel, Potent, and Selective First-In-class Inhibitor of HIV-1 Capsid Function Displays Nonclinical Pharmacokinetics Supporting Long-Acting Potential in Humans
Zheng, Jim, Yant, Stephen R, Ahmadyar, Shekeba, Chan, Tiffany Y, Chiu, Anna, Cihlar, Tomas, Link, John O, Lu, Bing, Mwangi, Judy, Rowe, William, Schroeder, Scott D, Stepan, George J, Wang, Kelly Wei, Subramanian, Raju, Tse, Winston C
Published in Open forum infectious diseases (26.11.2018)
Published in Open forum infectious diseases (26.11.2018)
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Clinical targeting of HIV capsid protein with a long-acting small molecule
Link, John O., Rhee, Martin S., Tse, Winston C., Zheng, Jim, Somoza, John R., Rowe, William, Begley, Rebecca, Chiu, Anna, Mulato, Andrew, Hansen, Derek, Singer, Eric, Tsai, Luong K., Bam, Rujuta A., Chou, Chien-Hung, Canales, Eda, Brizgys, Gediminas, Zhang, Jennifer R., Li, Jiayao, Graupe, Michael, Morganelli, Philip, Liu, Qi, Wu, Qiaoyin, Halcomb, Randall L., Saito, Roland D., Schroeder, Scott D., Lazerwith, Scott E., Bondy, Steven, Jin, Debi, Hung, Magdeleine, Novikov, Nikolai, Liu, Xiaohong, Villaseñor, Armando G., Cannizzaro, Carina E., Hu, Eric Y., Anderson, Robert L., Appleby, Todd C., Lu, Bing, Mwangi, Judy, Liclican, Albert, Niedziela-Majka, Anita, Papalia, Giuseppe A., Wong, Melanie H., Leavitt, Stephanie A., Xu, Yili, Koditek, David, Stepan, George J., Yu, Helen, Pagratis, Nikos, Clancy, Sheila, Ahmadyar, Shekeba, Cai, Terrence Z., Sellers, Scott, Wolckenhauer, Scott A., Ling, John, Callebaut, Christian, Margot, Nicolas, Ram, Renee R., Liu, Ya-Pei, Hyland, Rob, Sinclair, Gary I., Ruane, Peter J., Crofoot, Gordon E., McDonald, Cheryl K., Brainard, Diana M., Lad, Latesh, Swaminathan, Swami, Sundquist, Wesley I., Sakowicz, Roman, Chester, Anne E., Lee, William E., Daar, Eric S., Yant, Stephen R., Cihlar, Tomas
Published in Nature (London) (27.08.2020)
Published in Nature (London) (27.08.2020)
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Synthesis and evaluation of a novel bleomycin A2 analogue: continuing assessment of the linker domain
Boger, Dale L, Aquila, Brian M, Tse, Winston C, Searcey, Mark
Published in Tetrahedron letters (02.12.2000)
Published in Tetrahedron letters (02.12.2000)
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Torsional distortions in trimesitylsilanes and trimesitylgermanes
Lambert, Joseph B., Stern, Charlotte L., Zhao, Yan, Tse, Winston C., Shawl, Catherine E., Lentz, Kirk T., Kania, Lidia
Published in Journal of organometallic chemistry (15.10.1998)
Published in Journal of organometallic chemistry (15.10.1998)
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