Full atomistic model of prion structure and conversion
Spagnolli, Giovanni, Rigoli, Marta, Orioli, Simone, Sevillano, Alejandro M, Faccioli, Pietro, Wille, Holger, Biasini, Emiliano, Requena, Jesús R
Published in PLoS pathogens (01.07.2019)
Published in PLoS pathogens (01.07.2019)
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Journal Article
Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints
Minikel, Eric Vallabh, Zhao, Hien T, Le, Jason, O’Moore, Jill, Pitstick, Rose, Graffam, Samantha, Carlson, George A, Kavanaugh, Michael P, Kriz, Jasna, Kim, Jae Beom, Ma, Jiyan, Wille, Holger, Aiken, Judd, McKenzie, Deborah, Doh-ura, Katsumi, Beck, Matthew, O’Keefe, Rhonda, Stathopoulos, Jacquelyn, Caron, Tyler, Schreiber, Stuart L, Carroll, Jeffrey B, Kordasiewicz, Holly B, Cabin, Deborah E, Vallabh, Sonia M
Published in Nucleic acids research (04.11.2020)
Published in Nucleic acids research (04.11.2020)
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Journal Article
Conformational Diversity of Wild-type Tau Fibrils Specified by Templated Conformation Change
Frost, Bess, Ollesch, Julian, Wille, Holger, Diamond, Marc I.
Published in The Journal of biological chemistry (06.02.2009)
Published in The Journal of biological chemistry (06.02.2009)
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Journal Article
Seizures are a druggable mechanistic link between TBI and subsequent tauopathy
Alyenbaawi, Hadeel, Kanyo, Richard, Locskai, Laszlo F, Kamali-Jamil, Razieh, DuVal, Michèle G, Bai, Qing, Wille, Holger, Burton, Edward A, Allison, W Ted
Published in eLife (02.02.2021)
Published in eLife (02.02.2021)
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Journal Article
Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains
Duque Velásquez, Camilo, Kim, Chiye, Herbst, Allen, Daude, Nathalie, Garza, Maria Carmen, Wille, Holger, Aiken, Judd, McKenzie, Debbie
Published in Journal of virology (01.12.2015)
Published in Journal of virology (01.12.2015)
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Journal Article
The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy
Vázquez-Fernández, Ester, Vos, Matthijn R, Afanasyev, Pavel, Cebey, Lino, Sevillano, Alejandro M, Vidal, Enric, Rosa, Isaac, Renault, Ludovic, Ramos, Adriana, Peters, Peter J, Fernández, José Jesús, van Heel, Marin, Young, Howard S, Requena, Jesús R, Wille, Holger
Published in PLoS pathogens (01.09.2016)
Published in PLoS pathogens (01.09.2016)
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Journal Article
Protein thermal sensing regulates physiological amyloid aggregation
Marijan, Dane, Momchilova, Evgenia A, Burns, Daniel, Chandhok, Sahil, Zapf, Richard, Wille, Holger, Potoyan, Davit A, Audas, Timothy E
Published in Nature communications (09.02.2024)
Published in Nature communications (09.02.2024)
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Journal Article
Homogeneous nanodiscs of native membranes formed by stilbene-maleic-acid copolymers
Esmaili, Mansoore, Brown, Chanelle J, Shaykhutdinov, Rustem, Acevedo-Morantes, Claudia, Wang, Yong Liang, Wille, Holger, Gandour, Richard D, Turner, S. Richard, Overduin, Michael
Published in Nanoscale (20.08.2020)
Published in Nanoscale (20.08.2020)
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Journal Article
Asymmetric-flow field-flow fractionation of prions reveals a strain-specific continuum of quaternary structures with protease resistance developing at a hydrodynamic radius of 15 nm
Cortez, Leonardo M, Nemani, Satish K, Duque Velásquez, Camilo, Sriraman, Aishwarya, Wang, YongLiang, Wille, Holger, McKenzie, Debbie, Sim, Valerie L
Published in PLoS pathogens (01.06.2021)
Published in PLoS pathogens (01.06.2021)
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Journal Article
New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene
Hannaoui, Samia, Triscott, Elizabeth, Duque Velásquez, Camilo, Chang, Sheng Chun, Arifin, Maria Immaculata, Zemlyankina, Irina, Tang, Xinli, Bollinger, Trent, Wille, Holger, McKenzie, Debbie, Gilch, Sabine
Published in PLoS pathogens (26.07.2021)
Published in PLoS pathogens (26.07.2021)
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Journal Article
The human brain somatostatin interactome: SST binds selectively to P-type family ATPases
Solarski, Michael, Williams, Declan, Mehrabian, Mohadeseh, Wang, Hansen, Wille, Holger, Schmitt-Ulms, Gerold
Published in PloS one (28.05.2019)
Published in PloS one (28.05.2019)
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Journal Article
A Neuronal Culture System to Detect Prion Synaptotoxicity
Fang, Cheng, Imberdis, Thibaut, Garza, Maria Carmen, Wille, Holger, Harris, David A
Published in PLoS pathogens (01.05.2016)
Published in PLoS pathogens (01.05.2016)
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Journal Article
Native PLGA nanoparticles attenuate Aβ-seed induced tau aggregation under in vitro conditions: potential implication in Alzheimer's disease pathology
Paul, Pallabi Sil, Patel, Tark, Cho, Jae-Young, Yarahmady, Allan, Khalili, Aria, Semenchenko, Valentyna, Wille, Holger, Kulka, Marianna, Mok, Sue-Ann, Kar, Satyabrata
Published in Scientific reports (02.01.2024)
Published in Scientific reports (02.01.2024)
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Journal Article
Natural and Synthetic Prion Structure from X-Ray Fiber Diffraction
Wille, Holger, Bian, Wen, McDonald, Michele, Kendalls, Amy, Colby, David W., Bloch, Lillian, Ollesch, Julian, Borovinskiy, Alexander L., Cohen, Fred E., Prusiner, Stanley B., Stubbs, Gerald
Published in Proceedings of the National Academy of Sciences - PNAS (06.10.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (06.10.2009)
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Journal Article
Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers
Wang, Hansen, Muiznieks, Lisa D, Ghosh, Punam, Williams, Declan, Solarski, Michael, Fang, Andrew, Ruiz-Riquelme, Alejandro, Pomès, Régis, Watts, Joel C, Chakrabartty, Avi, Wille, Holger, Sharpe, Simon, Schmitt-Ulms, Gerold
Published in eLife (26.06.2017)
Published in eLife (26.06.2017)
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Journal Article