Search Results - "WIETHE, Robert W" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Blocking Alcoholic Steatosis in Mice with a Peripherally Restricted Purine Antagonist of the Type 1 Cannabinoid Receptor

Blocking Alcoholic Steatosis in Mice with a Peripherally Restricted Purine Antagonist of the Type 1 Cannabinoid Receptor

by Amato, George S, Manke, Amruta, Harris, Danni L, Wiethe, Robert W, Vasukuttan, Vineetha, Snyder, Rodney W, Lefever, Timothy W, Cortes, Ricardo, Zhang, Yanan, Wang, Shaobin, Runyon, Scott P, Maitra, Rangan
Published in Journal of medicinal chemistry (24.05.2018)

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Synthesis and pharmacological characterization of functionalized 6-piperazin-1-yl-purines as cannabinoid receptor 1 (CB1) inverse agonists

Synthesis and pharmacological characterization of functionalized 6-piperazin-1-yl-purines as cannabinoid receptor 1 (CB1) inverse agonists

by Amato, George S., Manke, Amruta, Vasukuttan, Vineetha, Wiethe, Robert W., Snyder, Rodney W., Runyon, Scott P., Maitra, Rangan
Published in Bioorganic & medicinal chemistry (15.08.2018)

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Array synthesis of progesterone receptor antagonists: 3-Aryl-1,2-diazepines

Array synthesis of progesterone receptor antagonists: 3-Aryl-1,2-diazepines

by Wiethe, Robert W., Stewart, Eugene L., Drewry, David H., Gray, David W., Mehbob, Abdul, Hoekstra, William J.
Published in Bioorganic & medicinal chemistry letters (15.07.2006)

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Identification of 1‑({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)‑1H‑pyrazol-3-yl]carbonyl}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin Receptor Type 2 Compound

Identification of 1‑({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)‑1H‑pyrazol-3-yl]carbonyl}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin Receptor Type 2 Compound

by Thomas, James B, Giddings, Angela M, Wiethe, Robert W, Olepu, Srinivas, Warner, Keith R, Sarret, Philippe, Gendron, Louis, Longpre, Jean-Michel, Zhang, Yanan, Runyon, Scott P, Gilmour, Brian P
Published in Journal of medicinal chemistry (26.06.2014)

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Identification of N‑[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)‑1H‑indol-1-yl)acetyl]‑l‑leucine (NTRC-824), a Neurotensin-like Nonpeptide Compound Selective for the Neurotensin Receptor Type 2

Identification of N‑[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)‑1H‑indol-1-yl)acetyl]‑l‑leucine (NTRC-824), a Neurotensin-like Nonpeptide Compound Selective for the Neurotensin Receptor Type 2

by Thomas, James B, Giddings, Angela M, Wiethe, Robert W, Olepu, Srinivas, Warner, Keith R, Sarret, Philippe, Gendron, Louis, Longpre, Jean-Michel, Zhang, Yanan, Runyon, Scott P, Gilmour, Brian P
Published in Journal of medicinal chemistry (11.09.2014)

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Identification and Characterization of 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) Antagonist

Identification and Characterization of 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) Antagonist

by Shearer, Barry G, Wiethe, Robert W, Ashe, Adam, Billin, Andrew N, Way, James M, Stanley, Thomas B, Wagner, Craig D, Xu, Robert X, Leesnitzer, Lisa M, Merrihew, Raymond V, Shearer, Todd W, Jeune, Michael R, Ulrich, John C, Willson, Timothy M
Published in Journal of medicinal chemistry (25.02.2010)

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Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-L-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2

Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-L-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2

by Thomas, James B., Giddings, Angela M., Olepu, Srinivas, Wiethe, Robert W., Harris, Danni L., Narayanan, Sanju, Warner, Keith R., Sarret, Philippe, Longpre, Jean-Michel, Runyon, Scott P., Gilmour, Brian P.
Published in Bioorganic & medicinal chemistry letters (15.01.2015)

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The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2

The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2

by Thomas, James B., Giddings, Angela M., Olepu, Srinivas, Wiethe, Robert W., Warner, Keith R., Sarret, Philippe, Longpre, Jean-Michel, Runyon, Scott P., Gilmour, Brian P.
Published in Bioorganic & medicinal chemistry letters (15.05.2015)

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Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2

Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2

by Thomas, James B, Vivancos, Mélanie, Giddings, Angela M, Wiethe, Robert W, Warner, Keith R, Murza, Alexandre, Besserer-Offroy, Élie, Longpré, Jean-Michel, Runyon, Scott P, Decker, Ann M, Gilmour, Brian P, Sarret, Philippe
Published in ACS chemical neuroscience (21.09.2016)

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Structure-Guided Design of N-Phenyl Tertiary Amines as Transrepression-Selective Liver X Receptor Modulators with Anti-Inflammatory Activity

Structure-Guided Design of N-Phenyl Tertiary Amines as Transrepression-Selective Liver X Receptor Modulators with Anti-Inflammatory Activity

by Chao, Esther Y, Caravella, Justin A, Watson, Mike A, Campobasso, Nino, Ghisletti, Serena, Billin, Andrew N, Galardi, Cristin, Wang, Ping, Laffitte, Bryan A, Iannone, Marie A, Goodwin, Bryan J, Nichols, Jason A, Parks, Derek J, Stewart, Eugene, Wiethe, Robert W, Williams, Shawn P, Smallwood, Angela, Pearce, Kenneth H, Glass, Christopher K, Willson, Timothy M, Zuercher, William J, Collins, Jon L
Published in Journal of medicinal chemistry (25.09.2008)

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The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones

The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones

by Willson, Timothy M, Cobb, Jeffery E, Cowan, David J, Wiethe, Robert W, Correa, Itzela D, Prakash, Shimoga R, Beck, Kelli D, Moore, Linda B, Kliewer, Steven A, Lehmann, Jürgen M
Published in Journal of medicinal chemistry (02.02.1996)

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2-Amino-4,6-diarylpyridines as novel ligands for the estrogen receptor

2-Amino-4,6-diarylpyridines as novel ligands for the estrogen receptor

by HENKE, Brad R, DREWRY, David H, JONES, Stacey A, STEWART, Eugene L, WEAVER, Susan L, WIETHE, Robert W
Published in Bioorganic & medicinal chemistry letters (23.07.2001)

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Identification of N -[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1 H -indol-1-yl)acetyl]- l -leucine (NTRC-824), a Neurotensin-like Nonpeptide Compound Selective for the Neurotensin Receptor Type 2

Identification of N -[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1 H -indol-1-yl)acetyl]- l -leucine (NTRC-824), a Neurotensin-like Nonpeptide Compound Selective for the Neurotensin Receptor Type 2

by Thomas, James B., Giddings, Angela M., Wiethe, Robert W., Olepu, Srinivas, Warner, Keith R., Sarret, Philippe, Gendron, Louis, Longpre, Jean-Michel, Zhang, Yanan, Runyon, Scott P., Gilmour, Brian P.
Published in Journal of medicinal chemistry (11.09.2014)

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Identification of 1-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1 H -pyrazol-3-yl]carbonyl}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin Receptor Type 2 Compound

Identification of 1-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1 H -pyrazol-3-yl]carbonyl}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin Receptor Type 2 Compound

by Thomas, James B., Giddings, Angela M., Wiethe, Robert W., Olepu, Srinivas, Warner, Keith R., Sarret, Philippe, Gendron, Louis, Longpre, Jean-Michel, Zhang, Yanan, Runyon, Scott P., Gilmour, Brian P.
Published in Journal of medicinal chemistry (26.06.2014)

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Identification of 1-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbon y l}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin Receptor Type 2 Compound

Identification of 1-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbon y l}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin Receptor Type 2 Compound

by Thomas, James B, Giddings, Angela M, Wiethe, Robert W, Olepu, Srinivas, Warner, Keith R, Sarret, Philippe, Gendron, Louis, Longpre, Jean-Michel, Zhang, Yanan, Runyon, Scott P, Gilmour, Brian P
Published in Journal of medicinal chemistry (23.05.2014)

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Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-le u cine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2

Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-le u cine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2

by Thomas, James B, Giddings, Angela M, Olepu, Srinivas, Wiethe, Robert W, Harris, Danni L, Narayanan, Sanju, Warner, Keith R, Sarret, Philippe, Longpre, Jean-Michel, Runyon, Scott P, Gilmour, Brian P
Published in Bioorganic & medicinal chemistry letters (05.01.2015)

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Journal Article

Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1 H -pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2

Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1 H -pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2

by Thomas, James B., Vivancos, Mélanie, Giddings, Angela M., Wiethe, Robert W., Warner, Keith R., Murza, Alexandre, Besserer-Offroy, Élie, Longpré, Jean-Michel, Runyon, Scott P., Decker, Ann M., Gilmour, Brian P., Sarret, Philippe
Published in ACS chemical neuroscience (21.09.2016)

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Journal Article

Identification and Characterization of 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethylbenzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) Antagonist

Identification and Characterization of 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethylbenzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) Antagonist

by SHEARER, Barry G, WIETHE, Robert W, SHEARER, Todd W, JEUNE, Michael R, ULRICH, John C, WILLSON, Timothy M, ASHE, Adam, BILLIN, Andrew N, WAY, James M, STANLEY, Thomas B, WAGNER, Craig D, XU, Robert X, LEESNITZER, Lisa M, MERRIHEW, Raymond V
Published in Journal of medicinal chemistry (2010)

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Fmoc mediated synthesis of Peptide Nucleic Acids

Fmoc mediated synthesis of Peptide Nucleic Acids

by Thomson, Stephen A., Josey, John A., Cadilla, Rodolfo, Gaul, Micheal D., Fred Hassman, C., Luzzio, Michael J., Pipe, Adrian J., Reed, Kathryn L., Ricca, Daniel J., Wiethe, Robert W., Noble, Stewart A.
Published in Tetrahedron (29.05.1995)

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Journal Article

Diaryl purine derivatives with improved bioavailability

Diaryl purine derivatives with improved bioavailability

by Amato, George S, Zhang, Yanan, Wiethe, Robert W, Maitra, Rangan
Year of Publication 08.07.2021

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