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Discovery of aryl ureas and aryl amides as potent and selective histamine H-3 receptor antagonists for the treatment of obesity (Part I)

Discovery of aryl ureas and aryl amides as potent and selective histamine H-3 receptor antagonists for the treatment of obesity (Part I)

by Gao, Zhongli, Hurst, William J., Guillot, Etienne, Czechtizky, Werngard, Lukasczyk, Ulrike, Nagorny, Raisa, Pruniaux, Marie-Pierre, Schwink, Lothar, Sanchez, Juan Antonio, Stengelin, Siegfried, Tang, Lei, Winkler, Irvin, Hendrix, James A., George, Pascal G.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)

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Journal Article

Discovery of aryl ureas and aryl amides as potent and selective histamine H-3 receptor antagonists for the treatment of obesity (Part II)

Discovery of aryl ureas and aryl amides as potent and selective histamine H-3 receptor antagonists for the treatment of obesity (Part II)

by Gao, Zhongli, Hurst, William J., Guillot, Etienne, Czechtizky, Werngard, Lukasczyk, Ulrike, Nagorny, Raisa, Pruniaux, Marie-Pierre, Schwink, Lothar, Sanchez, Juan Antonio, Stengelin, Siegfried, Tang, Lei, Winkler, Irvin, Hendrix, James A., George, Pascal G.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)

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Journal Article

Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (Part I)

Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (Part I)

by Gao, Zhongli, Hurst, William J., Guillot, Etienne, Czechtizky, Werngard, Lukasczyk, Ulrike, Nagorny, Raisa, Pruniaux, Marie-Pierre, Schwink, Lothar, Sanchez, Juan Antonio, Stengelin, Siegfried, Tang, Lei, Winkler, Irvin, Hendrix, James A., George, Pascal G.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)

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Journal Article

Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (Part II)

Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (Part II)

by Gao, Zhongli, Hurst, William J., Guillot, Etienne, Czechtizky, Werngard, Lukasczyk, Ulrike, Nagorny, Raisa, Pruniaux, Marie-Pierre, Schwink, Lothar, Sanchez, Juan Antonio, Stengelin, Siegfried, Tang, Lei, Winkler, Irvin, Hendrix, James A., George, Pascal G.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)

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Journal Article

Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance

Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance

by Hsiou, Y, Das, K, Ding, J, Clark, Jr, A D, Kleim, J P, Rösner, M, Winkler, I, Riess, G, Hughes, S H, Arnold, E
Published in Journal of molecular biology (27.11.1998)

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Journal Article

CEFODIZIME, AN AMINOTHIAZOLYL CEPHALOSPORIN: IV. INFLUENCE ON THE IMMUNE SYSTEM

CEFODIZIME, AN AMINOTHIAZOLYL CEPHALOSPORIN: IV. INFLUENCE ON THE IMMUNE SYSTEM

by LIMBERT, MICHAEL, BARTLETT, ROBERT R., DICKNEITE, GERHARD, KLESEL, NORBERT, SCHORLEMMER, HANS ULRICH, SEIBERT, GERHARD, WINKLER, IRVIN, SCHRINNER, ELMAR
Published in Journal of antibiotics (1984)

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Journal Article

ANTIBACTERIAL AND ANTIVIRAL PEPTIDES FROM ACTINOMADURA NAMIBIENSIS

ANTIBACTERIAL AND ANTIVIRAL PEPTIDES FROM ACTINOMADURA NAMIBIENSIS

by WINKLER IRVIN, BROENSTRUP MARK, SEIBERT GERHARD, SHELDRICK GEORGE M, SUSSMUTH RODERICH, MEINDL KATHRIN, GUEHRING HANS, WINK JOACHIM, TOTI LUIGI, VERTESY LASZLO, HOFFMANN HOLGER
Year of Publication 08.07.2009

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Patent

Selective Pressure of a Quinoxaline Nonnucleoside Inhibitor of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase (RT) on HIV-1 Replication Results in the Emergence of Nucleoside RT-Inhibitor-Specific (RT Leu-74 → Val or Ile and Val-75 → Leu or Ile) HIV-1 mutants

Selective Pressure of a Quinoxaline Nonnucleoside Inhibitor of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase (RT) on HIV-1 Replication Results in the Emergence of Nucleoside RT-Inhibitor-Specific (RT Leu-74 → Val or Ile and Val-75 → Leu or Ile) HIV-1 mutants

by Kleim, Jörg-Peter, Rösner, Manfred, Winkler, Irvin, Paessens, Arno, Kirsch, Reinhard, Hsiou, Yu, Arnold, Edward, Riess, Günther
Published in Proceedings of the National Academy of Sciences - PNAS (09.01.1996)

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In vitro selection for different mutational patterns in the HIV-1 reverse transcriptase using high and low selective pressure of the nonnucleoside reverse transcriptase inhibitor HBY 097

In vitro selection for different mutational patterns in the HIV-1 reverse transcriptase using high and low selective pressure of the nonnucleoside reverse transcriptase inhibitor HBY 097

by Kleim, J P, Winkler, I, Rösner, M, Kirsch, R, Rübsamen-Waigmann, H, Paessens, A, Riess, G
Published in Virology (New York, N.Y.) (28.04.1997)

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Journal Article

Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74 gives Val or Ile

Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74 gives Val or Ile

by Kleim, Jorg-Peter, Rosner, Manfred, Winkler, Irvin, Paessens, Arno
Published in Proceedings of the National Academy of Sciences - PNAS (09.01.1996)

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Journal Article

Antiviral Activity of the Human Immunodeficiency Virus Type 1—Specific Nonnucleoside Reverse Transcriptase Inhibitor HBY 097 Alone and in Combination with Zidovudine in a Phase II Study

Antiviral Activity of the Human Immunodeficiency Virus Type 1—Specific Nonnucleoside Reverse Transcriptase Inhibitor HBY 097 Alone and in Combination with Zidovudine in a Phase II Study

by Kleim, Jörg-Peter, Winters, Mark, Dunkler, Anke, Suarez, José-Ramon, Rieß, Günther, Winkler, Irvin, Balzarini, Jan, Oette, Dagmar, Merigan, Thomas C.
Published in The Journal of infectious diseases (01.03.1999)

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Journal Article

In VitroSelection for Different Mutational Patterns in the HIV-1 Reverse Transcriptase Using High and Low Selective Pressure of the Nonnucleoside Reverse Transcriptase Inhibitor HBY 097

In VitroSelection for Different Mutational Patterns in the HIV-1 Reverse Transcriptase Using High and Low Selective Pressure of the Nonnucleoside Reverse Transcriptase Inhibitor HBY 097

by Kleim, Jörg-Peter, Winkler, Irvin, Rösner, Manfred, Kirsch, Reinhard, Rübsamen-Waigmann, Helga, Paessens, Arno, Riess, Günther
Published in Virology (New York, N.Y.) (28.04.1997)

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Journal Article

Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance 1 1Edited by J. Karn

Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance 1 1Edited by J. Karn

by Hsiou, Yu, Das, Kalyan, Ding, Jianping, Clark, Arthur D., Kleim, Jörg-Peter, Rösner, Manfred, Winkler, Irvin, Riess, Günther, Hughes, Stephen H., Arnold, Edward
Published in Journal of molecular biology (01.11.1998)

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Journal Article

REGIOSELECTIVE SYNTHESIS AND ANTIVIRAL ACTIVITY OF PURINE NUCLEOSIDE ANALOGS WITH ACYCLIC SUBSTITUENTS AT N7

REGIOSELECTIVE SYNTHESIS AND ANTIVIRAL ACTIVITY OF PURINE NUCLEOSIDE ANALOGS WITH ACYCLIC SUBSTITUENTS AT N7

by JAHNE, G, KROHA, H, MULLER, A, HELSBERG, M, WINKLER, GROSS, G, SCHOLL, T
Published in Angewandte Chemie International Edition (17.03.1994)

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Journal Article

Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use

Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use

by GOSSEL, MATTHIAS, WINKLER, IRVIN, JAEHNE, GERHARD, KLABUNDE, THOMAS, STENGELIN, SIEGFIRD
Year of Publication 17.12.2014

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Patent

Retention of marked sensitivity to ( S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-Dihydroquinoxaline-2(1H)-Thione (HBY 097) by an azidothymidine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) strain subcultured in the combined presence of quinoxaline HBY 097 and 2′,3′-dideoxy-3′-thiacytidine (Lamivudine)

Retention of marked sensitivity to ( S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-Dihydroquinoxaline-2(1H)-Thione (HBY 097) by an azidothymidine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) strain subcultured in the combined presence of quinoxaline HBY 097 and 2′,3′-dideoxy-3′-thiacytidine (Lamivudine)

by Balzarini, Jan, Pelemans, Heidi, Riess, Gunther, Roesner, Manfred, Winkler, Irvin, De Ckrcq, Erik, Kleim, Jörg-Peter
Published in Biochemical pharmacology (01.03.1998)

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Journal Article

ARYL-SUBSTITUIERTE IMIDAZOLIDIN-2,4-DIONE, VERFAHREN ZU IHRER HERSTELLUNG, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND IHRE VERWENDUNG

ARYL-SUBSTITUIERTE IMIDAZOLIDIN-2,4-DIONE, VERFAHREN ZU IHRER HERSTELLUNG, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND IHRE VERWENDUNG

by GOSSEL, MATTHIAS, WINKLER, IRVIN, JAEHNE, GERHARD, STENGELIN, SIEGFRIED, KLABUNDE, THOMAS
Year of Publication 15.07.2011

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Patent

ARYL-SUBSTITUTED IMIDAZOLIDINE-2,4-DIONES, METHOD FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF

ARYL-SUBSTITUTED IMIDAZOLIDINE-2,4-DIONES, METHOD FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF

by GOSSEL, MATTHIAS, WINKLER, IRVIN, JAEHNE, GERHARD, STENGELIN, SIEGFRIED, KLABUNDE, THOMAS
Year of Publication 22.06.2011

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Patent

Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof

Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof

by WINKLER IRVIN, GOSSEL MATTHIAS, JAEHNE GERHARD, KLABUNDE THOMAS, STENGELIN SIEGFRIED
Year of Publication 03.03.2011

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Patent

Heterocycle-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising them and use thereof

Heterocycle-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising them and use thereof

by WINKLER IRVIN, GOSSEL MATTHIAS, JAEHNE GERHARD, KLABUNDE THOMAS, STENGELIN SIEGFRIED
Year of Publication 24.02.2011

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Patent

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