Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats
Harriman, Geraldine, Greenwood, Jeremy, Bhat, Sathesh, Huang, Xinyi, Wang, Ruiying, Paul, Debamita, Tong, Liang, Saha, Asish K., Westlin, William F., Kapeller, Rosana, Harwood, H. James
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2016)
Get full text
Journal Article
Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models
Svensson, Robert U, Parker, Seth J, Eichner, Lillian J, Kolar, Matthew J, Wallace, Martina, Brun, Sonja N, Lombardo, Portia S, Van Nostrand, Jeanine L, Hutchins, Amanda, Vera, Lilliana, Gerken, Laurie, Greenwood, Jeremy, Bhat, Sathesh, Harriman, Geraldine, Westlin, William F, Harwood, Jr, H James, Saghatelian, Alan, Kapeller, Rosana, Metallo, Christian M, Shaw, Reuben J
Published in Nature medicine (01.10.2016)
Published in Nature medicine (01.10.2016)
Get full text
Journal Article
Acetyl‐coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects: A randomized, double‐blind, crossover study
Stiede, Kathryn, Miao, Wenyan, Blanchette, Heather S., Beysen, Carine, Harriman, Geraldine, Harwood, H. James, Kelley, Heather, Kapeller, Rosana, Schmalbach, Tess, Westlin, William F.
Published in Hepatology (Baltimore, Md.) (01.08.2017)
Published in Hepatology (Baltimore, Md.) (01.08.2017)
Get full text
Journal Article
Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy
Kelly, Priscilla N, Romero, Donna L, Yang, Yibin, Shaffer, 3rd, Arthur L, Chaudhary, Divya, Robinson, Shaughnessy, Miao, Wenyan, Rui, Lixin, Westlin, William F, Kapeller, Rosana, Staudt, Louis M
Published in The Journal of experimental medicine (14.12.2015)
Published in The Journal of experimental medicine (14.12.2015)
Get full text
Journal Article
MYD88 L265P mutations identify a prognostic gene expression signature and a pathway for targeted inhibition in CLL
Improgo, Ma. Reina, Tesar, Bethany, Klitgaard, Josephine L., Magori‐Cohen, Reuma, Yu, Lijian, Kasar, Siddha, Chaudhary, Divya, Miao, Wenyan, Fernandes, Stacey M., Hoang, Kevin, Westlin, William F., Kim, Haesook T., Brown, Jennifer R.
Published in British journal of haematology (01.03.2019)
Published in British journal of haematology (01.03.2019)
Get full text
Journal Article
Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine
Singh, Juswinder, Hagel, Margit, Niu, Deqiang, St Martin, Thia, Sheets, Michael P, Qiao, Lixin, Bernard, Hugues, Karp, Russell M, Zhu, Zhendong, Labenski, Matthew T, Chaturvedi, Prasoon, Nacht, Mariana, Westlin, William F, Petter, Russell C
Published in Nature Chemical Biology (01.01.2011)
Published in Nature Chemical Biology (01.01.2011)
Get full text
Journal Article
A Methionine Aminopeptidase-2 Inhibitor, PPI-2458, for the Treatment of Rheumatoid Arthritis
Bernier, Sylvie G., Lazarus, Douglas D., Clark, Edward, Doyle, Beth, Labenski, Matthew T., Thompson, Charles D., Westlin, William F., Hannig, Gerhard, Erikson, R. L.
Published in Proceedings of the National Academy of Sciences - PNAS (20.07.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (20.07.2004)
Get full text
Journal Article
Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma
Lally, James S.V., Ghoshal, Sarani, DePeralta, Danielle K., Moaven, Omeed, Wei, Lan, Masia, Ricard, Erstad, Derek J., Fujiwara, Naoto, Leong, Vivian, Houde, Vanessa P., Anagnostopoulos, Alexander E., Wang, Alice, Broadfield, Lindsay A., Ford, Rebecca J., Foster, Robert A., Bates, Jamie, Sun, Hailing, Wang, Ting, Liu, Henry, Ray, Adrian S., Saha, Asish K., Greenwood, Jeremy, Bhat, Sathesh, Harriman, Geraldine, Miao, Wenyan, Rocnik, Jennifer L., Westlin, William F., Muti, Paola, Tsakiridis, Theodoros, Harwood, H. James, Kapeller, Rosana, Hoshida, Yujin, Tanabe, Kenneth K., Steinberg, Gregory R., Fuchs, Bryan C.
Published in Cell metabolism (08.01.2019)
Published in Cell metabolism (08.01.2019)
Get full text
Journal Article
Kidney transplantation from triple‐knockout pigs expressing multiple human proteins in cynomolgus macaques
Ma, David, Hirose, Takayuki, Lassiter, Grace, Sasaki, Hajime, Rosales, Ivy, Coe, Taylor M., Rickert, Charles G., Matheson, Rudy, Colvin, Robert B., Qin, Wenning, Kan, Yinan, Layer, Jacob V., Paragas, Violette B., Stiede, Kathryn, Hall, Katherine C., Youd, Michele E., Queiroz, Luis M., Westlin, William F., Curtis, Michael, Yang, Luhan, Markmann, James F., Kawai, Tatsuo
Published in American journal of transplantation (01.01.2022)
Published in American journal of transplantation (01.01.2022)
Get full text
Journal Article
Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans
Evans, Erica K, Tester, Richland, Aslanian, Sharon, Karp, Russell, Sheets, Michael, Labenski, Matthew T, Witowski, Steven R, Lounsbury, Heather, Chaturvedi, Prasoon, Mazdiyasni, Hormoz, Zhu, Zhendong, Nacht, Mariana, Freed, Martin I, Petter, Russell C, Dubrovskiy, Alex, Singh, Juswinder, Westlin, William F
Published in The Journal of pharmacology and experimental therapeutics (01.08.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2013)
Get full text
Journal Article
Extensive germline genome engineering in pigs
Yue, Yanan, Xu, Weihong, Kan, Yinan, Zhao, Hong-Ye, Zhou, Yixuan, Song, Xiaobin, Wu, Jiajia, Xiong, Juan, Goswami, Dharmendra, Yang, Meng, Lamriben, Lydia, Xu, Mengyuan, Zhang, Qi, Luo, Yu, Guo, Jianxiong, Mao, Shengyi, Jiao, Deling, Nguyen, Tien Dat, Li, Zhuo, Layer, Jacob V, Li, Mailin, Paragas, Violette, Youd, Michele E, Sun, Zhongquan, Ding, Yuan, Wang, Weilin, Dou, Hongwei, Song, Lingling, Wang, Xueqiong, Le, Lei, Fang, Xin, George, Haydy, Anand, Ranjith, Wang, Shi Yun, Westlin, William F, Güell, Marc, Markmann, James, Qin, Wenning, Gao, Yangbin, Wei, Hong-Jiang, Church, George M, Yang, Luhan
Published in Nature biomedical engineering (01.02.2021)
Published in Nature biomedical engineering (01.02.2021)
Get full text
Journal Article
In vitro and in vivo characterization of irreversible mutant-selective EGFR inhibitors that are wild-type sparing
Tjin Tham Sjin, Robert, Lee, Kwangho, Walter, Annette O, Dubrovskiy, Aleksandr, Sheets, Michael, Martin, Thia St, Labenski, Matthew T, Zhu, Zhendong, Tester, Richland, Karp, Russell, Medikonda, Aravind, Chaturvedi, Prasoon, Ren, Yixuan, Haringsma, Henry, Etter, Jeff, Raponi, Mitch, Simmons, Andrew D, Harding, Thomas C, Niu, Deqiang, Nacht, Mariana, Westlin, William F, Petter, Russell C, Allen, Andrew, Singh, Juswinder
Published in Molecular cancer therapeutics (01.06.2014)
Published in Molecular cancer therapeutics (01.06.2014)
Get full text
Journal Article
Genetic modifications designed for xenotransplantation attenuate sialoadhesin‐dependent binding of human erythrocytes to porcine macrophages
Petitpas, Kaitlyn, Habibabady, Zahra, Ritchie, Veronica, Connolly, Margaret R., Burdorf, Lars, Qin, Wenning, Kan, Yinan, Layer, Jacob V., Crabtree, Juliet N., Youd, Michele E., Westlin, William F., Magnani, Diogo M., Pierson, Richard N., Azimzadeh, Agnes M.
Published in Xenotransplantation (Københaven) (01.11.2022)
Published in Xenotransplantation (Københaven) (01.11.2022)
Get full text
Journal Article
A Novel Methionine Aminopeptidase-2 Inhibitor, PPI-2458, Inhibits Non–Hodgkin's Lymphoma Cell Proliferation In vitro and In vivo
Cooper, Andrew C, Karp, Russell M, Clark, Edward J, Taghizadeh, Nazbeh R, Hoyt, Jennifer G, Labenski, Matthew T, Murray, Michael J, Hannig, Gerhard, Westlin, William F, Thompson, Charles D
Published in Clinical cancer research (15.04.2006)
Published in Clinical cancer research (15.04.2006)
Get full text
Journal Article
Abstract 1048: Modulation of lipid metabolism through inhibition of acetyl-CoA carboxylase with ND-646 leads to potent inhibition of breast cancer cell growth in vitro and in vivo
Rocnik, Jennifer L., Miao, Wenyan, Harriman, Geraldine, Greenwood, Jeremy, Bhat, Sathesh, Harwood, H. James, Kapeller, Rosana, Westlin, William F.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Get full text
Journal Article
αvβ3 Integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in mice
REINMUTH, Niels, WENBIAO LIU, ELLIS, Lee M, AHMAD, Syed A, FAN, Fan, STOELTZING, Oliver, PARIKH, Alexander A, BUCANA, Corazon D, GALLICK, Gary E, NICKOLS, Maureen A, WESTLIN, William F
Published in Cancer research (Chicago, Ill.) (01.05.2003)
Get full text
Published in Cancer research (Chicago, Ill.) (01.05.2003)
Journal Article
Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis
Deng, Hongfeng, Bernier, Sylvie G, Doyle, Elisabeth, Lorusso, Jeanine, Morgan, Barry A, Westlin, William F, Evindar, Ghotas
Published in ACS medicinal chemistry letters (10.10.2013)
Published in ACS medicinal chemistry letters (10.10.2013)
Get full text
Journal Article
Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1
Evindar, Ghotas, Deng, Hongfeng, Bernier, Sylvie G, Doyle, Elisabeth, Lorusso, Jeanine, Morgan, Barry A, Westlin, William F
Published in Bioorganic & medicinal chemistry letters (15.01.2013)
Published in Bioorganic & medicinal chemistry letters (15.01.2013)
Get full text
Journal Article
Liver Selective Acetyl-CoA Carboxylase Inhibition Inhibits Hepatocellular Carcinoma in a Cirrhosis Model
DePeralta, Danielle K., MD, Wei, Lan, PhD, Harriman, Geraldine, PhD, Greenwood, Jeremy, Westlin, William F., PhD, Harwood, James, PhD, Bhat, Sathesh, Kapeller, Rosana, MD, PhD, Fuchs, Bryan C., PhD, Tanabe, Kenneth K., MD, FACS
Published in Journal of the American College of Surgeons (01.09.2014)
Published in Journal of the American College of Surgeons (01.09.2014)
Get full text
Journal Article