Inhibitors of cyclin-dependent kinases as cancer therapeutics
Whittaker, Steven R, Mallinger, Aurélie, Workman, Paul, Clarke, Paul A
Published in Pharmacology & therapeutics (Oxford) (01.05.2017)
Published in Pharmacology & therapeutics (Oxford) (01.05.2017)
Get full text
Journal Article
A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition
Whittaker, Steven R, Theurillat, Jean-Philippe, Van Allen, Eliezer, Wagle, Nikhil, Hsiao, Jessica, Cowley, Glenn S, Schadendorf, Dirk, Root, David E, Garraway, Levi A
Published in Cancer discovery (01.03.2013)
Published in Cancer discovery (01.03.2013)
Get full text
Journal Article
Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
Heidorn, Sonja J., Milagre, Carla, Whittaker, Steven, Nourry, Arnaud, Niculescu-Duvas, Ion, Dhomen, Nathalie, Hussain, Jahan, Reis-Filho, Jorge S., Springer, Caroline J., Pritchard, Catrin, Marais, Richard
Published in Cell (22.01.2010)
Published in Cell (22.01.2010)
Get full text
Journal Article
Increased inflammatory lipid metabolism and anaplerotic mitochondrial activation follow acquired resistance to vemurafenib in BRAF-mutant melanoma cells
Delgado-Goñi, Teresa, Galobart, Teresa Casals, Wantuch, Slawomir, Normantaite, Deimante, Leach, Martin O., Whittaker, Steven R., Beloueche-Babari, Mounia
Published in British journal of cancer (01.01.2020)
Published in British journal of cancer (01.01.2020)
Get full text
Journal Article
A genome-scale CRISPR screen identifies the ERBB and mTOR signalling networks as key determinants of response to PI3K inhibition in pancreatic cancer
Milton, Charlotte K, Self, Annette J, Clarke, Paul A, Banerji, Udai, Piccioni, Federica, Root, David E, Whittaker, Steven R
Published in Molecular cancer therapeutics (01.07.2020)
Published in Molecular cancer therapeutics (01.07.2020)
Get full text
Journal Article
Combined targeting of MEK and the glucocorticoid receptor for the treatment of RAS-mutant multiple myeloma
Sriskandarajah, Priya, De Haven Brandon, Alexis, MacLeod, Kenneth, Carragher, Neil O, Kirkin, Vladimir, Kaiser, Martin, Whittaker, Steven R
Published in BMC cancer (30.03.2020)
Published in BMC cancer (30.03.2020)
Get full text
Journal Article
Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer
Wagner, Steve, Vlachogiannis, Georgios, De Haven Brandon, Alexis, Valenti, Melanie, Box, Gary, Jenkins, Liam, Mancusi, Caterina, Self, Annette, Manodoro, Floriana, Assiotis, Ioannis, Robinson, Penny, Chauhan, Ritika, Rust, Alistair G., Matthews, Nik, Eason, Kate, Khan, Khurum, Starling, Naureen, Cunningham, David, Sadanandam, Anguraj, Isacke, Clare M., Kirkin, Vladimir, Valeri, Nicola, Whittaker, Steven R.
Published in Oncogene (01.03.2019)
Published in Oncogene (01.03.2019)
Get full text
Journal Article
Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor
Whittaker, Steven R., Barlow, Clare, Martin, Mathew P., Mancusi, Caterina, Wagner, Steve, Self, Annette, Barrie, Elaine, Te Poele, Robert, Sharp, Swee, Brown, Nathan, Wilson, Stuart, Jackson, Wayne, Fischer, Peter M., Clarke, Paul A., Walton, Michael I., McDonald, Edward, Blagg, Julian, Noble, Martin, Garrett, Michelle D., Workman, Paul
Published in Molecular oncology (01.03.2018)
Published in Molecular oncology (01.03.2018)
Get full text
Journal Article
Gatekeeper mutations mediate resistance to BRAF-targeted therapies
Whittaker, Steven, Kirk, Ruth, Hayward, Robert, Zambon, Alfonso, Viros, Amaya, Cantarino, Neus, Affolter, Annette, Nourry, Arnaud, Niculescu-Duvaz, Dan, Springer, Caroline, Marais, Richard
Published in Science translational medicine (09.06.2010)
Published in Science translational medicine (09.06.2010)
Get more information
Journal Article
The cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of cyclin D1, and activates the mitogen-activated protein kinase pathway
WHITTAKER, Steven R, WALTON, Mike I, GARRETT, Michelle D, WORKMAN, Paul
Published in Cancer research (Chicago, Ill.) (2004)
Published in Cancer research (Chicago, Ill.) (2004)
Get full text
Journal Article
Correction: Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer
Wagner, Steve, Vlachogiannis, Georgios, De Haven Brandon, Alexis, Valenti, Melanie, Box, Gary, Jenkins, Liam, Mancusi, Caterina, Self, Annette, Manodoro, Floriana, Assiotis, Ioannis, Robinson, Penny, Chauhan, Ritika, Rust, Alistair G., Matthews, Nik, Eason, Kate, Khan, Khurum, Starling, Naureen, Cunningham, David, Sadanandam, Anguraj, Isacke, Clare M., Kirkin, Vladimir, Valeri, Nicola, Whittaker, Steven R.
Published in Oncogene (01.07.2019)
Published in Oncogene (01.07.2019)
Get full text
Journal Article
A phospho-proteomic study of cetuximab resistance in KRAS/NRAS/BRAFV600 wild-type colorectal cancer
Georgiou, Alexandros, Stewart, Adam, Vlachogiannis, Georgios, Pickard, Lisa, Valeri, Nicola, Cunningham, David, Whittaker, Steven R., Banerji, Udai
Published in Cellular oncology (Dordrecht) (2021)
Published in Cellular oncology (Dordrecht) (2021)
Get full text
Journal Article
Tissue-Specific Human Extracellular Matrix Scaffolds Promote Pancreatic Tumour Progression and Chemotherapy Resistance
Al-Akkad, Walid, Acedo, Pilar, Vilia, Maria-Giovanna, Frenguelli, Luca, Ney, Alexander, Rodriguez-Hernandez, Irene, Labib, Peter L, Tamburrino, Domenico, Spoletini, Gabriele, Hall, Andrew R, Canestrari, Simone, Osnato, Anna, Garcia-Bernardo, Jose, Sejour, Leinal, Vassileva, Vessela, Vlachos, Ioannis S, Fusai, Giuseppe, Luong, Tu Vinh, Whittaker, Steven R, Pereira, Stephen P, Vallier, Ludovic, Pinzani, Massimo, Rombouts, Krista, Mazza, Giuseppe
Published in Cells (Basel, Switzerland) (01.11.2022)
Published in Cells (Basel, Switzerland) (01.11.2022)
Get full text
Journal Article
The Cyclin-Dependent Kinase Inhibitor Seliciclib (R-roscovitine; CYC202) Decreases the Expression of Mitotic Control Genes and Prevents Entry into Mitosis
Whittaker, Steven R., te Poele, Robert H., Chan, Florence, Linardopoulos, Spiros, Walton, Michael I., Garrett, Michelle D., Workman, Paul
Published in Cell cycle (Georgetown, Tex.) (15.12.2007)
Published in Cell cycle (Georgetown, Tex.) (15.12.2007)
Get full text
Journal Article
In vitro and In vivo Pharmacokinetic-Pharmacodynamic Relationships for the Trisubstituted Aminopurine Cyclin-Dependent Kinase Inhibitors Olomoucine, Bohemine and CYC202
RAYNAUD, Florence I, WHITTAKER, Steven R, VALENTI, Melanie, BRUNTON, Lisa, ECCLES, Suzanne, LANE, David P, WORKMAN, Paul, FISCHER, Peter M, MCCLUE, Steven, WALTON, Michael I, BARRIE, S. Elaine, GARRETT, Michelle D, ROGERS, Paul, CLARKE, Simon J, KELLAND, Lloyd R
Published in Clinical cancer research (01.07.2005)
Published in Clinical cancer research (01.07.2005)
Get full text
Journal Article
Molecular profiling and combinatorial activity of CCT 068127: a potent CDK 2 and CDK 9 inhibitor
Whittaker, Steven R., Barlow, Clare, Martin, Mathew P., Mancusi, Caterina, Wagner, Steve, Self, Annette, Barrie, Elaine, Te Poele, Robert, Sharp, Swee, Brown, Nathan, Wilson, Stuart, Jackson, Wayne, Fischer, Peter M., Clarke, Paul A., Walton, Michael I., McDonald, Edward, Blagg, Julian, Noble, Martin, Garrett, Michelle D., Workman, Paul
Published in Molecular oncology (01.03.2018)
Published in Molecular oncology (01.03.2018)
Get full text
Journal Article
Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors
Wilson, Stuart C., Atrash, Butrus, Barlow, Clare, Eccles, Susan, Fischer, Peter M., Hayes, Angela, Kelland, Lloyd, Jackson, Wayne, Jarman, Michael, Mirza, Amin, Moreno, Javier, Nutley, Bernard P., Raynaud, Florence I., Sheldrake, Peter, Walton, Mike, Westwood, Robert, Whittaker, Steven, Workman, Paul, McDonald, Edward
Published in Bioorganic & medicinal chemistry (15.11.2011)
Published in Bioorganic & medicinal chemistry (15.11.2011)
Get full text
Journal Article
Novel Inhibitors of the v-raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) Based on a 2,6-Disubstituted Pyrazine Scaffold
Niculescu-Duvaz, Ion, Roman, Esteban, Whittaker, Steven R, Friedlos, Frank, Kirk, Ruth, Scanlon, Ian J, Davies, Lawrence C, Niculescu-Duvaz, Dan, Marais, Richard, Springer, Caroline J
Published in Journal of medicinal chemistry (12.06.2008)
Published in Journal of medicinal chemistry (12.06.2008)
Get full text
Journal Article