Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen
Cheeseman, Matthew D, Chessum, Nicola E. A, Rye, Carl S, Pasqua, A. Elisa, Tucker, Michael J, Wilding, Birgit, Evans, Lindsay E, Lepri, Susan, Richards, Meirion, Sharp, Swee Y, Ali, Salyha, Rowlands, Martin, O’Fee, Lisa, Miah, Asadh, Hayes, Angela, Henley, Alan T, Powers, Marissa, te Poele, Robert, De Billy, Emmanuel, Pellegrino, Loredana, Raynaud, Florence, Burke, Rosemary, van Montfort, Rob L. M, Eccles, Suzanne A, Workman, Paul, Jones, Keith
Published in Journal of medicinal chemistry (12.01.2017)
Published in Journal of medicinal chemistry (12.01.2017)
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Journal Article
Targeting the Substrate Binding Site of E. coli Nitrile Reductase QueF by Modeling, Substrate and Enzyme Engineering
Wilding, Birgit, Winkler, Margit, Petschacher, Barbara, Kratzer, Regina, Egger, Sigrid, Steinkellner, Georg, Lyskowski, Andrzej, Nidetzky, Bernd, Gruber, Karl, Klempier, Norbert
Published in Chemistry : a European journal (27.05.2013)
Published in Chemistry : a European journal (27.05.2013)
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Journal Article
A practical synthesis of 5-functionalized thieno[2,3-d]pyrimidines
Wilding, Birgit, Faschauner, Stefan, Klempier, Norbert
Published in Tetrahedron letters (22.07.2015)
Published in Tetrahedron letters (22.07.2015)
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Journal Article
Kinetic Analysis and Probing with Substrate Analogues of the Reaction Pathway of the Nitrile Reductase QueF from Escherichia coli
Jung, Jihye, Czabany, Tibor, Wilding, Birgit, Klempier, Norbert, Nidetzky, Bernd
Published in The Journal of biological chemistry (02.12.2016)
Published in The Journal of biological chemistry (02.12.2016)
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Journal Article
Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)
Chessum, Nicola E. A, Sharp, Swee Y, Caldwell, John J, Pasqua, A. Elisa, Wilding, Birgit, Colombano, Giampiero, Collins, Ian, Ozer, Bugra, Richards, Meirion, Rowlands, Martin, Stubbs, Mark, Burke, Rosemary, McAndrew, P. Craig, Clarke, Paul A, Workman, Paul, Cheeseman, Matthew D, Jones, Keith
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Journal Article
Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime
Horvat, Melissa, Weilch, Victoria, Rädisch, Robert, Hecko, Sebastian, Schiefer, Astrid, Rudroff, Florian, Wilding, Birgit, Klempier, Norbert, Pátek, Miroslav, Martínková, Ludmila, Winkler, Margit
Published in Catalysis science & technology (04.01.2022)
Published in Catalysis science & technology (04.01.2022)
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Journal Article
Abstract 1472: Novel EGFR WT sparing, HER2 selective inhibitors for the treatment of HER2 exon 20 insertion driven tumors address a clear unmet medical need
Neumüller, Ralph A., Wilding, Birgit, Scharn, Dirk, Böse, Dietrich, Santoro, Valeria, Gerlach, Daniel, Ettmayer, Peter, Gerstberger, Thomas, Fuchs, Julian, Treu, Matthias, Zahn, Stephan, Baum, Anke, Chetta, Paolo, Pearson, Mark, McConnell, Darryl B., Kraut, Norbert, Solca, Flavio
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies
Pasqua, A. Elisa, Sharp, Swee Y., Chessum, Nicola E. A., Hayes, Angela, Pellegrino, Loredana, Tucker, Michael J., Miah, Asadh, Wilding, Birgit, Evans, Lindsay E., Rye, Carl S., Mok, N. Yi, Liu, Manjuan, Henley, Alan T., Gowan, Sharon, De Billy, Emmanuel, te Poele, Robert, Powers, Marissa, Eccles, Suzanne A., Clarke, Paul A., Raynaud, Florence I., Workman, Paul, Jones, Keith, Cheeseman, Matthew D.
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
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Journal Article
Chemoenzymatic one-pot reaction from carboxylic acid to nitrile oxime
Horvat, Melissa, Weilch, Victoria, Rädisch, Robert, Hecko, Sebastian, Schiefer, Astrid, Rudroff, Florian, Wilding, Birgit, Klempier, Norbert, Pátek, Miroslav, Martínková, Ludmila, Winkler, Margit
Published in Catalysis science & technology (04.01.2022)
Published in Catalysis science & technology (04.01.2022)
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Journal Article
Zongertinib (BI 1810631), an irreversible HER2 TKI, spares EGFR signaling and improves therapeutic response in preclinical models and patients with HER2-driven cancers
Wilding, Birgit, Woelflingseder, Lydia, Baum, Anke, Chylinski, Krzysztof, Vainorius, Gintautas, Gibson, Neil, Waizenegger, Irene C, Gerlach, Daniel, Augsten, Martin, Spreitzer, Fiona, Shirai, Yukina, Ikegami, Masachika, Tilandyova, Sylvia, Scharn, Dirk, Pearson, Mark A, Popow, Johannes, Obenauf, Anna C, Yamamoto, Noboru, Kondo, Shunsuke, Opdam, Frans L, Bruining, Annemarie, Kohsaka, Shinji, Kraut, Norbert, Heymach, John V, Solca, Flavio, Neumuller, Ralph A
Published in Cancer discovery (09.09.2024)
Published in Cancer discovery (09.09.2024)
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Journal Article
Nitrile Reductase from Geobacillus kaustophilus: A Potential Catalyst for a New Nitrile Biotransformation Reaction
Wilding, Birgit, Winkler, Margit, Petschacher, Barbara, Kratzer, Regina, Glieder, Anton, Klempier, Norbert
Published in Advanced synthesis & catalysis (13.08.2012)
Published in Advanced synthesis & catalysis (13.08.2012)
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Journal Article
The Nitrile-Forming Enzyme 7-Cyano-7-Deazaguanine Synthase from Geobacillus kaustophilus: A Reverse Nitrilase?
Winkler, Margit, Dokulil, Katharina, Weber, Hansjörg, Pavkov-Keller, Tea, Wilding, Birgit
Published in Chembiochem : a European journal of chemical biology (02.11.2015)
Published in Chembiochem : a European journal of chemical biology (02.11.2015)
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Journal Article
HER2 억제제로서의 [1,3]디아지노[5,4-d]피리미딘
WILDING BIRGIT, SCHARN DIRK, TREU MATTHIAS, PETRONCZKI MARK, FUCHS JULIAN, NEUMUELLER RALPH, BOESE DIETRICH, ENGELHARDT HARALD
Year of Publication 09.01.2023
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Year of Publication 09.01.2023
Patent
Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1
Wilding, Birgit, Pasqua, A. Elisa, E. A. Chessum, Nicola, Pierrat, Olivier A., Hahner, Tamas, Tomlin, Kathy, Shehu, Erald, Burke, Rosemary, Richards, G. Meirion, Whitton, Bradleigh, Arwert, Esther N., Thapaliya, Arjun, Salimraj, Ramya, van Montfort, Rob, Skawinska, Agi, Hayes, Angela, Raynaud, Florence, Chopra, Rajesh, Jones, Keith, Newton, Gary, Cheeseman, Matthew D.
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
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Journal Article
Targeting the Substrate Binding Site of E.coli Nitrile Reductase QueF by Modeling, Substrate and Enzyme Engineering
Wilding, Birgit, Winkler, Margit, Petschacher, Barbara, Kratzer, Regina, Egger, Sigrid, Steinkellner, Georg, Lyskowski, Andrzej, Nidetzky, Bernd, Gruber, Karl, Klempier, Norbert
Published in Chemistry : a European journal (27.05.2013)
Published in Chemistry : a European journal (27.05.2013)
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Journal Article
Abstract 2976: Confirmation of in-cell target engagement using the proteolysis targeting chimeras (PROTACs) against pirin
Sharp, Swee Y., Chessum, Nicola E., Caldwell, John J., Powers, Marissa V., Pasqua, A Elisa, Wilding, Birgit, Collins, Ian, Ozer, Bugra, Rowlands, Martin, Stubbs, Mark, Burke, Rosemary, Montfort, Rob L. van, Cheeseman, Matthew D., Clarke, Paul A., Workman, Paul, Jones, Keith
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
An investigation of nitrile transforming enzymes in the chemo-enzymatic synthesis of the taxol sidechain
Wilding, Birgit, Vesela, Alicja B., Perry, Justin J. B., Black, Gary W., Zhang, Meng, Martinkova, Ludmila, Klempier, Norbert
Published in Organic & biomolecular chemistry (28.07.2015)
Published in Organic & biomolecular chemistry (28.07.2015)
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Journal Article
An investigation of nitrile transforming enzymes in the chemo-enzymatic synthesis of the taxol sidechainElectronic supplementary information (ESI) available: NMR spectra of all compounds, experimental procedures for acid and amide reference materials, representative HPLC chromatograms of biotransformation reactions from non-chiral and chiral HPLC measurements, biotransformations with cosolvents, information on commercial enzyme preparations. See DOI: 10.1039/c5ob01191d
Wilding, Birgit, Veselá, Alicja B, Perry, Justin J. B, Black, Gary W, Zhang, Meng, Martínková, Ludmila, Klempier, Norbert
Year of Publication 08.07.2015
Year of Publication 08.07.2015
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Journal Article
Abstract C140: BI 1810631 is a novel EGFR wild-type sparing, HER2-selective small molecule inhibitor that efficiently blocks HER2 mutant-driven lung cancer
Neumüller, Ralph A., Wilding, Birgit, Scharn, Dirk, Baum, Anke, Augsten, Martin, Waizenegger, Irene, Kohsaka, Shinji, Santoro, Valeria, Chetta, Paolo, Woelflingseder, Lydia, Popow, Johannes, Gerlach, Daniel, Ettmayer, Peter, Gerstberger, Thomas, Fuchs, Julian, Treu, Matthias, Zahn, Stephan, Pearson, Mark, Petronczki, Mark, McConnell, Darryl B., Kraut, Norbert, Solca, Flavio
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article