Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol
Kempf, Dale J, Codacovi, Lynnmarie, Wang, Xiu Chun, Kohlbrenner, William E, Wideburg, Norman E, Saldivar, Ayda, Vasavanonda, Sudthida, Marsh, Kennan C, Bryant, Pamela
Published in Journal of medicinal chemistry (01.02.1993)
Published in Journal of medicinal chemistry (01.02.1993)
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Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy
Kempf, Dale J, Sham, Hing L, Marsh, Kennan C, Flentge, Charles A, Betebenner, David, Green, Brian E, McDonald, Edith, Vasavanonda, Sudthida, Saldivar, Ayda, Wideburg, Norman E, Kati, Warren M, Ruiz, Lisa, Zhao, Chen, Fino, LynnMarie, Patterson, Jean, Molla, Akhteruzzaman, Plattner, Jacob J, Norbeck, Daniel W
Published in Journal of medicinal chemistry (12.02.1998)
Published in Journal of medicinal chemistry (12.02.1998)
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Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands
XIAOQI CHEN, KEMPF, Dale J, LIN LI, SHAM, Hing L, VASAVANONDA, Sudthida, WIDEBURG, Norman E, SALDIVAR, Ayda, MARSH, Kennan C, MCDONALD, Edith, NORBECK, Daniel W
Published in Bioorganic & medicinal chemistry letters (03.11.2003)
Published in Bioorganic & medicinal chemistry letters (03.11.2003)
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Journal Article
Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P 2 ligands
Chen, Xiaoqi, Kempf, Dale J., Li, Lin, Sham, Hing L., Vasavanonda, Sudthida, Wideburg, Norman E., Saldivar, Ayda, Marsh, Kennan C., McDonald, Edith, Norbeck, Daniel W.
Published in Bioorganic & medicinal chemistry letters (01.11.2003)
Published in Bioorganic & medicinal chemistry letters (01.11.2003)
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Journal Article
Influence of stereochemistry on activity and binding modes for C2 symmetry-based diol inhibitors of HIV-1 protease
Hosur, Madhusoodan V, Bhat, T. Narayana, Kempf, Dale J, Baldwin, Eric T, Liu, Beishan, Gulnik, Sergei, Wideburg, Norman E, Norbeck, Daniel W, Appelt, Krzysztof, Erickson, John W
Published in Journal of the American Chemical Society (01.02.1994)
Published in Journal of the American Chemical Society (01.02.1994)
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Journal Article
A Novel, Picomolar Inhibitor of Human Immunodeficiency Virus Type 1 Protease
Sham, Hing L, Zhao, Chen, Stewart, Kent D, Betebenner, David A, Lin, Shuqun, Park, Chang H, Kong, Xiang-P, Rosenbrook, William, Herrin, Thomas, Madigan, Darold, Vasavanonda, Suthida, Lyons, Nicholas, Molla, Akhter, Saldivar, Ayda, Marsh, Kennan C, McDonald, Edith, Wideburg, Norman E, Denissen, Jon F, Robins, Terrel, Kempf, Dale J, Plattner, Jacob J, Norbeck, Daniel W
Published in Journal of medicinal chemistry (19.01.1996)
Published in Journal of medicinal chemistry (19.01.1996)
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Journal Article
Structure-based, C2 symmetric inhibitors of HIV protease
Kempf, Dale J, Norbeck, Daniel W, Codacovi, LynnMarie, Wang, Xiu Chun, Kohlbrenner, William E, Wideburg, Norman E, Paul, Deborah A, Knigge, Mark F, Vasavanonda, Sudthida
Published in Journal of medicinal chemistry (01.10.1990)
Published in Journal of medicinal chemistry (01.10.1990)
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POTENT INHIBITOR OF THE HUMAN RHINOVIRUS (HRV) 3C PROTEASE CONTAINING A BACKBONE MODIFIED GLUTAMINE
SHAM, HL, ROSENBROOK, W, KATI, W, BETEBENNER, DA, WIDEBURG, NE, SALDIVAR, A, PLATTNER, JJ, NORBECK, DW
Published in Journal of the Chemical Society, Perkin Transactions 1 (1995)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1995)
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Journal Article
ABT-538 is a Potent Inhibitor of Human Immunodeficiency Virus Protease and has High Oral Bioavailability in Humans
Kempf, Dale J., Marsh, Kennan C., Denissen, Jon F., McDonald, Edith, Vasavanonda, Sudthida, Flentge, Charles A., Green, Brian E., Fino, Lynnmarie, Park, Chang H., Kong, Xiang-Peng, Wideburg, Norman E., Saldivar, Ayda, Ruiz, Lisa, Kati, Warren M., Sham, Hing L., Robins, Terry, Stewart, Kent D., Hsu, Ann, Plattner, Jacob J., Leonard, John M., Norbeck, Daniel W.
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.1995)
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.1995)
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Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor
HO, D. D, TOYOSHIMA, T, HONGMEI MO, KEMPF, D. J, NORBECK, D, CHIH-MING CHEN, WIDEBURG, N. E, BURT, S. K, ERICKSON, J. W, SINGH, M. K
Published in Journal of Virology (01.03.1994)
Published in Journal of Virology (01.03.1994)
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Journal Article
Facile synthesis of potent HIV-1 protease inhibitors containing a novel pseudo-symmetric dipeptide isostere
SHAM, H. L, BETEBENNER, D. A, CHEN ZHAO, WIDEBURG, N. E, AYDA SALDIVAR, KEMPF, D. J, PLATTNER, J. J, NORBECK, D. W
Published in Journal of the Chemical Society. Chemical communications (1993)
Published in Journal of the Chemical Society. Chemical communications (1993)
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Journal Article
Synthesis of (2S,5S,4R)-2,5-diamino-3,3-difluoro-1,6-diphenylhydroxyhexane : the core unit of a potent HIV proteinase inhibitor
SHAM, H. L, WIDEBURG, N. E, SPANTON, S. G, KOHLBRENNER, W. E, BETEBENNER, D. A, KEMPF, D. J, NORBECK, D. W, PLATTNER, J. J, ERICKSON, J. W
Published in Journal of the Chemical Society. Chemical communications (1991)
Published in Journal of the Chemical Society. Chemical communications (1991)
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A NEW AMINOGLYCOSIDE ANTIBIOTIC COMPLEX-THE SELDOMYCINS: IV. THE STRUCTURE OF SELDOMYCIN FACTOR 5
MCALPINE, JAMES B., SINCLAIR, ARTHUR C., EGAN, RICHARD S., VAULT, R. LARRY DE, STANASZEK, RUTH S., CIROVIC, MOMIR, MUELLER, SANDRA L., GOODLEY, PAUL C., MAURITZ, ROBERT J., WIDEBURG, NORMAN E., MITSCHER, LESTER A., SHIRAHATA, KUNIKATSU, MATSUSHIMA, HIDEO, SATO, SEIJI, IIDA, TAKAO
Published in Journal of antibiotics (1977)
Published in Journal of antibiotics (1977)
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Evaluation of furofuran as a P2 ligand for symmetry-based HIV protease inhibitors
Chen, Xiaoqi, Li, Lin, Kempf, Dale J., Sham, Hing, Wideburg, Norman E., Saldivar, Ayda, Vasavanonda, Sudthida, Marsh, Kennan C., McDonald, Edith, Norbeck, Daniel W.
Published in Bioorganic & medicinal chemistry letters (03.12.1996)
Published in Bioorganic & medicinal chemistry letters (03.12.1996)
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Journal Article
Design of orally bioavailable, symmetry-based inhibitors of HIV protease
Kempf, Dale J., Marsh, Kennan C., Fino, Lynnmarie Codacovi, Bryant, Pamela, Craig-Kennard, Adrienne, Sham, Hing L., Zhao, Chen, Vasavanonda, Sudthida, Kohlbrenner, William E., Wideburg, Norman E., Saldivar, Ayda, Green, Brian E., Herrin, Thomas, Norbeck, Daniel W.
Published in Bioorganic & medicinal chemistry (01.09.1994)
Published in Bioorganic & medicinal chemistry (01.09.1994)
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Journal Article
Potent piperazine hydroxyethylamine HIV protease inhibitors containing novel P 3 ligands
Chen, Xiaoqi, Kempf, Dale J., Sham, Hing L., Green, Brian E., Molla, Akhteruzaman, Korneyeva, Marina, Vasavanonda, Sudthida, Wideburg, Norman E., Saldivar, Ayda, Marsh, Kennan C., McDonald, Edith, Norbeck, Daniel W.
Published in Bioorganic & medicinal chemistry letters (15.12.1998)
Published in Bioorganic & medicinal chemistry letters (15.12.1998)
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Journal Article
Potent piperazine hydroxyethylamine HIV protease inhibitors containing novel p3 ligands
XIAOQI CHEN, KEMPF, D. J, MCDONALD, E, NORBECK, D. W, SHAM, H. L, GREEN, B. E, MOLLA, A, KORNEYEVA, M, VASAVANONDA, S, WIDEBURG, N. E, SALDIVAR, A, MARSH, K. C
Published in Bioorganic & medicinal chemistry letters (15.12.1998)
Published in Bioorganic & medicinal chemistry letters (15.12.1998)
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Journal Article
Evaluation of substituted benzamides as P2 ligands for symmetry-based inhibitors of HIV protease
Kempf, Dale J., Flentge, Charles A., Wideburg, Norman E., Saldivar, Ayda, Vasavanonda, Sudthida, Norbeck, Daniel W.
Published in Bioorganic & medicinal chemistry letters (16.11.1995)
Published in Bioorganic & medicinal chemistry letters (16.11.1995)
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Journal Article
Evaluation of furofuran as a P 2 ligand for symmetry-based HIV protease inhibitors
Chen, Xiaoqi, Li, Lin, Kempf, Dale J., Sham, Hing, Wideburg, Norman E., Saldivar, Ayda, Vasavanonda, Sudthida, Marsh, Kennan C., McDonald, Edith, Norbeck, Daniel W.
Published in Bioorganic & medicinal chemistry letters (03.12.1996)
Published in Bioorganic & medicinal chemistry letters (03.12.1996)
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Journal Article
Novel Azacyclic Ureas That Are Potent Inhibitors of HIV-1 Protease
Sham, Hing L., Zhao, Chen, Marsh, Kennan C., Betebenner, David A., Lin, Shuqun, Jr, William Rosenbrook, Herrin, Thomas, Li, Leping, Madigan, Darold, Vasavanonda, Suthida, Molla, Akhter, Saldivar, Ayda, McDonald, Edith, Wideburg, Norman E., Kempf, Dale, Norbeck, Daniel W., Plattner, Jacob J.
Published in Biochemical and biophysical research communications (14.08.1996)
Published in Biochemical and biophysical research communications (14.08.1996)
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