A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner
Stemmer, Willem P C, Schellenberger, Volker, Wang, Chia-wei, Geething, Nathan C, Spink, Benjamin J, Campbell, Andrew, To, Wayne, Scholle, Michael D, Yin, Yong, Yao, Yi, Bogin, Oren, Cleland, Jeffrey L, Silverman, Joshua
Published in Nature biotechnology (01.12.2009)
Published in Nature biotechnology (01.12.2009)
Get full text
Journal Article
GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's disease model
Alters, Susan E, McLaughlin, Bryant, Spink, Benjamin, Lachinyan, Tigran, Wang, Chia-wei, Podust, Vladimir, Schellenberger, Volker, Stemmer, Willem P C
Published in PloS one (26.11.2012)
Published in PloS one (26.11.2012)
Get full text
Journal Article
A Novel Long-Acting Human Growth Hormone Fusion Protein (VRS-317): Enhanced In Vivo Potency and Half-Life
Cleland, Jeffrey L., Geething, Nathan C., Moore, Jerome A., Rogers, Brian C., Spink, Benjamin J., Wang, Chai-Wei, Alters, Susan E., Stemmer, Willem P.C., Schellenberger, Volker
Published in Journal of pharmaceutical sciences (01.08.2012)
Published in Journal of pharmaceutical sciences (01.08.2012)
Get full text
Journal Article
DNA shuffling of a family of genes from diverse species accelerates directed evolution
Stemmer, Willem P. C, Crameri, Andreas, Raillard, Sun-Ai, Bermudez, Ericka
Published in Nature (London) (15.01.1998)
Published in Nature (London) (15.01.1998)
Get full text
Journal Article
Genome shuffling leads to rapid phenotypic improvement in bacteria
del Cardayré, Stephen B, Zhang, Ying-Xin, Perry, Kim, Vinci, Victor A, Powell, Keith, Stemmer, Willem P. C
Published in Nature (London) (07.02.2002)
Published in Nature (London) (07.02.2002)
Get full text
Journal Article
Gcg-XTEN: an improved glucagon capable of preventing hypoglycemia without increasing baseline blood glucose
Geething, Nathan C, To, Wayne, Spink, Benjamin J, Scholle, Michael D, Wang, Chia-wei, Yin, Yong, Yao, Yi, Schellenberger, Volker, Cleland, Jeffrey L, Stemmer, Willem P C, Silverman, Joshua
Published in PloS one (14.04.2010)
Published in PloS one (14.04.2010)
Get full text
Journal Article
Genome shuffling of Lactobacillus for improved acid tolerance
del Cardayré, Stephen, Gavrilovic, Vesna, Ryan, Chris M, Patnaik, Ranjan, Louie, Susan, Stemmer, Willem P.C, Perry, Kim
Published in Nature biotechnology (01.07.2002)
Published in Nature biotechnology (01.07.2002)
Get full text
Journal Article
Improving the Catalytic Activity of a Thermophilic Enzyme at Low Temperatures
Merz, Astrid, Yee, Muh-ching, Szadkowski, Halina, Pappenberger, Günter, Crameri, Andreas, Stemmer, Willem P. C, Yanofsky, Charles, Kirschner, Kasper
Published in Biochemistry (Easton) (08.02.2000)
Published in Biochemistry (Easton) (08.02.2000)
Get full text
Journal Article
Directed Evolution and Biocatalysis
Powell, Keith A., Ramer, Sandra W., del Cardayré, Stephen B., Stemmer, Willem P. C., Tobin, Matthew B., Longchamp, Pascal F., Huisman, Gjalt W.
Published in Angewandte Chemie International Edition (05.11.2001)
Published in Angewandte Chemie International Edition (05.11.2001)
Get full text
Journal Article
Correction: GLP2-2G-XTEN: A Pharmaceutical Protein with Improved Serum Half-Life and Efficacy in a Rat Crohn’s Disease Model
Alters, Susan E., McLaughlin, Bryant, Spink, Benjamin, Lachinyan, Tigran, Wang, Chia-wei, Podust, Vladimir, Schellenberger, Volker, Stemmer, Willem P. C.
Published in PloS one (10.06.2013)
Published in PloS one (10.06.2013)
Get full text
Journal Article
Evolution of a Human Immunodeficiency Virus Type 1 Variant with Enhanced Replication in Pig-Tailed Macaque Cells by DNA Shuffling
Pekrun, Katja, Shibata, Riri, Igarashi, Tatsuhiko, Reed, Margaret, Sheppard, Liana, Patten, Philip A, Stemmer, Willem P C, Martin, Malcolm A, Soong, Nay-Wei
Published in Journal of Virology (01.03.2002)
Published in Journal of Virology (01.03.2002)
Get full text
Journal Article
GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's. PLoS One. 2012; 7(11): e50630
Alters, Susan E, McLaughlin, Bryant, Spink, Benjamin, Lachinyan, Tigran, Wang, Chia-Wei, Podust, Vladimir, Schellenberger, Volker, Stemmer, Willem P C
Published in PloS one (2013)
Published in PloS one (2013)
Get full text
Journal Article
Diverse plasmid DNA vectors by directed molecular evolution of cytomegalovirus promoters
Wright, Anne, Semyonov, Andrey, Dawes, Glenn, Crameri, Andreas, Lyons, Rick, Stemmer, Willem P C, Apt, Doris, Punnonen, Juha
Published in Human gene therapy (01.07.2005)
Published in Human gene therapy (01.07.2005)
Get more information
Journal Article