The support of human genetic evidence for approved drug indications
Nelson, Matthew R, Tipney, Hannah, Painter, Jeffery L, Shen, Judong, Nicoletti, Paola, Shen, Yufeng, Floratos, Aris, Sham, Pak Chung, Li, Mulin Jun, Wang, Junwen, Cardon, Lon R, Whittaker, John C, Sanseau, Philippe
Published in Nature genetics (01.08.2015)
Published in Nature genetics (01.08.2015)
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Simultaneous analysis of all SNPs in genome-wide and re-sequencing association studies
Hoggart, Clive J, Whittaker, John C, De Iorio, Maria, Balding, David J
Published in PLoS genetics (01.07.2008)
Published in PLoS genetics (01.07.2008)
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Selecting instruments for Mendelian randomization in the wake of genome-wide association studies
Swerdlow, Daniel I, Kuchenbaecker, Karoline B, Shah, Sonia, Sofat, Reecha, Holmes, Michael V, White, Jon, Mindell, Jennifer S, Kivimaki, Mika, Brunner, Eric J, Whittaker, John C, Casas, Juan P, Hingorani, Aroon D
Published in International journal of epidemiology (01.10.2016)
Published in International journal of epidemiology (01.10.2016)
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Evaluation of genetic markers as instruments for Mendelian randomization studies on vitamin D
Berry, Diane J, Vimaleswaran, Karani S, Whittaker, John C, Hingorani, Aroon D, Hyppönen, Elina
Published in PloS one (21.05.2012)
Published in PloS one (21.05.2012)
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Using genetic association data to guide drug discovery and development: Review of methods and applications
Burgess, Stephen, Mason, Amy M., Grant, Andrew J., Slob, Eric A.W., Gkatzionis, Apostolos, Zuber, Verena, Patel, Ashish, Tian, Haodong, Liu, Cunhao, Haynes, William G., Hovingh, G. Kees, Knudsen, Lotte Bjerre, Whittaker, John C., Gill, Dipender
Published in American journal of human genetics (02.02.2023)
Published in American journal of human genetics (02.02.2023)
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An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People
Nelson, Matthew R., Wegmann, Daniel, Ehm, Margaret G., Kessner, Darren, St. Jean, Pamela, Verzilli, Claudio, Shen, Judong, Tang, Zhengzheng, Bacanu, Silviu-Alin, Fraser, Dana, Warren, Liling, Aponte, Jennifer, Zawistowski, Matthew, Liu, Xiao, Zhang, Hao, Zhang, Yong, Li, Jun, Li, Yun, Li Li, Woollard, Peter, Topp, Simon, Hall, Matthew D., Nangle, Keith, Wang, Jun, Abecasis, Gonçalo, Cardon, Lon R., Zöllner, Sebastian, Whittaker, John C., Chissoe, Stephanie L., Novembre, John, Mooser, Vincent
Published in Science (American Association for the Advancement of Science) (06.07.2012)
Published in Science (American Association for the Advancement of Science) (06.07.2012)
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Doppler ultrasound is more accurate than pulse oximeter plethysmography in the measurement of systolic arterial pressure from the median caudal artery in anesthetized dogs
Whittaker, John H, Kapaldo, Nathaniel, Bortoluzzi, Eduarda M, Rankin, David C
Published in American journal of veterinary research (01.06.2024)
Published in American journal of veterinary research (01.06.2024)
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Evidence for an Interaction Between Familial Liability and Prenatal Exposure to Infection in the Causation of Schizophrenia
Clarke, Mary C., Tanskanen, Antti, Huttunen, Matti, Whittaker, John C., Cannon, Mary
Published in The American journal of psychiatry (01.09.2009)
Published in The American journal of psychiatry (01.09.2009)
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Conference Proceeding
Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials
Holmes, Michael V, DLSHTM, Newcombe, Paul, PhD, Hubacek, Jaroslav A, PhD, Sofat, Reecha, PhD, Ricketts, Sally L, PhD, Cooper, Jackie, MSc, Breteler, Monique MB, Prof, Bautista, Leonelo E, DrPH, Sharma, Pankaj, MD, Whittaker, John C, Prof, Smeeth, Liam, Prof, Fowkes, F Gerald R, Prof, Algra, Ale, Prof, Shmeleva, Veronika, MD, Szolnoki, Zoltan, PhD, Roest, Mark, PhD, Linnebank, Michael, MD, Zacho, Jeppe, MD, Nalls, Michael A, PhD, Singleton, Andrew B, PhD, Ferrucci, Luigi, MD, Hardy, John, Prof, Worrall, Bradford B, MD, Rich, Stephen S, Prof, Matarin, Mar, PhD, Norman, Paul E, FRACS, Flicker, Leon, FRACP, Almeida, Osvaldo P, Prof, van Bockxmeer, Frank M, Prof, Shimokata, Hiroshi, Prof, Khaw, Kay-Tee, Prof, Wareham, Nicholas J, Prof, Bobak, Martin, Prof, Sterne, Jonathan AC, Prof, Smith, George Davey, Prof, Talmud, Philippa J, Prof, van Duijn, Cornelia, Prof, Humphries, Steve E, Prof, Price, Jackie F, FFPH, Ebrahim, Shah, Prof, Lawlor, Debbie A, Prof, Hankey, Graeme J, FRACP, Meschia, James F, Prof, Sandhu, Manjinder S, PhD, Hingorani, Aroon D, Prof, Casas, Juan P, Dr
Published in The Lancet (British edition) (13.08.2011)
Published in The Lancet (British edition) (13.08.2011)
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HLA-DQA102:01 Is a Major Risk Factor for Lapatinib-Induced Hepatotoxicity in Women With Advanced Breast Cancer
SPRAGGS, Colin F, BUDDE, Laura R, CARDON, Lon R, BRILEY, Linda P, NAN BING, COX, Charles J, KING, Karen S, WHITTAKER, John C, MOOSER, Vincent E, PRESTON, Alaknanda J, STEIN, Steven H
Published in Journal of clinical oncology (20.02.2011)
Published in Journal of clinical oncology (20.02.2011)
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Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study
Talmud, Philippa J, Prof, Shah, Sonia, MSc, Whittall, Ros, MSc, Futema, Marta, BSc, Howard, Philip, BSc, Cooper, Jackie A, MSc, Harrison, Seamus C, MRCS, Li, KaWah, MSc, Drenos, Fotios, PhD, Karpe, Frederik, PhD, Neil, H Andrew W, Prof, Descamps, Olivier S, PhD, Langenberg, Claudia, PhD, Lench, Nicholas, PhD, Kivimaki, Mika, Prof, Whittaker, John, Prof, Hingorani, Aroon D, Prof, Kumari, Meena, PhD, Humphries, Steve E, Prof
Published in The Lancet (British edition) (13.04.2013)
Published in The Lancet (British edition) (13.04.2013)
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The role and interaction of imprinted genes in human fetal growth
Moore, Gudrun E., Ishida, Miho, Demetriou, Charalambos, Al-Olabi, Lara, Leon, Lydia J., Thomas, Anna C., Abu-Amero, Sayeda, Frost, Jennifer M., Stafford, Jaime L., Chaoqun, Yao, Duncan, Andrew J., Baigel, Rachel, Brimioulle, Marina, Iglesias-Platas, Isabel, Apostolidou, Sophia, Aggarwal, Reena, Whittaker, John C., Syngelaki, Argyro, Nicolaides, Kypros H., Regan, Lesley, Monk, David, Stanier, Philip
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (05.03.2015)
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (05.03.2015)
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The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
Swerdlow, Daniel I, Holmes, Michael V, Kuchenbaecker, Karoline B, Engmann, Jorgen E L, Shah, Tina, Sofat, Reecha, Guo, Yiran, Chung, Christina, Peasey, Anne, Pfister, Roman, Mooijaart, Simon P, Ireland, Helen A, Leusink, Maarten, Langenberg, Claudia, Li, Ka Wah, Palmen, Jutta, Howard, Philip, Cooper, Jackie A, Drenos, Fotios, Hardy, John, Nalls, Michael A, Li, Yun Rose, Lowe, Gordon, Stewart, Marlene, Bielinski, Suzette J, Peto, Julian, Timpson, Nicholas J, Gallacher, John, Dunlop, Malcolm, Houlston, Richard, Tomlinson, Ian, Tzoulaki, Ioanna, Luan, Jian'an, Boer, Jolanda M A, Forouhi, Nita G, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Schnabel, Renate B, Hubacek, Jaroslav A, Kubinova, Ruzena, Baceviciene, Migle, Tamosiunas, Abdonas, Pajak, Andrzej, Topor-Madry, Roman, Malyutina, Sofia, Baldassarre, Damiano, Sennblad, Bengt, Tremoli, Elena, de Faire, Ulf, Ferrucci, Luigi, Bandenelli, Stefania, Tanaka, Toshiko, Meschia, James F, Singleton, Andrew, Navis, Gerjan, Mateo Leach, Irene, Bakker, Stephan J L, Gansevoort, Ron T, Ford, Ian, Epstein, Stephen E, Burnett, Mary Susan, Devaney, Joe M, Jukema, J Wouter, Westendorp, Rudi G J, Jan de Borst, Gert, van der Graaf, Yolanda, de Jong, Pim A, Mailand-van der Zee, Anke-Hilse, Klungel, Olaf H, de Boer, Anthonius, Doevendans, Pieter A, Stephens, Jeffrey W, Eaton, Charles B, Robinson, Jennifer G, Manson, JoAnn E, Fowkes, F Gerry, Frayling, Timonthy M, Price, Jackie F, Whincup, Peter H, Morris, Richard W, Lawlor, Debbie A, Smith, George Davey, Ben-Shlomo, Yoav, Redline, Susan, Lange, Leslie A, Kumari, Meena, Wareham, Nick J, Verschuren, W M Monique, Benjamin, Emelia J, Whittaker, John C, Hamsten, Anders, Dudbridge, Frank, Delaney, J A Chris, Wong, Andrew, Kuh, Diana, Hardy, Rebecca, Castillo, Berta Almoguera, Connolly, John J, van der Harst, Pim, Brunner, Eric J
Published in The Lancet (British edition) (31.03.2012)
Published in The Lancet (British edition) (31.03.2012)
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Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic
Duncan, Christopher J A, Skouboe, Morten K, Howarth, Sophie, Hollensen, Anne K, Chen, Rui, Børresen, Malene L, Thompson, Benjamin J, Stremenova Spegarova, Jarmila, Hatton, Catherine F, Stæger, Frederik F, Andersen, Mette K, Whittaker, John, Paludan, Søren R, Jørgensen, Sofie E, Thomsen, Martin K, Mikkelsen, Jacob G, Heilmann, Carsten, Buhas, Daniela, Øbro, Nina F, Bay, Jakob T, Marquart, Hanne V, de la Morena, M Teresa, Klejka, Joseph A, Hirschfeld, Matthew, Borgwardt, Line, Forss, Isabel, Masmas, Tania, Poulsen, Anja, Noya, Francisco, Rouleau, Guy, Hansen, Torben, Zhou, Sirui, Albrechtsen, Anders, Alizadehfar, Reza, Allenspach, Eric J, Hambleton, Sophie, Mogensen, Trine H
Published in The Journal of experimental medicine (06.06.2022)
Published in The Journal of experimental medicine (06.06.2022)
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Journal Article
Sixty-five common genetic variants and prediction of type 2 diabetes
Talmud, Philippa J, Cooper, Jackie A, Morris, Richard W, Dudbridge, Frank, Shah, Tina, Engmann, Jorgen, Dale, Caroline, White, Jon, McLachlan, Stela, Zabaneh, Delilah, Wong, Andrew, Ong, Ken K, Gaunt, Tom, Holmes, Michael V, Lawlor, Debbie A, Richards, Marcus, Hardy, Rebecca, Kuh, Diana, Wareham, Nicholas, Langenberg, Claudia, Ben-Shlomo, Yoav, Wannamethee, S Goya, Strachan, Mark W J, Kumari, Meena, Whittaker, John C, Drenos, Fotios, Kivimaki, Mika, Hingorani, Aroon D, Price, Jacqueline F, Humphries, Steve E
Published in Diabetes (New York, N.Y.) (01.05.2015)
Published in Diabetes (New York, N.Y.) (01.05.2015)
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Journal Article
Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis
White, Jon, Dr, Sofat, Reecha, MRCP, Hemani, Gibran, PhD, Shah, Tina, PhD, Engmann, Jorgen, MSc, Dale, Caroline, PhD, Shah, Sonia, PhD, Kruger, Felix A, PhD, Giambartolomei, Claudia, PhD, Swerdlow, Daniel I, PhD, Palmer, Tom, PhD, McLachlan, Stela, PhD, Langenberg, Claudia, PhD, Zabaneh, Delilah, PhD, Lovering, Ruth, PhD, Cavadino, Alana, MSc, Jefferis, Barbara, PhD, Finan, Chris, PhD, Wong, Andrew, PhD, Amuzu, Antoinette, MA, Ong, Ken, PhD, Gaunt, Tom R, PhD, Warren, Helen, PhD, Davies, Teri-Louise, PhD, Drenos, Fotios, PhD, Cooper, Jackie, MSc, Ebrahim, Shah, Prof, Lawlor, Debbie A, Prof, Talmud, Philippa J, Prof, Humphries, Steve E, Prof, Power, Christine, Prof, Hypponen, Elina, Prof, Richards, Marcus, Prof, Hardy, Rebecca, Prof, Kuh, Diana, Prof, Wareham, Nicholas, Prof, Ben-Shlomo, Yoav, Prof, Day, Ian N, Prof, Whincup, Peter, Prof, Morris, Richard, Prof, Strachan, Mark W J, Prof, Price, Jacqueline, Prof, Kumari, Meena, Prof, Kivimaki, Mika, Prof, Plagnol, Vincent, PhD, Whittaker, John C, Prof, Smith, George Davey, Prof, Dudbridge, Frank, Prof, Casas, Juan P, Prof, Holmes, Michael V, Dr, Hingorani, Aroon D, Prof
Published in The lancet. Diabetes & endocrinology (01.04.2016)
Published in The lancet. Diabetes & endocrinology (01.04.2016)
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Journal Article
Refinement of variant selection for the LDL cholesterol genetic risk score in the diagnosis of the polygenic form of clinical familial hypercholesterolemia and replication in samples from 6 countries
Futema, Marta, Shah, Sonia, Cooper, Jackie A, Li, KaWah, Whittall, Ros A, Sharifi, Mahtab, Goldberg, Olivia, Drogari, Euridiki, Mollaki, Vasiliki, Wiegman, Albert, Defesche, Joep, D'Agostino, Maria N, D'Angelo, Antonietta, Rubba, Paolo, Fortunato, Giuliana, Waluś-Miarka, Małgorzata, Hegele, Robert A, Aderayo Bamimore, Mary, Durst, Ronen, Leitersdorf, Eran, Mulder, Monique T, Roeters van Lennep, Jeanine E, Sijbrands, Eric J G, Whittaker, John C, Talmud, Philippa J, Humphries, Steve E
Published in Clinical chemistry (Baltimore, Md.) (01.01.2015)
Published in Clinical chemistry (Baltimore, Md.) (01.01.2015)
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