The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection
Niu, Congrong, Livingston, Christine M, Li, Li, Beran, Rudolf K, Daffis, Stephane, Ramakrishnan, Dhivya, Burdette, Dara, Peiser, Leanne, Salas, Eduardo, Ramos, Hilario, Yu, Mei, Cheng, Guofeng, Strubin, Michel, Delaney, IV, William E, Fletcher, Simon P
Published in PloS one (17.01.2017)
Published in PloS one (17.01.2017)
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Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism
Niu, Congrong, Li, Li, Daffis, Stephane, Lucifora, Julie, Bonnin, Marc, Maadadi, Sarah, Salas, Eduardo, Chu, Ruth, Ramos, Hilario, Livingston, Christine M., Beran, Rudolf K., Garg, Abhishek V., Balsitis, Scott, Durantel, David, Zoulim, Fabien, Delaney, William E., Fletcher, Simon P.
Published in Journal of hepatology (01.05.2018)
Published in Journal of hepatology (01.05.2018)
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Cell-Free Hepatitis B Virus Capsid Assembly Dependent on the Core Protein C-Terminal Domain and Regulated by Phosphorylation
Ludgate, Laurie, Liu, Kuancheng, Luckenbaugh, Laurie, Streck, Nicholas, Eng, Stacey, Voitenleitner, Christian, Delaney, 4th, William E, Hu, Jianming
Published in Journal of virology (15.06.2016)
Published in Journal of virology (15.06.2016)
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Targeted Long-Read Sequencing Reveals Comprehensive Architecture, Burden, and Transcriptional Signatures from Hepatitis B Virus-Associated Integrations and Translocations in Hepatocellular Carcinoma Cell Lines
Ramirez, Ricardo, van Buuren, Nicholas, Gamelin, Lindsay, Soulette, Cameron, May, Lindsey, Han, Dong, Yu, Mei, Choy, Regina, Cheng, Guofeng, Bhardwaj, Neeru, Chiu, Joy, Muench, Robert C, Delaney, 4th, William E, Mo, Hongmei, Feierbach, Becket, Li, Li
Published in Journal of virology (09.09.2021)
Published in Journal of virology (09.09.2021)
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Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy
Burdette, Dara L, Lazerwith, Scott, Yang, Jenny, Chan, Henry L Y, Delaney Iv, William E, Fletcher, Simon P, Cihlar, Tomas, Feierbach, Becket
Published in PloS one (01.04.2022)
Published in PloS one (01.04.2022)
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Toll‐Like Receptor 8 Agonist GS‐9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B
Daffis, Stephane, Balsitis, Scott, Chamberlain, Jason, Zheng, Jim, Santos, Rex, Rowe, William, Ramakrishnan, Dhivya, Pattabiraman, Divya, Spurlock, Sandra, Chu, Ruth, Kang, Don, Mish, Michael, Ramirez, Ricardo, Li, Li, Li, Bei, Ma, Sarina, Hung, Magdeleine, Voitenleitner, Christian, Yon, Changsuek, Suresh, Manasa, Menne, Stephan, Cote, Paul, Delaney, William E., Mackman, Richard, Fletcher, Simon P.
Published in Hepatology (Baltimore, Md.) (01.01.2021)
Published in Hepatology (Baltimore, Md.) (01.01.2021)
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Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B
Mackman, Richard L, Mish, Michael, Chin, Gregory, Perry, Jason K, Appleby, Todd, Aktoudianakis, Vangelis, Metobo, Sammy, Pyun, Peter, Niu, Congrong, Daffis, Stephane, Yu, Helen, Zheng, Jim, Villasenor, Armando G, Zablocki, Jeff, Chamberlain, Jason, Jin, Haolun, Lee, Gary, Suekawa-Pirrone, Kimberley, Santos, Rex, Delaney, William E, Fletcher, Simon P
Published in Journal of medicinal chemistry (24.09.2020)
Published in Journal of medicinal chemistry (24.09.2020)
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Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo
Gorsuch, Cassandra L., Nemec, Paige, Yu, Mei, Xu, Simin, Han, Dong, Smith, Jeff, Lape, Janel, van Buuren, Nicholas, Ramirez, Ricardo, Muench, Robert C., Holdorf, Meghan M., Feierbach, Becket, Falls, Greg, Holt, Jason, Shoop, Wendy, Sevigny, Emma, Karriker, Forrest, Brown, Robert V., Joshi, Amod, Goodwin, Tyler, Tam, Ying K., Lin, Paulo J.C., Semple, Sean C., Leatherbury, Neil, Delaney IV, William E., Jantz, Derek, Rhoden Smith, Amy
Published in Molecular therapy (07.09.2022)
Published in Molecular therapy (07.09.2022)
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Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells
Li, Li, Barry, Vivian, Daffis, Stephane, Niu, Congrong, Huntzicker, Erik, French, Dorothy M., Mikaelian, Igor, Lanford, Robert E., Delaney, William E., Fletcher, Simon P.
Published in Journal of hepatology (01.05.2018)
Published in Journal of hepatology (01.05.2018)
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Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy
Werle-Lapostolle, Bettina, Bowden, Scott, Locarnini, Stephen, Wursthorn, Karsten, Petersen, Jorg, Lau, George, Trepo, Christian, Marcellin, Patrick, Goodman, Zachary, Delaney, 4th, William E, Xiong, Shelly, Brosgart, Carol L, Chen, Shan-Shan, Gibbs, Craig S, Zoulim, Fabien
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2004)
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2004)
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Novel Hepatitis C Virus Reporter Replicon Cell Lines Enable Efficient Antiviral Screening against Genotype 1a
Robinson, Margaret, Yang, Huiling, Sun, Siu-Chi, Peng, Betty, Tian, Yang, Pagratis, Nikos, Greenstein, Andrew E, Delaney, 4th, William E
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
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The Hepatitis B Virus Polymerase Mutation rtV173L Is Selected during Lamivudine Therapy and Enhances Viral Replication In Vitro
Delaney, 4th, William E, Yang, Huiling, Westland, Christopher E, Das, Kalyan, Arnold, Eddy, Gibbs, Craig S, Miller, Michael D, Xiong, Shelly
Published in Journal of Virology (01.11.2003)
Published in Journal of Virology (01.11.2003)
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Characterization of a Novel Capsid Assembly Modulator for the Treatment of Chronic Hepatitis B Virus Infection
Burdette, Dara, Hyrina, Anastasia, Song, Zhijuan, Beran, Rudolf K, Cheung, Tara, Gilmore, Sarah, Kobayashi, Tetsuya, Li, Li, Liu, Yang, Niedziela-Majka, Anita, Medley, Jonathan, Mehra, Upasana, Morganelli, Philip, Novikov, Nikolai, Niu, Congrong, Tam, Danny, Tang, Jennifer, Wang, Jianhong, Yue, Qin, Fletcher, Simon P, Holdorf, Meghan M, Delaney, 4th, William E, Feierbach, Becket, Lazerwith, Scott
Published in Antimicrobial agents and chemotherapy (24.01.2023)
Published in Antimicrobial agents and chemotherapy (24.01.2023)
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Preclinical Characterization of the Novel Hepatitis C Virus NS3 Protease Inhibitor GS-9451
HUILING YANG, ROBINSON, Margaret, HONGMEI MO, CHIN TAY, KRAWCZYK, Steve, SHENG, X. Christopher, KIM, Choung U, YANG, Chris, DELANEY, William E, CORSA, Amoreena C, PENG, Betty, GUOFENG CHENG, YANG TIAN, YUJIN WANG, PAKDAMAN, Rowchanak, MARIAN SHEN, XIAOPING QI
Published in Antimicrobial Agents and Chemotherapy (01.02.2014)
Published in Antimicrobial Agents and Chemotherapy (01.02.2014)
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Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease
Christopher Sheng, X., Appleby, Todd, Butler, Thomas, Cai, Ruby, Chen, Xiaowu, Cho, Aesop, Clarke, Michael O., Cottell, Jeromy, Delaney, William E., Doerffler, Edward, Link, John, Ji, Mingzhe, Pakdaman, Rowchanak, Pyun, Hyung-Jung, Wu, Qiaoyin, Xu, Jie, Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
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Novel Mutations in a Tissue Culture-Adapted Hepatitis C Virus Strain Improve Infectious-Virus Stability and Markedly Enhance Infection Kinetics
POKROVSKII, Maria V, BUSH, Caroline O, PAULSON, Matthew S, BERAN, Rudolf K. F, ROBINSON, Margaret F, GUOFENG CHENG, TIRUNAGARI, Neeraj, FENAUX, Martijn, GREENSTEIN, Andrew E, WEIDONG ZHONG, DELANEY, William E
Published in Journal of Virology (01.04.2011)
Published in Journal of Virology (01.04.2011)
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