The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia
Herman, Sarah E M, Montraveta, Arnau, Niemann, Carsten U, Mora-Jensen, Helena, Gulrajani, Michael, Krantz, Fanny, Mantel, Rose, Smith, Lisa L, McClanahan, Fabienne, Harrington, Bonnie K, Colomer, Dolors, Covey, Todd, Byrd, John C, Izumi, Raquel, Kaptein, Allard, Ulrich, Roger, Johnson, Amy J, Lannutti, Brian J, Wiestner, Adrian, Woyach, Jennifer A
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Published in Clinical cancer research (01.06.2017)
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Clonal evolution leading to ibrutinib resistance in chronic lymphocytic leukemia
Ahn, Inhye E., Underbayev, Chingiz, Albitar, Adam, Herman, Sarah E.M., Tian, Xin, Maric, Irina, Arthur, Diane C., Wake, Laura, Pittaluga, Stefania, Yuan, Constance M., Stetler-Stevenson, Maryalice, Soto, Susan, Valdez, Janet, Nierman, Pia, Lotter, Jennifer, Xi, Liqiang, Raffeld, Mark, Farooqui, Mohammed, Albitar, Maher, Wiestner, Adrian
Published in Blood (16.03.2017)
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Depth and durability of response to ibrutinib in CLL: 5-year follow-up of a phase 2 study
Ahn, Inhye E., Farooqui, Mohammed Z.H., Tian, Xin, Valdez, Janet, Sun, Clare, Soto, Susan, Lotter, Jennifer, Housel, Stephanie, Stetler-Stevenson, Maryalice, Yuan, Constance M., Maric, Irina, Calvo, Katherine R., Nierman, Pia, Hughes, Thomas E., Saba, Nakhle S., Marti, Gerald E., Pittaluga, Stefania, Herman, Sarah E.M., Niemann, Carsten U., Pedersen, Lone B., Geisler, Christian H., Childs, Richard, Aue, Georg, Wiestner, Adrian
Published in Blood (24.05.2018)
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Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia
FISKUS, Warren, SABA, Nakhle, AUSTIN, Christopher P, MADDOCKS, Kami, BYRD, John, MELNICK, Ari, PENG HUANG, WIESTNER, Adrian, BHALLA, Kapil N, MIN SHEN, GHIAS, Mondana, JINYUN LIU, DAS GUPTA, Soumyasri, CHAUHAN, Lata, RAO, Rekha, GUNEWARDENA, Sumedha, SCHORNO, Kevin
Published in Cancer research (Chicago, Ill.) (01.05.2014)
Published in Cancer research (Chicago, Ill.) (01.05.2014)
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The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy
Landau, Dan A, Sun, Clare, Rosebrock, Daniel, Herman, Sarah E M, Fein, Joshua, Sivina, Mariela, Underbayev, Chingiz, Liu, Delong, Hoellenriegel, Julia, Ravichandran, Sarangan, Farooqui, Mohammed Z H, Zhang, Wandi, Cibulskis, Carrie, Zviran, Asaf, Neuberg, Donna S, Livitz, Dimitri, Bozic, Ivana, Leshchiner, Ignaty, Getz, Gad, Burger, Jan A, Wiestner, Adrian, Wu, Catherine J
Published in Nature communications (19.12.2017)
Published in Nature communications (19.12.2017)
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Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: a phase 2, single-arm trial
Farooqui, Mohammed Z H, DO, Valdez, Janet, PA, Martyr, Sabrina, MD, Aue, Georg, MD, Saba, Nakhle, MD, Niemann, Carsten U, MD, Herman, Sarah E M, PhD, Tian, Xin, PhD, Marti, Gerald, MD, Soto, Susan, MSN, Hughes, Thomas E, PharmD, Jones, Jade, MD, Lipsky, Andrew, MD, Pittaluga, Stefania, MD, Stetler-Stevenson, Maryalice, MD, Yuan, Constance, MD, Lee, Yuh Shan, MD, Pedersen, Lone B, Geisler, Christian H, Prof, Calvo, Katherine R, MD, Arthur, Diane C, MD, Maric, Irina, MD, Childs, Richard, MD, Young, Neal S, MD, Wiestner, Adrian, Dr
Published in The lancet oncology (01.02.2015)
Published in The lancet oncology (01.02.2015)
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Siglec-6 is a target for chimeric antigen receptor T-cell treatment of chronic lymphocytic leukemia
Kovalovsky, Damian, Yoon, Jeong Heon, Cyr, Matthew G, Simon, Samantha, Voynova, Elisaveta, Rader, Christoph, Wiestner, Adrian, Alejo, Julie, Pittaluga, Stefania, Gress, Ronald E
Published in Leukemia (01.09.2021)
Published in Leukemia (01.09.2021)
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A CD19/CD3 bispecific antibody for effective immunotherapy of chronic lymphocytic leukemia in the ibrutinib era
Robinson, Hannah R., Qi, Junpeng, Cook, Erika M., Nichols, Cydney, Dadashian, Eman L., Underbayev, Chingiz, Herman, Sarah E.M., Saba, Nakhle S., Keyvanfar, Keyvan, Sun, Clare, Ahn, Inhye E., Baskar, Sivasubramanian, Rader, Christoph, Wiestner, Adrian
Published in Blood (02.08.2018)
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MALT1 Inhibition Is Efficacious in Both Naïve and Ibrutinib-Resistant Chronic Lymphocytic Leukemia
Saba, Nakhle S, Wong, Deanna H, Tanios, Georges, Iyer, Jessica R, Lobelle-Rich, Patricia, Dadashian, Eman L, Liu, Delong, Fontan, Lorena, Flemington, Erik K, Nichols, Cydney M, Underbayev, Chingiz, Safah, Hana, Melnick, Ari, Wiestner, Adrian, Herman, Sarah E M
Published in Cancer research (Chicago, Ill.) (15.12.2017)
Published in Cancer research (Chicago, Ill.) (15.12.2017)
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Lymphocyte activation gene 3: a novel therapeutic target in chronic lymphocytic leukemia
Shapiro, Mika, Herishanu, Yair, Katz, Ben-Zion, Dezorella, Nili, Sun, Clare, Kay, Sigi, Polliack, Aaron, Avivi, Irit, Wiestner, Adrian, Perry, Chava
Published in Haematologica (Roma) (01.05.2017)
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ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells
Wang, Qiuyan, Mora-Jensen, Helena, Weniger, Marc A, Perez-Galan, Patricia, Wolford, Chris, Hai, Tsonwin, Ron, David, Chen, Weiping, Trenkle, William, Wiestner, Adrian, Ye, Yihong
Published in Proceedings of the National Academy of Sciences - PNAS (17.02.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (17.02.2009)
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TLR Signaling Is Activated in Lymph Node-Resident CLL Cells and Is Only Partially Inhibited by Ibrutinib
Dadashian, Eman L, McAuley, Erin M, Liu, Delong, Shaffer, 3rd, Arthur L, Young, Ryan M, Iyer, Jessica R, Kruhlak, Michael J, Staudt, Louis M, Wiestner, Adrian, Herman, Sarah E M
Published in Cancer research (Chicago, Ill.) (15.01.2019)
Published in Cancer research (Chicago, Ill.) (15.01.2019)
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