Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15
Ting, Han, Goralski, Maria, Gaskill, Nicholas, Capota, Emanuela, Kim, Jiwoong, Ting, Tabitha C., Xie, Yang, Williams, Noelle S., Nijhawan, Deepak
Published in Science (American Association for the Advancement of Science) (28.04.2017)
Published in Science (American Association for the Advancement of Science) (28.04.2017)
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Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells
Lafita-Navarro, M Carmen, Venkateswaran, Niranjan, Kilgore, Jessica A, Kanji, Suman, Han, Jungsoo, Barnes, Spencer, Williams, Noelle S, Buszczak, Michael, Burma, Sandeep, Conacci-Sorrell, Maralice
Published in PLoS genetics (17.11.2020)
Published in PLoS genetics (17.11.2020)
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MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer
Venkateswaran, Niranjan, Lafita-Navarro, M Carmen, Hao, Yi-Heng, Kilgore, Jessica A, Perez-Castro, Lizbeth, Braverman, Jonathan, Borenstein-Auerbach, Nofit, Kim, Min, Lesner, Nicholas P, Mishra, Prashant, Brabletz, Thomas, Shay, Jerry W, DeBerardinis, Ralph J, Williams, Noelle S, Yilmaz, Omer H, Conacci-Sorrell, Maralice
Published in Genes & development (01.09.2019)
Published in Genes & development (01.09.2019)
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Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
Lum, Lawrence, Chen, Baozhi, Dodge, Michael E, Tang, Wei, Lu, Jianming, Ma, Zhiqiang, Fan, Chih-Wei, Wei, Shuguang, Hao, Wayne, Kilgore, Jessica, Williams, Noelle S, Roth, Michael G, Amatruda, James F, Chen, Chuo
Published in Nature chemical biology (01.02.2009)
Published in Nature chemical biology (01.02.2009)
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A mass balance approach for calculation of recovery and binding enables the use of ultrafiltration as a rapid method for measurement of plasma protein binding for even highly lipophilic compounds
Wang, Changguang, Williams, Noelle S.
Published in Journal of pharmaceutical and biomedical analysis (05.03.2013)
Published in Journal of pharmaceutical and biomedical analysis (05.03.2013)
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Journal Article
Utilizing Digital Health to Collect Electronic Patient-Reported Outcomes in Prostate Cancer: Single-Arm Pilot Trial
Tran, Christine, Dicker, Adam, Leiby, Benjamin, Gressen, Eric, Williams, Noelle, Jim, Heather
Published in Journal of medical Internet research (25.03.2020)
Published in Journal of medical Internet research (25.03.2020)
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NQO1-dependent, Tumor-selective Radiosensitization of Non-small Cell Lung Cancers
Motea, Edward A, Huang, Xiumei, Singh, Naveen, Kilgore, Jessica A, Williams, Noelle S, Xie, Xian-Jin, Gerber, David E, Beg, Muhammad S, Bey, Erik A, Boothman, David A
Published in Clinical cancer research (15.04.2019)
Published in Clinical cancer research (15.04.2019)
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Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study
McCarthy, James S, Prof, Lotharius, Julie, PhD, Rückle, Thomas, PhD, Chalon, Stephan, MD, Phillips, Margaret A, Prof, Elliott, Suzanne, PhD, Sekuloski, Silvana, PhD, Griffin, Paul, MD, Ng, Caroline L, PhD, Fidock, David A, Prof, Marquart, Louise, PhD, Williams, Noelle S, PhD, Gobeau, Nathalie, PhD, Bebrevska, Lidiya, PhD, Rosario, Maria, PhD, Marsh, Kennan, PhD, Möhrle, Jörg J, Dr
Published in The Lancet infectious diseases (01.06.2017)
Published in The Lancet infectious diseases (01.06.2017)
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A trimethoprim derivative impedes antibiotic resistance evolution
Manna, Madhu Sudan, Tamer, Yusuf Talha, Gaszek, Ilona, Poulides, Nicole, Ahmed, Ayesha, Wang, Xiaoyu, Toprak, Furkan C. R., Woodard, DaNae R., Koh, Andrew Y., Williams, Noelle S., Borek, Dominika, Atilgan, Ali Rana, Hulleman, John D., Atilgan, Canan, Tambar, Uttam, Toprak, Erdal
Published in Nature communications (19.05.2021)
Published in Nature communications (19.05.2021)
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Reducing acetylated tau is neuroprotective in brain injury
Shin, Min-Kyoo, Vázquez-Rosa, Edwin, Koh, Yeojung, Dhar, Matasha, Chaubey, Kalyani, Cintrón-Pérez, Coral J., Barker, Sarah, Miller, Emiko, Franke, Kathryn, Noterman, Maria F., Seth, Divya, Allen, Rachael S., Motz, Cara T., Rao, Sriganesh Ramachandra, Skelton, Lara A., Pardue, Machelle T., Fliesler, Steven J., Wang, Chao, Tracy, Tara E., Gan, Li, Liebl, Daniel J., Savarraj, Jude P.J., Torres, Glenda L., Ahnstedt, Hilda, McCullough, Louise D., Kitagawa, Ryan S., Choi, H. Alex, Zhang, Pengyue, Hou, Yuan, Chiang, Chien-Wei, Li, Lang, Ortiz, Francisco, Kilgore, Jessica A., Williams, Noelle S., Whitehair, Victoria C., Gefen, Tamar, Flanagan, Margaret E., Stamler, Jonathan S., Jain, Mukesh K., Kraus, Allison, Cheng, Feixiong, Reynolds, James D., Pieper, Andrew A.
Published in Cell (13.05.2021)
Published in Cell (13.05.2021)
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Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors
Huang, Xiumei, Motea, Edward A., Moore, Zachary R., Yao, Jun, Dong, Ying, Chakrabarti, Gaurab, Kilgore, Jessica A., Silvers, Molly A., Patidar, Praveen L., Cholka, Agnieszka, Fattah, Farjana, Cha, Yoonjeong, Anderson, Glenda G., Kusko, Rebecca, Peyton, Michael, Yan, Jingsheng, Xie, Xian-Jin, Sarode, Venetia, Williams, Noelle S., Minna, John D., Beg, Muhammad, Gerber, David E., Bey, Erik A., Boothman, David A.
Published in Cancer cell (12.12.2016)
Published in Cancer cell (12.12.2016)
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Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy
Ma, Xinpeng, Huang, Xiumei, Moore, Zachary, Huang, Gang, Kilgore, Jessica A., Wang, Yiguang, Hammer, Suntrea, Williams, Noelle S., Boothman, David A., Gao, Jinming
Published in Journal of controlled release (28.02.2015)
Published in Journal of controlled release (28.02.2015)
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Analogs of the anti-malaria drug mefloquine have broad-spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection
Guin, Soumitra, Montoya, Marhiah C, Wang, Xiaoyu, Zarnowski, Robert, Andes, David R, Meyers, Marvin J, Williams, Noelle S, Krysan, Damian J
Published in Antimicrobial agents and chemotherapy (04.10.2024)
Published in Antimicrobial agents and chemotherapy (04.10.2024)
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A male-derived nonribosomal peptide pheromone controls female schistosome development
Chen, Rui, Wang, Jipeng, Gradinaru, Irina, Vu, Hieu S., Geboers, Sophie, Naidoo, Jacinth, Ready, Joseph M., Williams, Noelle S., DeBerardinis, Ralph J., Ross, Elliott M., Collins, James J.
Published in Cell (28.04.2022)
Published in Cell (28.04.2022)
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An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris
Iyer, Kali R., Camara, Kaddy, Daniel-Ivad, Martin, Trilles, Richard, Pimentel-Elardo, Sheila M., Fossen, Jen L., Marchillo, Karen, Liu, Zhongle, Singh, Shakti, Muñoz, José F., Kim, Sang Hu, Porco, John A., Cuomo, Christina A., Williams, Noelle S., Ibrahim, Ashraf S., Edwards, John E., Andes, David R., Nodwell, Justin R., Brown, Lauren E., Whitesell, Luke, Robbins, Nicole, Cowen, Leah E.
Published in Nature communications (22.12.2020)
Published in Nature communications (22.12.2020)
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Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK‐925 and ARN‐776 in narcoleptic orexin/tTA; TetO‐DTA mice
Sun, Yu, Ranjan, Alok, Tisdale, Ryan, Ma, Shun‐Chieh, Park, Sunmee, Haire, Meghan, Heu, Jasmine, Morairty, Stephen R., Wang, Xiaoyu, Rosenbaum, Daniel M., Williams, Noelle S., De Brabander, Jef K., Kilduff, Thomas S.
Published in Journal of sleep research (01.08.2023)
Published in Journal of sleep research (01.08.2023)
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Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer
Zhang, Lu, Theodoropoulos, Panayotis C, Eskiocak, Ugur, Wang, Wentian, Moon, Young-Ah, Posner, Bruce, Williams, Noelle S, Wright, Woodring E, Kim, Sang Bum, Nijhawan, Deepak, De Brabander, Jef K, Shay, Jerry W
Published in Science translational medicine (19.10.2016)
Published in Science translational medicine (19.10.2016)
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Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency
Tesla, Rachel, Guhl, Charlotte, Werthmann, Gordon C., Dixon, Danielle, Cenik, Basar, Addepalli, Yesu, Liang, Jue, Fass, Daniel M., Rosenthal, Zachary, Haggarty, Stephen J., Williams, Noelle S., Posner, Bruce A., Ready, Joseph M., Herz, Joachim
Published in Nature communications (20.07.2024)
Published in Nature communications (20.07.2024)
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