Accelerating Lead Identification by High Throughput Virtual Screening: Prospective Case Studies from the Pharmaceutical Industry
Damm-Ganamet, Kelly L, Arora, Nidhi, Becart, Stephane, Edwards, James P, Lebsack, Alec D, McAllister, Heather M, Nelen, Marina I, Rao, Navin L, Westover, Lori, Wiener, John J. M, Mirzadegan, Taraneh
Published in Journal of chemical information and modeling (28.05.2019)
Published in Journal of chemical information and modeling (28.05.2019)
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Journal Article
Total Synthesis and Structural Revision of Callipeltoside C
Carpenter, Joseph, Northrup, Alan B., Chung, deMichael, Wiener, John J. M., Kim, Sung-Gon, MacMillan, David W. C.
Published in Angewandte Chemie International Edition (28.04.2008)
Published in Angewandte Chemie International Edition (28.04.2008)
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Journal Article
Recent advances in the design of cathepsin S inhibitors
Wiener, John J M, Sun, Siquan, Thurmond, Robin L
Published in Current topics in medicinal chemistry (01.05.2010)
Published in Current topics in medicinal chemistry (01.05.2010)
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Journal Article
Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions
Wiener, John J.M., Wickboldt, Alvah T., Wiener, Danielle K., Lee-Dutra, Alice, Edwards, James P., Karlsson, Lars, Nguyen, Steven, Sun, Siquan, Jones, Todd K., Grice, Cheryl A.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Journal Article
Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity
Tichenor, Mark S, Wiener, John J. M, Rao, Navin L, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D, Bacani, Genesis M, Wei, Jianmei, Chang, Leon, Murrey, Heather E, Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J, Wu, JieJun, Seierstad, Mark, Bembenek, Scott D, Leonard, Kristi A, Lebsack, Alec D, Venable, Jennifer D, Edwards, James P
Published in ACS medicinal chemistry letters (13.05.2021)
Published in ACS medicinal chemistry letters (13.05.2021)
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Journal Article
Single R-Group Polymorphisms (SRPs) and R-Cliffs: An Intuitive Framework for Analyzing and Visualizing Activity Cliffs in a Single Analog Series
Agrafiotis, Dimitris K., Wiener, John J. M., Skalkin, Andrew, Kolpak, Jeremy
Published in Journal of chemical information and modeling (23.05.2011)
Published in Journal of chemical information and modeling (23.05.2011)
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Journal Article
Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains
Wiener, John J.M., Gomez, Laurent, Venkatesan, Hariharan, Santillán, Alejandro, Allison, Brett D., Schwarz, Kimberly L., Shinde, Shirin, Tang, Liu, Hack, Michael D., Morrow, Brian J., Motley, S. Timothy, Goldschmidt, Raul M., Shaw, Karen Joy, Jones, Todd K., Grice, Cheryl A.
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
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Journal Article
Pyrazole-based arylalkyne Cathepsin S inhibitors. Part III: Modification of P4 region
Wiener, John J.M., Wickboldt, Alvah Tyson, Nguyen, Steven, Sun, Siquan, Rynberg, Raymond, Rizzolio, Michele, Karlsson, Lars, Edwards, James P., Grice, Cheryl A.
Published in Bioorganic & medicinal chemistry letters (15.02.2013)
Published in Bioorganic & medicinal chemistry letters (15.02.2013)
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Journal Article
Azabenzthiazole inhibitors of leukotriene A4 hydrolase
Tanis, Virginia M., Bacani, Genesis M., Blevitt, Jonathan M., Chrovian, Christa C., Crawford, Shelby, De Leon, Aimee, Fourie, Anne M., Gomez, Laurent, Grice, Cheryl A., Herman, Krystal, Kearney, Aaron M., Landry-Bayle, Adrienne M., Lee-Dutra, Alice, Nelson, Jay, Riley, Jason P., Santillán, Alejandro, Wiener, John J.M., Xue, Xiaohua, Young, Arlene L.
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase
Tichenor, Mark S., Wiener, John J. M., Rao, Navin L., Bacani, Genesis M., Wei, Jianmei, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D., Chang, Leon, Clancy, Kathleen W., Murrey, Heather E., Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J., Wu, Jiejun, Rui, Haopeng, Sepassi, Kia, Gaudiano, Marcello, Bekkers, Mariette, Cornelissen, Ivo, Packman, Kathryn, Seierstad, Mark, Xiouras, Christos, Bembenek, Scott D., Alexander, Richard, Milligan, Cynthia, Balasubramanian, Sriram, Lebsack, Alec D., Venable, Jennifer D., Philippar, Ulrike, Edwards, James P., Hirst, Gavin
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Journal Article
MAGL FAAH DUAL MAGL AND FAAH INHIBITORS
WEBER OLIVIA D, DUNCAN KATHARINE K, GRICE CHERYL A, CISAR JUSTIN S, FENG YU, WIENER JOHN J. M
Year of Publication 27.12.2023
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Year of Publication 27.12.2023
Patent
Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse
Eckert, William A., Wiener, John J.M., Cai, Hui, Ameriks, Michael K., Zhu, Jian, Ngo, Karen, Nguyen, Steven, Fung-Leung, Wai-Ping, Thurmond, Robin L., Grice, Cheryl, Edwards, James P., Chaplan, Sandra R., Karlsson, Lars, Sun, Siquan
Published in European journal of pharmacology (05.08.2020)
Published in European journal of pharmacology (05.08.2020)
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Journal Article
MAGL 억제제
WEBER OLIVIA D, SHAGHAFI MICHAEL B, MOODY JEANNE V, ALLAN AMY, RAFFAELE NICHOLAS, BUZARD DANIEL J, GRICE CHERYL A, CISAR JUSTIN S, WIENER JOHN J. M
Year of Publication 14.07.2023
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Year of Publication 14.07.2023
Patent
Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: Synthesis and preliminary SAR analysis
Gomez, Laurent, Hack, Michael D., Wu, Jiejun, Wiener, John J.M., Venkatesan, Hari, Santillán, Alejandro, Pippel, Daniel J., Mani, Neelakandha, Morrow, Brian J., Motley, S. Timothy, Shaw, Karen Joy, Wolin, Ronald, Grice, Cheryl A., Jones, Todd K.
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
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Journal Article
이중 MAGL 및 FAAH 저해제
WEBER OLIVIA D, DUNCAN KATHARINE K, GRICE CHERYL A, CISAR JUSTIN S, FENG YU, WIENER JOHN J. M
Year of Publication 22.11.2019
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Year of Publication 22.11.2019
Patent
피라졸 MAGL 저해제
WEBER OLIVIA D, SHAGHAFI MICHAEL B, DUNCAN KATHARINE K, BUZARD DANIEL J, GRICE CHERYL A, CISAR JUSTIN S, WIENER JOHN J. M
Year of Publication 30.01.2020
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Year of Publication 30.01.2020
Patent