Managing the challenge of chemically reactive metabolites in drug development
Park, B. Kevin, Tweedie, Donald J, Boobis, Alan, Clarke, Stephen, Goldring, Chris E. P, Jones, David, Kenna, J. Gerry, Lambert, Craig, Laverty, Hugh G, Naisbitt, Dean J, Nelson, Sidney, Nicoll-Griffith, Deborah A, Obach, R. Scott, Routledge, Philip, Smith, Dennis A, Vermeulen, Nico, Williams, Dominic P, Wilson, Ian D, Baillie, Thomas A
Published in Nature reviews. Drug discovery (01.04.2011)
Published in Nature reviews. Drug discovery (01.04.2011)
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Journal Article
Functionality of primary hepatic non-parenchymal cells in a 3D spheroid model and contribution to acetaminophen hepatotoxicity
Bell, Catherine C., Chouhan, Bhavik, Andersson, Linda C., Andersson, Håkan, Dear, James W., Williams, Dominic P., Söderberg, Magnus
Published in Archives of toxicology (01.04.2020)
Published in Archives of toxicology (01.04.2020)
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Journal Article
Characterization of a functional C3A liver spheroid model
Gaskell, Harriet, Sharma, Parveen, Colley, Helen E, Murdoch, Craig, Williams, Dominic P, Webb, Steven D
Published in Toxicology research (Cambridge) (01.01.2016)
Published in Toxicology research (Cambridge) (01.01.2016)
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Journal Article
Retraction Note: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity
Antoine, Daniel James, Williams, Dominic P, Kipar, Anja, Laverty, Hugh, Park, B Kevin
Published in Molecular medicine (Cambridge, Mass.) (30.12.2020)
Published in Molecular medicine (Cambridge, Mass.) (30.12.2020)
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Journal Article
High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo
Antoine, Daniel J., Williams, Dominic P., Kipar, Anja, Jenkins, Rosalind E., Regan, Sophie L., Sathish, Jean G., Kitteringham, Neil R., Park, B. Kevin
Published in Toxicological sciences (01.12.2009)
Published in Toxicological sciences (01.12.2009)
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Journal Article
Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury
Williams, C. David, Antoine, Daniel J., Shaw, Patrick J., Benson, Craig, Farhood, Anwar, Williams, Dominic P., Kanneganti, Thirumala-Devi, Park, B. Kevin, Jaeschke, Hartmut
Published in Toxicology and applied pharmacology (01.05.2011)
Published in Toxicology and applied pharmacology (01.05.2011)
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Journal Article
Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity
Antoine, Daniel James, Williams, Dominic P, Kipar, Anja, Laverty, Hugh, Park, B Kevin
Published in Molecular medicine (Cambridge, Mass.) (01.11.2010)
Published in Molecular medicine (Cambridge, Mass.) (01.11.2010)
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Journal Article
The role of metabolic activation in drug-induced hepatotoxicity
PARK, B. Kevin, KITTERINGHAM, Neil R, MAGGS, James L, PIRMOHAMED, Munir, WILLIAMS, Dominic P
Published in Annual review of pharmacology and toxicology (01.01.2005)
Published in Annual review of pharmacology and toxicology (01.01.2005)
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Journal Article
Expression of Concern to: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatoxicity
Antoine, Daniel James, Williams, Dominic P, Kipar, Anja, Laverty, Hugh, Park, B Kevin
Published in Molecular medicine (Cambridge, Mass.) (30.01.2020)
Published in Molecular medicine (Cambridge, Mass.) (30.01.2020)
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Journal Article
Acyl glucuronides: the good, the bad and the ugly
Regan, Sophie L., Maggs, James L., Hammond, Thomas G., Lambert, Craig, Williams, Dominic P., Park, B. Kevin
Published in Biopharmaceutics & drug disposition (01.10.2010)
Published in Biopharmaceutics & drug disposition (01.10.2010)
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Journal Article
Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress
O'Brien, Katie A, McNally, Ben D, Sowton, Alice P, Murgia, Antonio, Armitage, James, Thomas, Luke W, Krause, Fynn N, Maddalena, Lucas A, Francis, Ian, Kavanagh, Stefan, Williams, Dominic P, Ashcroft, Margaret, Griffin, Julian L, Lyon, Jonathan J, Murray, Andrew J
Published in BMC biology (15.12.2021)
Published in BMC biology (15.12.2021)
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A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function
Karageorgis, Anastassia, Lenhard, Stephen C, Yerby, Brittany, Forsgren, Mikael F, Liachenko, Serguei, Johansson, Edvin, Pilling, Mark A, Peterson, Richard A, Yang, Xi, Williams, Dominic P, Ungersma, Sharon E, Morgan, Ryan E, Brouwer, Kim L R, Jucker, Beat M, Hockings, Paul D
Published in PloS one (17.05.2018)
Published in PloS one (17.05.2018)
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Journal Article
Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients
Hammond, Thomas G, Meng, Xiaoli, Jenkins, Rosalind E, Maggs, James L, Castelazo, Anahi Santoyo, Regan, Sophie L, Bennett, Stuart N L, Earnshaw, Caroline J, Aithal, Guruprasad P, Pande, Ira, Kenna, J Gerry, Stachulski, Andrew V, Park, B Kevin, Williams, Dominic P
Published in The Journal of pharmacology and experimental therapeutics (01.08.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2014)
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Journal Article
The Generation, Detection, and Effects of Reactive Drug Metabolites
Stachulski, Andrew V., Baillie, Thomas A., Kevin Park, B., Scott Obach, R., Dalvie, Deepak K., Williams, Dominic P., Srivastava, Abhishek, Regan, Sophie L., Antoine, Daniel J., Goldring, Christopher E. P., Chia, Alvin J. L., Kitteringham, Neil R., Randle, Laura E., Callan, Hayley, Castrejon, J. Luis, Farrell, John, Naisbitt, Dean J., Lennard, Martin S.
Published in Medicinal research reviews (01.09.2013)
Published in Medicinal research reviews (01.09.2013)
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Journal Article
Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries
SRIVASTAVA, Abhishek, LIAN, Lu-Yun, MAGGS, James L, CHAPONDA, Masautso, PIRMOHAMED, Munir, WILLIAMS, Dominic P, KEVIN PARK, B
Published in Drug metabolism and disposition (01.01.2010)
Published in Drug metabolism and disposition (01.01.2010)
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Journal Article
Acridinediones: Selective and Potent Inhibitors of the Malaria Parasite Mitochondrial bc1 Complex
Biagini, Giancarlo A, Fisher, Nicholas, Berry, Neil, Stocks, Paul A, Meunier, Brigitte, Williams, Dominic P, Bonar-Law, Richard, Bray, Patrick G, Owen, Andrew, O'Neill, Paul M, Ward, Stephen A
Published in Molecular pharmacology (01.05.2008)
Published in Molecular pharmacology (01.05.2008)
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Journal Article
Synergistic Interactions between Commonly Used Food Additives in a Developmental Neurotoxicity Test
Lau, Karen, McLean, W. Graham, Williams, Dominic P., Howard, C. Vyvyan
Published in Toxicological sciences (01.03.2006)
Published in Toxicological sciences (01.03.2006)
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Journal Article
The Metabolism and Toxicity of Furosemide in the Wistar Rat and CD-1 Mouse: a Chemical and Biochemical Definition of the Toxicophore
Williams, Dominic P, Antoine, Daniel J, Butler, Philip J, Jones, Russell, Randle, Laura, Payne, Anthony, Howard, Martin, Gardner, Iain, Blagg, Julian, Park, B Kevin
Published in The Journal of pharmacology and experimental therapeutics (01.09.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2007)
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