Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy
Kempf, Dale J, Sham, Hing L, Marsh, Kennan C, Flentge, Charles A, Betebenner, David, Green, Brian E, McDonald, Edith, Vasavanonda, Sudthida, Saldivar, Ayda, Wideburg, Norman E, Kati, Warren M, Ruiz, Lisa, Zhao, Chen, Fino, LynnMarie, Patterson, Jean, Molla, Akhteruzzaman, Plattner, Jacob J, Norbeck, Daniel W
Published in Journal of medicinal chemistry (12.02.1998)
Published in Journal of medicinal chemistry (12.02.1998)
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Journal Article
Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor
HO, D. D, TOYOSHIMA, T, HONGMEI MO, KEMPF, D. J, NORBECK, D, CHIH-MING CHEN, WIDEBURG, N. E, BURT, S. K, ERICKSON, J. W, SINGH, M. K
Published in Journal of Virology (01.03.1994)
Published in Journal of Virology (01.03.1994)
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Journal Article
Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol
Kempf, Dale J, Codacovi, Lynnmarie, Wang, Xiu Chun, Kohlbrenner, William E, Wideburg, Norman E, Saldivar, Ayda, Vasavanonda, Sudthida, Marsh, Kennan C, Bryant, Pamela
Published in Journal of medicinal chemistry (01.02.1993)
Published in Journal of medicinal chemistry (01.02.1993)
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Journal Article
A Novel, Picomolar Inhibitor of Human Immunodeficiency Virus Type 1 Protease
Sham, Hing L, Zhao, Chen, Stewart, Kent D, Betebenner, David A, Lin, Shuqun, Park, Chang H, Kong, Xiang-P, Rosenbrook, William, Herrin, Thomas, Madigan, Darold, Vasavanonda, Suthida, Lyons, Nicholas, Molla, Akhter, Saldivar, Ayda, Marsh, Kennan C, McDonald, Edith, Wideburg, Norman E, Denissen, Jon F, Robins, Terrel, Kempf, Dale J, Plattner, Jacob J, Norbeck, Daniel W
Published in Journal of medicinal chemistry (19.01.1996)
Published in Journal of medicinal chemistry (19.01.1996)
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Journal Article
Potent piperazine hydroxyethylamine HIV protease inhibitors containing novel p3 ligands
XIAOQI CHEN, KEMPF, D. J, MCDONALD, E, NORBECK, D. W, SHAM, H. L, GREEN, B. E, MOLLA, A, KORNEYEVA, M, VASAVANONDA, S, WIDEBURG, N. E, SALDIVAR, A, MARSH, K. C
Published in Bioorganic & medicinal chemistry letters (15.12.1998)
Published in Bioorganic & medicinal chemistry letters (15.12.1998)
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Journal Article
Potent Inhibitors of the HIV-1 Protease with Good Oral Bioavailabilities
Sham, H.L., Zhao, C., Marsh, K.C., Betebenner, D.A., Lin, S.Q., Mcdonald, E., Vasavanonda, S., Wideburg, N., Saldivar, A., Robins, T., Kempf, D.J., Plattner, J.J., Norbeck, D.W.
Published in Biochemical and biophysical research communications (06.06.1995)
Published in Biochemical and biophysical research communications (06.06.1995)
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Journal Article
ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease
SHAM, H. L, KEMPF, D. J, BETEBENNER, D, KORNEYEVA, M, VASAVANONDA, S, MCDONALD, E, SALDIVAR, A, WIDEBURG, N, XIAOOI CHEN, PING NIU, CHANG PARK, JAYANTI, V, MOLLA, A, GRABOWSKI, B, GRANNEMAN, G. R, SUN, E, JAPOUR, A. J, LEONARD, J. M, PLATTNER, J. J, NORBECK, D. W, MARSH, K. C, KUMAR, G. N, CHEN, C.-M, KATI, W, STEWART, K, LAL, R, HSU, A
Published in Antimicrobial Agents and Chemotherapy (01.12.1998)
Published in Antimicrobial Agents and Chemotherapy (01.12.1998)
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Journal Article
Potent HIV-1 protease inhibitors with antiviral activities in vitro
Sham, Hing L., Betebenner, David A., Wideburg, Norman E., Saldivar, Ayda C., Kohlbrenner, William E., Vasavanonda, Sudthida, Kempf, Dale J., Norbeck, Daniel W., Zhao, Chen, Clement, Jacob J., Erickson, John E., Plattner, Jacob J.
Published in Biochemical and biophysical research communications (29.03.1991)
Published in Biochemical and biophysical research communications (29.03.1991)
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Journal Article
Novel Azacyclic Ureas That Are Potent Inhibitors of HIV-1 Protease
Sham, Hing L., Zhao, Chen, Marsh, Kennan C., Betebenner, David A., Lin, Shuqun, Jr, William Rosenbrook, Herrin, Thomas, Li, Leping, Madigan, Darold, Vasavanonda, Suthida, Molla, Akhter, Saldivar, Ayda, McDonald, Edith, Wideburg, Norman E., Kempf, Dale, Norbeck, Daniel W., Plattner, Jacob J.
Published in Biochemical and biophysical research communications (14.08.1996)
Published in Biochemical and biophysical research communications (14.08.1996)
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Journal Article
Lack of stereospecificity in the binding of the P2 amino acid of ritonavir to HIV protease
Kempf, Dale J., Molla, Akhteruzzaman, Marsh, Kennan C., Park, Chang, Rodrigues, A.David, Korneyeva, Marina, Vasavanonda, Sudthida, McDonald, Edith, Flentge, Charles A., Muchmore, Steven, Wideburg, Norman E., Saldivar, Ayda, Cooper, Art, Kati, Warren M., Stewart, Kent D., Norbeck, Daniel W.
Published in Bioorganic & medicinal chemistry letters (18.03.1997)
Published in Bioorganic & medicinal chemistry letters (18.03.1997)
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Journal Article
SYNTHETIC CHEMICAL DIVERSITY - SOLID-PHASE SYNTHESIS OF LIBRARIES OF C-2 SYMMETRICAL INHIBITORS OF HIV PROTEASE CONTAINING DIAMINO DIOL AND DIAMINO ALCOHOL CORES
WANG, GT, LI, S, WIDEBURG, N, KRAFFT, GA, KEMPF, DJ
Published in Journal of medicinal chemistry (04.08.1995)
Published in Journal of medicinal chemistry (04.08.1995)
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Journal Article
Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease
Erickson, J, Neidhart, D J, VanDrie, J, Kempf, D J, Wang, X C, Norbeck, D W, Plattner, J J, Rittenhouse, J W, Turon, M, Wideburg, N
Published in Science (American Association for the Advancement of Science) (03.08.1990)
Published in Science (American Association for the Advancement of Science) (03.08.1990)
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Journal Article
Influence of stereochemistry on activity and binding modes for C2 symmetry-based diol inhibitors of HIV-1 protease
Hosur, Madhusoodan V, Bhat, T. Narayana, Kempf, Dale J, Baldwin, Eric T, Liu, Beishan, Gulnik, Sergei, Wideburg, Norman E, Norbeck, Daniel W, Appelt, Krzysztof, Erickson, John W
Published in Journal of the American Chemical Society (01.02.1994)
Published in Journal of the American Chemical Society (01.02.1994)
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Journal Article
Synthetic chemical diversity: solid phase synthesis of libraries of C2 symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol cores
Wang, Gary T, Li, Sam, Wideburg, Norman, Krafft, Grant A, Kempf, Dale J
Published in Journal of medicinal chemistry (01.08.1995)
Published in Journal of medicinal chemistry (01.08.1995)
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Journal Article
Antiviral and pharmacokinetic properties of C2 symmetric inhibitors of the human immunodeficiency virus type 1 protease
Kempf, D J, Marsh, K C, Paul, D A, Knigge, M F, Norbeck, D W, Kohlbrenner, W E, Codacovi, L, Vasavanonda, S, Bryant, P, Wang, X C
Published in Antimicrobial Agents and Chemotherapy (01.11.1991)
Published in Antimicrobial Agents and Chemotherapy (01.11.1991)
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Journal Article
Design of orally bioavailable, symmetry-based inhibitors of HIV protease
Kempf, Dale J., Marsh, Kennan C., Fino, Lynnmarie Codacovi, Bryant, Pamela, Craig-Kennard, Adrienne, Sham, Hing L., Zhao, Chen, Vasavanonda, Sudthida, Kohlbrenner, William E., Wideburg, Norman E., Saldivar, Ayda, Green, Brian E., Herrin, Thomas, Norbeck, Daniel W.
Published in Bioorganic & medicinal chemistry (01.09.1994)
Published in Bioorganic & medicinal chemistry (01.09.1994)
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Journal Article
ABT-538 is a Potent Inhibitor of Human Immunodeficiency Virus Protease and has High Oral Bioavailability in Humans
Kempf, Dale J., Marsh, Kennan C., Denissen, Jon F., McDonald, Edith, Vasavanonda, Sudthida, Flentge, Charles A., Green, Brian E., Fino, Lynnmarie, Park, Chang H., Kong, Xiang-Peng, Wideburg, Norman E., Saldivar, Ayda, Ruiz, Lisa, Kati, Warren M., Sham, Hing L., Robins, Terry, Stewart, Kent D., Hsu, Ann, Plattner, Jacob J., Leonard, John M., Norbeck, Daniel W.
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.1995)
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.1995)
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Journal Article
Synthetic chemical diversity: Solid phase synthesis of libraries of C sub(2) symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol cores
Wang, G T, Li, S, Wideburg, N, Krafft, G A, Kempf, D J
Published in Journal of medicinal chemistry (01.01.1995)
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Published in Journal of medicinal chemistry (01.01.1995)
Journal Article
Synthesis of (2S,5S,4R)-2,5-diamino-3,3-difluoro-1,6-diphenylhydroxyhexane : the core unit of a potent HIV proteinase inhibitor
SHAM, H. L, WIDEBURG, N. E, SPANTON, S. G, KOHLBRENNER, W. E, BETEBENNER, D. A, KEMPF, D. J, NORBECK, D. W, PLATTNER, J. J, ERICKSON, J. W
Published in Journal of the Chemical Society. Chemical communications (1991)
Published in Journal of the Chemical Society. Chemical communications (1991)
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Journal Article
Influence of stereochemistry on activity and binding modes for C sub(2) symmetry-based diol inhibitors of HIV-1 protease
Hosur, M V, Bhat, T N, Kempf, D J, Baldwin, E T, Liu, B, Gulnik, S, Wideburg, N E, Norbeck, D W, Appelt, K, Erickson, J W
Published in Journal of the American Chemical Society (01.01.1994)
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Published in Journal of the American Chemical Society (01.01.1994)
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