Inhibition of Factor XIa as a New Approach to Anticoagulation
Schumacher, William A, Luettgen, Joseph M, Quan, Mimi L, Seiffert, Dietmar A
Published in Arteriosclerosis, thrombosis, and vascular biology (01.03.2010)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.03.2010)
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In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa
Wong, Pancras C., Quan, Mimi L., Watson, Carol A., Crain, Earl J., Harpel, Mark R., Rendina, Alan R., Luettgen, Joseph M., Wexler, Ruth R., Schumacher, William A., Seiffert, Dietmar A.
Published in Journal of thrombosis and thrombolysis (01.11.2015)
Published in Journal of thrombosis and thrombolysis (01.11.2015)
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Journal Article
Antithrombotic and hemostatic effects of a small molecule factor XIa inhibitor in rats
Schumacher, William A., Seiler, Steven E., Steinbacher, Thomas E, Stewart, Anne B., Bostwick, Jeffrey S., Hartl, Karen S., Liu, Eddie C., Ogletree, Martin L.
Published in European journal of pharmacology (10.09.2007)
Published in European journal of pharmacology (10.09.2007)
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Effect of the direct factor Xa inhibitor apixaban in rat models of thrombosis and hemostasis
Schumacher, William A, Bostwick, Jeffrey S, Stewart, Anne B, Steinbacher, Thomas E, Xin, Baomin, Wong, Pancras C
Published in Journal of cardiovascular pharmacology (01.06.2010)
Published in Journal of cardiovascular pharmacology (01.06.2010)
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Clopidogrel versus prasugrel in rabbits. Effects on thrombosis, haemostasis, platelet function and response variability
Wong, Pancras C, Crain, Earl J, Watson, Carol A, Hua, Ji, Schumacher, William A, Rehfuss, Robert
Published in Thrombosis and haemostasis (01.01.2009)
Published in Thrombosis and haemostasis (01.01.2009)
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Journal Article
Biomarker Optimization to Track the Antithrombotic and Hemostatic Effects of Clopidogrel in Rats
Schumacher, William A, Bostwick, Jeffrey S, Ogletree, Martin L, Stewart, Anne B, Steinbacher, Thomas E, Hua, Ji, Price, Laura A, Wong, Pancras C, Rehfuss, Robert P
Published in The Journal of pharmacology and experimental therapeutics (01.07.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2007)
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Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding
Wong, Pancras C, Seiffert, Dietmar, Bird, J Eileen, Watson, Carol A, Bostwick, Jeffrey S, Giancarli, Mary, Allegretto, Nick, Hua, Ji, Harden, David, Guay, Jocelyne, Callejo, Mario, Miller, Michael M, Lawrence, R Michael, Banville, Jacques, Guy, Julia, Maxwell, Brad D, Priestley, E Scott, Marinier, Anne, Wexler, Ruth R, Bouvier, Michel, Gordon, David A, Schumacher, William A, Yang, Jing
Published in Science translational medicine (04.01.2017)
Published in Science translational medicine (04.01.2017)
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Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure
Meng, Wei, Pi, Zulan, Brigance, Robert, Rossi, Karen A, Schumacher, William A, Bostwick, Jeffrey S, Gargalovic, Peter S, Onorato, Joelle M, Luk, Chiuwa E, Generaux, Claudia N, Wang, Tao, Wexler, Ruth R, Finlay, Heather J
Published in Journal of medicinal chemistry (23.12.2021)
Published in Journal of medicinal chemistry (23.12.2021)
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Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis
Zhang, Xiaojun, Jiang, Wen, Richter, Jeremy M., Bates, J. Alex, Reznik, Samuel K., Stachura, Sylwia, Rampulla, Richard, Doddalingappa, Dyamanna, Ulaganathan, Sankar, Hua, Ji, Bostwick, Jeffrey S., Sum, Chi, Posy, Shana, Malmstrom, Sarah, Dickey, Joyce, Harden, David, Lawrence, R. Michael, Guarino, Victor R., Schumacher, William A., Wong, Pancras, Yang, Jing, Gordon, David A., Wexler, Ruth R., Priestley, E. Scott
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Deficiency in thrombin-activatable fibrinolysis inhibitor (TAFI) protected mice from ferric chloride-induced vena cava thrombosis
Wang, Xinkang, Smith, Patricia L, Hsu, Mei-Yin, Tamasi, Joseph A, Bird, Eileen, Schumacher, William A
Published in Journal of thrombosis and thrombolysis (01.02.2007)
Published in Journal of thrombosis and thrombolysis (01.02.2007)
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Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate
Johnson, James A, Kim, Soong-Hoon, Jiang, Ji, Phillips, Monique, Schumacher, William A, Bostwick, Jeffrey S, Gargalovic, Peter S, Onorato, Joelle M, Luk, Chiuwa E, Generaux, Claudia, He, Yan, Chen, Xue-Qing, Xu, Carrie, Galella, Michael A, Wang, Tao, Gordon, David A, Wexler, Ruth R, Finlay, Heather J
Published in Journal of medicinal chemistry (25.03.2021)
Published in Journal of medicinal chemistry (25.03.2021)
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Effects of plasma kallikrein deficiency on haemostasis and thrombosis in mice: murine ortholog of the Fletcher trait
Bird, J Eileen, Smith, Patricia L, Wang, Xinkang, Schumacher, William A, Barbera, Frank, Revelli, Jean-Pierre, Seiffert, Dietmar
Published in Thrombosis and haemostasis (01.06.2012)
Published in Thrombosis and haemostasis (01.06.2012)
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Platelet aggregometry and receptor binding to predict the magnitude of antithrombotic and bleeding time effects of clopidogrel in rabbits
Wong, Pancras C, Crain, Earl J, Watson, Carol A, Jiang, Xiaosui, Hua, Ji, Bostwick, Jeffrey S, Ogletree, Martin L, Schumacher, William A, Rehfuss, Robert
Published in Journal of cardiovascular pharmacology (01.05.2007)
Published in Journal of cardiovascular pharmacology (01.05.2007)
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Identification of 6‑Hydroxypyrimidin-4(1H)‑one-3-carboxamides as Potent and Orally Active APJ Receptor Agonists
Pi, Zulan, Johnson, James A, Meng, Wei, Phillips, Monique, Schumacher, William A, Bostwick, Jeffrey S, Gargalovic, Peter S, Onorato, Joelle M, Generaux, Claudia N, Wang, Tao, He, Yan, Gordon, David A, Wexler, Ruth R, Finlay, Heather J
Published in ACS medicinal chemistry letters (11.11.2021)
Published in ACS medicinal chemistry letters (11.11.2021)
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Journal Article
Is exogenous tissue plasminogen activator necessary for antithrombotic efficacy of an inhibitor of thrombin activatable fibrinolysis inhibitor (TAFI) in rats?
Bird, Eileen, Tamura, James, Bostwick, Jeffrey S, Steinbacher, Thomas E, Stewart, Anne, Liu, Yizhi, Baumann, Jergen, Feyen, Jean, Tamasi, Joseph, Schumacher, William A
Published in Thrombosis research (2007)
Published in Thrombosis research (2007)
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Journal Article
New advances in treating thrombotic diseases
Schumacher, William A., Wang, Xinkang, Wong, Pancras C.
Published in Drug discovery today (01.09.2014)
Published in Drug discovery today (01.09.2014)
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Conformationally Constrained ortho-Anilino Diaryl Ureas: Discovery of 1‑(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y1 Antagonist
Qiao, Jennifer X, Wang, Tammy C, Ruel, Réjean, Thibeault, Carl, L’Heureux, Alexandre, Schumacher, William A, Spronk, Steven A, Hiebert, Sheldon, Bouthillier, Gilles, Lloyd, John, Pi, Zulan, Schnur, Dora M, Abell, Lynn M, Hua, Ji, Price, Laura A, Liu, Eddie, Wu, Qimin, Steinbacher, Thomas E, Bostwick, Jeffrey S, Chang, Ming, Zheng, Joanna, Gao, Qi, Ma, Baoqing, McDonnell, Patricia A, Huang, Christine S, Rehfuss, Robert, Wexler, Ruth R, Lam, Patrick Y. S
Published in Journal of medicinal chemistry (27.11.2013)
Published in Journal of medicinal chemistry (27.11.2013)
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A platelet target for venous thrombosis? P2Y1 deletion or antagonism protects mice from vena cava thrombosis
Bird, J. Eileen, Wang, Xinkang, Smith, Patricia L., Barbera, Frank, Huang, Christine, Schumacher, William A.
Published in Journal of thrombosis and thrombolysis (01.08.2012)
Published in Journal of thrombosis and thrombolysis (01.08.2012)
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