Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1
Tardif, Keith D, Rogers, Aaron, Cassiano, Jared, Roth, Bruce L, Cimbora, Daniel M, McKinnon, Rena, Peterson, Ashley, Douce, Thomas B, Robinson, Rosann, Dorweiler, Irene, Davis, Thaylon, Hess, Mark A, Ostanin, Kirill, Papac, Damon I, Baichwal, Vijay, McAlexander, Ian, Willardsen, J Adam, Saunders, Michael, Christophe, Hoarau, Kumar, D Vijay, Wettstein, Daniel A, Carlson, Robert O, Williams, Brandi L
Published in Molecular cancer therapeutics (01.12.2011)
Published in Molecular cancer therapeutics (01.12.2011)
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Journal Article
Discovery of a new HIV-1 inhibitor scaffold and synthesis of potential prodrugs of indazoles
Kim, Se-Ho, Markovitz, Benjamin, Trovato, Richard, Murphy, Brett R., Austin, Harry, Willardsen, Adam J., Baichwal, Vijay, Morham, Scott, Bajji, Ashok
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
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Journal Article
Discovery of N-methyl-4-(4-methoxyanilino)quinazolines as potent apoptosis inducers. Structure–activity relationship of the quinazoline ring
Sirisoma, Nilantha, Pervin, Azra, Zhang, Hong, Jiang, Songchun, Adam Willardsen, J., Anderson, Mark B., Mather, Gary, Pleiman, Christopher M., Kasibhatla, Shailaja, Tseng, Ben, Drewe, John, Cai, Sui Xiong
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Journal Article
Inhibition of eEF2-K by thieno[2,3- b]pyridine analogues
Lockman, Jeffrey W., Reeder, Matthew D., Suzuki, Kazuyuki, Ostanin, Kirill, Hoff, Ryan, Bhoite, Leena, Austin, Harry, Baichwal, Vijay, Adam Willardsen, J.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Journal Article
Discovery and SAR of Methylated Tetrahydropyranyl Derivatives as Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase (ICMT)
Judd, Weston R, Slattum, Paul M, Hoang, Khanh C, Bhoite, Leena, Valppu, Liisa, Alberts, Glen, Brown, Brita, Roth, Bruce, Ostanin, Kirill, Huang, Liwen, Wettstein, Daniel, Richards, Burt, Willardsen, J. Adam
Published in Journal of medicinal chemistry (28.07.2011)
Published in Journal of medicinal chemistry (28.07.2011)
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Journal Article
Design, Synthesis, and Biological Activity of Potent and Selective Inhibitors of Blood Coagulation Factor Xa
Willardsen, J. Adam, Dudley, Danette A, Cody, Wayne L, Chi, Liguo, McClanahan, Thomas B, Mertz, Thomas E, Potoczak, Ronald E, Narasimhan, Lakshmi S, Holland, Debra R, Rapundalo, Stephen T, Edmunds, Jeremy J
Published in Journal of medicinal chemistry (29.07.2004)
Published in Journal of medicinal chemistry (29.07.2004)
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Journal Article
2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97)
Bursavich, Matthew G., Parker, Daniel P., Willardsen, J. Adam, Gao, Zhong-Hua, Davis, Thaylon, Ostanin, Kirill, Robinson, Rosann, Peterson, Ashley, Cimbora, Daniel M., Zhu, Ju-Fen, Richards, Burt
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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Journal Article
Discovery of N-(4-Methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a Potent Apoptosis Inducer and Efficacious Anticancer Agent with High Blood Brain Barrier Penetration
Sirisoma, Nilantha, Pervin, Azra, Zhang, Hong, Jiang, Songchun, Willardsen, J. Adam, Anderson, Mark B, Mather, Gary, Pleiman, Christopher M, Kasibhatla, Shailaja, Tseng, Ben, Drewe, John, Cai, Sui Xiong
Published in Journal of medicinal chemistry (23.04.2009)
Published in Journal of medicinal chemistry (23.04.2009)
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Journal Article
Discovery of 2-Chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a Potent Inducer of Apoptosis with High In Vivo Activity
Sirisoma, Nilantha, Kasibhatla, Shailaja, Pervin, Azra, Zhang, Hong, Jiang, Songchun, Willardsen, J. Adam, Anderson, Mark B, Baichwal, Vijay, Mather, Gary G, Jessing, Kevin, Hussain, Raouf, Hoang, Khanh, Pleiman, Christopher M, Tseng, Ben, Drewe, John, Cai, Sui Xiong
Published in Journal of medicinal chemistry (14.08.2008)
Published in Journal of medicinal chemistry (14.08.2008)
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Journal Article
Synthesis of Substituted Quinazolines: Application to the Synthesis of Verubulin
Lockman, Jeffrey W., Klimova, Yevgeniya, Anderson, Mark B., Willardsen, J. Adam
Published in Synthetic communications (15.06.2012)
Published in Synthetic communications (15.06.2012)
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Journal Article
Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as Potent Inhibitors of Nicotinamide Phosphoribosyltransferase (Nampt)
Lockman, Jeffrey W, Murphy, Brett R, Zigar, Daniel F, Judd, Weston R, Slattum, Paul M, Gao, Zhong-Hua, Ostanin, Kirill, Green, Jeremy, McKinnon, Rena, Terry-Lorenzo, Ryan T, Fleischer, Tracey C, Boniface, J. Jay, Shenderovich, Mark, Willardsen, J. Adam
Published in Journal of medicinal chemistry (23.12.2010)
Published in Journal of medicinal chemistry (23.12.2010)
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Journal Article
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis
Cottrell, Graeme S, Amadesi, Silvia, Pikios, Stella, Camerer, Eric, Willardsen, J Adam, Murphy, Brett R, Caughey, George H, Wolters, Paul J, Coughlin, Shaun R, Peterson, Anders, Knecht, Wolfgang, Pothoulakis, Charalabos, Bunnett, Nigel W, Grady, Eileen F
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2007)
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2007)
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Journal Article
The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex—Part 2
Kohrt, Jeffrey T., Filipski, Kevin J., Cody, Wayne L., Cai, Cuiman, Dudley, Danette A., Van Huis, Chad A., Willardsen, J. Adam, Narasimhan, Lakshmi S., Zhang, Erli, Rapundalo, Stephen T., Saiya-Cork, Kamlai, Leadley, Robert J., Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
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Journal Article
The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex
Kohrt, Jeffrey T., Filipski, Kevin J., Cody, Wayne L., Cai, Cuiman, Dudley, Danette A., Van Huis, Chad A., Willardsen, J. Adam, Rapundalo, Stephen T., Saiya-Cork, Kamlai, Leadley, Robert J., Narasimhan, Lakshmi, Zhang, Erli, Whitlow, Marc, Adler, Marc, McLean, Kirk, Chou, Yuo-Ling, McKnight, Cecile, Arnaiz, Damian O., Shaw, Kenneth J., Light, David R., Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
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Journal Article
Total Synthesis and Structural Elucidation of the Antifungal Agent Papulacandin D
Barrett, Anthony G. M, Peña, Michael, Willardsen, J. Adam
Published in Journal of organic chemistry (09.02.1996)
Published in Journal of organic chemistry (09.02.1996)
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Journal Article
Chemical Proteomics Identifies Nampt as the Target of CB30865, An Orphan Cytotoxic Compound
Fleischer, Tracey C., Murphy, Brett R., Flick, Jeffrey S., Terry-Lorenzo, Ryan T., Gao, Zhong-Hua, Davis, Thaylon, McKinnon, Rena, Ostanin, Kirill, Willardsen, J. Adam, Boniface, J. Jay
Published in Chemistry & biology (25.06.2010)
Published in Chemistry & biology (25.06.2010)
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Journal Article
COMPOUNDS AND THERAPEUTIC USES THEREOF
JUDD WESTON R, BURSAVICH MATTHEW GREGORY, TERRY LORENZO RYAN T, MURPHY BRETT R, BONIFACE JAY J, LOCKMAN JEFFREY W, KIM, SE HO, WILLARDSEN ADAM J, YAGER KRAIG M, PARKER DANIEL P, KIM, IN CHUL, FLEISCHER TRACEY C, DASTRUP DAVID M, MCALEXANDER IAN A, ZIGAR DANIEL FEODORE
Year of Publication 02.05.2013
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Year of Publication 02.05.2013
Patent
Abstract LB-393: The cancer metabolism inhibitor MPC-9528 induces tumor regression in xenograft models with multiple dosing schedules by causing rapid and sustained reduction in tumor NAD
Baichwal, Vijay R., Willardsen, Adam J., Lockman, Jeff W., Murphy, Brett J., Gordillo, Ruth, Fleischer, Tracey C., Bradford, Chad L., Papac, Damon I., Mather, Gary G., Carlson, Robert O.
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Journal Article
Abstract LB-288: MPI-0486348: A novel inhibitor of nicotinamide phosphoribosyltransferase (Nampt) induces tumor regression in a preclinical model
Fleischer, Tracey C., Baichwal, Vijay R., Bradford, Chad L., Demie, Lynn, Green, Jeremy P., Hess, Mark A., Lockman, Jeffrey W., McKinnon, Rena, Ostanin, Kirill, Papac, Damon I., Reeves, Leslie F., Terry-Lorenzo, Ryan T., Willardsen, J Adam
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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