Acyclic cyanamide-based inhibitors of cathepsin K
Barrett, David G., Deaton, David N., Hassell, Anne M., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Payne, J. Alan, Shewchuk, Lisa M., Willard, Derril H., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (15.06.2005)
Published in Bioorganic & medicinal chemistry letters (15.06.2005)
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Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK293 cells
MOUNTJOY, KATHLEEN G, KONG, PHILIP L, TAYLOR, JOHN A, WILLARD, DERRIL H, WILKISON, WILLIAM O
Published in Physiological genomics (07.02.2001)
Published in Physiological genomics (07.02.2001)
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Design of Potent, Selective, and Orally Bioavailable Inhibitors of Cysteine Protease Cathepsin K
Tavares, Francis X, Boncek, Virginia, Deaton, David N, Hassell, Anne M, Long, Stacey T, Miller, Aaron B, Payne, Alan A, Miller, Larry R, Shewchuk, Lisa M, Wells-Knecht, Kevin, Willard, Derril H, Wright, Lois L, Zhou, Hui-Qiang
Published in Journal of medicinal chemistry (29.01.2004)
Published in Journal of medicinal chemistry (29.01.2004)
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Novel and potent cyclic cyanamide-based cathepsin K inhibitors
Deaton, David N., Hassell, Anne M., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Shewchuk, Lisa M., Tavares, Francis X., Willard, Derril H., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (01.04.2005)
Published in Bioorganic & medicinal chemistry letters (01.04.2005)
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Agouti structure and function: characterization of a potent .alpha.-melanocyte stimulating hormone receptor antagonist
Willard, Derril H, Bodnar, Wanda, Harris, Cole, Kiefer, Laura, Nichols, James S, Blanchard, Steven, Hoffman, Christine, Moyer, Mary, Burkhart, William
Published in Biochemistry (Easton) (26.09.1995)
Published in Biochemistry (Easton) (26.09.1995)
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Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?
Adkison, Kim K., Barrett, David G., Deaton, David N., Gampe, Robert T., Hassell, Anne M., Long, Stacey T., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Payne, J. Alan, Shewchuk, Lisa M., Wells-Knecht, Kevin J., Willard, Derril H., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
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Novel, potent P2–P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors
Barrett, David G., Catalano, John G., Deaton, David N., Hassell, Anne M., Long, Stacey T., Miller, Aaron B., Miller, Larry R., Ray, John A., Samano, Vicente, Shewchuk, Lisa M., Wells-Knecht, Kevin J., Willard, Derril H., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K
BARRETT, David G, BONCEK, Virginia M, PAYNE, J. Alan, RAY, John A, SAMANO, Vicente, SHEWCHUK, Lisa M, TAVARES, Francis X, WELLS-KNECHT, Kevin J, WILLARD, Derril H, WRIGHT, Lois L, ZHOU, Hui-Qiang Q, CATALANO, John G, DEATON, David N, HASSELL, Anne M, JURGENSEN, Cynthia H, LONG, Stacey T, MCFADYEN, Robert B, MILLER, Aaron B, MILLER, Larry R
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
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Journal Article
Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with good pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions
BARRETT, David G, CATALANO, John G, WRIGHT, Lois L, DEATON, David N, HASSELL, Anne M, LONG, Stacey T, MILLER, Aaron B, MILLER, Larry R, SHEWCHUK, Lisa M, WELLS-KNECHT, Kevin J, WILLARD, Derril H
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
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Exploration of the P1 SAR of aldehyde cathepsin K inhibitors
CATALANO, John G, DEATON, David N, FURFINE, Eric S, HASSELL, Annie M, MCFADYEN, Robert B, MILLER, Aaron B, MILLER, Larry R, SHEWCHUK, Lisa M, WILLARD, Derril H, WRIGHT, Lois L
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
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Solution Studies of Recombinant Human Stromal-Cell-Derived Factor-1
Holmes, William D., Consler, Thomas G., Dallas, Walter S., Rocque, Warren J., Willard, Derril H.
Published in Protein expression and purification (01.04.2001)
Published in Protein expression and purification (01.04.2001)
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Human Recombinant Phosphodiesterase 4B2B Binds (R)-Rolipram at a Single Site with Two Affinities
Rocque, Warren J, Tian, Gaochao, Wiseman, Jeffrey S, Holmes, William D, Zajac-Thompson, Irene, Willard, Derril H, Patel, Indravaden R, Wisely, G. Bruce, Clay, William C, Kadwell, Sue H, Hoffman, Christine R, Luther, Michael A
Published in Biochemistry (Easton) (18.11.1997)
Published in Biochemistry (Easton) (18.11.1997)
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Mutations in the Carboxyl Terminus of the Agouti Protein Decrease Agouti Inhibition of Ligand Binding to the Melanocortin Receptors
Kiefer, Laura L, Ittoop, Olivia R. R, Bunce, Keith, Truesdale, Anne T, Willard, Derril H, Nichols, James S, Blanchard, Steven G, Mountjoy, Kathleen, Chen, Wen-Ji, Wilkison, William O
Published in Biochemistry (Easton) (25.02.1997)
Published in Biochemistry (Easton) (25.02.1997)
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Detailed Characterization of a Purified Type 4 Phosphodiesterase, HSPDE4B2B: Differentiation of High- and Low-Affinity (R)-Rolipram Binding
Rocque, Warren J., Holmes, William D., Patel, Indravadan R., Dougherty, Robert W., Ittoop, Olivia, Overton, Laurie, Hoffman, Christine R., Wisely, G.Bruce, Willard, Derril H., Luther, Michael A.
Published in Protein expression and purification (01.03.1997)
Published in Protein expression and purification (01.03.1997)
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Exploration of the P2-P3 SAR of aldehyde cathepsin K inhibitors
BORES, Eric E, DEATON, David N, WRIGHT, Lois L, HASSELL, Anne M, MCFADYEN, Robert B, MILLER, Aaron B, MILLER, Larry R, PAULICK, Margot G, SHEWCHUK, Lisa M, THOMPSON, James B, WILLARD, Derril H
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
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Replication-Associated Activities of Purified Human Papillomavirus Type 11 E1 Helicase
Rocque, Warren J., Porter, David J.T., Barnes, Julie A., Dixon, Eric P., Lobe, David C., Su, Jui-Lan, Willard, Derril H., Gaillard, Richard, Condreay, J.Patrick, Clay, William C., Hoffman, Christine R., Overton, Laurie K., Pahel, Greg, Kost, Thomas A., Phelps, William C.
Published in Protein expression and purification (01.03.2000)
Published in Protein expression and purification (01.03.2000)
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Product Release Is the Major Contributor tok cat for the Hepatitis C Virus Helicase-catalyzed Strand Separation of Short Duplex DNA
Porter, David J.T., Short, Steven A., Hanlon, Mary H., Preugschat, Frank, Wilson, Jeanne E., Willard, Derril H., Consler, Thomas G.
Published in The Journal of biological chemistry (24.07.1998)
Published in The Journal of biological chemistry (24.07.1998)
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Catalytic Activity of the SH2 Domain of Human pp60c-src; Evidence from NMR, Mass Spectrometry, Site-Directed Mutagenesis and Kinetic Studies for an Inherent Phosphatase Activity
Boerner, Renee J, Consler, Thomas G, Gampe, Robert T, Weigl, Debbra, Willard, Derril H, Davis, Donald G, Edison, Ann M, Loganzo, Frank, Kassel, D. B
Published in Biochemistry (Easton) (01.11.1995)
Published in Biochemistry (Easton) (01.11.1995)
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