Progress towards a public chemogenomic set for protein kinases and a call for contributions
Drewry, David H, Wells, Carrow I, Andrews, David M, Angell, Richard, Al-Ali, Hassan, Axtman, Alison D, Capuzzi, Stephen J, Elkins, Jonathan M, Ettmayer, Peter, Frederiksen, Mathias, Gileadi, Opher, Gray, Nathanael, Hooper, Alice, Knapp, Stefan, Laufer, Stefan, Luecking, Ulrich, Michaelides, Michael, Müller, Susanne, Muratov, Eugene, Denny, R Aldrin, Saikatendu, Kumar S, Treiber, Daniel K, Zuercher, William J, Willson, Timothy M
Published in PloS one (02.08.2017)
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Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans
Smith, Susan H., Jayawickreme, Channa, Rickard, David J., Nicodeme, Edwige, Bui, Thi, Simmons, Cathy, Coquery, Christine M., Neil, Jessica, Pryor, William M., Mayhew, David, Rajpal, Deepak K., Creech, Katrina, Furst, Sylvia, Lee, James, Wu, Dalei, Rastinejad, Fraydoon, Willson, Timothy M., Viviani, Fabrice, Morris, David C., Moore, John T., Cote-Sierra, Javier
Published in Journal of investigative dermatology (01.10.2017)
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Too many roads not taken
Edwards, Aled M., Isserlin, Ruth, Bader, Gary D., Frye, Stephen V., Willson, Timothy M., Yu, Frank H.
Published in Nature (London) (10.02.2011)
Published in Nature (London) (10.02.2011)
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Quantifying CDK inhibitor selectivity in live cells
Wells, Carrow I., Vasta, James D., Corona, Cesear R., Wilkinson, Jennifer, Zimprich, Chad A., Ingold, Morgan R., Pickett, Julie E., Drewry, David H., Pugh, Kathryn M., Schwinn, Marie K., Hwang, Byounghoon (Brian), Zegzouti, Hicham, Huber, Kilian V. M., Cong, Mei, Meisenheimer, Poncho L., Willson, Timothy M., Robers, Matthew B.
Published in Nature communications (02.06.2020)
Published in Nature communications (02.06.2020)
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Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation
Pariollaud, Marie, Gibbs, Julie E, Hopwood, Thomas W, Brown, Sheila, Begley, Nicola, Vonslow, Ryan, Poolman, Toryn, Guo, Baoqiang, Saer, Ben, Jones, D Heulyn, Tellam, James P, Bresciani, Stefano, Tomkinson, Nicholas Co, Wojno-Picon, Justyna, Cooper, Anthony Wj, Daniels, Dion A, Trump, Ryan P, Grant, Daniel, Zuercher, William, Willson, Timothy M, MacDonald, Andrew S, Bolognese, Brian, Podolin, Patricia L, Sanchez, Yolanda, Loudon, Andrew Si, Ray, David W
Published in The Journal of clinical investigation (01.06.2018)
Published in The Journal of clinical investigation (01.06.2018)
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Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B
Chen, Peiling, Chaikuad, Apirat, Bamborough, Paul, Bantscheff, Marcus, Bountra, Chas, Chung, Chun-wa, Fedorov, Oleg, Grandi, Paola, Jung, David, Lesniak, Robert, Lindon, Matthew, Müller, Susanne, Philpott, Martin, Prinjha, Rab, Rogers, Catherine, Selenski, Carolyn, Tallant, Cynthia, Werner, Thilo, Willson, Timothy M, Knapp, Stefan, Drewry, David H
Published in Journal of medicinal chemistry (25.02.2016)
Published in Journal of medicinal chemistry (25.02.2016)
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Dual Inhibition of Mycobacterium tuberculosis and the Host TGFBR1 by an Anilinoquinazoline
Nandakumar, Meganathan, Ollodart, Anja, Fleck, Neil, Kapadia, Nirav R., Frando, Andrew, Boradia, Vishant, Smith, Jeffery L., Chen, Junxi, Zuercher, William J., Willson, Timothy M., Grundner, Christoph
Published in Journal of medicinal chemistry (09.11.2023)
Published in Journal of medicinal chemistry (09.11.2023)
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STOPLIGHT: A Hit Scoring Calculator
Wellnitz, James, Martin, Holli-Joi, Anwar Hossain, Mohammad, Rath, Marielle, Fox, Colton, Popov, Konstantin I., Willson, Timothy M., Muratov, Eugene N., Tropsha, Alexander
Published in Journal of chemical information and modeling (10.06.2024)
Published in Journal of chemical information and modeling (10.06.2024)
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ApoE Promotes the Proteolytic Degradation of Aβ
Jiang, Qingguang, Lee, C.Y. Daniel, Mandrekar, Shweta, Wilkinson, Brandy, Cramer, Paige, Zelcer, Noam, Mann, Karen, Lamb, Bruce, Willson, Timothy M., Collins, Jon L., Richardson, Jill C., Smith, Jonathan D., Comery, Thomas A., Riddell, David, Holtzman, David M., Tontonoz, Peter, Landreth, Gary E.
Published in Neuron (Cambridge, Mass.) (12.06.2008)
Published in Neuron (Cambridge, Mass.) (12.06.2008)
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Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3
Galal, Kareem A., Krämer, Andreas, Strickland, Benjamin G., Smith, Jeffery L., Dickmander, Rebekah J., Moorman, Nathaniel J., Willson, Timothy M.
Published in Bioorganic & medicinal chemistry letters (01.02.2024)
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Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells
Yang, Xuan, Smith, Jeffery L, Beck, Michael T, Wilkinson, Jennifer M, Michaud, Ani, Vasta, James D, Robers, Matthew B, Willson, Timothy M
Published in Molecules (Basel, Switzerland) (25.03.2023)
Published in Molecules (Basel, Switzerland) (25.03.2023)
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Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
Zhang, Y, Lee, F.Y, Barrera, G, Lee, H, Vales, C, Gonzalez, F.J, Willson, T.M, Edwards, P.A
Published in Proceedings of the National Academy of Sciences - PNAS (24.01.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (24.01.2006)
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SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)
Asquith, Christopher R. M, Berger, Benedict-Tilman, Wan, Jing, Bennett, James M, Capuzzi, Stephen J, Crona, Daniel J, Drewry, David H, East, Michael P, Elkins, Jonathan M, Fedorov, Oleg, Godoi, Paulo H, Hunter, Debra M, Knapp, Stefan, Müller, Susanne, Torrice, Chad D, Wells, Carrow I, Earp, H. Shelton, Willson, Timothy M, Zuercher, William J
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor
Zhang, Cunyu, Creech, Katrina L., Zuercher, William J., Willson, Timothy M.
Published in Scientific reports (10.07.2019)
Published in Scientific reports (10.07.2019)
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A data science roadmap for open science organizations engaged in early-stage drug discovery
Edfeldt, Kristina, Edwards, Aled M., Engkvist, Ola, Günther, Judith, Hartley, Matthew, Hulcoop, David G., Leach, Andrew R., Marsden, Brian D., Menge, Amelie, Misquitta, Leonie, Müller, Susanne, Owen, Dafydd R., Schütt, Kristof T., Skelton, Nicholas, Steffen, Andreas, Tropsha, Alexander, Vernet, Erik, Wang, Yanli, Wellnitz, James, Willson, Timothy M., Clevert, Djork-Arné, Haibe-Kains, Benjamin, Schiavone, Lovisa Holmberg, Schapira, Matthieu
Published in Nature communications (05.07.2024)
Published in Nature communications (05.07.2024)
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Fused Tetrahydroquinolines Are Interfering with Your Assay
Bashore, Frances M., Annor-Gyamfi, Joel, Du, Yuhong, Katis, Vittorio, Nwogbo, Felix, Flax, Raymond G., Frye, Stephen V., Pearce, Kenneth H., Fu, Haian, Willson, Timothy M., Drewry, David H., Axtman, Alison D.
Published in Journal of medicinal chemistry (09.11.2023)
Published in Journal of medicinal chemistry (09.11.2023)
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1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors
Asquith, Christopher R M, Godoi, Paulo H, Couñago, Rafael M, Laitinen, Tuomo, Scott, John W, Langendorf, Christopher G, Oakhill, Jonathan S, Drewry, David H, Zuercher, William J, Koutentis, Panayiotis A, Willson, Timothy M, Kalogirou, Andreas S
Published in Molecules (Basel, Switzerland) (19.05.2018)
Published in Molecules (Basel, Switzerland) (19.05.2018)
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