Design, Synthesis, and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5-(7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)
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Published in Journal of medicinal chemistry (27.03.2008)
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Activity of three selective estrogen receptor modulators on hormone-dependent responses in the mouse uterus and mammary gland
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A Mouse Model of Androgenetic Alopecia
Crabtree, Judy S, Kilbourne, Edward J, Peano, Bryan J, Chippari, Susan, Kenney, Thomas, McNally, Christopher, Wang, Wei, Harris, Heather A, Winneker, Richard C, Nagpal, Sunil, Thompson, Catherine C
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Identification of Pathway-Selective Estrogen Receptor Ligands That Inhibit NF-κB Transcriptional Activity
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Published in Proceedings of the National Academy of Sciences - PNAS (15.02.2005)
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Synthesis and Structure−Activity Relationship of Novel 6-Aryl-1,4- dihydrobenzo[d][1,3]oxazine-2-thiones as Progesterone Receptor Modulators Leading to the Potent and Selective Nonsteroidal Progesterone Receptor Agonist Tanaproget
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Published in Journal of medicinal chemistry (11.08.2005)
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Differing pharmacological activities of thiazolidinone analogs at the FSH receptor
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Molecular and Pharmacological Properties of a Potent and Selective Novel Nonsteroidal Progesterone Receptor Agonist Tanaproget
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Down-Regulation of Endometrial Matrix Metalloproteinase-3 and -7 Expression in Vitro and Therapeutic Regression of Experimental Endometriosis in Vivo by a Novel Nonsteroidal Progesterone Receptor Agonist, Tanaproget
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1-Methyl-1H-pyrrole-2-carbonitrile containing tetrahydronaphthalene derivatives as non-steroidal progesterone receptor antagonists
KERN, Jeffrey C, TEREFENKO, Eugene, TRYBULSKI, Eugene, BERRODIN, Thomas J, COHEN, Jeffrey, WINNEKER, Richard C, YUDT, Matthew R, ZHIMING ZHANG, YUAN ZHU, PUWEN ZHANG
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Allosteric Activation of the Follicle-stimulating Hormone (FSH) Receptor by Selective, Nonpeptide Agonists
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Published in The Journal of biological chemistry (12.05.2006)
Published in The Journal of biological chemistry (12.05.2006)
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A new generation of progesterone receptor modulators
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Published in Steroids (01.08.2008)
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Discovery of a novel mechanism of steroid receptor antagonism: WAY-255348 modulates progesterone receptor cellular localization and promoter interactions
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Published in Biochemical pharmacology (01.12.2011)
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Berrodin, Thomas J., Jelinsky, Scott A., Graciani, Nilsa, Butera, John A., Zhang, Zhiming, Nagpal, Sunil, Winneker, Richard C., Yudt, Matthew R.
Published in Biochemical pharmacology (15.01.2009)
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Loss of inhibitory insulin receptor substrate-1 phosphorylation is an early event in mammalian target of rapamycin-dependent endometrial hyperplasia and carcinoma
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SAR studies of 6-(arylamino)-4,4-disubstituted-1-methyl-1,4-dihydro-benzo[ d][1,3]oxazin-2-ones as progesterone receptor antagonists
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Dual acting norepinephrine reuptake inhibitors and 5-HT2A receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles
HEFFERNAN, GavinD, COGHLAN, Richard D, COSMI, Scott A, JOHNSTON, Grace H, KENNEY, Thomas, KOURY, Elizabeth, WINNEKER, Richard C, DEECHER, Darlene C, TRYBULSKI, Eugene J, MANAS, Eric S, MCDEVITT, Robert E, YANFANG LI, MAHANEY, Paige E, ROBICHAUD, Albert J, HUSELTON, Christine, ALFINITO, Peter, BRAY, Jenifer A
Published in Bioorganic & medicinal chemistry (15.11.2009)
Published in Bioorganic & medicinal chemistry (15.11.2009)
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