Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers
Pellegrini, Giovanni, Starkey Lewis, Phil J, Palmer, Luke, Hetzel, Udo, Goldring, Christopher E, Park, B. Kevin, Kipar, Anja, Williams, Dominic P
Published in Toxicology (Amsterdam) (15.12.2013)
Published in Toxicology (Amsterdam) (15.12.2013)
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Novel in vitro and mathematical models for the prediction of chemical toxicity
Williams, Dominic P, Shipley, Rebecca, Ellis, Marianne J, Webb, Steve, Ward, John, Gardner, Iain, Creton, Stuart
Published in Toxicology research (Cambridge) (01.01.2013)
Published in Toxicology research (Cambridge) (01.01.2013)
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Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals
Coulter, Eve M., Jenkinson, Claire, Farrell, John, Lavergne, Sidonie N., Pease, Camilla, White, Andrew, Aleksic, Maja, Basketter, David, Williams, Dominic P., King, Clodagh, Pirmohamed, Munir, Kevin Park, B., Naisbitt, Dean J.
Published in Journal of investigative dermatology (01.01.2010)
Published in Journal of investigative dermatology (01.01.2010)
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Erratum to “Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers” [314 (2–3) (2013) 262–266]
Pellegrini, Giovanni, Starkey Lewis, Phil J, Palmer, Luke, Hetzel, Udo, Goldring, Christopher E, Park, B. Kevin, Kipar, Anja, Williams, Dominic P
Published in Toxicology (Amsterdam) (06.04.2014)
Published in Toxicology (Amsterdam) (06.04.2014)
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Journal Article
Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore
Graham, Emma E, Walsh, Rachel J, Hirst, Charlotte M, Maggs, James L, Martin, Scott, Wild, Martin J, Wilson, Ian D, Harding, John R, Kenna, J Gerald, Peter, Raimund M, Williams, Dominic P, Park, B Kevin
Published in The Journal of pharmacology and experimental therapeutics (01.08.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2008)
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Investigation of toxic metabolites during drug development
Park, Kevin, Williams, Dominic P., Naisbitt, Dean J., Kitteringham, Neil R., Pirmohamed, Munir
Published in Toxicology and applied pharmacology (01.09.2005)
Published in Toxicology and applied pharmacology (01.09.2005)
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Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell‐Based Therapies
Heslop, James A., Hammond, Thomas G., Santeramo, Ilaria, Tort Piella, Agnès, Hopp, Isabel, Zhou, Jing, Baty, Roua, Graziano, Enrique I., Proto Marco, Bernabé, Caron, Alexis, Sköld, Patrik, Andrews, Peter W., Baxter, Melissa A., Hay, David C., Hamdam, Junnat, Sharpe, Michaela E., Patel, Sara, Jones, David R., Reinhardt, Jens, Danen, Erik H.J., Ben-David, Uri, Stacey, Glyn, Björquist, Petter, Piner, Jacqueline, Mills, John, Rowe, Cliff, Pellegrini, Giovanni, Sethu, Swaminathan, Antoine, Daniel J., Cross, Michael J., Murray, Patricia, Williams, Dominic P., Kitteringham, Neil R., Goldring, Chris E.P., Park, B. Kevin
Published in Stem cells translational medicine (01.04.2015)
Published in Stem cells translational medicine (01.04.2015)
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Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin
Jeyadevan, J. Prince, Bray, Patrick G, Chadwick, James, Mercer, Amy E, Byrne, Aoife, Ward, Stephen A, Park, B. Kevin, Williams, Dominic P, Cosstick, Rick, Davies, Jill, Higson, Adrian P, Irving, Ed, Posner, Gary H, O'Neill, Paul M
Published in Journal of medicinal chemistry (26.02.2004)
Published in Journal of medicinal chemistry (26.02.2004)
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Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist
Thaventhiran, Thilipan, Alhumeed, Naif, Yeang, Han X A, Sethu, Swaminathan, Downey, Jocelyn S, Alghanem, Ahmad F, Olayanju, Adedamola, Smith, Emma L, Cross, Michael J, Webb, Steven D, Williams, Dominic P, Bristow, Adrian, Ball, Christina, Stebbings, Richard, Sathish, Jean G
Published in mAbs (01.09.2014)
Published in mAbs (01.09.2014)
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RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity
Antoine, Daniel J., Jenkins, Rosalind E., Dear, James W., Williams, Dominic P., McGill, Mitchell R., Sharpe, Matthew R., Craig, Darren G., Simpson, Kenneth J., Jaeschke, Hartmut, Park, B. Kevin
Published in Journal of hepatology (01.05.2012)
Published in Journal of hepatology (01.05.2012)
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Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice
Randle, Laura E, Goldring, Chris E.P, Benson, Craig A, Metcalfe, Peter N, Kitteringham, Neil R, Park, B. Kevin, Williams, Dominic P
Published in Toxicology (Amsterdam) (20.01.2008)
Published in Toxicology (Amsterdam) (20.01.2008)
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Selection of new chemical entities with decreased potential for adverse drug reactions
Park, Kevin B., Dalton-Brown, Emma, Hirst, Charlotte, Williams, Dominic P.
Published in European journal of pharmacology (07.11.2006)
Published in European journal of pharmacology (07.11.2006)
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Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells
Martin, Philip, Riley, Robert, Thompson, Paul, Williams, Dominic, Back, David, Owen, Andrew
Published in Acta pharmacologica Sinica (01.01.2010)
Published in Acta pharmacologica Sinica (01.01.2010)
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Exploring the translational disconnect between the murine and human inflammatory response: analysis of LPS dose-response relationship in murine versus human cell lines and implications for translation into murine models of sepsis
McCarron, Eamon P, Williams, Dominic P, Antoine, Daniel J, Kipar, Anja, Lemm, Jana, Stehr, Sebastian, Welters, Ingeborg D
Published in Journal of inflammation research (01.01.2015)
Published in Journal of inflammation research (01.01.2015)
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Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis
Mercer, Amy E., Regan, Sophie L., Hirst, Charlotte M., Graham, Emma E., Antoine, Daniel J., Benson, Craig A., Williams, Dominic P., Foster, John, Kenna, J. Gerry, Park, B. Kevin
Published in Toxicology and applied pharmacology (15.09.2009)
Published in Toxicology and applied pharmacology (15.09.2009)
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