SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis
Tahlan, Kapil, Wilson, Regina, Kastrinsky, David B, Arora, Kriti, Nair, Vinod, Fischer, Elizabeth, Barnes, S. Whitney, Walker, John R, Alland, David, Barry, Clifton E., III, Boshoff, Helena I
Published in Antimicrobial Agents and Chemotherapy (01.04.2012)
Published in Antimicrobial Agents and Chemotherapy (01.04.2012)
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Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery
Meister, Stephan, Plouffe, David M., Kuhen, Kelli L., Bonamy, Ghislain M. C., Wu, Tao, Barnes, S. Whitney, Bopp, Selina E., Borboa, Rachel, Bright, A. Taylor, Che, Jianwei, Cohen, Steve, Dharia, Neekesh V., Gagaring, Kerstin, Gettayacamin, Montip, Gordon, Perry, Groessl, Todd, Kato, Nobutaka, Lee, Marcus C. S., McNamara, Case W., Fidock, David A., Nagle, Advait, Nam, Tae-gyu, Richmond, Wendy, Roland, Jason, Rottmann, Matthias, Zhou, Bin, Froissard, Patrick, Glynne, Richard J., Mazier, Dominique, Sattabongkot, Jetsumon, Schultz, Peter G., Tuntland, Tove, Walker, John R., Zhou, Yingyao, Chatterjee, Arnab, Diagana, Thierry T., Winzeler, Elizabeth A.
Published in Science (American Association for the Advancement of Science) (09.12.2011)
Published in Science (American Association for the Advancement of Science) (09.12.2011)
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Guide Swap enables genome-scale pooled CRISPR–Cas9 screening in human primary cells
Ting, Pamela Y., Parker, Albert E., Lee, J. Scott, Trussell, Chris, Sharif, Orzala, Luna, Fabio, Federe, Glenn, Barnes, S. Whitney, Walker, John R., Vance, Julie, Gao, Mu-Yun, Klock, Heath E., Clarkson, Scott, Russ, Carsten, Miraglia, Loren J., Cooke, Michael P., Boitano, Anthony E., McNamara, Peter, Lamb, John, Schmedt, Christian, Snead, Jennifer L.
Published in Nature methods (01.11.2018)
Published in Nature methods (01.11.2018)
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A high-throughput cigarette smoke-treated bronchosphere model for disease-relevant phenotypic compound screening
Beri, Pranjali, Woo, Young Jae, Schierenbeck, Katie, Chen, Kaisheng, Barnes, S Whitney, Ross, Olivia, Krutil, Douglas, Quackenbush, Doug, Fang, Bin, Walker, John, Barnes, William, Toyama, Erin Quan
Published in PloS one (29.06.2023)
Published in PloS one (29.06.2023)
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In vitro selection, via serial passage, of Clostridium difficile mutants with reduced susceptibility to fidaxomicin or vancomycin
Leeds, Jennifer A, Sachdeva, Meena, Mullin, Steve, Barnes, S Whitney, Ruzin, Alexey
Published in Journal of antimicrobial chemotherapy (01.01.2014)
Published in Journal of antimicrobial chemotherapy (01.01.2014)
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"3D, human renal proximal tubule (RPTEC-TERT1) organoids 'tubuloids' for translatable evaluation of nephrotoxins in high-throughput"
Vidal Yucha, Sarah E, Quackenbush, Doug, Chu, Tiffany, Lo, Frederick, Sutherland, Jeffrey J, Kuzu, Guray, Roberts, Christopher, Luna, Fabio, Barnes, S Whitney, Walker, John, Kuss, Pia
Published in PloS one (21.11.2022)
Published in PloS one (21.11.2022)
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A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction
Ting, Pamela Y, Borikar, Sneha, Kerrigan, John Ryan, Thomsen, Noel M, Aghania, Eamon, Hinman, Amelia E, Reyes, Alejandro, Pizzato, Nicolas, Fodor, Barna D, Wu, Fabian, Belew, Muluken S, Mao, Xiaohong, Wang, Jian, Chitnis, Shripad, Niu, Wei, Hachey, Amanda, Cobb, Jennifer S, Savage, Nikolas A, Burke, Ashley, Paulk, Joshiawa, Dovala, Dustin, Lin, James, Clifton, Matthew C, Ornelas, Elizabeth, Ma, Xiaolei, Ware, Nathaniel F, Sanchez, Carina C, Taraszka, John, Terranova, Remi, Knehr, Judith, Altorfer, Marc, Barnes, S Whitney, Beckwith, Rohan E J, Solomon, Jonathan M, Dales, Natalie A, Patterson, Andrew W, Wagner, Jürgen, Bouwmeester, Tewis, Dranoff, Glenn, Stevenson, Susan C, Bradner, James E
Published in Science (American Association for the Advancement of Science) (05.07.2024)
Published in Science (American Association for the Advancement of Science) (05.07.2024)
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A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
Pethe, Kevin, Sequeira, Patricia C, Agarwalla, Sanjay, Rhee, Kyu, Kuhen, Kelli, Phong, Wai Yee, Patel, Viral, Beer, David, Walker, John R, Duraiswamy, Jeyaraj, Jiricek, Jan, Keller, Thomas H, Chatterjee, Arnab, Tan, Mai Ping, Ujjini, Manjunatha, Rao, Srinivasa P.S, Camacho, Luis, Bifani, Pablo, Mak, Puiying A, Ma, Ida, Barnes, S. Whitney, Chen, Zhong, Plouffe, David, Thayalan, Pamela, Ng, Seow Hwee, Au, Melvin, Lee, Boon Heng, Tan, Bee Huat, Ravindran, Sindhu, Nanjundappa, Mahesh, Lin, Xiuhua, Goh, Anne, Lakshminarayana, Suresh B, Shoen, Carolyn, Cynamon, Michael, Kreiswirth, Barry, Dartois, Veronique, Peters, Eric C, Glynne, Richard, Brenner, Sydney, Dick, Thomas
Published in Nature communications (01.08.2010)
Published in Nature communications (01.08.2010)
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Mutations Reducing In Vitro Susceptibility to Novel LpxC Inhibitors in Pseudomonas aeruginosa and Interplay of Efflux and Nonefflux Mechanisms
Jones, Adriana K, Caughlan, Ruth E, Woods, Angela L, Uehara, Kyoko, Xie, Lili, Barnes, S Whitney, Walker, John R, Thompson, Katherine V, Ranjitkar, Srijan, Lee, Patrick S, Dean, Charles R
Published in Antimicrobial agents and chemotherapy (20.12.2019)
Published in Antimicrobial agents and chemotherapy (20.12.2019)
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Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease
Khare, Shilpi, Roach, Steven L, Barnes, S Whitney, Hoepfner, Dominic, Walker, John R, Chatterjee, Arnab K, Neitz, R Jeffrey, Arkin, Michelle R, McNamara, Case W, Ballard, Jaime, Lai, Yin, Fu, Yue, Molteni, Valentina, Yeh, Vince, McKerrow, James H, Glynne, Richard J, Supek, Frantisek
Published in PLoS pathogens (01.07.2015)
Published in PLoS pathogens (01.07.2015)
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Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes
Dharia, Neekesh V., Bright, A. Taylor, Westenberger, Scott J., Barnes, S. Whitney, Batalov, Serge, Kuhen, Kelli, Borboa, Rachel, Federe, Glenn C., McClean, Colleen M., Vinetz, Joseph M., Neyra, Victor, Llanos-Cuentas, Alejandro, Barnwell, John W., Walker, John R., Winzeler, Elizabeth A., James, Anthony A.
Published in Proceedings of the National Academy of Sciences - PNAS (16.11.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (16.11.2010)
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Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies
Daley, Stephen R, Coakley, Kristen M, Hu, Daniel Y, Randall, Katrina L, Jenne, Craig N, Limnander, Andre, Myers, Darienne R, Polakos, Noelle K, Enders, Anselm, Roots, Carla, Balakishnan, Bhavani, Miosge, Lisa A, Sjollema, Geoff, Bertram, Edward M, Field, Matthew A, Shao, Yunli, Andrews, T Daniel, Whittle, Belinda, Barnes, S Whitney, Walker, John R, Cyster, Jason G, Goodnow, Christopher C, Roose, Jeroen P
Published in eLife (12.12.2013)
Published in eLife (12.12.2013)
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Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression
Ranjitkar, Srijan, Jones, Adriana K, Mostafavi, Mina, Zwirko, Zachary, Iartchouk, Oleg, Barnes, S Whitney, Walker, John R, Willis, Thomas W, Lee, Patrick S, Dean, Charles R
Published in Antimicrobial agents and chemotherapy (01.02.2019)
Published in Antimicrobial agents and chemotherapy (01.02.2019)
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Genome-Wide Single-Nucleotide Polymorphism Analysis Defines Haplotype Patterns in Mouse
Wiltshire, Tim, Pletcher, Mathew T., Batalov, Serge, Barnes, S. Whitney, Tarantino, Lisa M., Cooke, Michael P., Wu, Hua, Smylie, Kevin, Santrosyan, Andrey, Copeland, Neal G., Jenkins, Nancy A., Kalush, Francis, Mural, Richard J., Glynne, Richard J., Kay, Steve A., Adams, Mark D., Fletcher, Colin F.
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.2003)
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Coresistance to Isoniazid and Ethionamide Maps to Mycothiol Biosynthetic Genes in Mycobacterium bovis
VILCHEZE, Catherine, AV-GAY, Yossef, WHITNEY BARNES, S, LARSEN, Michelle H, WALKER, John R, GLYNNE, Richard J, JACOBS, William R
Published in Antimicrobial Agents and Chemotherapy (01.09.2011)
Published in Antimicrobial Agents and Chemotherapy (01.09.2011)
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A high throughput cell stretch device for investigating mechanobiology in vitro
Pratt, Stephen J. P., Plunkett, Christopher M., Kuzu, Guray, Trinh, Ton, Barbara, Joshua, Choconta, Paula, Quackenbush, Doug, Huynh, Truc, Smith, Anders, Barnes, S. Whitney, New, Joel, Pierce, James, Walker, John R., Mainquist, James, King, Frederick J., Elliott, Jimmy, Hammack, Scott, Decker, Rebekah S.
Published in APL bioengineering (01.06.2024)
Published in APL bioengineering (01.06.2024)
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A high-throughput 3D cantilever array to model airway smooth muscle hypercontractility in asthma
Beri, Pranjali, Plunkett, Christopher, Barbara, Joshua, Shih, Chien-Cheng, Barnes, S. Whitney, Ross, Olivia, Choconta, Paula, Trinh, Ton, Gomez, Datzael, Litvin, Bella, Walker, John, Qiu, Minhua, Hammack, Scott, Toyama, Erin Quan
Published in APL bioengineering (01.06.2023)
Published in APL bioengineering (01.06.2023)
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Journal Article
Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse
Pletcher, Mathew T, McClurg, Philip, Batalov, Serge, Su, Andrew I, Barnes, S Whitney, Lagler, Erica, Korstanje, Ron, Wang, Xiaosong, Nusskern, Deborah, Bogue, Molly A, Mural, Richard J, Paigen, Beverly, Wiltshire, Tim
Published in PLoS biology (01.12.2004)
Published in PLoS biology (01.12.2004)
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Mechanisms Decreasing In Vitro Susceptibility to the LpxC Inhibitor CHIR-090 in the Gram-Negative Pathogen Pseudomonas aeruginosa
CAUGHLAN, Ruth E, JONES, Adriana K, DEAN, Charles R, DELUCIA, Angela M, WOODS, Angela L, LILI XIE, BING MA, BARNES, S. Whitney, WALKER, John R, SPRAGUE, Elizabeth R, XIA YANG
Published in Antimicrobial Agents and Chemotherapy (01.01.2012)
Published in Antimicrobial Agents and Chemotherapy (01.01.2012)
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Journal Article
Identification of elongation factor G as the conserved cellular target of argyrin B
Nyfeler, Beat, Hoepfner, Dominic, Palestrant, Deborah, Kirby, Christina A, Whitehead, Lewis, Yu, Robert, Deng, Gejing, Caughlan, Ruth E, Woods, Angela L, Jones, Adriana K, Barnes, S Whitney, Walker, John R, Gaulis, Swann, Hauy, Ervan, Brachmann, Saskia M, Krastel, Philipp, Studer, Christian, Riedl, Ralph, Estoppey, David, Aust, Thomas, Movva, N Rao, Wang, Zuncai, Salcius, Michael, Michaud, Gregory A, McAllister, Gregory, Murphy, Leon O, Tallarico, John A, Wilson, Christopher J, Dean, Charles R
Published in PloS one (10.09.2012)
Published in PloS one (10.09.2012)
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