Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays
Wilham, Jason M, Orrú, Christina D, Bessen, Richard A, Atarashi, Ryuichiro, Sano, Kazunori, Race, Brent, Meade-White, Kimberly D, Taubner, Lara M, Timmes, Andrew, Caughey, Byron
Published in PLoS pathogens (01.12.2010)
Published in PLoS pathogens (01.12.2010)
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Journal Article
In vitro detection of prionemia in TSE-infected cervids and hamsters
Elder, Alan M, Henderson, Davin M, Nalls, Amy V, Wilham, Jason M, Caughey, Byron W, Hoover, Edward A, Kincaid, Anthony E, Bartz, Jason C, Mathiason, Candace K
Published in PloS one (01.11.2013)
Published in PloS one (01.11.2013)
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Journal Article
Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease
McGuire, Lynne I., Peden, Alexander H., Orrú, Christina D., Wilham, Jason M., Appleford, Nigel E., Mallinson, Gary, Andrews, Mary, Head, Mark W., Caughey, Byron, Will, Robert G., Knight, Richard S. G., Green, Alison J. E.
Published in Annals of neurology (01.08.2012)
Published in Annals of neurology (01.08.2012)
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Journal Article
Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC
Vascellari, Sarah, Orrù, Christina D, Hughson, Andrew G, King, Declan, Barron, Rona, Wilham, Jason M, Baron, Gerald S, Race, Brent, Pani, Alessandra, Caughey, Byron
Published in PloS one (05.11.2012)
Published in PloS one (05.11.2012)
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Journal Article
Prion disease blood test using immunoprecipitation and improved quaking-induced conversion
Orrú, Christina D, Wilham, Jason M, Raymond, Lynne D, Kuhn, Franziska, Schroeder, Björn, Raeber, Alex J, Caughey, Byron
Published in mBio (01.07.2011)
Published in mBio (01.07.2011)
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Journal Article
Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking
Atarashi, Ryuichiro, Wilham, Jason M, Christensen, Leah, Hughson, Andrew G, Moore, Roger A, Johnson, Lisa M, Onwubiko, Henry A, Priola, Suzette A, Caughey, Byron
Published in Nature methods (01.03.2008)
Published in Nature methods (01.03.2008)
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Journal Article
Sensitive and specific detection of sporadic Creutzfeldt―Jakob disease brain prion protein using real-time quaking-induced conversion
PEDEN, Alexander H, MCGUIRE, Lynne I, GREEN, Alison J. E, HEAD, Mark W, APPLEFORD, Nigel E. J, MALLINSON, Gary, WILHAM, Jason M, ORRU, Christina D, CAUGHEY, Byron, IRONSIDE, James W, KNIGHT, Richard S, WILL, Robert G
Published in Journal of general virology (01.02.2012)
Published in Journal of general virology (01.02.2012)
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Journal Article
Prion shedding from olfactory neurons into nasal secretions
Bessen, Richard A, Shearin, Harold, Martinka, Scott, Boharski, Ryan, Lowe, Diana, Wilham, Jason M, Caughey, Byron, Wiley, James A
Published in PLoS pathogens (01.04.2010)
Published in PLoS pathogens (01.04.2010)
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Journal Article
New generation QuIC assays for prion seeding activity
Orru, Christina D., Wilham, Jason M., Vascellari, Sarah, Hughson, Andrew G., Caughey, Byron
Published in Prion (01.04.2012)
Published in Prion (01.04.2012)
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Journal Article
Asymmetric dimethylarginine inhibits HSP90 activity in pulmonary arterial endothelial cells: role of mitochondrial dysfunction
Sud, Neetu, Wells, Sandra M, Sharma, Shruti, Wiseman, Dean A, Wilham, Jason, Black, Stephen M
Published in American Journal of Physiology: Cell Physiology (01.06.2008)
Published in American Journal of Physiology: Cell Physiology (01.06.2008)
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Journal Article
Accelerated Shedding of Prions following Damage to the Olfactory Epithelium
Bessen, Richard A, Wilham, Jason M, Lowe, Diana, Watschke, Christopher P, Shearin, Harold, Martinka, Scott, Caughey, Byron, Wiley, James A
Published in Journal of Virology (01.02.2012)
Published in Journal of Virology (01.02.2012)
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Journal Article
Human variant Creutzfeldt-Jakob disease and sheep scrapie PrP(res) detection using seeded conversion of recombinant prion protein
Orrú, Christina D, Wilham, Jason M, Hughson, Andrew G, Raymond, Lynne D, McNally, Kristin L, Bossers, Alex, Ligios, Ciriaco, Caughey, Byron
Published in Protein engineering, design and selection (01.08.2009)
Published in Protein engineering, design and selection (01.08.2009)
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Journal Article
Bioactive Alkaloids of Frog Skin: Combinatorial Bioprospecting Reveals That Pumiliotoxins Have an Arthropod Source
Daly, John W., Kaneko, Tetsuo, Wilham, Jason, Garraffo, H. Martin, Spande, Thomas F., Espinosa, Alex, Donnelly, Maureen A.
Published in Proceedings of the National Academy of Sciences - PNAS (29.10.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (29.10.2002)
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Journal Article
Biologically active substances from amphibians: preliminary studies on anurans from twenty-one genera of Thailand
Daly, John W., Noimai, Naratitt, Kongkathip, Boonsong, Kongkathip, Ngampong, Wilham, Jason M., Garraffo, H. Martin, Kaneko, Tetsuo, Spande, Thomas F., Nimit, Yuth, Nabhitabhata, Jarujin, Chan-Ard, Tanya
Published in Toxicon (Oxford) (15.12.2004)
Published in Toxicon (Oxford) (15.12.2004)
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Journal Article
Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension
Sharma, Shruti, Sud, Neetu, Wiseman, Dean A, Carter, A. Lee, Kumar, Sanjiv, Hou, Yali, Rau, Thomas, Wilham, Jason, Harmon, Cynthia, Oishi, Peter, Fineman, Jeffrey R, Black, Stephen M
Published in American journal of physiology. Lung cellular and molecular physiology (01.01.2008)
Published in American journal of physiology. Lung cellular and molecular physiology (01.01.2008)
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Journal Article
Endothelial response to stress from exogenous Zn2+ resembles that of NO-mediated nitrosative stress, and is protected by MT-1 overexpression
Wiseman, Dean A, Wells, Sandra M, Wilham, Jason, Hubbard, Maryann, Welker, Jonathan E, Black, Stephen M
Published in American Journal of Physiology: Cell Physiology (01.09.2006)
Published in American Journal of Physiology: Cell Physiology (01.09.2006)
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Journal Article
Increased hydrogen peroxide downregulates soluble guanylate cyclase in the lungs of lambs with persistent pulmonary hypertension of the newborn
Wedgwood, Stephen, Steinhorn, Robin H, Bunderson, Melisa, Wilham, Jason, Lakshminrusimha, Satyan, Brennan, Lisa A, Black, Stephen M
Published in American journal of physiology. Lung cellular and molecular physiology (01.10.2005)
Published in American journal of physiology. Lung cellular and molecular physiology (01.10.2005)
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Journal Article
Human variant Creutzfeldt–Jakob disease and sheep scrapie PrPres detection using seeded conversion of recombinant prion protein
Orrú, Christina D., Wilham, Jason M., Hughson, Andrew G., Raymond, Lynne D., McNally, Kristin L., Bossers, Alex, Ligios, Ciriaco, Caughey, Byron
Published in Protein engineering, design and selection (01.08.2009)
Published in Protein engineering, design and selection (01.08.2009)
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Journal Article
Prion Seeding Activities of Mouse Scrapie Strains with Divergent PrP.sup.Sc Protease Sensitivities and Amyloid Plaque Content Using RT-QuIC and eQuIC
Vascellari, Sarah, Orrù, Christina D, Hughson, Andrew G, King, Declan, Barron, Rona, Wilham, Jason M, Baron, Gerald S, Race, Brent, Pani, Alessandra, Caughey, Byron
Published in PloS one (05.11.2012)
Published in PloS one (05.11.2012)
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Journal Article
RT-QuIC analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease
McGuire, Lynne I., Peden, Alexander H., Orrú, Christina D., Wilham, Jason M., Appleford, Nigel E., Mallinson, Gary, Andrews, Mary, Head, Mark W., Caughey, Byron, Will, Robert G., Knight, Richard S.G., Green, Alison J.E.
Published in Annals of neurology (01.08.2012)
Published in Annals of neurology (01.08.2012)
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Journal Article