Predicting Drug-Induced Liver Injury with Bayesian Machine Learning
Williams, Dominic P, Lazic, Stanley E, Foster, Alison J, Semenova, Elizaveta, Morgan, Paul
Published in Chemical research in toxicology (21.01.2020)
Published in Chemical research in toxicology (21.01.2020)
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Journal Article
Reactive Metabolites: Current and Emerging Risk and Hazard Assessments
Thompson, Richard A, Isin, Emre M, Ogese, Monday O, Mettetal, Jerome T, Williams, Dominic P
Published in Chemical research in toxicology (18.04.2016)
Published in Chemical research in toxicology (18.04.2016)
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Journal Article
Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury
Proctor, William R., Foster, Alison J., Vogt, Jennifer, Summers, Claire, Middleton, Brian, Pilling, Mark A., Shienson, Daniel, Kijanska, Monika, Ströbel, Simon, Kelm, Jens M., Morgan, Paul, Messner, Simon, Williams, Dominic
Published in Archives of toxicology (01.08.2017)
Published in Archives of toxicology (01.08.2017)
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Journal Article
Reproducing human and cross-species drug toxicities using a Liver-Chip
Jang, Kyung-Jin, Otieno, Monicah A, Ronxhi, Janey, Lim, Heng-Keang, Ewart, Lorna, Kodella, Konstantia R, Petropolis, Debora B, Kulkarni, Gauri, Rubins, Jonathan E, Conegliano, David, Nawroth, Janna, Simic, Damir, Lam, Wing, Singer, Monica, Barale, Erio, Singh, Bhanu, Sonee, Manisha, Streeter, Anthony J, Manthey, Carl, Jones, Barry, Srivastava, Abhishek, Andersson, Linda C, Williams, Dominic, Park, Hyoungshin, Barrile, Riccardo, Sliz, Josiah, Herland, Anna, Haney, Suzzette, Karalis, Katia, Ingber, Donald E, Hamilton, Geraldine A
Published in Science translational medicine (06.11.2019)
Published in Science translational medicine (06.11.2019)
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Journal Article
Managing the challenge of chemically reactive metabolites in drug development
Park, B. Kevin, Tweedie, Donald J, Boobis, Alan, Clarke, Stephen, Goldring, Chris E. P, Jones, David, Kenna, J. Gerry, Lambert, Craig, Laverty, Hugh G, Naisbitt, Dean J, Nelson, Sidney, Nicoll-Griffith, Deborah A, Obach, R. Scott, Routledge, Philip, Smith, Dennis A, Vermeulen, Nico, Williams, Dominic P, Wilson, Ian D, Baillie, Thomas A
Published in Nature reviews. Drug discovery (01.04.2011)
Published in Nature reviews. Drug discovery (01.04.2011)
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Journal Article
Functionality of primary hepatic non-parenchymal cells in a 3D spheroid model and contribution to acetaminophen hepatotoxicity
Bell, Catherine C., Chouhan, Bhavik, Andersson, Linda C., Andersson, Håkan, Dear, James W., Williams, Dominic P., Söderberg, Magnus
Published in Archives of toxicology (01.04.2020)
Published in Archives of toxicology (01.04.2020)
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Journal Article
Introducing an automated high content confocal imaging approach for Organs-on-Chips
Peel, Samantha, Corrigan, Adam M, Ehrhardt, Beate, Jang, Kyung-Jin, Caetano-Pinto, Pedro, Boeckeler, Matthew, Rubins, Jonathan E, Kodella, Konstantia, Petropolis, Debora B, Ronxhi, Janey, Kulkarni, Gauri, Foster, Alison J, Williams, Dominic, Hamilton, Geraldine A, Ewart, Lorna
Published in Lab on a chip (29.01.2019)
Published in Lab on a chip (29.01.2019)
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Journal Article
Characterization of a functional C3A liver spheroid model
Gaskell, Harriet, Sharma, Parveen, Colley, Helen E, Murdoch, Craig, Williams, Dominic P, Webb, Steven D
Published in Toxicology research (Cambridge) (01.01.2016)
Published in Toxicology research (Cambridge) (01.01.2016)
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Journal Article
Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity
Antoine, Daniel J, Jenkins, Rosalind E, Dear, James W, Williams, Dominic P, McGill, Mitchell R, Sharpe, Matthew R, Craig, Darren G, Simpson, Kenneth J, Jaeschke, Hartmut, Park, B. Kevin
Published in Journal of hepatology (01.01.2012)
Published in Journal of hepatology (01.01.2012)
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Journal Article
Leaf only SAM: A segment anything pipeline for zero-shot automated leaf segmentation
Williams, Dominic, Macfarlane, Fraser, Britten, Avril
Published in Smart agricultural technology (01.08.2024)
Published in Smart agricultural technology (01.08.2024)
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Journal Article
Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid
Foster, Alison J., Chouhan, Bhavik, Regan, Sophie L., Rollison, Helen, Amberntsson, Sara, Andersson, Linda C., Srivastava, Abhishek, Darnell, Malin, Cairns, Jonathan, Lazic, Stanley E., Jang, Kyung-Jin, Petropolis, Debora B., Kodella, Konstantia, Rubins, Jonathan E., Williams, Dominic, Hamilton, Geraldine A., Ewart, Lorna, Morgan, Paul
Published in Archives of toxicology (01.04.2019)
Published in Archives of toxicology (01.04.2019)
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Journal Article
A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function
Karageorgis, Anastassia, Lenhard, Stephen C, Yerby, Brittany, Forsgren, Mikael F, Liachenko, Serguei, Johansson, Edvin, Pilling, Mark A, Peterson, Richard A, Yang, Xi, Williams, Dominic P, Ungersma, Sharon E, Morgan, Ryan E, Brouwer, Kim L R, Jucker, Beat M, Hockings, Paul D
Published in PloS one (17.05.2018)
Published in PloS one (17.05.2018)
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Journal Article
Retraction Note: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity
Antoine, Daniel James, Williams, Dominic P, Kipar, Anja, Laverty, Hugh, Park, B Kevin
Published in Molecular medicine (Cambridge, Mass.) (30.12.2020)
Published in Molecular medicine (Cambridge, Mass.) (30.12.2020)
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Journal Article
The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity
Kamalian, Laleh, Douglas, Oisin, Jolly, Carol E., Snoeys, Jan, Simic, Damir, Monshouwer, Mario, Williams, Dominic P., Kevin Park, B., Chadwick, Amy E.
Published in Toxicology in vitro (01.12.2018)
Published in Toxicology in vitro (01.12.2018)
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Journal Article
High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo
Antoine, Daniel J., Williams, Dominic P., Kipar, Anja, Jenkins, Rosalind E., Regan, Sophie L., Sathish, Jean G., Kitteringham, Neil R., Park, B. Kevin
Published in Toxicological sciences (01.12.2009)
Published in Toxicological sciences (01.12.2009)
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On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships
McAleer, Christopher W., Pointon, Amy, Long, Christopher J., Brighton, Rocky L., Wilkin, Benjamin D., Bridges, L. Richard, Narasimhan Sriram, Narasimham, Fabre, Kristin, McDougall, Robin, Muse, Victorine P., Mettetal, Jerome T., Srivastava, Abhishek, Williams, Dominic, Schnepper, Mark T., Roles, Jeff L., Shuler, Michael L., Hickman, James J., Ewart, Lorna
Published in Scientific reports (03.07.2019)
Published in Scientific reports (03.07.2019)
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Journal Article
Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity
Reddyhoff, Dennis, Ward, John, Williams, Dominic, Regan, Sophie, Webb, Steven
Published in Journal of theoretical biology (07.12.2015)
Published in Journal of theoretical biology (07.12.2015)
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Journal Article
Investigation of the functional impact of CHED- and FECD4-associated SLC4A11 mutations in human corneal endothelial cells
Chung, Doug D, Chen, Angela C, Choo, Charlene H, Zhang, Wenlin, Williams, Dominic, Griffis, Christopher G, Bonezzi, Paul, Jatavallabhula, Kavya, Sampath, Alapakkam P, Aldave, Anthony J
Published in PloS one (22.01.2024)
Published in PloS one (22.01.2024)
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