Identification of 1-{2-[4-chloro-1 '-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4 '-piperidine]-1-yl] phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent
Jeon, Yoon T., Yang, Wu, Qiao, Jennifer X., Li, Ling, Ruel, Rejean, Thibeault, Carl, Hiebert, Sheldon, Wang, Tammy C., Wang, Yufeng, Liu, Yajun, Clark, Charles G., Wong, Henry S., Zhu, Juliang, Wu, Dauh-Rurng, Sun, Dawn, Chen, Bang-Chi, Mathur, Arvind, Chacko, Silvi A., Malley, Mary, Chen, Xue-Qing, Shen, Hong, Huang, Christine S., Schumacher, William A., Bostwick, Jeffrey S., Stewart, Anne B., Price, Laura A., Hua, Ji, Li, Danshi, Levesque, Paul C., Seiffert, Dietmar A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y. S.
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
Get full text
Journal Article
Discovery of diarylurea P2Y(1) antagonists with improved aqueous solubility
Wang, Tammy C., Qia, Jennifer X., Clark, Charles G., Jua, Ji, Price, Laura A., Wu, Qimin, Chang, Ming, Zheng, Joanna, Huang, Christine S., Everlof, Gerry, Schumacher, William A., Wong, Pancras C., Seiffert, Dietmar A., Stewart, Anne B., Bostwick, Jeffrey S., Crain, Earl J., Watson, Carol A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y. S.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Get full text
Journal Article
Discovery of diarylurea P2Y1 antagonists with improved aqueous solubility
Wang, Tammy C., Qiao, Jennifer X., Clark, Charles G., Jua, Ji, Price, Laura A., Wu, Qimin, Chang, Ming, Zheng, Joanna, Huang, Christine S., Everlof, Gerry, Schumacher, William A., Wong, Pancras C., Seiffert, Dietmar A., Stewart, Anne B., Bostwick, Jeffrey S., Crain, Earl J., Watson, Carol A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Get full text
Journal Article
Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold
Bolton, Scott A., Sutton, James C., Anumula, Rushith, Bisacchi, Gregory S., Jacobson, Bruce, Slusarchyk, William A., Treuner, Uwe D., Wu, Shung C., Zhao, Guohua, Pi, Zulan, Sheriff, Steven, Smirk, Rebecca A., Bisaha, Sharon, Cheney, Daniel L., Wei, Anzhi, Schumacher, William A., Hartl, Karen S., Liu, Eddie, Zahler, Robert, Seiler, Steven M.
Published in Bioorganic & medicinal chemistry letters (15.09.2013)
Published in Bioorganic & medicinal chemistry letters (15.09.2013)
Get full text
Journal Article
Does plexin-B1, a semaphorin 4D receptor, play a role in thrombosis?
Bird, Eileen, Smith, Patricia L, Seiffert, Dietmar, Psaltis, George C, Huang, Jinwen, Schumacher, William A
Published in Thrombosis research (01.06.2013)
Published in Thrombosis research (01.06.2013)
Get full text
Journal Article
4-Benzothiazole-7-hydroxyindolinyl Diaryl Ureas Are Potent P2Y1 Antagonists with Favorable Pharmacokinetics: Low Clearance and Small Volume of Distribution
Qiao, Jennifer X., Wang, Tammy C., Hiebert, Sheldon, Hu, Carol H., Schumacher, William A., Spronk, Steven A., Clark, Charles G., Han, Ying, Hua, Ji, Price, Laura A., Shen, Hong, Chacko, Silvi A., Everlof, Gerry, Bostwick, Jeffrey S., Steinbacher, Thomas E., Li, Yi-Xin, Huang, Christine S., Seiffert, Dietmar A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y. S.
Published in ChemMedChem (01.10.2014)
Published in ChemMedChem (01.10.2014)
Get full text
Journal Article
Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats
Wang, Xinkang, Feuerstein, Giora Z, Xu, Lin, Wang, Hugh, Schumacher, William A, Ogletree, Martin L, Taub, Rebecca, Duan, James J-W, Decicco, Carl P, Liu, Rui-Qin
Published in Molecular pharmacology (01.04.2004)
Published in Molecular pharmacology (01.04.2004)
Get full text
Journal Article
Design, Structure−Activity Relationships, X-ray Crystal Structure, and Energetic Contributions of a Critical P1 Pharmacophore: 3-Chloroindole-7-yl-Based Factor Xa Inhibitors
Shi, Yan, Sitkoff, Doree, Zhang, Jing, Klei, Herbert E, Kish, Kevin, Liu, Eddie C.-K, Hartl, Karen S, Seiler, Steve M, Chang, Ming, Huang, Christine, Youssef, Sonia, Steinbacher, Thomas E, Schumacher, William A, Grazier, Nyeemah, Pudzianowski, Andrew, Apedo, Atsu, Discenza, Lorell, Yanchunas, Joseph, Stein, Philip D, Atwal, Karnail S
Published in Journal of medicinal chemistry (11.12.2008)
Published in Journal of medicinal chemistry (11.12.2008)
Get full text
Journal Article
Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors
Shi, Yan, O’Connor, Stephen P., Sitkoff, Doree, Zhang, Jing, Shi, Mengxiao, Bisaha, Sharon N., Wang, Ying, Li, Chi, Ruan, Zheming, Michael Lawrence, R., Klei, Herbert E., Kish, Kevin, Liu, Eddie C.-K., Seiler, Steve M., Schweizer, Liang, Steinbacher, Thomas E., Schumacher, William A., Robl, Jeffrey A., Macor, John E., Atwal, Karnail S., Stein, Philip D.
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
Get full text
Journal Article
Aroylguanidine-based factor Xa inhibitors: The discovery of BMS-344577
Shi, Yan, Li, Chi, O’Connor, Stephen P., Zhang, Jing, Shi, Mengxiao, Bisaha, Sharon N., Wang, Ying, Sitkoff, Doree, Pudzianowski, Andrew T., Huang, Christine, Klei, Herbert E., Kish, Kevin, Yanchunas, Joseph, Liu, Eddie C.-K., Hartl, Karen S., Seiler, Steve M., Steinbacher, Thomas E., Schumacher, William A., Atwal, Karnail S., Stein, Philip D.
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
Get full text
Journal Article
Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors
Shi, Yan, Zhang, Jing, Shi, Mengxiao, O’Connor, Stephen P., Bisaha, Sharon N., Li, Chi, Sitkoff, Doree, Pudzianowski, Andrew T., Chong, Saeho, Klei, Herbert E., Kish, Kevin, Yanchunas, Joseph, Liu, Eddie C.-K., Hartl, Karen S., Seiler, Steve M., Steinbacher, Thomas E., Schumacher, William A., Atwal, Karnail S., Stein, Philip D.
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Get full text
Journal Article
Prediction of the therapeutic index of marketed anti-coagulants and anti-platelet agents by guinea pig models of thrombosis and hemostasis
Bird, J. Eileen, Giancarli, Mary R, Allegretto, Nick, Barbera, Frank, Wong, Pancras, Schumacher, William A, Ogletree, Martin L, Seiffert, Dietmar
Published in Thrombosis research (2008)
Published in Thrombosis research (2008)
Get full text
Journal Article
Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors
Sutton, James C, Bolton, Scott A, Hartl, Karen S, Huang, Ming-Hsing, Jacobs, Glenn, Meng, Wei, Ogletree, Martin L, Pi, Zulan, Schumacher, William A, Seiler, Steven M, Slusarchyk, William A, Treuner, Uwe, Zahler, Robert, Zhao, Guohua, Bisacchi, Gregory S
Published in Bioorganic & medicinal chemistry letters (04.11.2002)
Published in Bioorganic & medicinal chemistry letters (04.11.2002)
Get full text
Journal Article
Synthesis of potent and highly selective inhibitors of human tryptase
Slusarchyk, William A., Bolton, Scott A., Hartl, Karen S., Huang, Ming-Hsing, Jacobs, Glenn, Meng, Wei, Ogletree, Martin L., Pi, Zulan, Schumacher, William A., Seiler, Steven M., Sutton, James C., Treuner, Uwe, Zahler, Robert, Zhao, Guohua, Bisacchi, Gregory S.
Published in Bioorganic & medicinal chemistry letters (04.11.2002)
Published in Bioorganic & medicinal chemistry letters (04.11.2002)
Get full text
Journal Article
Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors
Shi, Yan, Zhang, Jing, Stein, Philip D., Shi, Mengxiao, O’Connor, Stephen P., Bisaha, Sharon N., Li, Chi, Atwal, Karnail S., Bisacchi, Gregory S., Sitkoff, Doree, Pudzianowski, Andrew T., Liu, Eddie C., Hartl, Karen S., Seiler, Steven M., Youssef, Sonia, Steinbacher, Thomas E., Schumacher, William A., Rendina, Alan R., Bozarth, Jeffrey M., Peterson, Tara L., Zhang, Ge, Zahler, Robert
Published in Bioorganic & medicinal chemistry letters (15.12.2005)
Published in Bioorganic & medicinal chemistry letters (15.12.2005)
Get full text
Journal Article
Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues
Das, Jagabandhu, Kimball, S.David, Reid, Joyce A., Wang, Tammy C., Lau, Wan F., Roberts, Daniel G.M., Seiler, Steven M., Schumacher, William A., Ogletree, Martin L.
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Get full text
Journal Article
Molecular design and structure–Activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664
Das, Jagabandhu, Kimball, S.David, Hall, Steven E., Han, Wen-Ching, Iwanowicz, Edwin, Lin, James, Moquin, Robert V., Reid, Joyce A., Sack, John S., Malley, Mary F., Chang, Chiehying Y., Chong, Saeho, Wang-Iverson, David B., Roberts, Daniel G.M., Seiler, Steven M., Schumacher, William A., Ogletree, Martin L.
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Get full text
Journal Article
Conformationally Constrained ortho-Anilino Diaryl Ureas: Discovery of 1-(2-(1 '-Neopentylspiro[indoline-3,4 '-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y(1) Antagonist
Qiao, Jennifer X., Wang, Tammy C., Ruel, Rejean, Thibeault, Carl, L'Heureux, Alexandre, Schumacher, William A., Spronk, Steven A., Hiebert, Sheldon, Bouthillier, Gilles, Lloyd, John, Pi, Zulan, Schnur, Dora M., Abell, Lynn M., Hua, Ji, Price, Laura A., Liu, Eddie, Wu, Qimin, Steinbacher, Thomas E., Bostwick, Jeffrey S., Chang, Ming, Zheng, Joanna, Gao, Qi, Ma, Baoqing, McDonnell, Patricia A., Huang, Christine S., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y. S.
Published in Journal of medicinal chemistry (28.11.2013)
Published in Journal of medicinal chemistry (28.11.2013)
Get full text
Journal Article