A novel praziquantel solid lipid nanoparticle formulation shows enhanced bioavailability and antischistosomal efficacy against murine S. mansoni infection
Radwan, Amr, El-Lakkany, Naglaa M, William, Samia, El-Feky, Gina S, Al-Shorbagy, Muhammad Y, Saleh, Samira, Botros, Sanaa
Published in Parasites & vectors (17.06.2019)
Published in Parasites & vectors (17.06.2019)
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Journal Article
To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A?
Zheng, Yang, Schroeder, Susanne, Kanev, Georgi K, Botros, Sanaa S, William, Samia, Sabra, Abdel-Nasser A, Maes, Louis, Caljon, Guy, Gil, Carmen, Martinez, Ana, Salado, Irene G, Augustyns, Koen, Edink, Ewald, Sijm, Maarten, de Heuvel, Erik, de Esch, Iwan J P, van der Meer, Tiffany, Siderius, Marco, Sterk, Geert Jan, Brown, David, Leurs, Rob
Published in International journal of molecular sciences (06.04.2023)
Published in International journal of molecular sciences (06.04.2023)
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Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages
Munday, Jane C, Kunz, Stefan, Kalejaiye, Titilola D, Siderius, Marco, Schroeder, Susanne, Paape, Daniel, Alghamdi, Ali H, Abbasi, Zainab, Huang, Sheng Xiang, Donachie, Anne-Marie, William, Samia, Sabra, Abdel Nasser, Sterk, Geert Jan, Botros, Sanaa S, Brown, David G, Hoffman, Charles S, Leurs, Rob, de Koning, Harry P
Published in PLoS neglected tropical diseases (01.07.2020)
Published in PLoS neglected tropical diseases (01.07.2020)
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Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools
Sebastian-Perez, Victor, García-Rubia, Alfonso, Seif el-Din, Sayed H., Sabra, Abdel-Nasser A., El-Lakkany, Naglaa M., William, Samia, Blundell, Tom L., Maes, Louis, Martinez, Ana, Campillo, Nuria E., Botros, Sanaa S., Gil, Carmen
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2020)
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2020)
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Journal Article
Synthesis and in vitro evaluation of new benzothiazole derivatives as schistosomicidal agents
Mahran, Mona A, William, Samia, Ramzy, Fatem, Sembel, Amira M
Published in Molecules (Basel, Switzerland) (26.03.2007)
Published in Molecules (Basel, Switzerland) (26.03.2007)
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Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity
Botros, Sanaa S., William, Samia, Sabra, Abdel-Nasser A., El-Lakkany, Naglaa M., Seif el-Din, Sayed H., García-Rubia, Alfonso, Sebastián-Pérez, Victor, Blaazer, Antoni R., de Heuvel, Erik, Sijm, Maarten, Zheng, Yang, Salado, Irene G., Munday, Jane C., Maes, Louis, de Esch, Iwan J.P., Sterk, Geert J., Augustyns, Koen, Leurs, Rob, Gil, Carmen, De Koning, Harry P.
Published in International journal for parasitology -- drugs and drug resistance (01.04.2019)
Published in International journal for parasitology -- drugs and drug resistance (01.04.2019)
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Journal Article
Antischistosomal Activity of Hexadecyloxypropyl Cyclic 9-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]Adenine and Other Alkoxyalkyl Esters of Acyclic Nucleoside Phosphonates Assessed by Schistosome Worm Killing In Vitro
BOTROS, Sanaa S, WILLIAM, Samia, BEADLE, James R, VALIAEVA, Nadejda, HOSTETLER, Karl Y
Published in Antimicrobial Agents and Chemotherapy (01.12.2009)
Published in Antimicrobial Agents and Chemotherapy (01.12.2009)
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Journal Article
Schistosomicidal and hepatoprotective activity of gamma-aminobutyric acid (GABA) alone or combined with praziquantel against Schistosoma mansoni infection in murine model
Fahmy, Azza Moustafa, William, Samia, Hegab, Amany, TM, Diab
Published in Experimental parasitology (01.07.2022)
Published in Experimental parasitology (01.07.2022)
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Journal Article
Therapeutic efficacy of candidate antischistosomal drugs in a murine model of schistosomiasis mansoni
Mohammad, Omnia Sobhi, Hussein, Hesham Mohammed, Abdel-Sayed, Samia William, Mohamed, Ghada Adel, Shehata, Mai Abdel Sameaa
Published in Parasitology research (1987) (01.05.2024)
Published in Parasitology research (1987) (01.05.2024)
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Ailanthus excelsa leaf extract: Chemical characterization, antischistosomal activity, and in silico study of isolated phenolic compounds as promising thioredoxin glutathione reductase inhibitors
Mohammed, Hala Sh, William, Samia, Aboushousha, Tarek, Taleb, Hoda M. Abu, Sabour, Rehab, Ghareeb, Mosad A.
Published in Journal of applied pharmaceutical science (2023)
Published in Journal of applied pharmaceutical science (2023)
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Journal Article
MCR Synthesis of Praziquantel Derivatives
Liu, Haixia, William, Samia, Herdtweck, Eberhardt, Botros, Sanaa, Dömling, Alexander
Published in Chemical biology & drug design (01.04.2012)
Published in Chemical biology & drug design (01.04.2012)
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Journal Article
Itraconazole, a cytochrome P450 inhibitor, enhanced the efficacy of praziquantel against Schistosoma mansoni infection and alleviated liver injury in mice
Sabra, Abdel-Nasser A., Salem, Maha B., William, Samia, Hammam, Olfat A., El-Lakkany, Naglaa M.
Published in Experimental parasitology (01.08.2022)
Published in Experimental parasitology (01.08.2022)
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Journal Article
To Target or Not to Target ISchistosoma mansoni/I Cyclic Nucleotide Phosphodiesterase 4A?
Zheng, Yang, Schroeder, Susanne, Kanev, Georgi K, Botros, Sanaa S, William, Samia, Sabra, Abdel-Nasser A, Maes, Louis, Caljon, Guy, Gil, Carmen, Ma, Salado, Irene G, Augustyns, Koen, Edink, Ewald, Sijm, Maarten, de Heuvel, Erik, de Esch, Iwan J. P, van der Meer, Tiffany, Siderius, Marco, Sterk, Geert Jan, Brown, David, Leurs, Rob
Published in International journal of molecular sciences (01.04.2023)
Published in International journal of molecular sciences (01.04.2023)
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Journal Article
The phosphodiesterase-4 inhibitor roflumilast impacts Schistosoma mansoni ovipositing in vitro but displays only modest antischistosomal activity in vivo
Botros, Sanaa S., El-Lakkany, Naglaa M., Seif el-Din, Sayed H., William, Samia, Sabra, Abdel-Nasser, Hammam, Olfat A., de Koning, Harry P.
Published in Experimental parasitology (01.01.2020)
Published in Experimental parasitology (01.01.2020)
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Journal Article
Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers
Ismail, M, Botros, S, Metwally, A, William, S, Farghally, A, Tao, LF, Day, TA, Bennett, JL
Published in The American journal of tropical medicine and hygiene (01.06.1999)
Published in The American journal of tropical medicine and hygiene (01.06.1999)
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Journal Article
Effect of praziquantel on the immature stages of Schistosoma haematobium
Botros, Sanaa, Pica-Mattoccia, Livia, William, Samia, El-Lakkani, Naglaa, Cioli, Donato
Published in International journal for parasitology (01.11.2005)
Published in International journal for parasitology (01.11.2005)
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